Yuan-Ping Pang, PhD

  • 7263 Citations
  • 47 Scopus h-Index
1990 …2019
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Research Output 1990 2019

  • 7263 Citations
  • 47 Scopus h-Index
  • 171 Article
  • 2 Chapter
  • 1 Conference contribution
  • 1 Comment/debate
2019

A pilot clinical trial testing topical resiquimod and a xenopeptide as immune adjuvants for a melanoma vaccine targeting MART-1

Block, M. S., Nevala, W. K., Pang, Y. P., Allred, J. B., Strand, C. & Markovic, S. N., Aug 1 2019, In : Melanoma research. 29, 4, p. 420-427 8 p.

Research output: Contribution to journalArticle

resiquimod
Melanoma
Vaccines
Clinical Trials
Appointments and Schedules

Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression

Ke, Z., Hu, S., Cui, W., Sun, J., Zhang, S., Mak, S., Wang, J., Tang, J., Pang, Y-P., Han, Y. & Tong, K., Sep 1 2019, In : Neurochemistry International. 128, p. 143-153 11 p.

Research output: Contribution to journalArticle

Exercise Therapy
Transient Ischemic Attack
N-Methyl-D-Aspartate Receptors
Vascular Endothelial Growth Factor A
Pharmaceutical Preparations
Open Access
Brain
Alzheimer Disease
Animals
Animal Models
Modulation

Remote activation of a latent epitope in an autoantigen decoded with simulated b-factors

Pang, Y. P., Moura, M. C., Thompson, G. E., Nelson, D. R., Hummel, A. M., Jenne, D. E., Emerling, D., Volkmuth, W., Robinson, W. H. & Specks, U., Jan 1 2019, In : Frontiers in immunology. 10, OCT, 2467.

Research output: Contribution to journalArticle

Open Access
Autoantigens
Myeloblastin
Granulomatosis with Polyangiitis
Epitopes
Mutation
2017
3 Citations (Scopus)

How fast fast-folding proteins fold in silico

Pang, Y-P., Oct 7 2017, In : Biochemical and Biophysical Research Communications. 492, 1, p. 135-139 5 p.

Research output: Contribution to journalArticle

Protein folding
Protein Folding
Computer Simulation
Molecular Dynamics Simulation
Conformations
7 Citations (Scopus)
Enzyme inhibition
Electrophorus
Acetylcholinesterase
Assays
Benchmarking
2016
9 Citations (Scopus)

FF12MC: A revised AMBER forcefield and new protein simulation protocol

Pang, Y-P., Oct 1 2016, In : Proteins: Structure, Function and Bioinformatics. 84, 10, p. 1490-1516 27 p.

Research output: Contribution to journalArticle

Proteins
Molecular Dynamics Simulation
Molecular dynamics
Torsional stress
Computer simulation
36 Citations (Scopus)

Prime, shock, and kill: Priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size

Cummins, N. W., Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., De Araujo Correia, M. C. M., Sampath, R., Rizza, S., O'Brien, D., Yao, J. D., Kaufmann, S. H. & Badley, A. D., Apr 1 2016, In : Journal of Virology. 90, 8, p. 4032-4048 17 p.

Research output: Contribution to journalArticle

antagonists
Shock
T-lymphocytes
HIV
T-Lymphocytes
9 Citations (Scopus)
Molecular dynamics
Sampling
Computer simulation
Proteins
Aprotinin
2015
6 Citations (Scopus)
Cryogenics
Protein folding
Crystal structure
Protein Folding
Bond length
4 Citations (Scopus)
8 Citations (Scopus)

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

Hu, S. Q., Wang, R., Cui, W., Mak, S. H., Li, G., Hu, Y. J., Lee, M. Y., Pang, Y-P. & Han, Y. F., Dec 1 2015, In : CNS Neuroscience and Therapeutics. 21, 12, p. 953-961 9 p.

