William Stephen Brimijoin, PhD

  • 6715 Citations
  • 43 Scopus h-Index
1970 …2019
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Research Output 1970 2019

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Article
2019
Amyloid Plaques
Acetylcholinesterase
Conformations
Alzheimer Disease
Amyloid
2018
6 Citations (Scopus)

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Steyn, F. J., Ngo, S. T., Chen, V. P., Bailey-Downs, L. C., Xie, T. Y., Ghadami, M., Brimijoin, W. S., Freeman, W. M., Rubinstein, M., Low, M. J. & Stout, M. B., Feb 1 2018, In : Aging Cell. 17, 1, e12703.

Research output: Contribution to journalArticle

Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Feeding Behavior
Weight Loss
Estradiol
21 Citations (Scopus)

Cholinesterases and the fine line between poison and remedy

Pope, C. N. & Brimijoin, W. S., Jan 1 2018, (Accepted/In press) In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Poisons
Cholinesterases
Acetylcholinesterase
Cholinesterase Inhibitors

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

Seo, S., Mathison, A., Grzenda, A., Podratz, J., Calvo, E., Brimijoin, W. S., Windebank, A. J., Iovanna, J., Lomberk, G. & Urrutia, R., Dec 1 2018, In : Scientific Reports. 8, 1, 15077.

Research output: Contribution to journalArticle

Nerve Growth Factor
Cyclic AMP-Dependent Protein Kinases
Cell Differentiation
Heterochromatin
PC12 Cells
2017
7 Citations (Scopus)
Butyrylcholinesterase
Obese Mice
Ghrelin
Body Weight
Obesity
8 Citations (Scopus)

Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis

Chen, V. P., Gao, Y., Geng, L. & Brimijoin, W. S., Sep 1 2017, In : International Journal of Obesity. 41, 9, p. 1413-1419 7 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Homeostasis
Eating
Glucose
2 Citations (Scopus)

Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase

Brimijoin, W. S. & Tye, S. J., Jul 15 2017, (Accepted/In press) In : Cellular and Molecular Neurobiology. p. 1-6 6 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Anxiety
Bites and Stings
Neuropeptides
6 Citations (Scopus)

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Larrimore, K. E., Kazan, I. C., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Bolia, A., Brimijoin, W. S., Zhan, C. G., Ozkan, S. B. & Mor, T. S., Dec 1 2017, In : Scientific Reports. 7, 1, 10419.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cholinesterases
Hydrolases
Cocaine
Enzymes
2 Citations (Scopus)

Polyionic complexes of butyrylcholinesterase and poly-L-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat

Hester, K., Liu, J., Flynn, N., Sultatos, L. G., Geng, L., Brimijoin, W. S., Ramsey, J. D., Hartson, S., Ranjan, A. & Pope, C., Sep 25 2017, In : Chemico-Biological Interactions. 275, p. 86-94 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ethylene Glycol
Catalysis
Polyethylene glycols
Lysine
2 Citations (Scopus)

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Gao, Y., Geng, L., Chen, V. P. & Brimijoin, W. S., Jul 8 2017, In : Molecules (Basel, Switzerland). 22, 7

Research output: Contribution to journalArticle

Gene transfer
Butyrylcholinesterase
Ghrelin
Viral Genes
genes
2016
11 Citations (Scopus)

Butyrylcholinesterase deficiency promotes adipose tissue growth and hepatic lipid accumulation in male mice on high-fat diet

Chen, V. P., Gao, Y., Geng, L., Stout, M. B., Jensen, M. D. & Brimijoin, W. S., Aug 1 2016, In : Endocrinology. 157, 8, p. 3086-3095 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
High Fat Diet
Adipose Tissue
Knockout Mice
Lipids
4 Citations (Scopus)

Cocaine hydrolase gene transfer demonstrates cardiac safety and efficacy against cocaine-induced QT prolongation in mice

Murthy, V., Reyes, S., Geng, L., Gao, Y. & Brimijoin, W. S., Mar 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 3, p. 720-725 6 p.

Research output: Contribution to journalArticle

Hydrolases
Cocaine
Safety
Butyrylcholinesterase
Genes
5 Citations (Scopus)

Long-term blockade of cocaine self-administration and locomotor activation in rats by an adenoviral vector-delivered cocaine hydrolase

Smethells, J. R., Swalve, N., Brimijoin, W. S., Gao, Y., Parks, R. J., Greer, A. & Carroll, M. E., May 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 2, p. 375-381 7 p.

