Yuri Ann Saito Loftus, MD MPH

Former affiliation
  • 2920 Citations
  • 26 Scopus h-Index
20002019
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Research Output 2000 2019

  • 2920 Citations
  • 26 Scopus h-Index
  • 57 Article
  • 6 Chapter
  • 2 Book
  • 1 Editorial
2000
183 Citations (Scopus)

A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome

Saito Loftus, Y. A., Locke, G. R., Talley, N. J., Zinsmeister, A. R., Fett, S. L. & Melton, L. J., 2000, In : American Journal of Gastroenterology. 95, 10, p. 2816-2824 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Defecation
Cross-Sectional Studies
Gastroenterology
Epidemiologic Studies
2002
15 Citations (Scopus)

Origin of adenocarcinoma in a transplanted liver determined by microsatellite analysis

Kakar, S., Burgart, L. J., Charlton, M. R., Saito Loftus, Y. A., Halling, K. & Thibodeau, S. N., 2002, In : Human Pathology. 33, 4, p. 435-436 2 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Adenocarcinoma
Tissue Donors
Liver
DNA
445 Citations (Scopus)

The epidemiology of irritable bowel syndrome in North America: A systematic review

Saito Loftus, Y. A., Schoenfeld, P. & Locke, G. R., Aug 2002, In : American Journal of Gastroenterology. 97, 8, p. 1910-1915 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
North America
Epidemiology
Constipation
Manuscripts
2003
63 Citations (Scopus)

The effect of new diagnostic criteria for irritable bowel syndrome on community prevalence estimates

Saito Loftus, Y. A., Talley, N. J., Melton, L. J., Fett, S., Zinsmeister, A. R. & Locke, G. R., Dec 2003, In : Neurogastroenterology and Motility. 15, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Confidence Intervals
2004
48 Citations (Scopus)

Effects of multidisciplinary education on outcomes in patients with irritable bowel syndrome

Saito Loftus, Y. A., Prather, C. M., Van Dyke, C. T., Fett, S., Zinsmeister, A. R. & Locke, G. R., Jul 2004, In : Clinical Gastroenterology and Hepatology. 2, 7, p. 576-584 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Education
Patient Acceptance of Health Care
Life Style
Health

Management of functional abdominal pain

Saito Loftus, Y. A. & Fox, J. C., Aug 2004, In : Current Treatment Options in Gastroenterology. 7, 4, p. 279-290 12 p.

Research output: Contribution to journalArticle

Abdominal Pain
Antidepressive Agents
Tricyclic Antidepressive Agents
Therapeutics
Psychology
2005
5 Citations (Scopus)
Receptor, Serotonin, 5-HT2A
Irritable Bowel Syndrome
Threonine
Genetic Predisposition to Disease
Gene Frequency
114 Citations (Scopus)

Diet and functional gastrointestinal disorders: A population-based case-control study

Saito Loftus, Y. A., Locke, G. R., Weaver, A. L., Zinsmeister, A. R. & Talley, N. J., Dec 2005, In : American Journal of Gastroenterology. 100, 12, p. 2743-2748 6 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Case-Control Studies
Diet
Food
Population
55 Citations (Scopus)

The genetics of irritable bowel syndrome

Saito Loftus, Y. A., Petersen, G. M., Locke, G. R. & Talley, N. J., Nov 2005, In : Clinical Gastroenterology and Hepatology. 3, 11, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Epidemiologic Methods
Genetic Techniques
Twin Studies
Gastrointestinal Diseases
2006
20 Citations (Scopus)
Gastrointestinal Diseases
Genetic Association Studies
Genotype
Disease Susceptibility
Genes
5 Citations (Scopus)

Clinical application of pharmacogenetics in gastrointestinal diseases

Saito Loftus, Y. A. & Camilleri, M., Oct 2006, In : Expert Opinion on Pharmacotherapy. 7, 14, p. 1857-1869 13 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Pharmacogenetics
Gastroenterology
Irritable Bowel Syndrome
Dyspepsia
51 Citations (Scopus)

Is There an Association Between GNβ3-C825T Genotype and Lower Functional Gastrointestinal Disorders?

Andresen, V., Camilleri, M., Kim, H. J., Stephens, D. A., Carlson, P. J., Talley, N. J., Saito Loftus, Y. A., Urrutia, R. & Zinsmeister, A. R., Jul 2006, In : Gastroenterology. 130, 7, p. 1985-1994 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Genotype
Irritable Bowel Syndrome
Dyspepsia
Abdominal Pain

Response to Drs. Thomas and Kareem [2]

Saito Loftus, Y. A., Locke, G. R. & Talley, N. J., Sep 2006, In : American Journal of Gastroenterology. 101, 9, p. 2163 1 p.

