Zhifu Sun, MD, MS

  • 4557 Citations
  • 35 Scopus h-Index
20042020

Research output per year

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Research Output

2020

MCAM abnormal expression and clinical outcome associations are highly cancer dependent as revealed through pan-cancer analysis

An, Y., Wei, N., Cheng, X., Li, Y., Liu, H., Wang, J., Xu, Z., Sun, Z. & Zhang, X., Mar 23 2020, In : Briefings in bioinformatics. 21, 2, p. 709-718 10 p.

Research output: Contribution to journalReview article

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis

Liu, H., Zhang, B. & Sun, Z., Jan 1 2020, In : Cancer Communications. 40, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

Open Access
2019

Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway

Song, Y. A., Ma, T., Zhang, X. Y., Cheng, X. S., Olajuyin, A. M., Sun, Z. D. & Zhang, X. J., May 2 2019, In : Cancer Cell International. 19, 1, 117.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Apatinib reverses paclitaxel-resistant lung cancer cells (A549) through blocking the function of ABCB1 transporter

Zhang, Q., Song, Y., Cheng, X., Xu, Z., Matthew, O. A., Wang, J., Sun, Z. & Zhang, X., Jan 1 2019, In : Anticancer research. 39, 10, p. 5461-5471 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Association between ALS and retroviruses: Evidence from bioinformatics analysis

Klein, J. P., Sun, Z. & Staff, N. P., Dec 20 2019, In : BMC bioinformatics. 20, 680.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Discovery, validation, and application of novel methylated DNA markers for detection of esophageal cancer in plasma

Qin, Y., Wu, C. W., Taylor, W. R., Sawas, T., Burger, K. N., Mahoney, D. W., Sun, Z., Yab, T. C., Lidgard, G. P., Allawi, H. T., Buttar, N. S., Smyrk, T. C., Iyer, P. G., Katzka, D. A., Ahlquist, D. A. & Kisiel, J. B., Dec 15 2019, In : Clinical Cancer Research. 25, 24, p. 7396-7403 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Ankam, S., Rovini, A., Baheti, S., Hrstka, R., Wu, Y., Schmidt, K., Wang, H., Madigan, N., Koenig, L. S., Stelzig, K., Resch, Z., Klein, C. J., Sun, Z. & Staff, N. P., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

Open Access

Predict drug sensitivity of cancer cells with pathway activity inference

Wang, X., Sun, Z. D., Zimmermann, M. T., Bugrim, A. & Kocher, J-P., Jan 31 2019, In : BMC Medical Genomics. 12, 15.

Research output: Contribution to journalArticle

4 Scopus citations

Use of FFPE-derived DNA in next generation sequencing: DNA extraction methods

Mcdonough, S. J., Bhagwate, A., Sun, Z., Wang, C., Zschunke, M., Gorman, J. A., Kopp, K. J. & Cunninghamid, J. M., Apr 1 2019, In : PloS one. 14, 4, e0211400.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Androgen Mediation—and Antiandrogens Mitigation—of the Epidermal Growth Factor Receptor (EGFR) Inhibitor–Induced Rash: Results From a Pilot Randomized Trial and Small Translational Case Series

Le-Rademacher, J., Rowland, K., Atherton, P. J., Dakhil, C., Sun, Z., Tan, A., Schmidt, L., Nguyen, P. L., Radecki Breitkopf, C., Pittelkow, M., Tindall, D., Menon, S. & Jatoi, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hospice and Palliative Medicine.

Research output: Contribution to journalArticle

Contraction of T cell richness in lung cancer brain metastases

Mansfield, A., Ren, H., Sutor, S., Sarangi, V., Nair, A., Davila, J., Elsbernd, L. R., Udell, J. B., Dronca, R. S., Park, S. S., Markovic, S. N., Sun, Z. D., Halling, K. C., Nevala, W. K., Aubry, M. C., Dong, H. M. & Jen, J., Dec 1 2018, In : Scientific Reports. 8, 1, 2171.

Research output: Contribution to journalArticle

21 Scopus citations

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Lomberk, G., Blum, Y., Nicolle, R., Nair, A., Gaonkar, K. S., Marisa, L., Mathison, A., Sun, Z., Yan, H., Elarouci, N., Armenoult, L., Ayadi, M., Ordog, T., Lee, J. H., Oliver, G., Klee, E., Moutardier, V., Gayet, O., Bian, B., Duconseil, P. & 13 others, Gilabert, M., Bigonnet, M., Garcia, S., Turrini, O., Delpero, J. R., Giovannini, M., Grandval, P., Gasmi, M., Secq, V., De Reyniès, A., Dusetti, N., Iovanna, J. & Urrutia, R., Dec 1 2018, In : Nature communications. 9, 1, 1978.

