Wolfgang Singer, MD

  • 2478 Citations
  • 28 Scopus h-Index
19992020

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Article
1999

Cold face test demonstrates parasympathetic cardiac dysfunction in familial dysautonomia

Hilz, M. J., Stemper, B., Sauer, P., Haertl, U., Singer, W. & Axelrod, F. B., Jun 1 1999, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 276, 6 45-6, p. R1833-R1839

Research output: Contribution to journalArticle

52 Scopus citations
2000

Abnormal vasoreaction to arousal stimuli - An early sign of diabetic sympathetic neuropathy demonstrated by laser Doppler flowmetry

Hilz, M. J., Hecht, M. J., Berghoff, M., Singer, W. & Neundoerfer, B., Jan 1 2000, In : Journal of Clinical Neurophysiology. 17, 4, p. 419-425 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS)

Tani, H., Singer, W., McPhee, B. R., Opfer-Gehrking, T. L., Haruma, K., Kajiyama, G. & Low, P. A., Dec 28 2000, In : Autonomic Neuroscience: Basic and Clinical. 86, 1-2, p. 107-113 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
2001

Influence of posture on the Valsalva manoeuvre

Singer, W., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., Apr 30 2001, In : Clinical Science. 100, 4, p. 433-440 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2002

Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome

Singer, W., Shen, W. K., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., Mar 2002, In : Mayo Clinic proceedings. 77, 3, p. 246-252 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2003

Acetylcholinesterase inhibition: A novel approach in the treatment of neurogenic orthostatic hypotension

Singer, W., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J., Bharucha, A. E. & Low, P. A., Sep 1 2003, In : Journal of Neurology, Neurosurgery and Psychiatry. 74, 9, p. 1294-1298 5 p.

Research output: Contribution to journalArticle

127 Scopus citations

Heart rate-dependent electrocardiogram abnormalities in patients with postural tachycardia syndrome

Singer, W., Shen, W. K., Opfer-Gehrking, T. L., McPhee, B. R., Hilz, M. J. & Low, P. A., Jan 31 2003, In : Autonomic Neuroscience: Basic and Clinical. 103, 1-2, p. 106-113 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies

Singer, W., Spies, J. M., McArthur, J., Low, J., Griffin, J. W., Nickander, K. K., Gordon, V. & Low, P. A., Feb 24 2004, In : Neurology. 62, 4, p. 612-618 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
2006

Acetylcholinesterase inhibition in patients with orthostatic intolerance

Singer, W., Opfer-Gehrking, T. L., Nickander, K. K., Hines, S. M. & Low, P. A., Oct 2006, In : Journal of Clinical Neurophysiology. 23, 5, p. 477-482 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pyridostigmine treatment trial in neurogenic orthostatic hypotension

Singer, W., Sandroni, P., Opfer-Gehrking, T. L., Suarez, G. A., Klein, C. M., Hines, S., O'Brien, P. C., Slezak, J. & Low, P. A., Apr 1 2006, In : Archives of neurology. 63, 4, p. 513-518 6 p.

Research output: Contribution to journalArticle

172 Scopus citations
2007

Adrenergic and vagal baroreflex sensitivity in autonomic failure

Schrezenmaier, C., Singer, W., Swift, N. M., Sletten, D., Tanabe, J. & Low, P. A., Mar 2007, In : Archives of neurology. 64, 3, p. 381-386 6 p.

Research output: Contribution to journalArticle

66 Scopus citations
2008

Invited Article: Autonomic ganglia: Target and novel therapeutic tool

Vernino, S., Sandroni, P., Singer, W. & Low, P. A., May 2008, In : Neurology. 70, 20, p. 1926-1932 7 p.

Research output: Contribution to journalArticle

89 Scopus citations
2009

Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure

Lipp, A., Sandroni, P., Ahlskog, J. E., Fealey, R. D., Kimpinski, K., Iodice, V., Gehrking, T. L., Weigand, S. D., Sletten, D. M., Gehrking, J. A., Nickander, K. K., Singer, W., Maraganore, D. M., Gilman, S., Wenning, G. K., Shults, C. W. & Low, P. A., Jun 2009, In : Archives of neurology. 66, 6, p. 742-750 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

The beautiful feet of neuropathy

Singer, W., Engelstad, J. K. & Dyck, P. J. B., Apr 7 2009, In : Neurology. 72, 14, 1 p.