Research output: Contribution to journalArticle

2007
55 Citations (Scopus)

A genetic association study of 5-HTT LPR and GNβ3 C825T polymorphisms with irritable bowel syndrome

Saito Loftus, Y. A., Locke, G. R., Zimmerman, J. M., Holtmann, G., Slusser, J. P., De Andrade, M., Petersen, G. M. & Talley, N. J., Jun 2007, In : Neurogastroenterology and Motility. 19, 6, p. 465-470 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genetic Association Studies
Gene Frequency
Outpatients
Genotype
2008
5 Citations (Scopus)

Genes and irritable bowel syndrome: Is there a link?

Saito Loftus, Y. A., 2008, In : Current Gastroenterology Reports. 10, 4, p. 355-362 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genes
Inborn Genetic Diseases
Genetic Loci
Gastrointestinal Diseases
1 Citation (Scopus)

Genetic Epidemiology

Saito Loftus, Y. A. & Petersen, G. M., Apr 15 2008, GI Epidemiology. Blackwell Publishing Ltd, p. 97-102 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inborn Genetic Diseases
Molecular Epidemiology
Infection
48 Citations (Scopus)

Genetics of irritable bowel syndrome

Saito Loftus, Y. A. & Talley, N. J., Aug 2008, In : American Journal of Gastroenterology. 103, 8, p. 2100-2104 5 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gene-Environment Interaction
Genetic Research
Twin Studies
Genetic Association Studies
6 Citations (Scopus)

GI Epidemiology

Talley, N. J., Locke, G. R. & Saito Loftus, Y. A., Apr 15 2008, Blackwell Publishing Ltd. 270 p.

Research output: Book/ReportBook

Gastroenterology
Epidemiology
Molecular Epidemiology
Colorectal Surgery
Evidence-Based Medicine
2 Citations (Scopus)

Irritable Bowel Syndrome

Saito Loftus, Y. A., Talley, N. J. & Locke, G. R., Apr 15 2008, GI Epidemiology. Blackwell Publishing Ltd, p. 176-183 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Irritable Bowel Syndrome
Neurotransmitter Agents
50 Citations (Scopus)

Irritable bowel syndrome aggregates strongly in families: A family-based case-control study

Saito Loftus, Y. A., Zimmerman, J. M., S. Harmsen, W., De Andrade, M., Locke, G. R., Petersen, G. M. & Talley, N. J., Jul 2008, In : Neurogastroenterology and Motility. 20, 7, p. 790-797 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
9 Citations (Scopus)

Pharmacogenomics in gastrointestinal disorders

Camilleri, M. & Saito Loftus, Y. A., 2008, Methods in Molecular Biology. Humana Press, Vol. 448. p. 395-412 18 p. (Methods in Molecular Biology; vol. 448).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmacogenetics
Gastroenterology
Irritable Bowel Syndrome
Helicobacter Infections
Human Genome

Pharmacogenomics in gastrointestinal disorders

Camilleri, M. & Saito, Y. A., 2008, Methods in Molecular Biology. Vol. 448. p. 395-412 18 p. (Methods in Molecular Biology; vol. 448).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmacogenetics
Gastroenterology
Irritable Bowel Syndrome
Helicobacter Infections
Human Genome

Preface

Talley, N. J., Locke, G. R. & Saito Loftus, Y. A., Apr 15 2008, In : Unknown Journal.

Research output: Contribution to journalArticle

2009
3 Citations (Scopus)

AJG series: Molecular biology for clinicians

Saito Loftus, Y. A. & Talley, N. J., Oct 2009, In : American Journal of Gastroenterology. 104, 10, p. 2583-2587 5 p.

Research output: Contribution to journalArticle

Molecular Biology
Pharmaceutical Preparations
Pharmacogenetics
Genetic Code
Gastrointestinal Diseases
80 Citations (Scopus)

Sodium channel mutation in irritable bowel syndrome: Evidence for an ion channelopathy

Saito Loftus, Y. A., Strege, P. R., Tester, D. J., Locke, G. R., Talley, N. J., Bernard, C. E., Rae, J. L., Makielski, J. C., Ackerman, M. J. & Farrugia, G., Feb 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 2

Research output: Contribution to journalArticle

Channelopathies
Sodium Channels
Irritable Bowel Syndrome
Ions
Mutation
2010
27 Citations (Scopus)

A randomized, double-blind, placebo-controlled trial of st john's wort for treating irritable bowel syndrome

