Wolfgang Singer, MD

  • 2535 Citations
  • 28 Scopus h-Index
19992020

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"Unequivocally abnormal" vs "usual" signs and symptoms for proficient diagnosis of diabetic polyneuropathy: Cl vs N Phys trial

Dyck, P. J., Overland, C. J., Low, P. A., Litchy, W. J., Davies, J. L., Dyck, P. J. B., Carter, R. E., Melton, L. J., Andersen, H., Albers, J. W., Bolton, C. F., England, J. D., Klein, C. J., Llewelyn, G., Mauermann, M. L., Russell, J. W., Selvarajah, D., Singer, W., Smith, A. G., Tesfaye, S. & 1 others, Vella, A., Dec 2012, In : Archives of neurology. 69, 12, p. 1609-1614 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
9 Scopus citations

The role of autonomic testing in the differentiation of Parkinson's disease from multiple system atrophy

Kimpinski, K., Iodice, V., Burton, D. D., Camilleri, M., Mullan, B. P., Lipp, A., Sandroni, P., Gehrking, T. L., Sletten, D. M., Ahlskog, J. E., Fealey, R. D., Singer, W. & Low, P. A., Jun 15 2012, In : Journal of the neurological sciences. 317, 1-2, p. 92-96 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

The beautiful feet of neuropathy

Singer, W., Engelstad, J. K. & Dyck, P. J. B., Apr 7 2009, In : Neurology. 72, 14, 1 p.

Research output: Contribution to journalArticle

Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

McCarter, S. J., Feemster, J. C., Tabatabai, G. M., Sandness, D. J., Timm, P. C., McCarter, A. R., Talley, H. N., Junna, M. R., Savica, R., Singer, W., Coon, E. A., Benarroch, E. E., Josephs, K. A., Boeve, B. F., Silber, M. H. & St. Louis, E. K., Dec 1 2019, In : Annals of neurology. 86, 6, p. 969-974 6 p.

Research output: Contribution to journalArticle

Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS)

Tani, H., Singer, W., McPhee, B. R., Opfer-Gehrking, T. L., Haruma, K., Kajiyama, G. & Low, P. A., Dec 28 2000, In : Autonomic Neuroscience: Basic and Clinical. 86, 1-2, p. 107-113 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: CI vs. NPhys trial

Dyck, P. J., Overland, C. J., Low, P. A., Litchy, W. J., Davies, J. L., Dyck, P. J. B., O'Brien, P. C., Albers, J. W., Andersen, H., Bolton, C. F., England, J. D., Klein, C. J., Llewelyn, J. G., Mauermann, M. L., Russell, J. W., Singer, W., Smith, A. G., Tesfaye, S. & Vella, A., Aug 2010, In : Muscle and Nerve. 42, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

Sex and gender influence symptom manifestation and survival in multiple system atrophy

Coon, E. A., Nelson, R. M., Sletten, D. M., Suarez, M. D., Ahlskog, J. E., Benarroch, E. E., Sandroni, P., Mandrekar, J. N., Low, P. A. & Singer, W., Jul 2019, In : Autonomic Neuroscience: Basic and Clinical. 219, p. 49-52 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Retinal and pontine striations: Neurodiagnostic signs of autosomal recessive spastic ataxia of charlevoix-saguenay

Leavitt, J. A., Singer, W., Brown, W. L., Pulido, J. S. & Brodsky, M. C., Dec 8 2014, In : Journal of Neuro-Ophthalmology. 34, 4, p. 369-371 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Refined quantitation of sweat gland innervation

Minota, K., Schmeichel, A. M., Gehrking, J. A., Mandrekar, J. N., Low, P. A. & Singer, W., 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 5, p. 453-459 7 p.

Research output: Contribution to journalArticle

Pyridostigmine treatment trial in neurogenic orthostatic hypotension

Singer, W., Sandroni, P., Opfer-Gehrking, T. L., Suarez, G. A., Klein, C. M., Hines, S., O'Brien, P. C., Slezak, J. & Low, P. A., Apr 2006, In : Archives of neurology. 63, 4, p. 513-518 6 p.