Research output: Contribution to journalArticle

2010

Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: CI vs. NPhys trial

Dyck, P. J., Overland, C. J., Low, P. A., Litchy, W. J., Davies, J. L., Dyck, P. J. B., O'Brien, P. C., Albers, J. W., Andersen, H., Bolton, C. F., England, J. D., Klein, C. J., Llewelyn, J. G., Mauermann, M. L., Russell, J. W., Singer, W., Smith, A. G., Tesfaye, S. & Vella, A., Aug 2010, In : Muscle and Nerve. 42, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

125 Scopus citations
2011

A middle-aged woman with nausea, weight loss, and orthostatic hypotension

Singer, W., Yung, I. O., Wollmann, R., Kelly, T. & Keegan, B. M., Aug 2 2011, In : Neurology. 77, 5, p. 489-495 7 p.

Research output: Contribution to journalArticle

2012

Amyloid-like IgM deposition neuropathy: A distinct clinico-pathologic and proteomic profiled disorder

Figueroa, J. J., Bosch, E. P., Dyck, P. J. B., Singer, W., Vrana, J. A., Theis, J. D., Dogan, A. & Klein, C. J., Jun 2012, In : Journal of the Peripheral Nervous System. 17, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

A prospective, 1-year follow-up study of postural tachycardia syndrome

Kimpinski, K., Figueroa, J. J., Singer, W., Sletten, D. M., Iodice, V., Sandroni, P., Fischer, P. R., Opfer-Gehrking, T. L., Gehrking, J. A. & Low, P. A., Aug 2012, In : Mayo Clinic proceedings. 87, 8, p. 746-752 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests

Iodice, V., Lipp, A., Ahlskog, J. E., Sandroni, P., Fealey, R. D., Parisi, J. E., Matsumoto, J. Y., Benarroch, E. E., Kimpinski, K., Singer, W., Gehrking, T. L., Gehrking, J. A., Sletten, D. M., Schmeichel, A. M., Bower, J. H., Gilman, S., Figueroa, J. & Low, P. A., Apr 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 4, p. 453-459 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

COMPASS 31: A refined and abbreviated composite autonomic symptom score

Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J. & Singer, W., Dec 2012, In : Mayo Clinic proceedings. 87, 12, p. 1196-1201 6 p.

Research output: Contribution to journalArticle

127 Scopus citations

Deconditioning in patients with orthostatic intolerance

Parsaik, A., Allison, T. G., Singer, W., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A. & Sandroni, P., Oct 2 2012, In : Neurology. 79, 14, p. 1435-1439 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Postural tachycardia in children and adolescents: What is abnormal?

Singer, W., Sletten, D. M., Opfer-Gehrking, T. L., Brands, C. K., Fischer, P. R. & Low, P. A., Feb 2012, In : Journal of Pediatrics. 160, 2, p. 222-226 5 p.

Research output: Contribution to journalArticle

122 Scopus citations

The role of autonomic testing in the differentiation of Parkinson's disease from multiple system atrophy

Kimpinski, K., Iodice, V., Burton, D. D., Camilleri, M., Mullan, B. P., Lipp, A., Sandroni, P., Gehrking, T. L., Sletten, D. M., Ahlskog, J. E., Fealey, R. D., Singer, W. & Low, P. A., Jun 15 2012, In : Journal of the neurological sciences. 317, 1-2, p. 92-96 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

"Unequivocally abnormal" vs "usual" signs and symptoms for proficient diagnosis of diabetic polyneuropathy: Cl vs N Phys trial

Dyck, P. J., Overland, C. J., Low, P. A., Litchy, W. J., Davies, J. L., Dyck, P. J. B., Carter, R. E., Melton, L. J., Andersen, H., Albers, J. W., Bolton, C. F., England, J. D., Klein, C. J., Llewelyn, G., Mauermann, M. L., Russell, J. W., Selvarajah, D., Singer, W., Smith, A. G., Tesfaye, S. & 1 others, Vella, A., Dec 2012, In : Archives of neurology. 69, 12, p. 1609-1614 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Central hyperadrenergic state after lightning strike

