Y.s. Prakash, MD, PhD

Chair, Department of Physiology and Biomedical Engineering, Vice-Chair, Department of Anesthesiology

  • 6547 Citations
  • 45 Scopus h-Index
1993 …2020

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Article
2020

Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells

Bhallamudi, S., Connell, J., Pabelick, C. M., Prakash, Y. S. & Sathish, V., Jan 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 1, p. L112-L124

Research output: Contribution to journalArticle

1 Scopus citations

It's about time: Clocks in the developing lung

Bartman, C. M., Matveyenko, A. & Prakash, Y. S., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Upregulation of airway smooth muscle calcium-sensing receptor by low-molecular-weight hyaluronan

Lazrak, A., Yu, Z., Doran, S., Jian, M. Y., Creighton, J., Laube, M., Garantziotis, S., Prakash, Y. S. & Matalon, S., Mar 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 3, p. L459-L471

Research output: Contribution to journalArticle

2019
Open Access
3 Scopus citations

Calcium sensing receptor in developing human airway smooth muscle

Roesler, A. M., Wicher, S. A., Ravix, J., Britt, R. J., Manlove, L., Teske, J. J., Cummings, K., Thompson, M. A., Farver, C., MacFarlane, P., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

1 Scopus citations

Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model

Vogel, E. R., Manlove, L. J., Kuipers, I., Thompson, M. A., Fang, Y. H., Freeman, M. R., Britt, R. J., Faksh, A., Yang, B., Prakash, Y. S. & Pabelick, C. M., Jul 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 1, p. L99-L108

Research output: Contribution to journalArticle

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis

Ligresti, G., Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Choi, K. M., Haak, A. J., Aravamudhan, A., Roden, A., Prakash, Y. S., Lomberk, G., Urrutia, R. A. & Tschumperlin, D. J., Jan 1 2019, In : JCI Insight. 4, 12, e127111.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cellular senescence in the lung across the age spectrum

Parikh, P., Wicher, S., Khandalavala, K., Pabelick, C. M., Britt, R. J. & Prakash, Y. S., May 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 5, p. L826-L842

Research output: Contribution to journalArticle

3 Scopus citations

Differential estrogen-receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF-κB pathway

Ambhore, N. S., Kalidhindi, R. S. R., Pabelick, C. M., Hawse, J. R., Prakash, Y. S. & Sathish, V., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13935-13950 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells

Parikh, P., Britt, R. J., Manlove, L. J., Wicher, S. A., Roesler, A., Ravix, J., Teske, J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., LeBrasseur, N. K., Tschumperlin, D. J., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Moderate hyperoxia induces senescence in developing human lung fibroblasts

You, K., Parikh, P., Khandalavala, K., Wicher, S. A., Manlove, L., Yang, B., Roesler, A., Roos, B. B., Teske, J. J., Britt, R. D., Pabelick, C. M. & Prakash, Y. S., Nov 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 5, p. L525-L536

Research output: Contribution to journalArticle

2 Scopus citations

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Haak, A. J., Choi, K. M., Manlove, L. J., Prakash, Y. S., Tschumperlin, D. J. & Ligresti, G., Jan 1 2019, In : Thorax.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
9 Scopus citations

Secretory inositol polyphosphate 4-phosphatase protects against airway inflammation and remodeling

Khanna, K., Chaudhuri, R., Aich, J., Pattnaik, B., Panda, L., Prakash, Y. S., Mabalirajan, U., Ghosh, B. & Agrawal, A., Apr 1 2019, In : American journal of respiratory cell and molecular biology. 60, 4, p. 399-412 14 p.

Research output: Contribution to journalArticle

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D. L., Tan, Q., Meridew, J., Espinosa, A. M. D., Aravamudhan, A., Maiers, J. L., Britt, R. D., Roden, A. C., Pabelick, C. M., Prakash, Y. S., Nouraie, S. M., Li, X., Zhang, Y., Kass, D. J. & 5 others, Lagares, D., Tager, A. M., Varelas, X., Shah, V. H. & Tschumperlin, D. J., Oct 30 2019, In : Science translational medicine. 11, 516, eaau6296.

Research output: Contribution to journalArticle

4 Scopus citations

Senescence in the lung: is this getting old?

Morty, R. E. & Prakash, Y. S., May 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 5, p. L822-L825

Research output: Contribution to journalArticle

1 Scopus citations

Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma

Britt, R. J., Thompson, M. A., Wicher, S. A., Manlove, L. J., Roesler, A., Fang, Y. H., Roos, C., Smith, L., Miller, J. D., Pabelick, C. M. & Prakash, Y. S., Feb 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 3024-3034 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2 Scopus citations

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Sep 17 2019, In : Immunity. 51, 3, p. 491-507.e7

Research output: Contribution to journalArticle

7 Scopus citations
2018

Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice

Fong, V., Hsu, A., Wu, E., Looney, A. P., Ganesan, P., Ren, X., Sheppard, D., Wicher, S. A., Thompson, M. A., Britt, R. J., Prakash, Y. S. & Bhattacharya, M., Nov 2 2018, In : JCI insight. 3, 21

Research output: Contribution to journalArticle

Open Access

Ca2+ Entry Through Reverse Mode Na+/Ca2+ Exchanger Contributes to Store Operated Channel-Mediated Neointima Formation After Arterial Injury

Liu, B., Zhang, B., Huang, S., Yang, L., Roos, C. M., Thompson, M. A., Prakash, Y. S., Zang, J., Miller, J. D. & Guo, R., Jan 1 2018, (Accepted/In press) In : Canadian Journal of Cardiology.