Research output: Contribution to journalArticle

174 Scopus citations

Pure autonomic failure: Predictors of conversion to clinical CNS involvement

Singer, W., Berini, S. E., Sandroni, P., Fealey, R. D., Coon, E. A., Suarez, M. D., Benarroch, E. E. & Low, P. A., Mar 21 2017, In : Neurology. 88, 12, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies

Singer, W., Spies, J. M., McArthur, J., Low, J., Griffin, J. W., Nickander, K. K., Gordon, V. & Low, P. A., Feb 24 2004, In : Neurology. 62, 4, p. 612-618 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure

Lipp, A., Sandroni, P., Ahlskog, J. E., Fealey, R. D., Kimpinski, K., Iodice, V., Gehrking, T. L., Weigand, S. D., Sletten, D. M., Gehrking, J. A., Nickander, K. K., Singer, W., Maraganore, D. M., Gilman, S., Wenning, G. K., Shults, C. W. & Low, P. A., Jun 2009, In : Archives of neurology. 66, 6, p. 742-750 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension

Van Gerpen, J. A., Al-Shaikh, R. H., Tipton, P. W., Wszolek, Z. K., Uitti, R. J., Ferman, T. J., Dickson, D. W., Benarroch, E. E., Singer, W., Cutsforth-Gregory, J. K., Heckman, M. G., Brushaber, D. E., Josephs, K. A., Low, P. A., Ahlskog, J. E. & Cheshire, W. P., Oct 1 2019, In : Neurology. 93, 14, p. E1339-E1347

Research output: Contribution to journalArticle

4 Scopus citations

Proficiency of nerve conduction using standard methods and reference values (cl. NPhys Trial 4)

The CI. Nphys Trial 4 Investigators, Dec 1 2014, In : Muscle and Nerve. 50, 6, p. 900-908 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Predicting phenoconversion in pure autonomic failure

Coon, E. A., Mandrekar, J. N., Berini, S. E., Benarroch, E. E., Sandroni, P., Low, P. A. & Singer, W., Aug 18 2020, In : Neurology. 95, 7, p. e889-e897

Research output: Contribution to journalArticle

Postural tachycardia in children and adolescents: What is abnormal?

Singer, W., Sletten, D. M., Opfer-Gehrking, T. L., Brands, C. K., Fischer, P. R. & Low, P. A., Feb 2012, In : Journal of Pediatrics. 160, 2, p. 222-226 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Orthostatic intolerance without postural tachycardia: How much dysautonomia?

Parsaik, A. K., Singer, W., Allison, T. G., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A. & Sandroni, P., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 181-188 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies

Autonomic Disorders Consortium, Mar 2018, In : Annals of neurology. 83, 3, p. 522-531 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Natural history of pure autonomic failure: A United States prospective cohort

on behalf of the Autonomic Disorders Consortium, Feb 1 2017, In : Annals of neurology. 81, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Natural history of multiple system atrophy in the USA: A prospective cohort study

Low, P. A., Reich, S. G., Jankovic, J., Shults, C. W., Stern, M. B., Novak, P., Tanner, C. M., Gilman, S., Marshall, F. J., Wooten, F., Racette, B., Chelimsky, T., Singer, W., Sletten, D. M., Sandroni, P. & Mandrekar, J., Jul 1 2015, In : The Lancet Neurology. 14, 7, p. 710-719 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. & Ross, O. A., Apr 2018, In : Movement Disorders. 33, 4, p. 647-650 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Multiple system atrophy: Prognostic indicators of survival

