• 11037 Citations
  • 59 Scopus h-Index
1976 …2020

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Article
2020

Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis

Peeraphatdit, T. B., Kamath, P. S., Karpyak, V. M., Davis, B., Desai, V., Liangpunsakul, S., Sanyal, A., Chalasani, N., Shah, V. H. & Simonetto, D. A., Feb 2020, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 477-485.e5

Research output: Contribution to journalArticle

2 Scopus citations

Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12

Arab, J. P., Cabrera, D., Sehrawat, T. S., Jalan-Sakrikar, N., Verma, V. K., Simonetto, D., Cao, S., Yaqoob, U., Leon, J., Freire, M., Vargas, J. I., De Assuncao, T. M., Kwon, J. H., Guo, Y., Kostallari, E., Cai, Q., Kisseleva, T., Oh, Y., Arrese, M., Huebert, R. C. & 1 others, Shah, V. H., Jan 1 2020, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalArticle

Open Access

Increasing Burden of Acute-On-Chronic Liver Failure among Alcohol-Associated Liver Disease in the Young Population in the United States

Singal, A. K., Arora, S., Wong, R. J., Satapathy, S. K., Shah, V. H., Kuo, Y. F. & Kamath, P. S., Jan 1 2020, In : American Journal of Gastroenterology. 115, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis

Asrani, S. K., Trotter, J., Lake, J., Ahmed, A., Bonagura, A., Cameron, A., DiMartini, A., Gonzalez, S., Im, G., Martin, P., Mathurin, P., Mellinger, J., Rice, J. P., Shah, V. H., Terrault, N., Wall, A., Winder, S. & Klintmalm, G., Jan 1 2020, In : Liver Transplantation. 26, 1, p. 127-140 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis

Mindikoglu, A. L., Coarfa, C., Opekun, A. R., Shah, V. H., Arab, J. P., Lazaridis, K. N., Putluri, N., Ambati, C. R., Robertson, M. J., Devaraj, S., Jalal, P. K., Rana, A., Goss, J. A., Dowling, T. C., Weir, M. R., Seliger, S. L., Raufman, J. P., Bernard, D. W. & Vierling, J. M., Jan 1 2020, In : Future Science OA. 6, 2

Research output: Contribution to journalArticle

Open Access

Persistent Hyperactivation of Endothelial Cells in Patients with Alcoholic Hepatitis

Xia, Y., Yang, J., Sanyal, A. J., Shah, V. H., Chalasani, N. P., Yu, Q., Zheng, X. & Li, W., Jan 1 2020, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Serum Transferrin Is an Independent Predictor of Mortality in Severe Alcoholic Hepatitis

Atkinson, S. R., Hamesch, K., Spivak, I., Guldiken, N., Cabezas, J., Argemi, J., Theurl, I., Zoller, H., Cao, S., Mathurin, P., Shah, V. H., Trautwein, C., Bataller, R., Thursz, M. R. & Strnad, P., Mar 1 2020, In : The American Journal of Gastroenterology. 115, 3, p. 398-405 8 p.

Research output: Contribution to journalArticle

Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs

Shaheen, M. F., Joo, D. J., Ross, J. J., Anderson, B. D., Chen, H. S., Huebert, R. C., Li, Y., Amiot, B., Young, A., Zlochiver, V., Nelson, E., Mounajjed, T., Dietz, A. B., Michalak, G., Steiner, B. G., Davidow, D. S., Paradise, C. R., van Wijnen, A. J., Shah, V. H., Liu, M. & 1 others, Nyberg, S. L., Apr 1 2020, In : Nature Biomedical Engineering. 4, 4, p. 437-445 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Role of Three-Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Allen, A. M., Shah, V. H., Therneau, T. M., Venkatesh, S. K., Mounajjed, T., Larson, J. J., Mara, K. C., Schulte, P. J., Kellogg, T. A., Kendrick, M. L., McKenzie, T. J., Greiner, S. M., Li, J., Glaser, K. J., Wells, M. L., Chen, J., Ehman, R. L. & Yin, M., Feb 1 2020, In : Hepatology. 71, 2, p. 510-521 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Alcohol abstinence does not fully reverse abnormalities of mucosal-associated invariant T cells in the blood of patients with alcoholic hepatitis