Parsaik, A. K., Ahlskog, J. E., Singer, W., Gelfman, R., Sheldon, S. H., Seime, R. J., Craft, J. M., Staab, J. P., Kantor, B. & Low, P. A., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 169-173 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gastric emptying in postural tachycardia syndrome: A preliminary report

Park, K. J., Singer, W., Sletten, D. M., Low, P. A. & Bharucha, A. E., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 163-167 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Orthostatic intolerance without postural tachycardia: How much dysautonomia?

Parsaik, A. K., Singer, W., Allison, T. G., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A. & Sandroni, P., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 181-188 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

A report of the autonomic symptom profile in patients with fibromyalgia

Vincent, A., McAllister, S. J., Singer, W., Toussaint, L. L., Sletten, D. M., Whipple, M. O. & Low, P. A., Mar 2014, In : Journal of Clinical Rheumatology. 20, 2, p. 106-108 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Comparison of baroreflex sensitivity with a fall and rise in blood pressure induced by the valsalva manoeuvre

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D. & Low, P. A., 2014, In : Clinical Science. 127, 5, p. 307-313 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Decreased orthostatic adrenergic reactivity in non-dipping postural tachycardia syndrome

Figueroa, J. J., Bott-Kitslaar, D. M., Mercado, J. A., Basford, J. R., Sandroni, P., Shen, W. K., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. A. & Singer, W., Oct 1 2014, In : Autonomic Neuroscience: Basic and Clinical. 185, p. 107-111 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Determination of vagal baroreflex sensitivity in normal subjects

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D., Kihara, M. & Low, P. A., Oct 1 2014, In : Muscle and Nerve. 50, 4, p. 535-540 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Efficacy and safety of rifampicin for multiple system atrophy: A randomised, double-blind, placebo-controlled trial

Low, P. A., Robertson, D., Gilman, S., Kaufmann, H., Singer, W., Biaggioni, I., Freeman, R., Perlman, S., Hauser, R. A., Cheshire, W., Lessig, S., Vernino, S., Mandrekar, J., Dupont, W. D., Chelimsky, T. & Galpern, W. R., Mar 2014, In : The Lancet Neurology. 13, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Multicenter trial of the proficiency of smart quantitative sensation tests

Dyck, P. J., Argyros, B., Russell, J. W., Gahnstrom, L. E., Nalepa, S., Albers, J. W., Lodermeier, K. A., Zafft, A. J., Dyck, P. J. B., Klein, C. J., Litchy, W. J., Davies, J. L., Carter, R. E., Melton, L. J., Low, P. A., Overland, C. J., Andersen, H., England, J. D., Llewelyn, G., Mauermann, M. L. & 5 others, Selvarajah, D., Singer, W., Smith, G., Tesfaye, S. & Vella, A., May 2014, In : Muscle and Nerve. 49, 5, p. 645-653 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Multiple system atrophy: Prognostic indicators of survival

Figueroa, J. J., Singer, W., Parsaik, A., Benarroch, E. E., Ahlskog, J. E., Fealey, R. D., Parisi, J. E., Sandroni, P., Mandrekar, J., Iodice, V., Low, P. A. & Bower, J. H., Aug 2014, In : Movement Disorders. 29, 9, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Proficiency of nerve conduction using standard methods and reference values (cl. NPhys Trial 4)

The CI. Nphys Trial 4 Investigators, Dec 1 2014, In : Muscle and Nerve. 50, 6, p. 900-908 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Retinal and pontine striations: Neurodiagnostic signs of autosomal recessive spastic ataxia of charlevoix-saguenay

Leavitt, J. A., Singer, W., Brown, W. L., Pulido, J. S. & Brodsky, M. C., Dec 8 2014, In : Journal of Neuro-Ophthalmology. 34, 4, p. 369-371 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Clinical features and autonomic testing predict survival in multiple system atrophy

