• 32571 Citations
  • 78 Scopus h-Index
1993 …2020

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2020

Circulating extracellular vesicle-encapsulated HULC is a potential biomarker for human pancreatic cancer

Takahashi, K., Ota, Y., Kogure, T., Suzuki, Y., Iwamoto, H., Yamakita, K., Kitano, Y., Fujii, S., Haneda, M., Patel, T. & Ota, T., Jan 1 2020, In : Cancer Science. 111, 1, p. 98-111 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study

Antwi, S. O., Petrick, J. L., Campbell, P. T., Norez, D. A., Stevens, V. L., Liao, L. M., Roberts, L. R., Patel, T. & McGlynn, K. A., Jan 1 2020, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice

Matsuda, A., Moirangthem, A., Angom, R. S., Ishiguro, K., Driscoll, J., Yan, I. K., Mukhopadhyay, D. & Patel, T., May 1 2020, In : Journal of Applied Toxicology. 40, 5, p. 706-718 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids

Murillo, O. D., Thistlethwaite, W., Rozowsky, J., Subramanian, S. L., Lucero, R., Shah, N., Jackson, A. R., Srinivasan, S., Chung, A., Laurent, C. D., Kitchen, R. R., Galeev, T., Warrell, J., Diao, J. A., Welsh, J. A., Hanspers, K., Riutta, A., Burgstaller-Muehlbacher, S., Shah, R. V., Yeri, A. & 38 others, Jenkins, L. M., Ahsen, M. E., Cordon-Cardo, C., Dogra, N., Gifford, S. M., Smith, J. T., Stolovitzky, G., Tewari, A. K., Wunsch, B. H., Yadav, K. K., Danielson, K. M., Filant, J., Moeller, C., Nejad, P., Paul, A., Simonson, B., Wong, D. K., Zhang, X., Balaj, L., Gandhi, R., Sood, A. K., Alexander, R. P., Wang, L., Wu, C., Wong, D. T. W., Galas, D. J., Van Keuren-Jensen, K., Patel, T., Jones, J. C., Das, S., Cheung, K. H., Pico, A. R., Su, A. I., Raffai, R. L., Laurent, L. C., Roth, M. E., Gerstein, M. B. & Milosavljevic, A., Apr 4 2019, In : Cell. 177, 2, p. 463-477.e15

Research output: Contribution to journalArticle

31 Scopus citations

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

Hlady, R. A., Zhao, X., Pan, X., Dong Yang, J., Ahmed, F., Antwi, S. O., Giama, N. H., Patel, T., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 1 2019, In : Theranostics. 9, 24, p. 7239-7250 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Individualized Ablation of Hepatocellular Carcinoma: Tailored Approaches across the Phenotype Spectrum

Devcic, Z., Elboraey, M., Vidal, L., Mody, K., Harnois, D., Patel, T. & Toskich, B. B., 2019, In : Seminars in Interventional Radiology. 36, 4, p. 287-297 11 p.

Research output: Contribution to journalArticle

Open Access

Isolation of tissue extracellular vesicles from the liver

Ishiguro, K., Yan, I. K. & Patel, T., Aug 2019, In : Journal of Visualized Experiments. 2019, 150, e58649.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Risk of de novo hepatocellular carcinoma following use of direct acting antiviral medications for treatment of chronic hepatitis C

Antwi, S. O., Van Houten, H. K., Sangaralingham, L. R. & Patel, T., 2019, In : Cancer Prevention Research. 12, 12, p. 891-902 12 p.

Research output: Contribution to journalArticle

Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation

Srinivasan, S., Yeri, A., Cheah, P. S., Chung, A., Danielson, K., De Hoff, P., Filant, J., Laurent, C. D., Laurent, L. D., Magee, R., Moeller, C., Murthy, V. L., Nejad, P., Paul, A., Rigoutsos, I., Rodosthenous, R., Shah, R. V., Simonson, B., To, C., Wong, D. & 14 others, Yan, I. K., Zhang, X., Balaj, L., Breakefield, X. O., Daaboul, G., Gandhi, R., Lapidus, J., Londin, E., Patel, T., Raffai, R. L., Sood, A. K., Alexander, R. P., Das, S. & Laurent, L. C., Apr 4 2019, In : Cell. 177, 2, p. 446-462.e16

Research output: Contribution to journalArticle

40 Scopus citations

Therapeutic Efficacy of Vitamin D in Experimental c-MET-β-Catenin-Driven Hepatocellular Cancer

