• 2656 Citations
  • 18 Scopus h-Index
20022020
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Research Output 2002 2019

  • 2656 Citations
  • 18 Scopus h-Index
  • 28 Article
  • 2 Review article
  • 1 Chapter
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Article
2019

Disruption of Robo2-Baiap2 integrated signaling drives cystic disease

Li, Q., Cui, S., Ma, Q., Liu, Y., Yu, H., Geng, G., Agborbesong, E., Ren, C., Wei, K., Zhang, Y., Yang, J., Bai, X., Cai, G., Xie, Y., Li, X. & Chen, X., Sep 19 2019, In : JCI Insight. 4, 18, e127602.

Research output: Contribution to journalArticle

Open Access
Cystic Kidney Diseases
Kidney
Claudin-2
Cysts
Epithelium

MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease

Salah, S. M., Meisenheimer, J. D., Rao, R., Peda, J. D., Wallace, D. P., Foster, D., Li, X., Li, X., Zhou, X., Vallejo, J. A., Wacker, M. J., Fields, T. A. & Swenson-Fields, K. I., Jan 1 2019, In : American Journal of Physiology - Renal Physiology. 317, 2, p. F343-F360

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Pulmonary Edema
Kidney
Macrophages
Cysts
2018
4 Citations (Scopus)

Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis

Trott, J. F., Hwang, V. J., Ishimaru, T., Chmiel, K. J., Zhou, J. X., Shim, K., Stewart, B. J., Mahjoub, M. R., Jen, K. Y., Barupal, D. K., Li, X. & Weiss, R. H., Dec 1 2018, In : American journal of physiology. Renal physiology. 315, 6, p. F1855-F1868

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Arginine
Glutamine
Renal Cell Carcinoma
Metabolic Diseases
18 Citations (Scopus)

Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression

Li, L. X., Zhou, J. X., Calvet, J. P., Godwin, A. K., Jensen, R. A. & Li, X., Mar 1 2018, In : Cell Death and Disease. 9, 3, 326.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Methyltransferases
Lysine
Breast Neoplasms
Methylation
2017
3 Citations (Scopus)

Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease

Hwang, V. J., Zhou, X., Chen, X., Trott, J., Abu Aboud, O., Shim, K., Dionne, L. K., Chmiel, K. J., Senapedis, W., Baloglu, E., Mahjoub, M. R., Li, X. & Weiss, R. H., Oct 1 2017, In : Kidney International. 92, 4, p. 922-933 12 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Catenins
Niacinamide
Transferases
NAD
8 Citations (Scopus)

Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease

Raman, A., Reif, G. A., Dai, Y., Khanna, A., Li, X., Astleford, L., Parnell, S. C., Calvet, J. P. & Wallace, D. P., Sep 1 2017, In : Journal of the American Society of Nephrology. 28, 9, p. 2708-2719 12 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cysts
Fibrosis
Kidney
Growth
16 Citations (Scopus)

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Li, L. X., Fan, L. X., Zhou, J. X., Grantham, J. J., Calvet, J. P., Sage, J. & Li, X., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2751-2764 14 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Methyltransferases
Lysine
Cysts
Kidney
2016
7 Citations (Scopus)

A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease

Kakade, V. R., Tao, S., Rajagopal, M., Zhou, X., Li, X., Yu, A. S. L., Calvet, J. P., Pandey, P. & Rao, R., Jan 1 2016, In : Journal of Molecular Cell Biology. 8, 6, p. 464-476 13 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Cyclic AMP Response Element-Binding Protein
Polycystic Kidney Diseases
Kidney
Disease Progression
2015
7 Citations (Scopus)

17β-estradiol ameliorates oxygen-induced retinopathy in the early hyperoxic phase

Zhang, H., Wang, X., Xu, K., Wang, Y., Wang, Y., Liu, X., Zhang, X., Wang, L. & Li, X., Feb 20 2015, In : Biochemical and Biophysical Research Communications. 457, 4, p. 700-705 6 p.

Research output: Contribution to journalArticle

NADP
Retinopathy of Prematurity
Retina
Estradiol
Oxidoreductases
50 Citations (Scopus)

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

Chen, L., Zhou, X., Fan, L. X., Yao, Y., Swenson-Fields, K. I., Gadjeva, M., Wallace, D. P., Peters, D. J. M., Yu, A., Grantham, J. J. & Li, X., Jan 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2399-2412 14 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
Cysts
Kidney
28 Citations (Scopus)

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

Zhou, X., Fan, L. X., Peters, D. J. M., Trudel, M., Bradner, J. E. & Li, X., Jul 15 2015, In : Human Molecular Genetics. 24, 14, p. 3982-3993 12 p., ddv136.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Cysts
Kidney
Growth
Epithelial Cells
13 Citations (Scopus)

TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling

Zhou, J. X., Fan, L. X., Li, X., Calvet, J. P. & Li, X., Jun 25 2015, In : PLoS One. 10, 6, e0131043.

Research output: Contribution to journalArticle

cyclin-dependent kinase
Cell proliferation
mitogen-activated protein kinase
tumor necrosis factor-alpha
cell proliferation
2014
15 Citations (Scopus)

Developmental signaling: Does it bridge the gap between cilia dysfunction and renal cystogenesis?

Tran, P. V., Sharma, M., Li, X. & Calvet, J. P., Jan 1 2014, In : Birth Defects Research Part C - Embryo Today: Reviews. 102, 2, p. 159-173 15 p.

Research output: Contribution to journalArticle

Cilia
Cystic Kidney Diseases
Kidney
Wnt Signaling Pathway
Morphogenesis
22 Citations (Scopus)

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-pacsin 2-N-wasp complex

Yao, G., Su, X., Nguyen, V., Roberts, K., Li, X., Takakura, A., Plomann, M. & Zhou, J., Jan 1 2014, In : Human Molecular Genetics. 23, 10, p. 2769-2779 11 p., ddt672.