Figueroa, J. J., Singer, W., Parsaik, A., Benarroch, E. E., Ahlskog, J. E., Fealey, R. D., Parisi, J. E., Sandroni, P., Mandrekar, J., Iodice, V., Low, P. A. & Bower, J. H., Aug 2014, In : Movement Disorders. 29, 9, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Multicenter trial of the proficiency of smart quantitative sensation tests

Dyck, P. J., Argyros, B., Russell, J. W., Gahnstrom, L. E., Nalepa, S., Albers, J. W., Lodermeier, K. A., Zafft, A. J., Dyck, P. J. B., Klein, C. J., Litchy, W. J., Davies, J. L., Carter, R. E., Melton, L. J., Low, P. A., Overland, C. J., Andersen, H., England, J. D., Llewelyn, G., Mauermann, M. L. & 5 others, Selvarajah, D., Singer, W., Smith, G., Tesfaye, S. & Vella, A., May 2014, In : Muscle and Nerve. 49, 5, p. 645-653 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

MAPT haplotype diversity in multiple system atrophy

Labbé, C., Heckman, M. G., Lorenzo-Betancor, O., Murray, M. E., Ogaki, K., Soto-Ortolaza, A. I., Walton, R. L., Fujioka, S., Koga, S., Uitti, R. J., van Gerpen, J. A., Petersen, R. C., Graff-Radford, N. R., Younkin, S. G., Boeve, B. F., Cheshire, W. P., Low, P. A., Sandroni, P., Coon, E. A., Singer, W. & 3 others, Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Sep 1 2016, In : Parkinsonism and Related Disorders. 30, p. 40-45 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival

McCarter, S. J., Coon, E. A., Savica, R., St Louis, E. K., Bower, J. H., Benarroch, E. E., Sandroni, P., Low, P. & Singer, W., Aug 1 2020, In : Movement Disorders. 35, 8, p. 1462-1466 5 p.

Research output: Contribution to journalArticle

Invited Article: Autonomic ganglia: Target and novel therapeutic tool

Vernino, S., Sandroni, P., Singer, W. & Low, P. A., May 2008, In : Neurology. 70, 20, p. 1926-1932 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy

Singer, W., Dietz, A. B., Zeller, A. D., Gehrking, T. L., Schmelzer, J. D., Schmeichel, A. M., Gehrking, J. A., Suarez, M. D., Sletten, D. M., Minota Pacheco, K. V., Coon, E. A., Sandroni, P., Benarroch, E. E., Fealey, R. D., Matsumoto, J. Y., Bower, J. H., Hassan, A., Mckeon, A., Windebank, A. J., Mandrekar, J. N. & 1 others, Low, P. A., Jul 2 2019, In : Neurology. 93, 1, p. E77-E87

Research output: Contribution to journalArticle

10 Scopus citations

Influence of posture on the Valsalva manoeuvre

Singer, W., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., 2001, In : Clinical Science. 100, 4, p. 433-440 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Human papillomavirus vaccine (HPV) and autonomic disorders: A position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Jan 1 2019, In : Autonomic Neuroscience: Basic and Clinical. 102550.

Research output: Contribution to journalArticle

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Jan 2020, In : Autonomic Neuroscience: Basic and Clinical. 223, 102550.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Feb 1 2020, In : Clinical Autonomic Research. 30, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Heart rate-dependent electrocardiogram abnormalities in patients with postural tachycardia syndrome

Singer, W., Shen, W. K., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., Jan 31 2003, In : Autonomic Neuroscience: Basic and Clinical. 103, 1-2, p. 106-113 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gi dysfunctions in diabetic gastroenteropathy, their relationships with symptoms, and effects of a GLP-1 antagonist

Chakraborty, S., Halland, M., Burton, D., Desai, A., Neja, B., Low, P., Singer, W., Camilleri, M., Zinsmeister, A. R. & Bharucha, A. E., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 1967-1977 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gastric emptying in postural tachycardia syndrome: A preliminary report

Park, K. J., Singer, W., Sletten, D. M., Low, P. A. & Bharucha, A. E., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 163-167 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure

Cutsforth-Gregory, J. K., McKeon, A., Coon, E. A., Sletten, D. M., Suarez, M., Sandroni, P., Singer, W., Benarroch, E. E., Fealey, R. D. & Low, P. A., Oct 2018, In : Mayo Clinic proceedings. 93, 10, p. 1440-1447 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome

Singer, W., Shen, W. K., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., Mar 2002, In : Mayo Clinic proceedings. 77, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Elimination of spurious absent sweat response in QSWEAT recordings

Corfits, J., Singer, W., Sandroni, P., Fealey, R. D., Coon, E. A., Benarroch, E. E., Berini, S. E., Mauermann, M. L., Sletten, D. M., Cutsforth-Gregory, J. K., Schmelzer, J. D. & Low, P. A., Dec 2019, In : Autonomic Neuroscience: Basic and Clinical. 222, 102589.

Research output: Contribution to journalArticle

Efficacy and safety of rifampicin for multiple system atrophy: A randomised, double-blind, placebo-controlled trial

Low, P. A., Robertson, D., Gilman, S., Kaufmann, H., Singer, W., Biaggioni, I., Freeman, R., Perlman, S., Hauser, R. A., Cheshire, W., Lessig, S., Vernino, S., Mandrekar, J., Dupont, W. D., Chelimsky, T. & Galpern, W. R., Mar 2014, In : The Lancet Neurology. 13, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension

Figueroa, J. J., Singer, W., Sandroni, P., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. & Basford, J. R., Mar 1 2015, In : Archives of Physical Medicine and Rehabilitation. 96, 3, p. 505-510 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Earlier age of onset in multiple system atrophy with smoking and heavy alcohol use

Jackson, L., Coon, E. A., Ahlskog, J. E., Bower, J. H., Sandroni, P., Benarroch, E. E., Mandrekar, J. N., Low, P. A. & Singer, W., Sep 2019, In : Parkinsonism and Related Disorders. 66, p. 212-215 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy?

Coon, E. A., Ahlskog, J. E., Silber, M. H., Fealey, R. D., Benarroch, E. E., Sandroni, P., Mandrekar, J. N., Low, P. A. & Singer, W., Mar 2018, In : Parkinsonism and Related Disorders. 48, p. 51-53 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome

Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2015, In : Neurogastroenterology and Motility. 27, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

Shahnawaz, M., Mukherjee, A., Pritzkow, S., Mendez, N., Rabadia, P., Liu, X., Hu, B., Schmeichel, A., Singer, W., Wu, G., Tsai, A. L., Shirani, H., Nilsson, K. P. R., Low, P. A. & Soto, C., Feb 13 2020, In : Nature. 578, 7794, p. 273-277 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Determination of vagal baroreflex sensitivity in normal subjects

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D., Kihara, M. & Low, P. A., Oct 1 2014, In : Muscle and Nerve. 50, 4, p. 535-540 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Decreased orthostatic adrenergic reactivity in non-dipping postural tachycardia syndrome

Figueroa, J. J., Bott-Kitslaar, D. M., Mercado, J. A., Basford, J. R., Sandroni, P., Shen, W. K., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. A. & Singer, W., Oct 1 2014, In : Autonomic Neuroscience: Basic and Clinical. 185, p. 107-111 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Deconditioning in patients with orthostatic intolerance

Parsaik, A., Allison, T. G., Singer, W., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A. & Sandroni, P., Oct 2 2012, In : Neurology. 79, 14, p. 1435-1439 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Conjugal multiple system atrophy: Chance, shared risk factors, or evidence of transmissibility?

Coon, E. A., Rocca, W., Melson, C. S., Ahlskog, J. E., Matsumoto, J. Y., Low, P. A. & Singer, W., Oct 2019, In : Parkinsonism and Related Disorders. 67, p. 10-13 4 p.

Research output: Contribution to journalArticle

4 Scopus citations