Yuri Ann Saito Loftus, MD MPH

Former affiliation
  • 2958 Citations
  • 26 Scopus h-Index
20002019
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Research Output 2000 2019

  • 2958 Citations
  • 26 Scopus h-Index
  • 57 Article
  • 6 Chapter
  • 2 Book
  • 1 Editorial
Article
9 Citations (Scopus)

A case-control comparison of direct healthcare-provider medical costs of chronic idiopathic constipation and irritable bowel syndrome with constipation in a community-based cohort

Herrick, L. M., Spalding, W. M., Saito Loftus, Y. A., Moriarty, J. & Schleck, C., Nov 10 2016, (Accepted/In press) In : Journal of Medical Economics. p. 1-7 7 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Constipation
Health Personnel
Costs and Cost Analysis
Outpatients
15 Citations (Scopus)

A case-control study of childhood trauma in the development of irritable bowel syndrome

Halland, M., Almazar, A., Lee, R., Atkinson, E., Larson, J., Talley, N. J. & Saito Loftus, Y. A., 2014, In : Neurogastroenterology and Motility. 26, 7, p. 990-998 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
Wounds and Injuries
Odds Ratio
Self Report
183 Citations (Scopus)

A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome

Saito Loftus, Y. A., Locke, G. R., Talley, N. J., Zinsmeister, A. R., Fett, S. L. & Melton, L. J., 2000, In : American Journal of Gastroenterology. 95, 10, p. 2816-2824 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Defecation
Cross-Sectional Studies
Gastroenterology
Epidemiologic Studies
55 Citations (Scopus)

A genetic association study of 5-HTT LPR and GNβ3 C825T polymorphisms with irritable bowel syndrome

Saito Loftus, Y. A., Locke, G. R., Zimmerman, J. M., Holtmann, G., Slusser, J. P., De Andrade, M., Petersen, G. M. & Talley, N. J., Jun 2007, In : Neurogastroenterology and Motility. 19, 6, p. 465-470 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genetic Association Studies
Gene Frequency
Outpatients
Genotype
3 Citations (Scopus)

AJG series: Molecular biology for clinicians

Saito Loftus, Y. A. & Talley, N. J., Oct 2009, In : American Journal of Gastroenterology. 104, 10, p. 2583-2587 5 p.

Research output: Contribution to journalArticle

Molecular Biology
Pharmaceutical Preparations
Pharmacogenetics
Genetic Code
Gastrointestinal Diseases
32 Citations (Scopus)

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

for the ACG Task Force on Management of Irritable Bowel Syndrome, Jun 27 2018, (Accepted/In press) In : American Journal of Gastroenterology. p. 1-18 18 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gastroenterology
308 Citations (Scopus)

American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation

Ford, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Quigley, E. M. M., 2014, In : American Journal of Gastroenterology. 109, SUPPL. 1

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gastroenterology
Constipation
Chronic Disease
29 Citations (Scopus)

A randomized, double-blind, placebo-controlled trial of st john's wort for treating irritable bowel syndrome

Saito Loftus, Y. A., Rey, E., Almazar-Elder, A. E., Harmsen, W. S., Zinsmeister, A. R., Locke, G. R. & Talley, N. J., Jan 2010, In : American Journal of Gastroenterology. 105, 1, p. 170-177 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Placebos
Constipation
Therapeutics
Antidepressive Agents
5 Citations (Scopus)
Receptor, Serotonin, 5-HT2A
Irritable Bowel Syndrome
Threonine
Genetic Predisposition to Disease
Gene Frequency
27 Citations (Scopus)

A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome

Dionne, J., Ford, A. C., Yuan, Y., Chey, W. D., Lacy, B. E., Saito Loftus, Y. A., Quigley, E. M. M. & Moayyedi, P., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Gluten-Free Diet
Irritable Bowel Syndrome
Meta-Analysis
Diet
Monosaccharides
20 Citations (Scopus)
Gastrointestinal Diseases
Genetic Association Studies
Genotype
Disease Susceptibility
Genes

Celiac disease is uncommon in irritable bowel syndrome in the USA

Almazar, A. E., Talley, N. J., Larson, J. J., Atkinson, E. J., Murray, J. A. & Saito Loftus, Y. A., Jan 1 2018, In : European Journal of Gastroenterology and Hepatology. 30, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Celiac Disease
Antibodies
Genetic Testing
Indirect Fluorescent Antibody Technique
16 Citations (Scopus)

Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria

Hellström, P. M., Saito Loftus, Y. A., Bytzer, P., Tack, J., Mueller-Lissner, S. & Chang, L., Jul 2011, In : American Journal of Gastroenterology. 106, 7, p. 1299-1307 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Acute Pain
Pain
Defecation
Constipation
5 Citations (Scopus)