Research output: Contribution to journalArticle

34 Scopus citations

Erratum: Author Correction: UClncR: Ultrafast and comprehensive long non-coding RNA detection from RNA-seq (Scientific reports (2017) 7 1 (14196))

Sun, Z., Nair, A., Chen, X., Prodduturi, N., Wang, J. & Kocher, J. P., Mar 20 2018, In : Scientific reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements

Luchtel, R. A., Dasari, S., Oishi, N., Pedersen, M. B., Hu, G., Rech, K. L., Ketterling, R. P., Sidhu, J., Wang, X., Katoh, R., Dogan, A., Kip, N. S., Cunningham, J. M., Sun, Z., Baheti, S., Porcher, J. C., Said, J. W., Jiang, L., Hamilton-Dutoit, S. J., Møller, M. B. & 10 others, Nørgaard, P., Bennani, N. N., Chng, W. J., Huang, G., Link, B. K., Facchetti, F., Cerhan, J. R., D’Amore, F., Ansell, S. M. & Feldman, A. L., Sep 27 2018, In : Blood. 132, 13, p. 1386-1398 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Nomogram prediction of overall survival for patients with non-small-cell lung cancer incorporating pretreatment peripheral blood markers

Xie, D., Allen, M. S., Marks, R., Jiang, G., Sun, Z., Nichols, F., Zhang, M., Chen, C., Aubry, M. C., Jatoi, A., Garces, Y. I., Mansfield, A., Wigle, D., Molina, J., Deschamps, C. & Yang, P., Jun 1 2018, In : European Journal of Cardio-Thoracic Surgery. 53, 6, p. 1214-1222 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pathways impacted by genomic alterations in pulmonary carcinoid tumors

Asiedu, M. K., Thomas, C. F., Dong, J., Schulte, S. C., Khadka, P., Sun, Z. D., Kosari, F., Jen, J., Molina, J. R., Vasmatzis, G., Kuang, R., Aubry, M. C., Yang, P. & Wigle, D. A., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1691-1704 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Statistical method evaluation for differentially methylated CpGs in base resolution next-generation DNA sequencing data

Zhang, Y., Baheti, S. & Sun, Z. D., May 1 2018, In : Briefings in Bioinformatics. 19, 3, p. 374-386 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Adipose tissue DNA methylome changes in development of new-onset diabetes after kidney transplantation

Baheti, S., Singh, P., Zhang, Y., Evans, J., Jensen, M. D., Somers, V., Kocher, J-P., Sun, Z. D. & Chakkera, H. M., Nov 1 2017, In : Epigenomics. 9, 11, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comprehensive genomic profiling of a rare thyroid follicular dendritic cell sarcoma

Davila, J. I., Starr, J. S., Attia, S., Wang, C., Knudson, R. A., Necela, B. M., Sarangi, V., Sun, Z. D., Ren, Y., Casler, J. D., Menke, D. M., Oliver, G. R., Joseph, R. W., Copland, J. A. III., Parker, A., Kocher, J-P., Thompson, E. A., Smallridge, R. C. & Asmann, Y., Sep 15 2017, In : Rare Tumors. 9, 2, p. 50-53 4 p., 6834.

Research output: Contribution to journalArticle

1 Scopus citations

Comprehensive profiling of lincRNAs in lung adenocarcinoma of never smokers reveals their roles in cancer development and prognosis

Li, Y., Wang, Z., Nair, A., Song, W., Yang, P., Zhang, X. & Sun, Z. D., Nov 13 2017, In : Genes. 8, 11, 321.

Research output: Contribution to journalArticle

4 Scopus citations

Genetic predisposition to lung cancer: Comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies

Wang, J., Liu, Q., Yuan, S., Xie, W., Liu, Y., Xiang, Y., Wu, N., Wu, L., Ma, X., Cai, T., Zhang, Y., Sun, Z. D. & Li, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 8371.

Research output: Contribution to journalArticle

25 Scopus citations

Indel detection from RNA-seq data: Tool evaluation and strategies for accurate detection of actionable mutations

Sun, Z. D., Bhagwate, A., Prodduturi, N., Yang, P. & Kocher, J-P., Nov 1 2017, In : Briefings in Bioinformatics. 18, 6, p. 973-983 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

Sarmento, O. F., Svingen, P. A., Xiong, Y., Sun, Z. D., Bamidele, A. O., Mathison, A. J., Smyrk, T. C., Nair, A. A., Gonzalez, M. M., Sagstetter, M. R., Baheti, S., McGovern, D. P. B., Friton, J. J., Papadakis, K., Gautam, G., Xavier, R. J., Urrutia, R. A. & Faubion, W. A., Jan 13 2017, In : Journal of Biological Chemistry. 292, 2, p. 706-722 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

UClncR: Ultrafast and comprehensive long non-coding RNA detection from RNA-seq

Sun, Z. D., Nair, A., Chen, X., Prodduturi, N., Wang, J. & Kocher, J-P., Dec 1 2017, In : Scientific Reports. 7, 1, 14196.