Research output: Contribution to journalArticle

Amyloid
Tacrine
Alzheimer Disease
Intraventricular Infusions
Oxygen
6 Citations (Scopus)
Molecular Dynamics Simulation
Molecular dynamics
Sampling
Computer simulation
Temperature
23 Citations (Scopus)

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Animals
Animal Models
Modulation
Glycogen Synthase Kinase 3
30 Citations (Scopus)

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

Lee, S. B., Kim, J. J., Nam, H. J., Gao, B., Yin, P., Qin, B., Yi, S. Y., Ham, H., Evans, D., Kim, S. H., Zhang, J., Deng, M., Liu, T., Zhang, H., Billadeau, D. D., Wang, L. M., Giaime, E., Shen, J., Pang, Y-P., Jen, J. & 2 others, Van Deursen, J. & Lou, Z., Feb 19 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Genomic Instability
Mitosis
Anaphase-Promoting Complex-Cyclosome
Ubiquitin-Protein Ligases
Carcinogenesis
29 Citations (Scopus)

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

Brimijoin, W. S., Chen, V. P., Pang, Y-P., Geng, L. & Gao, Y., Nov 16 2015, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Nutrition
Aggression
Weight Gain
54 Citations (Scopus)

Plasma butyrylcholinesterase regulates ghrelin to control aggression

Chen, V. P., Gao, Y., Geng, L., Parks, R. J., Pang, Y-P. & Brimijoin, W. S., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 2251-2256 6 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Aggression
Hydrolysis
Cocaine-Related Disorders
20 Citations (Scopus)

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

Chang, L., Cui, W., Yang, Y., Xu, S., Zhou, W., Fu, H., Hu, S., Mak, S., Hu, J., Wang, Q., Pui-Yan Ma, V., Chung-Lit Choi, T., Dik-Lung Ma, E., Tao, L., Pang, Y-P., Rowan, M. J., Anwyl, R., Han, Y. & Wang, Q., Jul 21 2015, In : Scientific Reports. 5, 10256.

Research output: Contribution to journalArticle

Amyloid
Tacrine
Long-Term Potentiation
Cholinesterase Inhibitors
Alzheimer Disease
6 Citations (Scopus)

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway

Hu, S. Q., Cui, W., Mak, S. H., Choi, C. L., Hu, Y. J., Li, G., Tsim, K. W. K., Pang, Y-P. & Han, Y. F., Jun 1 2015, In : CNS Neuroscience and Therapeutics. 21, 6, p. 520-529 10 p.

Research output: Contribution to journalArticle

alpha7 Nicotinic Acetylcholine Receptor
MAP Kinase Signaling System
PC12 Cells
Neurites
Neurodegenerative Diseases
16 Citations (Scopus)

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer

Hu, S., Cui, W., Mak, S., Xu, D., Hu, Y., Tang, J., Choi, C., Lee, M., Pang, Y-P. & Han, Y., Jul 6 2015, In : ACS Chemical Neuroscience. 6, 9, p. 1536-1545 10 p.

Research output: Contribution to journalArticle

Dimers
Neurons
Extracellular Signal-Regulated MAP Kinases
Chemical activation
PC12 Cells
7 Citations (Scopus)
Conformations
Secondary Protein Structure
Molecular Dynamics Simulation
Proteins
Lennard-Jones potential
2014
19 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
39 Citations (Scopus)

Evaluation of the BH3-only protein Puma as a direct Bak activator

Dai, H., Pang, Y-P., Ramirez-Alvarado, M. & Kaufmann, S. H., Jan 3 2014, In : Journal of Biological Chemistry. 289, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

Puma
Oligomerization
Noxae
Proteins
Membranes
9 Citations (Scopus)
acetylcholinesterase
insect pests
insecticides
beneficial insects
insects
12 Citations (Scopus)
Molecular Dynamics Simulation
Molecular dynamics
Sampling
Conformations
Computer simulation
2013
33 Citations (Scopus)

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

Hu, S., Cui, W., Mak, S., Tang, J., Choi, C., Pang, Y-P. & Han, Y., Mar 2013, In : Neurochemistry International. 62, 4, p. 468-477 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Glutamic Acid
Nitric Oxide
Memantine
Inhibitory Concentration 50
6 Citations (Scopus)

Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins

Yu, S., Park, J. G., Kahn, J. N., Tumer, N. E. & Pang, Y-P., Dec 2 2013, In : Scientific Reports. 3, 3397.

Research output: Contribution to journalArticle

Ribosome Inactivating Proteins
Ricin
Antidotes
Cytoprotection
20 Citations (Scopus)

Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases

Dou, D., Park, J. G., Rana, S., Madden, B. J., Jiang, H. & Pang, Y-P., 2013, In : Scientific Reports. 3, 1068.