Research output: Contribution to journalArticle

Wasps
Actin Cytoskeleton
Cell Movement
Polycystic Kidney Diseases
Epithelial Cells
19 Citations (Scopus)

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1

Zhou, X., Fan, L. X., Li, K., Ramchandran, R., Calvet, J. P. & Li, X., Mar 1 2014, In : Human Molecular Genetics. 23, 6, p. 1644-1655 12 p., ddt556.

Research output: Contribution to journalArticle

Centrosome
Cilia
Polyploidy
Morpholinos
Niacinamide
2013
66 Citations (Scopus)

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

Zhou, X., Fan, L. X., Sweeney, W. E., Denu, J. M., Avner, E. D. & Li, X., Jul 1 2013, In : Journal of Clinical Investigation. 123, 7, p. 3084-3098 15 p.

Research output: Contribution to journalArticle

Sirtuin 1
Autosomal Dominant Polycystic Kidney
Cysts
Kidney
Epithelial Cells
19 Citations (Scopus)

Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts

Fan, L. X., Zhou, X., Sweeney, W. E., Wallace, D. P., Avner, E. D., Grantham, J. J. & Li, X., Dec 9 2013, In : Journal of the American Society of Nephrology. 24, 12, p. 2010-2022 13 p.

Research output: Contribution to journalArticle

Caspases
Cysts
Mitochondria
Cell Death
Epithelial Cells
2012
41 Citations (Scopus)

HDAC6 Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation in Renal Epithelial Cells

Liu, W., Fan, L. X., Zhou, X., Sweeney, W. E., Avner, E. D. & Li, X., Nov 13 2012, In : PLoS One. 7, 11, e49418.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylases
kidney cells
Epidermal Growth Factor Receptor
epithelial cells
32 Citations (Scopus)

Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation

Li, X., Fan, L. X., Magenheimer, B., Calvet, J. P. & Li, X., Jan 1 2012, In : Kidney International. 81, 1, p. 76-85 10 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylases
Retinoblastoma
Cysts
Epithelial Cells
2010
61 Citations (Scopus)

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

Xia, S., Li, X., Johnson, T., Seidel, C., Wallace, D. P. & Li, R., Apr 1 2010, In : Development. 137, 7, p. 1075-1084 10 p.

Research output: Contribution to journalArticle

TRPP Cation Channels
Histone Deacetylases
Cysts
MEF2 Transcription Factors
Kidney
2008
54 Citations (Scopus)

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5′ end of Pkd1

Starremans, P. G., Li, X., Finnerty, P. E., Guo, L., Takakura, A., Neilson, E. G. & Zhou, J., Jan 1 2008, In : Kidney International. 73, 12, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cysts
Nephrons
Aquaporin 2
Cystic Kidney Diseases
89 Citations (Scopus)

A tumor necrosis factor-α-mediated pathway promoting autosomal dominant polycystic kidney disease

Li, X., Magenheimer, B. S., Xia, S., Johnson, T., Wallace, D. P., Calvet, J. P. & Li, R., Aug 1 2008, In : Nature Medicine. 14, 8, p. 863-868 6 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Tumor Necrosis Factor-alpha
Cysts
TRPP Cation Channels
Kidney
2007
126 Citations (Scopus)

Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia

Wang, S., Zhang, J., Nauli, S. M., Li, X., Starremans, P. G., Luo, Y., Roberts, K. A. & Zhou, J., Apr 1 2007, In : Molecular and Cellular Biology. 27, 8, p. 3241-3252 12 p.

Research output: Contribution to journalArticle

Epithelium
Calcium
Kidney
Cilia
Epitopes
2005
144 Citations (Scopus)

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

Li, X., Luo, Y., Starremans, P. G., McNamara, C. A., Pei, Y. & Zhou, J., Dec 1 2005, In : Nature Cell Biology. 7, 12, p. 1102-1112 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Autosomal Dominant Polycystic Kidney
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p21
Cystic Kidney Diseases
2004
115 Citations (Scopus)

Gating of the polycystin ion channel signaling complex in neurons and kidney cells.

Delmas, P., Nauli, S. M., Li, X., Coste, B., Osorio, N., Crest, M., Brown, D. A. & Zhou, J., Jan 1 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 6, p. 740-742 3 p.

Research output: Contribution to journalArticle

Ion Channel Gating
TRPP Cation Channels
Ion Channels
Neurons
Kidney
2003
138 Citations (Scopus)

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

Luo, Y., Vassilev, P. M., Li, X., Kawanabe, Y. & Zhou, J., Apr 1 2003, In : Molecular and Cellular Biology. 23, 7, p. 2600-2607 8 p.

Research output: Contribution to journalArticle

Cations
Epithelium
Cell Membrane
Kidney
Endoplasmic Reticulum
1400 Citations (Scopus)

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., Ingber, D. E. & Zhou, J., Feb 1 2003, In : Nature Genetics. 33, 2, p. 129-137 9 p.

Research output: Contribution to journalArticle

Cilia
Polycystic Kidney Diseases
Kidney
Epithelium
Autosomal Dominant Polycystic Kidney
2002
135 Citations (Scopus)

Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2

Delmas, P., Nomura, H., Li, X., Lakkis, M., Luo, Y., Segal, Y., Fernández-Fernández, J. M., Harris, P. C., Frischauf, A. M., Brown, D. A. & Zhou, J., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11276-11283 8 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Chemical activation
Autosomal Dominant Polycystic Kidney
Gq-G11 GTP-Binding Protein alpha Subunits
TRPP Cation Channels