Research output: Contribution to journalArticle

11 Scopus citations
2016

A genetic cell context-dependent role for ZEB1 in lung cancer

Zhang, T., Guo, L., Creighton, C. J., Lu, Q., Gibbons, D. L., Yi, E. S., Deng, B., Molina, J. R., Sun, Z. D., Yang, P. & Yang, Y. D., Jul 26 2016, In : Nature Communications. 7, 12231.

Research output: Contribution to journalArticle

31 Scopus citations

ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: Progresses and future directions

Yan, H. D., Tian, S., Slager, S. L. & Sun, Z. D., Sep 1 2016, In : Epigenomics. 8, 9, p. 1239-1258 20 p.

Research output: Contribution to journalReview article

8 Scopus citations

Custom gene capture and next-generation sequencing to resolve discordant ALK status by FISH and IHC in lung adenocarcinoma

Jang, J. S., Wang, X., Vedell, P. T., Wen, J., Zhang, J., Ellison, D. W., Evans, J. M., Johnson, S. H., Yang, P., Sukov, W. R., Oliveir, A. M., Vasmatzis, G., Sun, Z. D., Jen, J. & Yi, E. S., Nov 13 2016, In : Journal of Thoracic Oncology. 11, 11, p. 1891-1900 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China

Wu, G., Liu, X., Liu, S., Shu, J., Sun, Z. D. & Luo, B., May 1 2016, In : Intervirology. 58, 6, p. 386-392 7 p.

Research output: Contribution to journalArticle

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci

Allen, M., Burgess, J. D., Ballard, T., Serie, D., Wang, X., Younkin, C. S., Sun, Z., Kouri, N., Baheti, S., Wang, C., Carrasquillo, M. M., Nguyen, T., Lincoln, S., Malphrus, K., Murray, M., Golde, T. E., Price, N. D., Younkin, S. G., Schellenberg, G. D., Asmann, Y. & 4 others, Ordog, T., Crook, J., Dickson, D. & Ertekin-Taner, N., Aug 1 2016, In : Acta neuropathologica. 132, 2, p. 197-211 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies

Yan, H. D., Tian, S., Slager, S. L., Sun, Z. D. & Ordog, T., Jan 15 2016, In : American Journal of Epidemiology. 183, 2, p. 96-109 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Long noncoding and circular RNAs in lung cancer: Advances and perspectives

Xie, W., Yuan, S., Sun, Z. D. & Li, Y., Sep 1 2016, In : Epigenomics. 8, 9, p. 1275-1287 13 p.

Research output: Contribution to journalReview article

39 Scopus citations

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

Lee, S. B., She, J., Deng, B., Kim, J. J., De Andrade, M., Na, J., Sun, Z. D., Wampfler, J. A., Cunningham, J. M., Wu, Y., Limper, A. H., Aubry, M. C., Wendt, C., Biterman, P., Yang, P. & Lou, Z., 2016, In : Oncotarget. 7, 28, p. 44211-44223 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery

White, W. M., Sun, Z. D., Borowski, K. S., Brost, B. C., Davies, N. P., Rose, C. H. & Garovic, V. D., Apr 11 2016, (Accepted/In press) In : Hypertension in Pregnancy. p. 1-11 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeted alignment and end repair elimination increase alignment and methylation measure accuracy for reduced representation bisulfite sequencing data

Baheti, S., Kanwar, R., Goelzenleuchter, M., Kocher, J. P. A., Beutler, A. S. & Sun, Z., Feb 27 2016, In : BMC genomics. 17, 1, 149.

Research output: Contribution to journalArticle

X chromosome abnormal inactivation: A unique factor for women's diseases?

Wu, C. & Sun, Z. D., Apr 1 2016, In : Epigenomics. 8, 4, p. 447-450 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015
40 Scopus citations

Chromosome X genomic and epigenomic aberrations and clinical implications in breast cancer by base resolution profiling

Sun, Z. D., Prodduturi, N., Sun, S. Y., Thompson, E. A. & Kocher, J-P., Oct 1 2015, In : Epigenomics. 7, 7, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Common oncogene mutations and novel SND1-BRAF transcript fusion in lung adenocarcinoma from never smokers

Jang, J. S., Lee, A., Li, J., Liyanage, H., Yang, Y. D., Guo, L., Asmann, Y., Li, P. W., Erickson-Johnson, M., Sakai, Y., Sun, Z. D., Jeon, H. S., Hwang, H., Bungum, A. O., Edell, E., Simon, V. A., Kopp, K. J., Eckloff, B., Oliveira, A. M., Wieben, E. D. & 6 others, Aubry, M. C., Yi, E., Wigle, D. A., Diasio, R. B., Yang, P. & Jen, J., May 18 2015, In : Scientific Reports. 5, 9755.