Saito Loftus, Y. A., Rey, E., Almazar-Elder, A. E., Harmsen, W. S., Zinsmeister, A. R., Locke, G. R. & Talley, N. J., Jan 2010, In : American Journal of Gastroenterology. 105, 1, p. 170-177 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Placebos
Constipation
Therapeutics
Antidepressive Agents
63 Citations (Scopus)

Familial aggregation of irritable bowel syndrome: A family case-control study

Saito Loftus, Y. A., Petersen, G. M., Larson, J. J., Atkinson, E. J., Fridley, B. L., De Andrade, M., Locke, G. R., Zimmerman, J. M., Almazar-Elder, A. E. & Talley, N. J., Apr 2010, In : American Journal of Gastroenterology. 105, 4, p. 833-841 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
Habits
Odds Ratio
Environmental Exposure
61 Citations (Scopus)

Genetic Approaches to Functional Gastrointestinal Disorders

Saito Loftus, Y. A., Mitra, N. & Mayer, E. A., Apr 2010, In : Gastroenterology. 138, 4, p. 1276-1285 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Genes
Irritable Bowel Syndrome
Phenotype
Genome
2011
16 Citations (Scopus)

Characteristics of acute pain attacks in patients with irritable bowel syndrome meeting Rome III criteria

Hellström, P. M., Saito Loftus, Y. A., Bytzer, P., Tack, J., Mueller-Lissner, S. & Chang, L., Jul 2011, In : American Journal of Gastroenterology. 106, 7, p. 1299-1307 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Acute Pain
Pain
Defecation
Constipation
70 Citations (Scopus)

Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

Choung, R. S., Ruff, K. C., Malhotra, A., Herrick, L., Locke, G. R., Harmsen, W. S., Zinsmeister, A. R., Talley, N. J. & Saito Loftus, Y. A., May 2011, In : Alimentary Pharmacology and Therapeutics. 33, 9, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Steatorrhea
Diverticulum
Narcotics
Inflammatory Bowel Diseases

Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture: Authors' reply

Saito Loftus, Y. A., Choung, R. S., Zinsmeister, A. R. & Talley, N. J., Jun 2011, In : Alimentary Pharmacology and Therapeutics. 33, 12, p. 1379-1380 2 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

The Role of Genetics in IBS

Saito Loftus, Y. A., Mar 2011, In : Gastroenterology Clinics of North America. 40, 1, p. 45-67 23 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genes
2012
18 Citations (Scopus)

The role of 5-HTT LPR and GNβ3 825C>T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS)

Saito Loftus, Y. A., Larson, J. J., Atkinson, E. J., Ryu, E., Almazar, A. E., Petersen, G. M. & Talley, N. J., Oct 2012, In : Digestive Diseases and Sciences. 57, 10, p. 2650-2657 8 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Irritable Bowel Syndrome
Age of Onset
Infection
Psychiatry
2014
14 Citations (Scopus)

A case-control study of childhood trauma in the development of irritable bowel syndrome

Halland, M., Almazar, A., Lee, R., Atkinson, E., Larson, J., Talley, N. J. & Saito Loftus, Y. A., 2014, In : Neurogastroenterology and Motility. 26, 7, p. 990-998 9 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Case-Control Studies
Wounds and Injuries
Odds Ratio
Self Report
302 Citations (Scopus)

American college of gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation

Ford, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Quigley, E. M. M., 2014, In : American Journal of Gastroenterology. 109, SUPPL. 1

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Gastroenterology
Constipation
Chronic Disease
231 Citations (Scopus)

Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis.

Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Moayyedi, P., 2014, In : The American journal of gastroenterology. 109, 9

Research output: Contribution to journalArticle

Hypnosis
Irritable Bowel Syndrome
Antidepressive Agents
Meta-Analysis
Psychology
316 Citations (Scopus)

Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis

Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Moayyedi, P., Oct 1 2014, In : The American journal of gastroenterology. 109, 10, p. 1547-1562 16 p.