Research output: Contribution to journalArticle

2 Scopus citations

Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation

Ambhore, N. S., Katragadda, R., Raju Kalidhindi, R. S., Thompson, M. A., Pabelick, C. M., Prakash, Y. S. & Sathish, V., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

10 Scopus citations

Female sex and gender in lung/sleep health and disease: Increased understanding of basic biological, pathophysiological, and behavioral mechanisms leading to better health for female patients with lung disease

Han, M. L. K., Arteaga-Solis, E., Blenis, J., Bourjeily, G., Clegg, D. J., DeMeo, D., Duffy, J., Gaston, B., Heller, N. M., Hemnes, A., Henske, E. P., Jain, R., Lahm, T., Lancaster, L. H., Lee, J., Legato, M. J., McKee, S., Mehra, R., Morris, A., Prakash, Y. S. & 7 others, Stampfli, M. R., Gopal-Srivastava, R., Laposky, A. D., Punturieri, A., Reineck, L., Tigno, X. & Clayton, J., Oct 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 7, p. 850-858 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses

Cheon, I. S., Son, Y. M., Jiang, L., Goplen, N. P., Kaplan, M. H., Limper, A. H., Kita, H., Paczesny, S., Prakash, Y. S., Tepper, R., Ahlfeld, S. K. & Sun, J., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

10 Scopus citations

Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis

Mantilla, C. B., Zhan, W. Z., Gransee, H. M., Prakash, Y. S. & Sieck, G. C., Jan 1 2018, (Accepted/In press) In : Journal of Comparative Neurology.

Research output: Contribution to journalArticle

3 Scopus citations

RNAi screening identifies a mechanosensitive ROCK-JAK2- STAT3 network central to myofibroblast activation

Oh, R. S., Haak, A. J., Smith, K. M. J., Ligresti, G., Choi, K. M., Xie, T., Wang, S., Walters, P. R., Thompson, M. A., Freeman, M. R., Manlove, L. J., Chu, V. M., Feghali-Bostwick, C., Roden, A., Schymeinsky, J., Pabelick, C. M., Prakash, Y. S., Vassallo, R. & Tschumperlin, D. J., May 15 2018, In : Journal of Cell Science. 131, 10, jcs209932.

Research output: Contribution to journalArticle

11 Scopus citations

TRPC6 and TRPC4 Heteromultimerization Mediates Store Depletion-Activated NCX1 Reversal in Proliferative Vascular Smooth Muscle Cells

Zhang, B., Liu, B., Roos, C. M., Thompson, M. A., Prakash, Y. S., Miller, J. D. & Guo, R. W., Jan 1 2018, In : Channels (Austin, Tex.). 12, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

Open Access
2017

Brain-derived neurotrophic factor and airway fibrosis in asthma

Freeman, M. R., Sathish, V., Manlove, L., Wang, S., Britt, R. J., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S., 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 2, p. L360-L370

Research output: Contribution to journalArticle

7 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature Communications. 8, 14532.

Research output: Contribution to journalArticle

254 Scopus citations

Differential Expression of Estrogen Receptor Variants in Response to Inflammation Signals in Human Airway Smooth Muscle

Aravamudan, B., Goorhouse, K. J., Unnikrishnan, G., Thompson, M. A., Pabelick, C. M., Hawse, J. R., Prakash, Y. S. & Sathish, V., Jul 1 2017, In : Journal of Cellular Physiology. 232, 7, p. 1754-1760 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mitochondrial Dysfunction in Airway Disease

Prakash, Y. S., Pabelick, C. M. & Sieck, G. C., Sep 1 2017, In : Chest. 152, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Moderate hyperoxia induces extracellular matrix remodeling by human fetal airway smooth muscle cells

Vogel, E. R., Britt, R. J., Faksh, A., Kuipers, I., Pandya, H., Prakash, Y. S., Martin, R. J. & Pabelick, C. M., Feb 1 2017, In : Pediatric Research. 81, 2, p. 376-383 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

TNFα decreases mitochondrial movement in human airway smooth muscle

Delmotte, P., Zavaletta, V. A., Thompson, M. A., Prakash, Y. S. & Sieck, G. C., 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 1, p. L166-L176

Research output: Contribution to journalArticle

4 Scopus citations
2016

An official American thoracic society workshop report: Evaluation and management of asthma in the elderly

behalf of the ATS ad hoc Committee on Asthma in the Elderly, Nov 1 2016, In : Annals of the American Thoracic Society. 13, 11, p. 2064-2077 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Cystic fibrosis transmembrane conductance regulator in sarcoplasmic reticulum of airway smooth muscle: Implications for airway contractility