Clinical application of pharmacogenetics in gastrointestinal diseases

Saito Loftus, Y. A. & Camilleri, M., Oct 2006, In : Expert Opinion on Pharmacotherapy. 7, 14, p. 1857-1869 13 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Pharmacogenetics
Gastroenterology
Irritable Bowel Syndrome
Dyspepsia
71 Citations (Scopus)

Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

Choung, R. S., Ruff, K. C., Malhotra, A., Herrick, L., Locke, G. R., Harmsen, W. S., Zinsmeister, A. R., Talley, N. J. & Saito Loftus, Y. A., May 2011, In : Alimentary Pharmacology and Therapeutics. 33, 9, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Steatorrhea
Diverticulum
Narcotics
Inflammatory Bowel Diseases

Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture: Authors' reply

Saito Loftus, Y. A., Choung, R. S., Zinsmeister, A. R. & Talley, N. J., Jun 2011, In : Alimentary Pharmacology and Therapeutics. 33, 12, p. 1379-1380 2 p.

Research output: Contribution to journalArticle

Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome

Almazar, A. E., Chang, J. Y., Larson, J. J., Atkinson, E. J., Locke, G. R., Talley, N. J. & Saito Loftus, Y. A., Jun 16 2018, (Accepted/In press) In : Journal of Clinical Gastroenterology.

Research output: Contribution to journalArticle

Lactase
Irritable Bowel Syndrome
Self Report
Breath Tests
Methane
114 Citations (Scopus)

Diet and functional gastrointestinal disorders: A population-based case-control study

Saito Loftus, Y. A., Locke, G. R., Weaver, A. L., Zinsmeister, A. R. & Talley, N. J., Dec 2005, In : American Journal of Gastroenterology. 100, 12, p. 2743-2748 6 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Case-Control Studies
Diet
Food
Population

Early Infections and the Risk of Irritable Bowel Syndrome: A Case-Control Study

Krajicek, E. J., Almazar, A. E., Larson, J. J., Atkinson, E. J., Talley, N. J. & Saito Loftus, Y. A., Jun 21 2017, (Accepted/In press) In : Journal of Clinical Gastroenterology.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
Infection
Bronchitis
Odds Ratio
111 Citations (Scopus)

Effect of amitriptyline and escitalopram on functional dyspepsia: A multicenter, randomized controlled study

Talley, N. J., Richard Locke, G., Saito Loftus, Y. A., Almazar, A. E., Bouras, E. P., Howden, C. W., Lacy, B. E., Dibaise, J. K., Prather, C. M., Abraham, B. P., El-Serag, H. B., Moayyedi, P., Herrick, L. M., Szarka, L., Camilleri, M., Hamilton, F. A., Schleck, C. D., Tilkes, K. E. & Zinsmeister, A. R., Aug 1 2015, In : Gastroenterology. 149, 2, p. 340-349.e2

Research output: Contribution to journalArticle

Citalopram
Amitriptyline
Dyspepsia
Gastric Emptying
Antidepressive Agents
237 Citations (Scopus)

Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis.

Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Moayyedi, P., 2014, In : The American journal of gastroenterology. 109, 9

Research output: Contribution to journalArticle

Hypnosis
Irritable Bowel Syndrome
Antidepressive Agents
Meta-Analysis
Psychology
4 Citations (Scopus)

Effects of Amitriptyline and Escitalopram on Sleep and Mood in Patients With Functional Dyspepsia

Herrick, L. M., Camilleri, M., Schleck, C. D., Zinsmeister, A. R., Saito Loftus, Y. A. & Talley, N. J., Mar 1 2018, In : Clinical Gastroenterology and Hepatology. 16, 3, p. 401-406.e2

Research output: Contribution to journalArticle

Citalopram
Amitriptyline
Dyspepsia
Sleep
Antidepressive Agents
7 Citations (Scopus)

Effects of antidepressants on gastric function in patients with functional dyspepsia

Lacy, B. E., Saito Loftus, Y. A., Camilleri, M., Bouras, E., DiBaise, J. K., Herrick, L. M., Szarka, L., Tilkes, K., Zinsmeister, A. R. & Talley, N. J., Feb 1 2018, In : American Journal of Gastroenterology. 113, 2, p. 216-224 9 p.

