William Stephen Brimijoin, PhD

  • 6896 Citations
  • 43 Scopus h-Index
1970 …2020

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Article
2020

A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior

Larrimore, K. E., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Stefanko, K., Kilbourne, J., Brimijoin, S., Zhan, C. G., Neisewander, J. & Mor, T. S., Aug 30 2020, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 102, 109961.

Research output: Contribution to journalArticle

Systemic Safety of a Recombinant AAV8 Vector for Human Cocaine Hydrolase Gene Therapy: A Good Laboratory Practice Preclinical Study in Mice

Chen, V. P., Gao, Y., Geng, L., Steele, M., Jenks, N., Peng, K. W. & Brimijoin, S., Jan 2020, In : Human gene therapy. 31, 1-2, p. 70-79 10 p.

Research output: Contribution to journalArticle

Open Access
2019
1 Scopus citations
2018

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Steyn, F. J., Ngo, S. T., Chen, V. P., Bailey-Downs, L. C., Xie, T. Y., Ghadami, M., Brimijoin, W. S., Freeman, W. M., Rubinstein, M., Low, M. J. & Stout, M. B., Feb 1 2018, In : Aging Cell. 17, 1, e12703.

Research output: Contribution to journalArticle

10 Scopus citations

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

Seo, S., Mathison, A., Grzenda, A., Podratz, J., Calvo, E., Brimijoin, S., Windebank, A., Iovanna, J., Lomberk, G. & Urrutia, R., Dec 1 2018, In : Scientific reports. 8, 1, 15077.

Research output: Contribution to journalArticle

2017
10 Scopus citations

Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis

Chen, V. P., Gao, Y., Geng, L. & Brimijoin, W. S., Sep 1 2017, In : International Journal of Obesity. 41, 9, p. 1413-1419 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Larrimore, K. E., Kazan, I. C., Kannan, L., Kendle, R. P., Jamal, T., Barcus, M., Bolia, A., Brimijoin, S., Zhan, C. G., Ozkan, S. B. & Mor, T. S., Dec 1 2017, In : Scientific reports. 7, 1, 10419.

Research output: Contribution to journalArticle

8 Scopus citations

Polyionic complexes of butyrylcholinesterase and poly-L-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat

Hester, K., Liu, J., Flynn, N., Sultatos, L. G., Geng, L., Brimijoin, S., Ramsey, J. D., Hartson, S., Ranjan, A. & Pope, C., Sep 25 2017, In : Chemico-biological interactions. 275, p. 86-94 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Gao, Y., Geng, L., Chen, V. P. & Brimijoin, W. S., Jul 8 2017, In : Molecules (Basel, Switzerland). 22, 7

Research output: Contribution to journalArticle

3 Scopus citations
2016

Butyrylcholinesterase deficiency promotes adipose tissue growth and hepatic lipid accumulation in male mice on high-fat diet

Chen, V. P., Gao, Y., Geng, L., Stout, M. B., Jensen, M. D. & Brimijoin, W. S., Aug 1 2016, In : Endocrinology. 157, 8, p. 3086-3095 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cocaine hydrolase gene transfer demonstrates cardiac safety and efficacy against cocaine-induced QT prolongation in mice

Murthy, V., Reyes, S., Geng, L., Gao, Y. & Brimijoin, W. S., Mar 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 3, p. 720-725 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Long-term blockade of cocaine self-administration and locomotor activation in rats by an adenoviral vector-delivered cocaine hydrolase

Smethells, J. R., Swalve, N., Brimijoin, W. S., Gao, Y., Parks, R. J., Greer, A. & Carroll, M. E., May 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 2, p. 375-381 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

Peng, H., Brimijoin, S., Hrabovska, A., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Jan 5 2016, In : Chemico-biological interactions. 243, p. 82-90 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences

Peng, H., Brimijoin, S., Hrabovska, A., Targosova, K., Krejci, E., Blake, T. A., Johnson, R. C., Masson, P. & Lockridge, O., Oct 5 2015, In : Chemico-biological interactions. 240, p. 336-345 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase

Pope, C., Uchea, C., Flynn, N., Poindexter, K., Geng, L., Brimijoin, W. S., Hartson, S., Ranjan, A., Ramsey, J. D. & Liu, J., Dec 1 2015, In : Biochemical Pharmacology. 98, 3, p. 531-539 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase

Chen, X., Huang, X., Geng, L., Xue, L., Hou, S., Zheng, X., Brimijoin, S., Zheng, F. & Zhan, C. G., Mar 1 2015, In : Biochemical Journal. 466, p. 243-251 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

Brimijoin, W. S., Chen, V. P., Pang, Y-P., Geng, L. & Gao, Y., Nov 16 2015, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

32 Scopus citations

Plasma butyrylcholinesterase regulates ghrelin to control aggression

Chen, V. P., Gao, Y., Geng, L., Parks, R. J., Pang, Y. P. & Brimijoin, S., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 2251-2256 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin

Schopfer, L. M., Lockridge, O. & Brimijoin, W. S., Dec 1 2015, In : General and Comparative Endocrinology. 224, p. 61-68 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Radiometric assay of ghrelin hydrolase activity and 3H-ghrelin distribution into mouse tissues

Chen, V. P., Gao, Y., Geng, L. & Brimijoin, W. S., Dec 15 2015, In : Biochemical Pharmacology. 98, 4, p. 732-739 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase

Murthy, V., Geng, L., Gao, Y., Zhang, B., Miller, J. D., Reyes, S. & Brimijoin, W. S., Mar 27 2015, (Accepted/In press) In : Cellular and Molecular Neurobiology.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: Evidence for enzymatic activity

Zlebnik, N. E., Brimijoin, S., Gao, Y., Saykao, A. T., Parks, R. J. & Carroll, M. E., May 2014, In : Neuropsychopharmacology. 39, 6, p. 1538-1546 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N. K., White, T. A., Parks, R. J. & Brimijoin, S., Jul 16 2014, In : Vaccine. 32, 33, p. 4155-4162 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N., White, T. & Brimijoin, S., Jun 2014, In : Journal of Molecular Neuroscience. 53, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice

Brimijoin, S., Orson, F., Kosten, T. R., Kinsey, B., Shen, X. Y., White, S. J. & Gao, Y., Mar 25 2013, In : Chemico-biological interactions. 203, 1, p. 212-216 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage

Gao, Y., Geng, L., Orson, F., Kinsey, B., Kosten, T. R., Shen, X. & Brimijoin, S., Mar 25 2013, In : Chemico-Biological Interactions. 203, 1, p. 208-211 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Gene Transfer of Mutant Mouse Cholinesterase Provides High Lifetime Expression and Reduced Cocaine Responses with No Evident Toxicity

Geng, L., Gao, Y., Chen, X., Hou, S., Zhan, C. G., Radic, Z., Parks, R. J., Russell, S. J., Pham, L. & Brimijoin, S., Jun 28 2013, In : PloS one. 8, 6, e67446.

Research output: Contribution to journalArticle

30 Scopus citations

Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

Larrimore, K. E., Barcus, M., Kannan, L., Gao, Y., Zhan, C. G., Brimijoin, S. & Mor, T., Mar 25 2013, In : Chemico-biological interactions. 203, 1, p. 217-220 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
15 Scopus citations
2012

Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months

Anker, J. J., Brimijoin, S., Gao, Y., Geng, L., Zlebnik, N. E., Parks, R. J. & Carroll, M. E., Apr 15 2012, In : Biological psychiatry. 71, 8, p. 700-705 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion

Carroll, M. E., Zlebnik, N. E., Anker, J. J., Kosten, T. R., Orson, F. M., Shen, X., Kinsey, B., Parks, R. J., Gao, Y. & Brimijoin, S., Aug 17 2012, In : PloS one. 7, 8, e43536.

Research output: Contribution to journalArticle

24 Scopus citations

Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells

Seo, S., Lomberk, G., Mathison, A., Buttar, N., Podratz, J., Calvo, E., Iovanna, J., Brimijoin, S., Windebank, A. & Urrutia, R., Apr 13 2012, In : Journal of Biological Chemistry. 287, 16, p. 12723-12735 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats

Carroll, M. E., Gao, Y., Brimijoin, S. & Anker, J. J., Feb 1 2011, In : Psychopharmacology. 213, 4, p. 817-829 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2010

Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

Polsinelli, G. A., Singh, S. K., Mishra, R. K., Suranyi, R., Ragsdale, D. W., Pang, Y. P. & Brimijoin, S., Sep 1 2010, In : Chemico-biological interactions. 187, 1-3, p. 142-147 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