Research output: Contribution to journalArticle

Self Administration
Hydrolases
Cocaine
Locomotion
Cocaine-Related Disorders
6 Citations (Scopus)

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

Peng, H., Brimijoin, W. S., Hrabovska, A., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Jan 5 2016, In : Chemico-Biological Interactions. 243, p. 82-90 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Animals
Monoclonal Antibodies
Plasmas
Carboxylesterase
2015
12 Citations (Scopus)

Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: K<inf>D</inf> values, binding pairs, and amino acid sequences

Peng, H., Brimijoin, W. S., Hrabovska, A., Targosova, K., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Oct 5 2015, In : Chemico-Biological Interactions. 240, p. 336-345 10 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Amino Acid Sequence
Monoclonal Antibodies
Amino Acids
Epitopes
3 Citations (Scopus)
7 Citations (Scopus)

In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase

Pope, C., Uchea, C., Flynn, N., Poindexter, K., Geng, L., Brimijoin, W. S., Hartson, S., Ranjan, A., Ramsey, J. D. & Liu, J., Dec 1 2015, In : Biochemical Pharmacology. 98, 3, p. 531-539 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Copolymers
Molecular Weight
Paraoxon
Enzymes
10 Citations (Scopus)

Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase

Chen, X., Huang, X., Geng, L., Xue, L., Hou, S., Zheng, X., Brimijoin, W. S., Zheng, F. & Zhan, C. G., Mar 1 2015, In : Biochemical Journal. 466, p. 243-251 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Hydrolases
Cocaine
Kinetics
Substrates
26 Citations (Scopus)

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

Brimijoin, W. S., Chen, V. P., Pang, Y-P., Geng, L. & Gao, Y., Nov 16 2015, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Nutrition
Aggression
Weight Gain
52 Citations (Scopus)

Plasma butyrylcholinesterase regulates ghrelin to control aggression

Chen, V. P., Gao, Y., Geng, L., Parks, R. J., Pang, Y-P. & Brimijoin, W. S., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 2251-2256 6 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Ghrelin
Aggression
Hydrolysis
Cocaine-Related Disorders
23 Citations (Scopus)

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin

Schopfer, L. M., Lockridge, O. & Brimijoin, W. S., Dec 1 2015, In : General and Comparative Endocrinology. 224, p. 61-68 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
ghrelin
Ghrelin
cholinesterase
Hydrolysis
6 Citations (Scopus)

Radiometric assay of ghrelin hydrolase activity and 3H-ghrelin distribution into mouse tissues

Chen, V. P., Gao, Y., Geng, L. & Brimijoin, W. S., Dec 15 2015, In : Biochemical Pharmacology. 98, 4, p. 732-739 8 p.

Research output: Contribution to journalArticle

Ghrelin
Hydrolases
Assays
Tissue
Enzymatic hydrolysis
3 Citations (Scopus)

Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase

Murthy, V., Geng, L., Gao, Y., Zhang, B., Miller, J. D., Reyes, S. & Brimijoin, W. S., Mar 27 2015, (Accepted/In press) In : Cellular and Molecular Neurobiology.

Research output: Contribution to journalArticle

Hydrolases
Reward
Cocaine
Butyrylcholinesterase
Benzoic Acid
2014
14 Citations (Scopus)

Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: Evidence for enzymatic activity

Zlebnik, N. E., Brimijoin, W. S., Gao, Y., Saykao, A. T., Parks, R. J. & Carroll, M. E., 2014, In : Neuropsychopharmacology. 39, 6, p. 1538-1546 9 p.