Coon, E. A., Sletten, D. M., Suarez, M. D., Mandrekar, J. N., Ahlskog, J. E., Bower, J. H., Matsumoto, J. Y., Silber, M. H., Benarroch, E. E., Fealey, R. D., Sandroni, P., Low, P. A. & Singer, W., Dec 1 2015, In : Brain. 138, 12, p. 3623-3631 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome

Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2015, In : Neurogastroenterology and Motility. 27, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension

Figueroa, J. J., Singer, W., Sandroni, P., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. & Basford, J. R., Mar 1 2015, In : Archives of Physical Medicine and Rehabilitation. 96, 3, p. 505-510 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Natural history of multiple system atrophy in the USA: A prospective cohort study

Low, P. A., Reich, S. G., Jankovic, J., Shults, C. W., Stern, M. B., Novak, P., Tanner, C. M., Gilman, S., Marshall, F. J., Wooten, F., Racette, B., Chelimsky, T., Singer, W., Sletten, D. M., Sandroni, P. & Mandrekar, J., Jul 1 2015, In : The Lancet Neurology. 14, 7, p. 710-719 10 p.

Research output: Contribution to journalArticle

115 Scopus citations
2016

MAPT haplotype diversity in multiple system atrophy

Labbé, C., Heckman, M. G., Lorenzo-Betancor, O., Murray, M. E., Ogaki, K., Soto-Ortolaza, A. I., Walton, R. L., Fujioka, S., Koga, S., Uitti, R. J., van Gerpen, J. A., Petersen, R. C., Graff-Radford, N. R., Younkin, S. G., Boeve, B. F., Cheshire, W. P., Low, P. A., Sandroni, P., Coon, E. A., Singer, W. & 3 others, Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Sep 1 2016, In : Parkinsonism and Related Disorders. 30, p. 40-45 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
9 Scopus citations
2017

Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction

Coon, E. A., Fealey, R. D., Sletten, D. M., Mandrekar, J. N., Benarroch, E. E., Sandroni, P., Low, P. A. & Singer, W., Mar 1 2017, In : Movement Disorders. 32, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Autonomic function testing: Compliance and consequences

Rasmussen, T. K., Hansen, J., Low, P. A., Sandroni, P., Singer, W., Jensen, T. S. & Terkelsen, A. J., 2017, (Accepted/In press) In : Autonomic Neuroscience: Basic and Clinical.

Research output: Contribution to journalArticle

2 Scopus citations

Natural history of pure autonomic failure: A United States prospective cohort

on behalf of the Autonomic Disorders Consortium, Feb 1 2017, In : Annals of neurology. 81, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Pure autonomic failure: Predictors of conversion to clinical CNS involvement

Singer, W., Berini, S. E., Sandroni, P., Fealey, R. D., Coon, E. A., Suarez, M. D., Benarroch, E. E. & Low, P. A., Mar 21 2017, In : Neurology. 88, 12, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2018

Association study between multiple system atrophy and TREM2 p.R47H

Ogaki, K., Heckman, M. G., Koga, S., Martens, Y. A., Labbé, C., Lorenzo-Betancor, O., Walton, R. L., Soto, A. I., Vargas, E. R., Fujioka, S., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Younkin, S. G., Wszolek, Z. K., Low, P. A., Singer, W., Bu, G., Dickson, D. W. & Ross, O. A., Aug 1 2018, In : Neurology: Genetics. 4, 4, e257.

Research output: Contribution to journalArticle

3 Scopus citations

Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy?

Coon, E. A., Ahlskog, J. E., Silber, M. H., Fealey, R. D., Benarroch, E. E., Sandroni, P., Mandrekar, J. N., Low, P. A. & Singer, W., Mar 2018, In : Parkinsonism and Related Disorders. 48, p. 51-53 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure

Cutsforth-Gregory, J. K., McKeon, A., Coon, E. A., Sletten, D. M., Suarez, M., Sandroni, P., Singer, W., Benarroch, E. E., Fealey, R. D. & Low, P. A., Oct 2018, In : Mayo Clinic proceedings. 93, 10, p. 1440-1447 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. & Ross, O. A., Apr 2018, In : Movement Disorders. 33, 4, p. 647-650 4 p.

Research output: Contribution to journalArticle

7 Scopus citations