Li, W., Lin, E. L., Liangpunsakul, S., Lan, J., Chalasani, S., Rane, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Radaeva, S., Crabb, D. W., Chalasani, N. & Yu, Q., Jun 1 2019, In : Clinical and translational gastroenterology. 10, 6, e-00052.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

Szabo, G., Kamath, P. S., Shah, V., Thursz, M. & Mathurin, P., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

10 Scopus citations
13 Scopus citations

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Argemi, J., Latasa, M. U., Atkinson, S. R., Blokhin, I. O., Massey, V., Gue, J. P., Cabezas, J., Lozano, J. J., Van Booven, D., Bell, A., Cao, S., Vernetti, L. A., Arab, J. P., Ventura-Cots, M., Edmunds, L. R., Fondevilla, C., Stärkel, P., Dubuquoy, L., Louvet, A., Odena, G. & 20 others, Gomez, J. L., Aragon, T., Altamirano, J., Caballeria, J., Jurczak, M. J., Taylor, D. L., Berasain, C., Wahlestedt, C., Monga, S. P., Morgan, M. Y., Sancho-Bru, P., Mathurin, P., Furuya, S., Lackner, C., Rusyn, I., Shah, V. H., Thursz, M. R., Mann, J., Avila, M. A. & Bataller, R., Dec 1 2019, In : Nature communications. 10, 1, 3126.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Martin-Mateos, R., De Assuncao, T. M., Arab, J. P., Jalan-Sakrikar, N., Yaqoob, U., Greuter, T., Verma, V. K., Mathison, A. J., Cao, S., Lomberk, G., Mathurin, P., Urrutia, R., Huebert, R. C. & Shah, V. H., 2019, In : CMGH. 7, 1, p. 197-209 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
Open Access

Incidence and Risk Factors Associated with 30-Day Readmission for Alcoholic Hepatitis

Garg, S. K., Sarvepalli, S., Singh, D., Obaitan, I., Peeraphatdit, T., Jophlin, L., Asrani, S. K., Shah, V. H. & Leise, M. D., Nov 1 2019, In : Journal of clinical gastroenterology. 53, 10, p. 759-764 6 p.

Research output: Contribution to journalArticle

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D., Yaqoob, U., Cao, S., Revzin, A., Beyder, A., Wang, R. A., Kamath, P. S., Kubes, P. & Shah, V., Jul 1 2019, In : Gastroenterology. 157, 1, p. 193-209.e9

Research output: Contribution to journalArticle

13 Scopus citations

Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells

Wang, L., Feng, Y., Xie, X., Wu, H., Su, X. N., Qi, J., Xin, W., Gao, L., Zhang, Y., Shah, V. H. & Zhu, Q., May 2019, In : EBioMedicine. 43, p. 525-536 12 p.

Research output: Contribution to journalArticle

Open Access

p300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β–Stimulated Hepatic Stellate Cells

Wang, Y., Tu, K., Liu, D., Guo, L., Chen, Y., Li, Q., Maiers, J. L., Liu, Z., Shah, V. H., Dou, C., Tschumperlin, D., Voneschen, L., Yang, R. & Kang, N., Oct 1 2019, In : Hepatology. 70, 4, p. 1409-1423 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Prevalence and Predictors of Third-Generation Cephalosporin Resistance in the Empirical Treatment of Spontaneous Bacterial Peritonitis

Sunjaya, D. B., Lennon, R. J., Shah, V., Kamath, P. S. & Simonetto, D., Aug 1 2019, In : Mayo Clinic proceedings. 94, 8, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension

Abraldes, J. G., Trebicka, J., Chalasani, N., D’Amico, G., Rockey, D. C., Shah, V. H., Bosch, J. & Garcia-Tsao, G., Mar 2019, In : Hepatology. 69, 3, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis

Jalan-Sakrikar, N., De Assuncao, T. M., Shi, G., Aseem, S. O., Chi, C., Shah, V. & Huebert, R. C., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Response to Forrest et al

Singal, A. K., Bataller, R., Ahn, J., Kamath, P. S. & Shah, V., Jan 1 2019, In : The American journal of gastroenterology. 114, 1, 1 p.