Research output: Contribution to journalArticle

Dyspepsia
Gastric Emptying
Antidepressive Agents
Stomach
Amitriptyline
48 Citations (Scopus)

Effects of multidisciplinary education on outcomes in patients with irritable bowel syndrome

Saito Loftus, Y. A., Prather, C. M., Van Dyke, C. T., Fett, S., Zinsmeister, A. R. & Locke, G. R., Jul 2004, In : Clinical Gastroenterology and Hepatology. 2, 7, p. 576-584 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Education
Patient Acceptance of Health Care
Life Style
Health
322 Citations (Scopus)

Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis

Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Moayyedi, P., Oct 1 2014, In : The American journal of gastroenterology. 109, 10, p. 1547-1562 16 p.

Research output: Contribution to journalArticle

Synbiotics
Prebiotics
Irritable Bowel Syndrome
Probiotics
Constipation
64 Citations (Scopus)

Familial aggregation of irritable bowel syndrome: A family case-control study

Saito Loftus, Y. A., Petersen, G. M., Larson, J. J., Atkinson, E. J., Fridley, B. L., De Andrade, M., Locke, G. R., Zimmerman, J. M., Almazar-Elder, A. E. & Talley, N. J., Apr 2010, In : American Journal of Gastroenterology. 105, 4, p. 833-841 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
Habits
Odds Ratio
Environmental Exposure
5 Citations (Scopus)

Genes and irritable bowel syndrome: Is there a link?

Saito Loftus, Y. A., 2008, In : Current Gastroenterology Reports. 10, 4, p. 355-362 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genes
Inborn Genetic Diseases
Genetic Loci
Gastrointestinal Diseases
61 Citations (Scopus)

Genetic Approaches to Functional Gastrointestinal Disorders

Saito Loftus, Y. A., Mitra, N. & Mayer, E. A., Apr 2010, In : Gastroenterology. 138, 4, p. 1276-1285 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Genes
Irritable Bowel Syndrome
Phenotype
Genome
48 Citations (Scopus)

Genetics of irritable bowel syndrome

Saito Loftus, Y. A. & Talley, N. J., Aug 2008, In : American Journal of Gastroenterology. 103, 8, p. 2100-2104 5 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gene-Environment Interaction
Genetic Research
Twin Studies
Genetic Association Studies
10 Citations (Scopus)

Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome

Holliday, E. G., Attia, J., Hancock, S., Koloski, N., McEvoy, M., Peel, R., D'Amato, M., Agréus, L., Nyhlin, H., Andreasson, A., Almazar, A. E., Saito Loftus, Y. A., Scott, R. J. & Talley, N. J., 2014, In : American Journal of Gastroenterology. 109, 5, p. 770-772 3 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genome-Wide Association Study
Cadherins
Genetic Markers
Sweden
1 Citation (Scopus)

Identification and validation of functional gastrointestinal disorder subtypes using latent class analysis: a population-based study

Zinsmeister, A. R., Herrick, L. M., Saito Loftus, Y. A., Schleck, C. D. & Talley, N. J., Nov 3 2017, (Accepted/In press) In : Scandinavian Journal of Gastroenterology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Population
Abdomen
Calibration
Surveys and Questionnaires
18 Citations (Scopus)
Manometry
Routine Diagnostic Tests
Immunotherapy
Radionuclide Imaging
Autoimmunity
18 Citations (Scopus)

Irritable bowel syndrome: New and emerging treatments

Halland, M. & Saito Loftus, Y. A., Jun 18 2015, In : BMJ (Online). 350, h1622.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Therapeutics
Pharmacology
Developed Countries
Abdominal Pain
50 Citations (Scopus)

Irritable bowel syndrome aggregates strongly in families: A family-based case-control study

Saito Loftus, Y. A., Zimmerman, J. M., S. Harmsen, W., De Andrade, M., Locke, G. R., Petersen, G. M. & Talley, N. J., Jul 2008, In : Neurogastroenterology and Motility. 20, 7, p. 790-797 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
4 Citations (Scopus)

Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk

Raslau, D., Herrick, L. M., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., Almazar, A., Talley, N. J. & Saito Loftus, Y. A., Oct 1 2016, In : Neurogastroenterology and Motility. 28, 10, p. 1518-1524 7 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Birth Weight
Logistic Models
Maternal Age
Low Birth Weight Infant
8 Citations (Scopus)

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

Channelopathies
Irritable Bowel Syndrome
Mutation
Missense Mutation
Smooth Muscle
51 Citations (Scopus)

Is There an Association Between GNβ3-C825T Genotype and Lower Functional Gastrointestinal Disorders?