Research output: Contribution to journalArticle

Self Administration
Hydrolases
Cocaine
Butyrylcholinesterase
Tetraisopropylpyrophosphamide
18 Citations (Scopus)

Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N. K., White, T. A., Parks, R. J. & Brimijoin, W. S., Jul 16 2014, In : Vaccine. 32, 33, p. 4155-4162 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
cocaine
gene therapy
cholinesterase
Genetic Therapy
16 Citations (Scopus)

Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N. K., White, T. & Brimijoin, W. S., 2014, In : Journal of Molecular Neuroscience. 53, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

Neuromuscular Agents
Butyrylcholinesterase
Hydrolases
Cocaine
Genetic Therapy
10 Citations (Scopus)

The future potential for cocaine vaccines

Orson, F. M., Wang, R., Brimijoin, W. S., Kinsey, B. M., Singh, R. A. K., Ramakrishnan, M., Wang, H. Y. & Kosten, T. R., 2014, In : Expert Opinion on Biological Therapy. 14, 9, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

Cocaine
Vaccines
Complementary Therapies
Antibody Formation
Antibodies
2013
19 Citations (Scopus)

Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice

Brimijoin, W. S., Orson, F., Kosten, T. R., Kinsey, B., Shen, X. Y., White, S. J. & Gao, Y., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 212-216 5 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Pharmacokinetics
Hydrolases
Locomotion
Cocaine
14 Citations (Scopus)

Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage

Gao, Y., Geng, L., Orson, F., Kinsey, B., Kosten, T. R., Shen, X. & Brimijoin, W. S., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 208-211 4 p.

Research output: Contribution to journalArticle

Viral Vaccines
Gene transfer
Viral Genes
Hydrolases
Cocaine
27 Citations (Scopus)

Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity

Geng, L., Gao, Y., Chen, X., Hou, S., Zhan, C. G., Radic, Z., Parks, R. J., Russell, S. J., Pham, L. & Brimijoin, W. S., Jun 28 2013, In : PLoS One. 8, 6, e67446.

Research output: Contribution to journalArticle

Gene transfer
cocaine
cholinesterase
Cholinesterases
Cocaine
10 Citations (Scopus)

Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

Larrimore, K. E., Barcus, M., Kannan, L., Gao, Y., Zhan, C. G., Brimijoin, W. S. & Mor, T., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 217-220 4 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Hydrolases
Cocaine
Recurrence
Cocaine-Related Disorders
24 Citations (Scopus)

Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse

Brimijoin, W. S., Shen, X., Orson, F. & Kosten, T., Mar 2013, In : Expert Review of Vaccines. 12, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Cocaine
Substance-Related Disorders
Vaccines
Cocaine-Related Disorders
15 Citations (Scopus)
Putamen
Nucleus Accumbens
Morphine
Cues
Self Administration
2012
23 Citations (Scopus)

Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months

Anker, J. J., Brimijoin, W. S., Gao, Y., Geng, L., Zlebnik, N. E., Parks, R. J. & Carroll, M. E., Apr 15 2012, In : Biological Psychiatry. 71, 8, p. 700-705 6 p.

Research output: Contribution to journalArticle

Hydrolases
Cocaine
Butyrylcholinesterase
Cocaine-Related Disorders
Dextroamphetamine
14 Citations (Scopus)

Cocaine hydrolase gene therapy for cocaine abuse

Brimijoin, W. S. & Gao, Y., Feb 2012, In : Future Medicinal Chemistry. 4, 2, p. 151-162 12 p.

Research output: Contribution to journalArticle

Cocaine-Related Disorders
Hydrolases
Cocaine
Genetic Therapy
Technology Transfer
23 Citations (Scopus)

Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion

Carroll, M. E., Zlebnik, N. E., Anker, J. J., Kosten, T. R., Orson, F. M., Shen, X., Kinsey, B., Parks, R. J., Gao, Y. & Brimijoin, W. S., Aug 17 2012, In : PLoS One. 7, 8, e43536.

Research output: Contribution to journalArticle

Gene transfer
cocaine
Hydrolases
Locomotion
hydrolases
25 Citations (Scopus)

Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells

Seo, S., Lomberk, G., Mathison, A., Buttar, N. S., Podratz, J., Calvo, E., Iovanna, J., Brimijoin, W. S., Windebank, A. J. & Urrutia, R., Apr 13 2012, In : Journal of Biological Chemistry. 287, 16, p. 12723-12735 13 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Chromatin Assembly and Disassembly
Dopamine D2 Receptors
Chromatin
Transcription
31 Citations (Scopus)

Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides

Pang, Y-P., Brimijoin, W. S., Ragsdale, D. W., Zhu, K. Y. & Suranyi, R., Apr 2012, In : Current Drug Targets. 13, 4, p. 471-482 12 p.