Research output: Contribution to journalArticle

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D. L., Tan, Q., Meridew, J., Espinosa, A. M. D., Aravamudhan, A., Maiers, J. L., Britt, R. D., Roden, A. C., Pabelick, C. M., Prakash, Y. S., Nouraie, S. M., Li, X., Zhang, Y., Kass, D. J. & 5 others, Lagares, D., Tager, A. M., Varelas, X., Shah, V. H. & Tschumperlin, D. J., Oct 30 2019, In : Science translational medicine. 11, 516, eaau6296.

Research output: Contribution to journalArticle

6 Scopus citations

Transforming growth factor (TGF) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation

Liu, Z., Li, C., Kang, N., Malhi, H., Shah, V. H. & Maiers, J. L., Mar 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3137-3151 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Alcohol-related liver disease: Time for action

Bataller, R., Arteel, G. E., Moreno, C. & Shah, V., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

4 Scopus citations

A Validated Score Predicts Acute Kidney Injury and Survival in Patients With Alcoholic Hepatitis

Sujan, R., Cruz-Lemini, M., Altamirano, J., Simonetto, D., Maiwall, R., Axley, P., Richardson, T., Desai, V., Cabezas, J., Vargas, V., Kamath, P. S., Shah, V., Sarin, S. K., Bataller, R. & Singal, A. K., Dec 1 2018, In : Liver Transplantation. 24, 12, p. 1655-1664 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Current trials and novel therapeutic targets for alcoholic hepatitis

Singal, A. K. & Shah, V., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

8 Scopus citations

Endothelial JAK2V617Fdoes not enhance liver lesions in mice with Budd-Chiari syndrome

Poisson, J., Hilscher, M. B., Tanguy, M., Hammoutene, A., Boulanger, C. M., Villeval, J. L., Simonetto, D., Valla, D., Shah, V. & Rautou, P. E., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2

Kostallari, E., Hirsova, P., Prasnicka, A., Verma, V. K., Yaqoob, U., Wongjarupong, N., Roberts, L. R. & Shah, V., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

13 Scopus citations

Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts

Jophlin, L. L., Koutalos, Y., Chen, C., Shah, V. & Rockey, D. C., Nov 1 2018, In : American journal of physiology. Gastrointestinal and liver physiology. 315, 5, p. G713-G721

Research output: Contribution to journalArticle

7 Scopus citations

Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience

Sunjaya, D. B., Ramos, G. P., Neto, M. B. B., Lennon, R., Mounajjed, T., Shah, V., Kamath, P. S. & Simonetto, D., May 27 2018, In : World Journal of Hepatology. 10, 5, p. 417-424 8 p.

Research output: Contribution to journalArticle

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

Dou, C., Liu, Z., Tu, K., Zhang, H., Chen, C., Yaqoob, U., Wang, Y., Wen, J., Van Deursen, J., Sicard, D., Tschumperlin, D. J., Zou, H., Huang, W. C., Urrutia, R., Shah, V. & Kang, N., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2209-2221.e14

Research output: Contribution to journalArticle

30 Scopus citations

PNPLA3 association with alcoholic liver disease in a cohort of heavy drinkers

Kolla, B. P., Schneekloth, T. D., Biernacka, J. M., Shah, V., Lazaridis, K. N., Geske, J. & Karpyak, V. M., Jan 1 2018, In : Alcohol and Alcoholism. 53, 4, p. 357-360 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis

Samala, N., Lourens, S. G., Shah, V., Kamath, P. S., Sanyal, A. J., Crabb, D. W., Tang, Q., Radaeva, S., Liangpunsakul, S. & Chalasani, N., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

2 Scopus citations

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

Puri, P., Liangpunsakul, S., Christensen, J. E., Shah, V., Kamath, P. S., Gores, G. J., Walker, S., Comerford, M., Katz, B., Borst, A., Yu, Q., Kumar, D. P., Mirshahi, F., Radaeva, S., Chalasani, N. P., Crabb, D. W. & Sanyal, A. J., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

29 Scopus citations

Too Stiff, Too Late.. Timing Is Everything in Antiangiogenic Treatment of Liver Fibrosis

Greuter, T. & Shah, V., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Viral Hepatitis: Knowledge and Treatments for Hepatitis B and C Virus and Associated Transplantation and Neoplasia

Sherman, K. E. & Shah, V., Feb 1 2018, In : Gastroenterology. 154, 3, p. 453-456 4 p.