Andresen, V., Camilleri, M., Kim, H. J., Stephens, D. A., Carlson, P. J., Talley, N. J., Saito Loftus, Y. A., Urrutia, R. & Zinsmeister, A. R., Jul 2006, In : Gastroenterology. 130, 7, p. 1985-1994 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Genotype
Irritable Bowel Syndrome
Dyspepsia
Abdominal Pain
2 Citations (Scopus)

Letter: Role of GNβ3 polymorphisms in oesophageal adenocarcinoma and gastroesophageal reflux disease

Brummond, N. R., Saito Loftus, Y. A., Locke, G. R., Larson, J. J., Atkinson, E. J., Romero, Y. & Talley, N. J., Mar 1 2015, In : Alimentary Pharmacology and Therapeutics. 41, 6, p. 600-601 2 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Esophageal Neoplasms
Gastroesophageal Reflux
Case-Control Studies
Adenocarcinoma
55 Citations (Scopus)

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito Loftus, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

NAV1.5 Voltage-Gated Sodium Channel
Channelopathies
Irritable Bowel Syndrome
Mutation
Mexiletine

Management of functional abdominal pain

Saito Loftus, Y. A. & Fox, J. C., Aug 2004, In : Current Treatment Options in Gastroenterology. 7, 4, p. 279-290 12 p.

Research output: Contribution to journalArticle

Abdominal Pain
Antidepressive Agents
Tricyclic Antidepressive Agents
Therapeutics
Psychology
15 Citations (Scopus)

Origin of adenocarcinoma in a transplanted liver determined by microsatellite analysis

Kakar, S., Burgart, L. J., Charlton, M. R., Saito Loftus, Y. A., Halling, K. & Thibodeau, S. N., 2002, In : Human Pathology. 33, 4, p. 435-436 2 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Adenocarcinoma
Tissue Donors
Liver
DNA
9 Citations (Scopus)

Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial

Saito Loftus, Y. A., Locke, G. R., Almazar, A. E., Bouras, E. P., Howden, C. W., Lacy, B. E., DiBaise, J. K., Prather, C. M., Abraham, B. P., El-Serag, H. B., Moayyedi, P., Herrick, L. M., Szarka, L., Camilleri, M., Hamilton, F. A., Schleck, C. D., Tilkes, K. E., Zinsmeister, A. R. & Talley, N. J., Mar 14 2017, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Dyspepsia
Antidepressive Agents
Genotype
Citalopram
Amitriptyline

Preface

Talley, N. J., Locke, G. R. & Saito Loftus, Y. A., Apr 15 2008, In : Unknown Journal.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Prevalence and risk factors for dysphagia: A USA community study

Cho, S. Y., Choung, R. S., Saito Loftus, Y. A., Schleck, C. D., Zinsmeister, A. R., Locke, G. R. & Talley, N. J., Feb 1 2015, In : Neurogastroenterology and Motility. 27, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Deglutition Disorders
Esophageal Diseases
Gastroesophageal Reflux
Medical Records
Logistic Models

Quantifying Rome symptoms for diagnosis of the irritable bowel syndrome

Chang, J. Y., Almazar, A. E., Richard Locke, G., Larson, J. J., Atkinson, E. J., Talley, N. J. & Saito Loftus, Y. A., Sep 1 2018, In : Neurogastroenterology and Motility. 30, 9, e13356.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Logistic Models
Gastrointestinal Diseases
Case-Control Studies
Physicians

Randomised clinical trial: pregabalin vs placebo for irritable bowel syndrome

Saito Loftus, Y. A., Almazar, A. E., Tilkes, K. E., Choung, R. S., Van Norstrand, M. D., Schleck, C. D., Zinsmeister, A. R. & Talley, N. J., Feb 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 4, p. 389-397 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Randomized Controlled Trials
Placebos
Pain
Diarrhea

Reply

FDTT Investigators, Feb 1 2016, In : Gastroenterology. 150, 2, p. 532-533 2 p.

Research output: Contribution to journalArticle

Citalopram
Amitriptyline
Tricyclic Antidepressive Agents
Dyspepsia
Serotonin Uptake Inhibitors

Response to Drs. Thomas and Kareem [2]

Saito Loftus, Y. A., Locke, G. R. & Talley, N. J., Sep 2006, In : American Journal of Gastroenterology. 101, 9, p. 2163 1 p.

Research output: Contribution to journalArticle

SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journalArticle

Open Access
NAV1.5 Voltage-Gated Sodium Channel
Cardiac Myocytes
Smooth Muscle
Channelopathies
Pressure
82 Citations (Scopus)

Sodium channel mutation in irritable bowel syndrome: Evidence for an ion channelopathy

Saito Loftus, Y. A., Strege, P. R., Tester, D. J., Locke, G. R., Talley, N. J., Bernard, C. E., Rae, J. L., Makielski, J. C., Ackerman, M. J. & Farrugia, G., Feb 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 2

Research output: Contribution to journalArticle

Channelopathies
Sodium Channels
Irritable Bowel Syndrome
Ions
Mutation