Research output: Contribution to journalArticle

Acetylcholinesterase
Insecticides
Insects
Cysteine
Toxicity
2011
24 Citations (Scopus)

Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats

Carroll, M. E., Gao, Y., Brimijoin, W. S. & Anker, J. J., Feb 2011, In : Psychopharmacology. 213, 4, p. 817-829 13 p.

Research output: Contribution to journalArticle

Self Administration
Hydrolases
Cocaine
Appointments and Schedules
Reward
10 Citations (Scopus)
Viral Genes
Drug Users
Cocaine
Recurrence
Antibodies
2010
10 Citations (Scopus)

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

Polsinelli, G. A., Singh, S. K., Mishra, R. K., Suranyi, R., Ragsdale, D. W., Pang, Y-P. & Brimijoin, W. S., Sep 2010, In : Chemico-Biological Interactions. 187, 1-3, p. 142-147 6 p.

Research output: Contribution to journalArticle

Bedbugs
Blattellidae
Periplaneta
Cholinesterase Inhibitors
Beetles
25 Citations (Scopus)

The concept of pharmacologic cocaine interception as a treatment for drug abuse

Gao, Y., Orson, F. M., Kinsey, B., Kosten, T. & Brimijoin, W. S., Sep 2010, In : Chemico-Biological Interactions. 187, 1-3, p. 421-424 4 p.

Research output: Contribution to journalArticle

Cocaine
Substance-Related Disorders
Pharmaceutical Preparations
Hydrolases
Antibodies
2009
1 Citation (Scopus)
Acetylcholinesterase
Dextrans
Amyloid
Lysosomal-Associated Membrane Protein 1
Pinocytosis
10 Citations (Scopus)

Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats

Ray, A., Liu, J., Karanth, S., Gao, Y., Brimijoin, W. S. & Pope, C., May 1 2009, In : Toxicology and Applied Pharmacology. 236, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

Paraoxon
Cholinesterases
Acetylcholine
Rats
Corpus Striatum
17 Citations (Scopus)
Neostriatum
Hydrolases
Cocaine
Genetic Therapy
Drug-Seeking Behavior
31 Citations (Scopus)

Selective and irreversible inhibitors of aphid acetylcholinesterases: Steps toward human-safe insecticides

Pang, Y-P., Singh, S. K., Gao, Y., Lassiter, T. L., Mishra, R. K., Zhu, K. Y. & Brimijoin, W. S., 2009, In : PLoS One. 4, 2, e4349.

Research output: Contribution to journalArticle

Aphids
Cholinesterase Inhibitors
Acetylcholinesterase
acetylcholinesterase
Insecticides
26 Citations (Scopus)

Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases

Pang, Y-P., Ekström, F., Polsinelli, G. A., Gao, Y., Rana, S., Hua, D. H., Andersson, B., Andersson, P. O., Peng, L., Singh, S. K., Mishra, R. K., Zhu, K. Y., Fallon, A. M., Ragsdale, D. W. & Brimijoin, W. S., Aug 28 2009, In : PLoS One. 4, 8, e6851.

Research output: Contribution to journalArticle

mosquito-borne diseases
Cholinesterase Inhibitors
Acetylcholinesterase
acetylcholinesterase
Culicidae
5 Citations (Scopus)

Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves

Tang, H., Pavel, J., Saavedra, J. M. & Brimijoin, W. S., Apr 2009, In : Neuropeptides. 43, 2, p. 81-92 12 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Sciatic Nerve
Ligation
Axons
Axonal Transport
2008
90 Citations (Scopus)

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats

Brimijoin, W. S., Gao, Y., Anker, J. J., Gliddon, L. A., LaFleur, D., Shah, R., Zhao, Q., Singh, M. & Carroll, M. E., Oct 2008, In : Neuropsychopharmacology. 33, 11, p. 2715-2725 11 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Hydrolases
Drug-Related Side Effects and Adverse Reactions
Cocaine
Seizures
44 Citations (Scopus)

An albumin-butyrylcholinesterase for cocaine toxicity and addiction: Catalytic and pharmacokinetic properties

Gao, Y., LaFleur, D., Shah, R., Zhao, Q., Singh, M. & Brimijoin, W. S., Sep 25 2008, In : Chemico-Biological Interactions. 175, 1-3, p. 83-87 5 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cocaine-Related Disorders
Pharmacokinetics
Cocaine
Toxicity