Research output: Contribution to journalArticle

26 Scopus citations

Correction: Folate receptor-α (FOLR1) expression and function in triple negative tumors

Necela, B. M., Crozier, J. A., Andorfer, C. A., Lewis-Tuffin, L., Kachergus, J. M., Geiger, X. J., Kalari, K. R., Serie, D. J., Sun, Z., Moreno Aspitia, A., O'Shannessy, D. J., Maltzman, J. D., McCullough, A. E., Pockaj, B. A., Cunliffe, H. E., Ballman, K. V., Thompson, E. A. & Perez, E. A., Apr 30 2015, In : PLoS One. 10, 4, e0127133.

Research output: Contribution to journalArticle

4 Scopus citations

CpGFilter: Model-based CpG probe filtering with replicates for epigenome-wide association studies

Chen, J., Just, A. C., Schwartz, J., Hou, L., Jafari, N., Sun, Z. D., Kocher, J-P., Baccarelli, A. & Lin, X., Apr 23 2015, In : Bioinformatics. 32, 3, p. 469-471 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

DNA methylation and RNA expression profiles in lung adenocarcinomas of never-smokers

Mansfield, A., Wang, L., Cunningham, J. M., Jen, J., Kolbert, C. P., Sun, Z. D. & Yang, P., May 1 2015, In : Cancer genetics. 208, 5, p. 253-260 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

DNA methylation profiling: Comparison of genome-wide sequencing methods and the Infinium Human Methylation 450 Bead Chip

Walker, D. L., Bhagwate, A. V., Baheti, S., Smalley, R. L., Hilker, C. A., Sun, Z. D. & Cunningham, J. M., Dec 1 2015, In : Epigenomics. 7, 8, p. 1287-1302 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer

Huang, X., Yuan, T., Liang, M., Du, M., Xia, S., Dittmar, R., Wang, D., See, W., Costello, B. A., Quevedo, F., Tan, W., Nandy, D., Bevan, G. H., Longenbach, S., Sun, Z., Lu, Y., Wang, T., Thibodeau, S. N., Boardman, L., Kohli, M. & 1 others, Wang, L., Jan 1 2015, In : European urology. 67, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

246 Scopus citations

Folate receptor-a (FOLR1) expression and function in triple negative tumors

Necela, B. M., Crazier, J. A., Andorfer, C. A., Lewis-Tuffin, L., Kachergus, J. M., Geiger, X. J., Kalari, K. R., Serie, D. J., Sun, Z. D., Aspita, A. M., O'Shannessy, D. J., Maltzman, J. D., McCullough, A. E., Pockaj, B. A., Cunliffe, H. E., Ballman, K. V., Thompson, E. A. & Perez, E. A., Mar 27 2015, In : PLoS One. 10, 3, e0122209.

Research output: Contribution to journalArticle

50 Scopus citations

Folate receptor-α (FOLR1) expression and function in triple negative tumors

Necela, B. M., Crozier, J. A., Andorfer, C. A., Lewis-Tuffin, L., Kachergus, J. M., Geiger, X. J., Kalari, K. R., Serie, D. J., Sun, Z. D., Aspita, A. M., O'Shannessy, D. J., Maltzman, J. D., McCullough, A. E., Pockaj, B. A., Cunliffe, H. E., Ballman, K. V., Thompson, E. A. & Perez, E. A., Mar 27 2015, In : PLoS One. 10, 3, e0122209.

Research output: Contribution to journalArticle

4 Scopus citations

LncRNA MALAT1 enhances oncogenic activities of EZH2 in castrationresistant prostate cancer

Wang, D., Ding, L., Wang, L., Zhao, Y., Sun, Z., Karnes, R. J., Zhang, J. & Huang, H., Jan 1 2015, In : Oncotarget. 6, 38, p. 41045-41055 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

New DNA methylation markers for pancreatic cancer: Discovery, tissue validation, and pilot testing in pancreatic juice

Kisiel, J. B., Raimondo, M., Taylor, W. R., Yab, T. C., Mahoney, W. D., Sun, Z. D., Middha, S., Baheti, S., Zou, H., Smyrk, T. C., Boardman, L. A., Petersen, G. M. & Ahlquist, D. A., Oct 1 2015, In : Clinical Cancer Research. 21, 19, p. 4473-4481 9 p.

Research output: Contribution to journalArticle

57 Scopus citations