Research output: Contribution to journalArticle

Cholinesterase Inhibitors
Acetylcholinesterase
Culicidae
Malaria
Insecticides
36 Citations (Scopus)

Regulation of error-prone translesion synthesis by Spartan/C1orf124

Kim, M. S., Machida, Y., Vashisht, A. A., Wohlschlegel, J. A., Pang, Y-P. & Machida, Y., Feb 2013, In : Nucleic Acids Research. 41, 3, p. 1661-1668 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Proliferating Cell Nuclear Antigen
Metalloproteases
DNA-Directed DNA Polymerase
Zinc
17 Citations (Scopus)

Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway

Hu, S. Q., Cui, W., Xu, D. P., Mak, S. H., Tang, J., Choi, C. L., Pang, Y-P. & Han, Y. F., Oct 2013, In : CNS Neuroscience and Therapeutics. 19, 10, p. 764-772 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-2
Apoptosis
Neurons
Glycogen Synthase Kinase 3
MAP Kinase Signaling System
2012
32 Citations (Scopus)

Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects

Yao, L., Li, W., She, H., Dou, J., Jia, L., He, Y., Yang, Q., Zhu, J., Cápiro, N. L., Walker, D. I., Pennell, K. D., Pang, Y-P., Liu, Y., Han, Y. & Mao, Z., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34246-34255 10 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Dopaminergic Neurons
Neurons
Transcription Factors
Chemical activation
31 Citations (Scopus)

Bak conformational changes induced by ligand binding: Insight into BH3 domain binding and bak homo-oligomerization

Pang, Y-P., Dai, H., Smith, A., Meng, X. W., Schneider, P. A. & Kaufmann, S. H., 2012, In : Scientific Reports. 2, 257.

Research output: Contribution to journalArticle

Noxae
Ligands
Molecular Dynamics Simulation
Proteins
24 Citations (Scopus)

Chemical structure of retro-2, a compound that protects cells against ribosome-inactivating proteins

Park, J. G., Kahn, J. N., Tumer, N. E. & Pang, Y-P., 2012, In : Scientific Reports. 2, 00631.

Research output: Contribution to journalArticle

Ribosome Inactivating Proteins
Ricin
Cytoprotection
Shiga Toxins
Nose
58 Citations (Scopus)

Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum

Lu, Y., Park, Y., Gao, X., Zhang, X., Yao, J., Pang, Y-P., Jiang, H. & Zhu, K. Y., 2012, In : Scientific Reports. 2, 288.

Research output: Contribution to journalArticle

Tribolium
Gene Silencing
Acetylcholinesterase
Insecticides
Cholinergic Agents
30 Citations (Scopus)

Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle

Lu, Y., Pang, Y-P., Park, Y., Gao, X., Yao, J., Zhang, X. & Zhu, K. Y., Feb 16 2012, In : PLoS One. 7, 2, e32288.

Research output: Contribution to journalArticle

Tribolium castaneum
Beetles
Flour
Phylogeny
Acetylcholinesterase
32 Citations (Scopus)

Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides

Pang, Y-P., Brimijoin, W. S., Ragsdale, D. W., Zhu, K. Y. & Suranyi, R., Apr 2012, In : Current Drug Targets. 13, 4, p. 471-482 12 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Insecticides
Insects
Cysteine
Toxicity
2011
24 Citations (Scopus)

Small-molecule inhibitor leads of Ribosome-inactivating proteins developed using the doorstop approach

Pang, Y-P., Park, J. G., Wang, S., Vummenthala, A., Mishra, R. K., McLaughlin, J. E., Di, R., Kahn, J. N., Tumer, N. E., Janosi, L., Davis, J. & Millard, C. B., 2011, In : PLoS One. 6, 3, e17883.

Research output: Contribution to journalArticle

Ribosome Inactivating Proteins
ribosomes
ricin
Ricin
Molecules
93 Citations (Scopus)

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Dai, H., Smith, A., Meng, X. W., Schneider, P. A., Pang, Y-P. & Kaufmann, S. H., Jul 11 2011, In : Journal of Cell Biology. 194, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Proteins
Cytochromes c
bcl-2 Homologous Antagonist-Killer Protein
Surface Plasmon Resonance
Point Mutation
2010
26 Citations (Scopus)

Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: Reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad

Hörnberg, A., Artursson, E., Wärme, R., Pang, Y-P. & Ekström, F., Feb 1 2010, In : Biochemical Pharmacology. 79, 3, p. 507-515 9 p.

