Verline Justilien, PhD

  • 998 Citations
  • 16 Scopus h-Index
20072019
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Research Output 2007 2019

  • 998 Citations
  • 16 Scopus h-Index
  • 22 Article
  • 1 Short survey
  • 1 Review article
2019
1 Citation (Scopus)

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167 12 p.

Research output: Contribution to journalArticle

Catenins
Protein Kinase C
Neoplasms
Stem Cells
Wnt Signaling Pathway
2018

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Lung
Neoplastic Stem Cells
Phenotype
2017
33 Citations (Scopus)

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Ribosomal DNA
Guanine Nucleotide Exchange Factors
Carcinogenesis
Protein Kinase C
2 Citations (Scopus)

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Jun 30 2017, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Squamous Cell Carcinoma
rho GTP-Binding Proteins
Ribosomes
2016
14 Citations (Scopus)

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Protein Kinase C
Carcinogenesis
Carcinoma
Growth
31 Citations (Scopus)

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phenotype
Asymmetric Cell Division
Adenocarcinoma of lung
Neoplastic Stem Cells
5 Citations (Scopus)

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.

Research output: Contribution to journalShort survey

Squamous Cell Carcinoma
Lung
Neoplasms
Lung Neoplasms

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Protein Kinases
Protein Kinase C
Drug Combinations
Tumors
Lung Neoplasms
18 Citations (Scopus)

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Neoplasms
Squamous Cell Carcinoma
Lung
2015
67 Citations (Scopus)
Neoplastic Stem Cells
Maintenance
HhAntag691
Neoplasms
Phenotype

Role of transcription regulatory complexes and epigenetic modifications in driving the cell fate decisions

Ali, S. A., Justilien, V., Bukhari, S. Z. H., Lee, J. & Shakoori, A. R., Jan 1 2015, In : Pakistan Journal of Zoology. 47, 1, p. 287-293 7 p.

Research output: Contribution to journalArticle

epigenetics
transcription (genetics)
neoplasms
cells
stems
2014
50 Citations (Scopus)

Atypical Protein Kinase Cι as a human oncogene and therapeutic target

Parker, P. J., Justilien, V., Riou, P., Linch, M. & Fields, A. P., Mar 1 2014, In : Biochemical Pharmacology. 88, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Isoenzymes
Phosphorylation
Neoplasms
148 Citations (Scopus)

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer Cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

Acyltransferases
Oncogenes
Protein Kinase C
Squamous Cell Carcinoma
Lung
2013
6 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Therapeutics
Cause of Death
2012
51 Citations (Scopus)

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Neoplastic Stem Cells
lung neoplasms
Stem cells
2011
22 Citations (Scopus)

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PLoS One. 6, 10, e26439.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Alveolar Epithelial Cells
lung neoplasms
Stem cells
45 Citations (Scopus)

Oncogenic activity of Ect2 is regulated through protein kinase Cι-mediated phosphorylation

Justilien, V., Jameison, L., Der, C. J., Rossman, K. L. & Fields, A. P., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8149-8157 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Non-Small Cell Lung Carcinoma
Protein Kinase C
RNA Interference
Guanine Nucleotide Exchange Factors
33 Citations (Scopus)

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

O'Neill, A. K., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A. & Newton, A. C., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43559-43568 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Cell Movement
Substrates
Phosphorylation
Scaffolds
2010
58 Citations (Scopus)

The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer

Fields, A. P. & Justilien, V., 2010, In : Advances in Enzyme Regulation. 50, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins
Neoplastic Cell Transformation
Guanine Nucleotide Exchange Factors
RNA Interference
Tumor Cell Line
2009
80 Citations (Scopus)

Ect2 links the PKC-Par6α complex to Rac1 activation and cellular transformation

Justilien, V. & Fields, A. P., Oct 15 2009, In : Oncogene. 28, 41, p. 3597-3607 11 p.

Research output: Contribution to journalArticle

Protein Kinase C
Epithelial Cells
Non-Small Cell Lung Carcinoma
RNA Interference
Guanine Nucleotide Exchange Factors
2008
62 Citations (Scopus)

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Frederick, L. A., Matthews, J. A., Jamieson, L., Justilien, V., Thompson, E. A., Radisky, D. C. & Fields, A. P., Aug 14 2008, In : Oncogene. 27, 35, p. 4841-4853 13 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 10
Protein Kinase C
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Growth
2007
60 Citations (Scopus)

Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme

Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W. W. & Lewin, A. S., Jan 1 2007, In : Experimental Eye Research. 84, 1, p. 44-52 9 p.

Research output: Contribution to journalArticle

Catalytic RNA
Rhodopsin
Alleles
Messenger RNA
Transgenic Rats
159 Citations (Scopus)

SOD2 knockdown mouse model of early AMD

Justilien, V., Pang, J. J., Renganathan, K., Zhan, X., Crabb, J. W., So, R. K., Sparrow, J. R., Hauswirth, W. W. & Lewin, A. S., Oct 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4407-4420 14 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Macular Degeneration
Catalytic RNA
Superoxide Dismutase
Dependovirus
53 Citations (Scopus)

Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery

Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W. W. & Lewin, A. S., Apr 1 2007, In : Vision Research. 47, 9, p. 1202-1208 7 p.

Research output: Contribution to journalArticle

Dependovirus
Rhodopsin
Small Interfering RNA
Messenger RNA
HEK293 Cells