Research output: Contribution to journalArticle

Synbiotics
Prebiotics
Irritable Bowel Syndrome
Probiotics
Constipation

Epidemiology of Irritable Bowel Syndrome

Choung, R. S. & Saito Loftus, Y. A., Jan 13 2014, GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell, p. 222-234 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Irritable Bowel Syndrome
Epidemiology
Absenteeism
Gastrointestinal Diseases
Health Care Costs
10 Citations (Scopus)

Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome

Holliday, E. G., Attia, J., Hancock, S., Koloski, N., McEvoy, M., Peel, R., D'Amato, M., Agréus, L., Nyhlin, H., Andreasson, A., Almazar, A. E., Saito Loftus, Y. A., Scott, R. J. & Talley, N. J., 2014, In : American Journal of Gastroenterology. 109, 5, p. 770-772 3 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Genome-Wide Association Study
Cadherins
Genetic Markers
Sweden

GI Epidemiology: Diseases and Clinical Methodology: Second Edition

Talley, N. J., Locke, G. R., Moayyedi, P., West, J., Ford, A. C. & Saito Loftus, Y. A., Jan 13 2014, Wiley Blackwell. 413 p.

Research output: Book/ReportBook

Epidemiology
Gastrointestinal Diseases
Hepatitis C
Hepatitis B
Checklist

How to Do Genetic and Molecular Epidemiologic Research

Saito Loftus, Y. A., Jan 13 2014, GI Epidemiology: Diseases and Clinical Methodology: Second Edition. Wiley Blackwell, p. 98-105 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Biology
Molecular Epidemiology
Research
Epidemiology
Biochemical Phenomena
18 Citations (Scopus)
Manometry
Routine Diagnostic Tests
Immunotherapy
Radionuclide Imaging
Autoimmunity
52 Citations (Scopus)

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito Loftus, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

NAV1.5 Voltage-Gated Sodium Channel
Channelopathies
Irritable Bowel Syndrome
Mutation
Mexiletine
102 Citations (Scopus)

The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis.

Moayyedi, P., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Ford, A. C., 2014, In : The American journal of gastroenterology. 109, 9, p. 1367-1374 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Meta-Analysis
Confidence Intervals
Numbers Needed To Treat
Randomized Controlled Trials
2015
110 Citations (Scopus)

Effect of amitriptyline and escitalopram on functional dyspepsia: A multicenter, randomized controlled study

Talley, N. J., Richard Locke, G., Saito Loftus, Y. A., Almazar, A. E., Bouras, E. P., Howden, C. W., Lacy, B. E., Dibaise, J. K., Prather, C. M., Abraham, B. P., El-Serag, H. B., Moayyedi, P., Herrick, L. M., Szarka, L., Camilleri, M., Hamilton, F. A., Schleck, C. D., Tilkes, K. E. & Zinsmeister, A. R., Aug 1 2015, In : Gastroenterology. 149, 2, p. 340-349.e2

Research output: Contribution to journalArticle

Citalopram
Amitriptyline
Dyspepsia
Gastric Emptying
Antidepressive Agents
18 Citations (Scopus)

Irritable bowel syndrome: New and emerging treatments

Halland, M. & Saito Loftus, Y. A., Jun 18 2015, In : BMJ (Online). 350, h1622.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Therapeutics
Pharmacology
Developed Countries
Abdominal Pain
2 Citations (Scopus)

Letter: Role of GNβ3 polymorphisms in oesophageal adenocarcinoma and gastroesophageal reflux disease

Brummond, N. R., Saito Loftus, Y. A., Locke, G. R., Larson, J. J., Atkinson, E. J., Romero, Y. & Talley, N. J., Mar 1 2015, In : Alimentary Pharmacology and Therapeutics. 41, 6, p. 600-601 2 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Esophageal Neoplasms
Gastroesophageal Reflux
Case-Control Studies
Adenocarcinoma
32 Citations (Scopus)

Prevalence and risk factors for dysphagia: A USA community study

Cho, S. Y., Choung, R. S., Saito Loftus, Y. A., Schleck, C. D., Zinsmeister, A. R., Locke, G. R. & Talley, N. J., Feb 1 2015, In : Neurogastroenterology and Motility. 27, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Deglutition Disorders
Esophageal Diseases
Gastroesophageal Reflux
Medical Records
Logistic Models
31 Citations (Scopus)

The effect of dietary intervention on irritable bowel syndrome: A systematic review

Moayyedi, P., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito Loftus, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R. & Ford, A. C., Aug 20 2015, In : Clinical and Translational Gastroenterology. 6, 8, e107.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Diet
Numbers Needed To Treat
MEDLINE
Meta-Analysis
2016
9 Citations (Scopus)

A case-control comparison of direct healthcare-provider medical costs of chronic idiopathic constipation and irritable bowel syndrome with constipation in a community-based cohort

Herrick, L. M., Spalding, W. M., Saito Loftus, Y. A., Moriarty, J. & Schleck, C., Nov 10 2016, (Accepted/In press) In : Journal of Medical Economics. p. 1-7 7 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Constipation
Health Personnel
Costs and Cost Analysis
Outpatients