Research output: Contribution to journalArticle

2017

Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study

Li, W., Amet, T., Xing, Y., Yang, D., Liangpunsakul, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Katz, B. P., Radaeva, S., Crabb, D. W., Chalasani, N. & Yu, Q., Aug 2017, In : Hepatology. 66, 2, p. 575-590 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis

for the TREAT Consortium, Nov 2 2017, In : Scandinavian Journal of Gastroenterology. 52, 11, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Distinguishing between hepatic inflammation and fibrosis with MR elastography

Yin, M., Glaser, K. J., Manduca, A., Mounajjed, T., Malhi, H. M., Simonetto, D., Wang, R., Yang, L., Mao, S. A., Glorioso, J. M., Elgilani, F. M., Ward, C. J., Harris, P. C., Nyberg, S., Shah, V. & Ehman, R. L., Sep 1 2017, In : Radiology. 284, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Gut–liver axis, cirrhosis and portal hypertension: the chicken and the egg

Arab, J. P., Martin-Mateos, R. M. & Shah, V., May 26 2017, (Accepted/In press) In : Hepatology International. p. 1-10 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate–Induced Cell Migration

Wang, R., Ding, Q., De Assuncao, T. M., Mounajjed, T., Maiers, J., Dou, C., Cao, S., Yaqoob, U., Huebert, R. C. & Shah, V., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 134-145 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Improving survival in ACLF: growing evidence for use of G-CSF

Simonetto, D., Shah, V. & Kamath, P. S., Nov 9 2017, (Accepted/In press) In : Hepatology International. p. 1-3 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
19 Scopus citations

Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death

Liu, Y., Verma, V. K., Malhi, H. M., Gores, G. J., Kamath, P. S., Sanyal, A., Chalasani, N., Gao, B. & Shah, V., Sep 5 2017, In : American Journal of Physiology - Cell Physiology. 313, 3, p. C305-C313

Research output: Contribution to journalArticle

6 Scopus citations

Reply to ''Alcohol and Liver Transplantation''

Russ, K. B., Chen, N. W., Kamath, P. S., Shah, V., Kuo, Y. F. & Singal, A. K., Jan 1 2017, In : Alcohol and alcoholism (Oxford, Oxfordshire). 52, 1, p. 127 1 p.

Research output: Contribution to journalArticle

Transcriptional Induction of Periostin by a Sulfatase 2-TGFb1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma

Chen, G., Nakamura, I., Dhanasekaran, R., Iguchi, E., Tolosa, E. J., Romecin, P. A., Vera, R. E., Almada, L. L., Miamen, A. G., Chaiteerakij, R., Zhou, M., Asiedu, M. K., Moser, C. D., Han, S., Hu, C., Banini, B. A., Oseini, A. M., Chen, Y., Fang, Y., Yang, D. & 10 others, Shaleh, H. M., Wang, S., Wu, D., Song, T., Lee, J. S., Thorgeirsson, S. S., Chevet, E., Shah, V., Fernandez-Zapico, M. E. & Roberts, L. R., Feb 1 2017, In : Cancer Research. 77, 3, p. 632-645 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

Verma, V. K., Li, H., Wang, R., Hirsova, P., Mushref, M., Liu, Y., Cao, S., Contreras, P. C., Malhi, H. M., Kamath, P. S., Gores, G. J. & Shah, V., Mar 1 2016, In : Journal of Hepatology. 64, 3, p. 651-660 10 p.

Research output: Contribution to journalArticle

75 Scopus citations