Cook, D. P., Rector, M. V., Bouzek, D. C., Michalski, A. S., Gansemer, N. D., Reznikov, L. R., Li, X., Stroik, M. R., Ostedgaard, L. S., Alaiwa, M. H. A., Thompson, M. A., Prakash, Y. S., Krishnan, R., Meyerholz, D. K., Seow, C. Y. & Stoltz, D. A., Feb 15 2016, In : American Journal of Respiratory and Critical Care Medicine. 193, 4, p. 417-426 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model

Faksh, A., Britt, R. J., Vogel, E. R., Kuipers, I., Thompson, M. A., Sieck, G. C., Pabelick, C. M., Martin, R. J. & Prakash, Y. S., Mar 1 2016, In : Pediatric Research. 79, 3, p. 391-400 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

Aravamudan, B., Thompson, M., Sieck, G. C., Vassallo, R., Pabelick, C. M. & Prakash, Y. S., 2016, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

7 Scopus citations

Hyperinsulinemia adversely affects lung structure and function

Singh, S., Bodas, M., Bhatraju, N. K., Pattnaik, B., Gheware, A., Parameswaran, P. K., Thompson, M., Freeman, M., Mabalirajan, U., Gosens, R., Ghosh, B., Pabelick, C. M., Linneberg, A., Prakash, Y. S. & Agrawal, A., Mar 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 9, p. L837-L845

Research output: Contribution to journalArticle

22 Scopus citations

Mechanisms of BDNF regulation in asthmatic airway smooth muscle

Aravamudan, B., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S., Aug 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 2, p. 270-279 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension

Eirin, A., Ebrahimi, B., Kwon, S. H., Fiala, J. A., Williams, B. J., Woollard, J. R., He, Q., Gupta, R. C., Sabbah, H. N., Prakash, Y. S., Textor, S. C., Lerman, A. & Lerman, L. O., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003118.

Research output: Contribution to journalArticle

29 Scopus citations

Secreted brain-derived neurotrophic factor and asthma severity

Wang, S., Sathish, V., Freeman, M., Thompson, M., Pabelick, C. M. & Prakash, Y. S., Feb 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 54, 2, p. 297 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion From Human Airway Smooth Muscle Cells

Wang, S. Y., Freeman, M. R., Sathish, V., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S., Jul 1 2016, In : Journal of Cellular Physiology. 231, 7, p. 1586-1592 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

TLR3 activation increases chemokine expression in human fetal airway smooth muscle cells

Faksh, A., Britt, R. J., Vogel, E. R., Thompson, M. A., Pandya, H. C., Martin, R. J., Pabelick, C. M. & Prakash, Y. S., 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 2, p. L202-L211

Research output: Contribution to journalArticle

8 Scopus citations
2015

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Yarova, P. L., Stewart, A. L., Sathish, V., Britt, R. J., Thompson, M. A., P Lowe, A. P., Freeman, M., Aravamudan, B., Kita, H., Brennan, S. C., Schepelmann, M., Davies, T., Yung, S., Cholisoh, Z., Kidd, E. J., Ford, W. R., Broadley, K. J., Rietdorf, K., Chang, W., Bin Khayat, M. E. & 7 others, Ward, D. T., Corrigan, C. J., T Ward, J. P., Kemp, P. J., Pabelick, C. M., Prakash, Y. S. & Riccardi, D., Apr 22 2015, In : Science Translational Medicine. 7, 284

Research output: Contribution to journalArticle

62 Scopus citations

CAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle

Thompson, M. A., Britt, R. J., Kuipers, I., Stewart, A., Thu, J., Pandya, H. C., MacFarlane, P., Pabelick, C. M., Martin, R. J. & Prakash, Y. S., 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2506-2514 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle

Sathish, V., Freeman, M. R., Long, E., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S., Jun 25 2015, (Accepted/In press) In : Cellular Physiology and Biochemistry. p. 1101-1115 15 p.

Research output: Contribution to journalArticle

18 Scopus citations
20 Scopus citations

Control of nanoparticle penetration into biofilms through surface design

Li, X., Yeh, Y. C., Giri, K., Mout, R., Landis, R. F., Prakash, Y. S. & Rotello, V. M., Jan 7 2015, In : Chemical Communications. 51, 2, p. 282-285 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Fetal human airway smooth muscle cell production of leukocyte chemoattractants is differentially regulated by fluticasone

Pearson, H., Britt, R. J., Pabelick, C. M., Prakash, Y. S., Amrani, Y. & Pandya, H. C., Dec 1 2015, In : Pediatric Research. 78, 6, p. 650-656 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells

Giri, K., Pabelick, C. M., Mukherjee, P. & Prakash, Y. S., Nov 26 2015, (Accepted/In press) In : Apoptosis. p. 1-11 11 p.

Research output: Contribution to journalArticle

8 Scopus citations