Research output: Contribution to journalArticle

Oximes
Acetylcholinesterase
Crystal structure
Insecticides
Conformations
10 Citations (Scopus)

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

Polsinelli, G. A., Singh, S. K., Mishra, R. K., Suranyi, R., Ragsdale, D. W., Pang, Y-P. & Brimijoin, W. S., Sep 2010, In : Chemico-Biological Interactions. 187, 1-3, p. 142-147 6 p.

Research output: Contribution to journalArticle

Bedbugs
Blattellidae
Periplaneta
Cholinesterase Inhibitors
Beetles
16 Citations (Scopus)

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

Wille, T., Ekström, F., Lee, J. C., Pang, Y-P., Thiermann, H. & Worek, F., Sep 2010, In : Biochemical Pharmacology. 80, 6, p. 941-946 6 p.

Research output: Contribution to journalArticle

Organophosphorus Compounds
Acetylcholinesterase
Oximes
Kinetics
Sarin
1 Citation (Scopus)

One-compound-multi-targets at amyloid β cascade offered by Bis(7)-Cognitin, a novel anti-Alzheimer's dimer

Li, W., Fu, H., Youdim, M. B. H., Pang, Y-P. & Han, Y., 2010, Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Springer Netherlands, p. 165-183 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid
Alzheimer Disease
Neuroprotective Agents
Acetylcholinesterase
tau Proteins
30 Citations (Scopus)

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin

Luo, J., Li, W., Zhao, Y., Fu, H., Ma, D. L., Tang, J., Li, C., Peoples, R. W., Li, F., Wang, Q., Huang, P., Xia, J., Pang, Y-P. & Han, Y., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 19947-19958 12 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Dimers
Dizocilpine Maleate
Memantine
N-Methylaspartate
37 Citations (Scopus)

Small molecules showing significant protection of mice against botulinum neurotoxin serotype a

Pang, Y-P., Davis, J., Wang, S., Park, J. G., Nambiar, M. P., Schmidt, J. J. & Millard, C. B., 2010, In : PLoS One. 5, 4, e10129.

Research output: Contribution to journalArticle

botulinum toxin
Neurotoxins
serotypes
Molecules
Botulism
2009
10 Citations (Scopus)

A selective small-molecule inhibitor of c-Jun N-terminal kinase 1

Yao, K., Cho, Y. Y., Bode, A. M., Vummenthala, A., Park, J. G., Liu, K., Pang, Y-P. & Dong, Z., Jul 7 2009, In : FEBS Letters. 583, 13, p. 2208-2212 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 8
Protein Kinases
Assays
Medical problems
Molecules
64 Citations (Scopus)

Configurational Entropy in Protein-Peptide Binding: . Computational Study of Tsg101 Ubiquitin E2 Variant Domain with an HIV-Derived PTAP Nonapeptide

Killian, B. J., Kravitz, J. Y., Somani, S., Dasgupta, P., Pang, Y-P. & Gilson, M. K., Jun 5 2009, In : Journal of Molecular Biology. 389, 2, p. 315-335 21 p.

Research output: Contribution to journalArticle

Entropy
Ubiquitin
Protein Binding
HIV
Peptides
Cholinesterase Inhibitors
High performance liquid chromatography
Chromatography
Mass spectrometry
Rats
4 Citations (Scopus)

Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons

Zhou, L., Liu, Y. W., Peoples, R. W., Yang, M., Tian, X., Ai, Y. X., Pang, Y-P., Li, Z. W., Han, Y. F. & Li, C. Y., Jul 2009, In : Neuropharmacology. 57, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Neurons
GABA-A Receptors
1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine
Inhibition (Psychology)
63 Citations (Scopus)

Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets

Li, W., Mak, M., Jiang, H., Wang, Q., Pang, Y-P., Chen, K. & Han, Y., Jan 2009, In : Neurotherapeutics. 6, 1, p. 187-201 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Tacrine
Aptitude
Molecular Pathology
Amyloid beta-Protein Precursor