The concept of pharmacologic cocaine interception as a treatment for drug abuse

Gao, Y., Orson, F. M., Kinsey, B., Kosten, T. & Brimijoin, S., Sep 1 2010, In : Chemico-biological interactions. 187, 1-3, p. 421-424 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
2009

Amyloid-beta alters trafficking of internalized acetylcholinesterase and dextran

Hu, W., Gray, N. W. & Brimijoin, S., Dec 1 2009, In : International Journal of Physiology, Pathophysiology and Pharmacology. 1, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats

Ray, A., Liu, J., Karanth, S., Gao, Y., Brimijoin, S. & Pope, C., May 1 2009, In : Toxicology and Applied Pharmacology. 236, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lasting reduction of cocaine action in neostriatum - A hydrolase gene therapy approach

Gao, Y. & Brimijoin, S., Aug 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 2, p. 449-457 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Selective and irreversible inhibitors of aphid acetylcholinesterases: Steps toward human-safe insecticides

Pang, Y-P., Singh, S. K., Gao, Y., Lassiter, T. L., Mishra, R. K., Zhu, K. Y. & Brimijoin, W. S., 2009, In : PLoS One. 4, 2, e4349.

Research output: Contribution to journalArticle

31 Scopus citations

Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases

Pang, Y. P., Ekström, F., Polsinelli, G. A., Gao, Y., Rana, S., Hua, D. H., Andersson, B., Andersson, P. O., Peng, L., Singh, S. K., Mishra, R. K., Zhu, K. Y., Fallon, A. M., Ragsdale, D. W. & Brimijoin, S., Aug 28 2009, In : PloS one. 4, 8, e6851.

Research output: Contribution to journalArticle

27 Scopus citations

Type-1 angiotensin receptors are expressed and transported in motor and sensory axons of rat sciatic nerves

Tang, H., Pavel, J., Saavedra, J. M. & Brimijoin, S., Apr 1 2009, In : Neuropeptides. 43, 2, p. 81-92 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2008

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats

Brimijoin, S., Gao, Y., Anker, J. J., Gliddon, L. A., LaFleur, D., Shah, R., Zhao, Q., Singh, M. & Carroll, M. E., Oct 1 2008, In : Neuropsychopharmacology. 33, 11, p. 2715-2725 11 p.

Research output: Contribution to journalArticle

97 Scopus citations

An albumin-butyrylcholinesterase for cocaine toxicity and addiction: Catalytic and pharmacokinetic properties

Gao, Y., LaFleur, D., Shah, R., Zhao, Q., Singh, M. & Brimijoin, S., Sep 25 2008, In : Chemico-Biological Interactions. 175, 1-3, p. 83-87 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage

Tang, H., Pavel, J., Saavedra, J. M. & Brimijoin, S., Sep 1 2008, In : Neurological research. 30, 7, p. 751-760 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expression and transport of Angiotensin II AT1 receptors in spinal cord, dorsal root ganglia and sciatic nerve of the rat

Pavel, J., Tang, H., Brimijoin, S., Moughamian, A., Nishioku, T., Benicky, J. & Saavedra, J. M., Dec 30 2008, In : Brain Research. 1246, p. 111-122 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos

Lassiter, T. L. & Brimijoin, S., Mar 1 2008, In : Neurotoxicology and Teratology. 30, 2, p. 125-130 6 p.

Research output: Contribution to journalArticle

64 Scopus citations
2007

A method to determine precise benchmark doses for carbamate anticholinesterases

Lassiter, T. L. & Brimijoin, S., Mar 15 2007, In : Toxicological Sciences. 96, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease

García-Ayllón, M. S., Silveyra, M. X., Andreasen, N., Brimijoin, S., Blennow, K. & Sáez-Valero, J., Jun 1 2007, In : Journal of neurochemistry. 101, 6, p. 1701-1711 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ε4 allele, in relation to cognitive function and cerebral glucose metabolism

Darreh-Shori, T., Brimijoin, S., Kadir, A., Almkvist, O. & Nordberg, A., Nov 1 2006, In : Neurobiology of Disease. 24, 2, p. 326-333 8 p.

Research output: Contribution to journalArticle

46 Scopus citations