Matsuda, A., Ishiguro, K., Yan, I. K. & Patel, T. C., Apr 18 2019, In : Gene expression. 19, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

2018

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

102 Scopus citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

281 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

52 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

29 Scopus citations

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

282 Scopus citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

80 Scopus citations

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

114 Scopus citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

329 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

38 Scopus citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

102 Scopus citations

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

Wen, H. J., Walsh, M. P., Yan, I. K., Takahashi, K., Fields, A. & Patel, T., Apr 27 2018, In : iScience. 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

57 Scopus citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

104 Scopus citations

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

142 Scopus citations

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

23 Scopus citations

Large Differences in Small RNA Composition Between Human Biofluids

Godoy, P. M., Bhakta, N. R., Barczak, A. J., Cakmak, H., Fisher, S., MacKenzie, T. C., Patel, T., Price, R. W., Smith, J. F., Woodruff, P. G. & Erle, D. J., Oct 30 2018, In : Cell reports. 25, 5, p. 1346-1358 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Liver transplantation for intrahepatic cholangiocarcinoma

Lee, D. D., Croome, K. P., Musto, K. R., Melendez, J., Tranesh, G., Nakhleh, R., Taner, C. B., Nguyen, J. H., Patel, T. C. & Harnois, D., May 1 2018, In : Liver Transplantation. 24, 5, p. 634-644 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

138 Scopus citations

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

29 Scopus citations

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 338-354.e15

Research output: Contribution to journalArticle

152 Scopus citations

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

36 Scopus citations

Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice

George, J., Yan, I. K. & Patel, T. C., May 10 2018, (Accepted/In press) In : Laboratory Investigation. p. 1-16 16 p.

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

367 Scopus citations

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

The Cancer Genome Atlas Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 282-300.e2

Research output: Contribution to journalArticle

59 Scopus citations

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

89 Scopus citations

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

148 Scopus citations

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 305-320.e10

Research output: Contribution to journalArticle

76 Scopus citations
10 Scopus citations
6 Scopus citations

Response to loco-regional therapy predicts outcomes after liver transplantation for combined hepatocellular-cholangiocarcinoma

Antwi, S. O., Habboush, Y. Y., Chase, L. A., Lee, D. D. & Patel, T., Nov 1 2018, In : Annals of hepatology. 17, 6, p. 969-979 11 p.

Research output: Contribution to journalArticle

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 271-281.e7

Research output: Contribution to journalArticle

111 Scopus citations

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

78 Scopus citations

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

110 Scopus citations

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 270-281.e3

Research output: Contribution to journalArticle

46 Scopus citations

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 313-326.e5

Research output: Contribution to journalArticle

113 Scopus citations

The Immune Landscape of Cancer

The Cancer Genome Atlas Research Network, Apr 17 2018, In : Immunity. 48, 4, p. 812-830.e14

Research output: Contribution to journalArticle

512 Scopus citations
2017

A novel community driven software for functional enrichment analysis of extracellular vesicles data

Pathan, M., Keerthikumar, S., Chisanga, D., Alessandro, R., Ang, C. S., Askenase, P., Batagov, A. O., Benito-Martin, A., Camussi, G., Clayton, A., Collino, F., di Vizio, D., Falcon-Perez, J. M., Fonseca, P., Fonseka, P., Fontana, S., Gho, Y. S., Hendrix, A., Nolte-’T Hoen, E., Iraci, N. & 27 others, Kastaniegaard, K., Kislinger, T., Kowal, J., Kurochkin, I. V., Leonardi, T., Liang, Y., Llorente, A., Lunavat, T. R., Maji, S., Monteleone, F., Øverbye, A., Panaretakis, T., Patel, T., Peinado, H., Pluchino, S., Principe, S., Ronquist, G., Royo, F., Sahoo, S., Spinelli, C., Stensballe, A., Théry, C., van Herwijnen, M. J. C., Wauben, M., Welton, J. L., Zhao, K. & Mathivanan, S., 2017, In : Journal of Extracellular Vesicles. 6, 1, 1321455.

Research output: Contribution to journalArticle

88 Scopus citations

BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma

Parasramka, M., Yan, I. K., Wang, X., Nguyen, P., Matsuda, A., Maji, S., Foye, C., Asmann, Y. & Patel, T., Jan 25 2017, In : Molecular cancer. 16, 1, 22.

Research output: Contribution to journalArticle

40 Scopus citations