Timothy R DeGrado, PhD

  • 4860 Citations
  • 37 Scopus h-Index
1983 …2020

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Research Output

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2002

Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography

Mathew, R. J., Wilson, W. H., Turkington, T. G., Hawk, T. C., Coleman, R. E., DeGrado, T. R. & Provenzale, J., Dec 30 2002, In : Psychiatry Research - Neuroimaging. 116, 3, p. 173-185 13 p.

Research output: Contribution to journalArticle

80 Scopus citations
2001

An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure

Taylor, M., Wallhaus, T. R., Degrado, T. R., Russell, D. C., Stanko, P., Nickles, R. J. & Stone, C. K., Feb 8 2001, In : Journal of Nuclear Medicine. 42, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

185 Scopus citations

Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused?

Hughes, G. C., Landolfo, C. K., Yin, B., DeGrado, T. R., Coleman, R. E., Landolfo, K. P. & Lowe, J. E., Jul 24 2001, In : Annals of Thoracic Surgery. 72, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure

Wallhaus, T. R., Taylor, M., DeGrado, T. R., Russell, D. C., Stanko, P., Nickles, R. J. & Stone, C. K., May 22 2001, In : Circulation. 103, 20, p. 2441-2446 6 p.

Research output: Contribution to journalArticle

Open Access
212 Scopus citations

Synthesis and evaluation of 18F-labeled choline analogs as oncologic PET tracers

DeGrado, T. R., Baldwin, S. W., Wang, S., Orr, M. D., Liao, R. P., Friedman, H. S., Reiman, R., Price, D. T. & Coleman, R. E., Dec 1 2001, In : Journal of Nuclear Medicine. 42, 12, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

289 Scopus citations

Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: Initial findings in prostate cancer

Degrado, T. R., Coleman, R. E., Wang, S., Baldwin, S. W., Orr, M. D., Robertson, C. N., Polascik, T. J. & Price, D. T., Jan 1 2001, In : Cancer research. 61, 1, p. 110-117 8 p.

Research output: Contribution to journalArticle

322 Scopus citations
2000

An experimental model of chronic myocardial hibernation

St. Louis, J. D., Chad Hughes, G., Kypson, A. P., DeGrado, T. R., Donovan, C. L., Edward Coleman, R., Yin, B., Steenbergen, C., Landolfo, K. P. & Lowe, J. E., May 1 2000, In : Annals of Thoracic Surgery. 69, 5, p. 1351-1357 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Induction of angiogenesis after TMR: A comparison of holmium: YAG, CO2, and excimer lasers

Hughes, G. C., Kypson, A. P., Annex, B. H., Yin, B., St. Louis, J. D., Biswas, S. S., Coleman, R. E., Degrado, T. R., Donovan, C. L., Landolfo, K. P. & Lowe, J. E., Jan 1 2000, In : Annals of Thoracic Surgery. 70, 2, p. 504-509 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Preliminary evaluation of 15-[18F]fluoro-3-oxa-pentadecanoate as a PET tracer of hepatic fatty acid oxidation

DeGrado, T. R., Wang, S. & Rockey, D. C., Jan 1 2000, In : Journal of Nuclear Medicine. 41, 10, p. 1727-1736 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and preliminary evaluation of 18F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation

Degrado, T. R., Wang, S., Holden, J. E., Nickles, R. J., Taylor, M. & Stone, C. K., Apr 1 2000, In : Nuclear Medicine and Biology. 27, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Tracer kinetic modeling in nuclear cardiology

DeGrado, T. R., Bergmann, S. R., Ng, C. K. & Raffel, D. M., Jan 1 2000, In : Journal of Nuclear Cardiology. 7, 6, p. 686-700 15 p.

Research output: Contribution to journalArticle

18 Scopus citations
1999

Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium

Hughes, G. C., Kypson, A. P., St. Louis, J. D., Annex, B. H., Coleman, R. E., Degrado, T. R., Donovan, C. L., Lowe, J. E. & Landolfo, K. P., Jun 1 1999, In : Annals of Thoracic Surgery. 67, 6, p. 1714-1720 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

Mathew, R. J., Wilson, W. H., Chiu, N. Y., Turkington, T. G., Degrado, T. R. & Coleman, R. E., Jan 1 1999, In : Acta Psychiatrica Scandinavica. 100, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

88 Scopus citations
1998

Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia

Renstrom, B., Rommelfanger, S., Stone, C. K., DeGrado, T. R., Carlson, K. J., Scarbrough, E., Nickles, R. J., Liedtke, A. J. & Holden, J. E., Oct 1 1998, In : Journal of Nuclear Medicine. 39, 10, p. 1684-1689 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effects of specific activity on meta-[131I]iodobenzylguanidine kinetics in isolated rat heart

DeGrado, T. R., Zalutsky, M. R., Coleman, R. E. & Vaidyanathan, G., Jan 1 1998, In : Nuclear Medicine and Biology. 25, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: Application to m-iodobenzylguanidine

Vaidyanathan, G., Zalutsky, M. R. & DeGrado, T. R., Nov 1 1998, In : Bioconjugate Chemistry. 9, 6, p. 758-764 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Myocardial uptake of the fatty acid analog 14-fluorine-18-fluoro-6- thia-heptadecanoic acid in comparison to beta-oxidation rates by tritiated palmitate

Stone, C. K., Pooley, R. A., DeGrado, T. R., Renstrom, B., Nickles, R. J., Nellis, S. H., Liedtke, A. J. & Holden, J. E., Oct 1 1998, In : Journal of Nuclear Medicine. 39, 10, p. 1690-1696 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia

Hughes, G. C., Lowe, J. E., Kypson, A. P., St Louis, J. D., Pippen, A. M., Peters, K. G., Coleman, R. E., DeGrado, T. R., Donovan, C. L., Annex, B. H. & Landolfo, K. P., Dec 1 1998, In : Annals of Thoracic Surgery. 66, 6, p. 2029-2036 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Quantification of myocardial perfusion by MRI after coronary occlusion

Vallée, J. P. M., Sostman, H. D., MacFall, J. R., DeGrado, T. R., Zhang, J., Sebbag, L., Cobb, F. R., Wheeler, T., Hedlund, L. W., Turkington, T. G., Spritzer, C. E. & Coleman, R. E., Aug 1 1998, In : Magnetic Resonance in Medicine. 40, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transcapillary transport of metaiodobenzylguanidine (MIBG) in isolated rat heart

Degrado, T. R. & Wang, S., Jul 1 1998, In : Nuclear Medicine and Biology. 25, 5, p. 455-465 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
1997

Alignment of dynamic cardiac PET images for correction of motion

Turkington, T. G., Degrado, T. R., Hanson, M. W. & Edward Coleman, R., Dec 1 1997, In : IEEE Transactions on Nuclear Science. 44, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Marijuana intoxication and brain activation in marijuana smokers

Mathew, R. J., Wilson, W. H., Coleman, R. E., Turkington, T. G. & Degrado, T. R., May 2 1997, In : Life Sciences. 60, 23, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

98 Scopus citations
1996

Adult age differences in regional cerebral blood flow during visual word identification: Evidence from H215O PET

Madden, D. J., Turkington, T. G., Coleman, R. E., Provenzale, J. M., DeGrado, T. R. & Hoffman, J. M., Apr 1996, In : NeuroImage. 3, 2, p. 127-142 16 p.

Research output: Contribution to journalArticle

98 Scopus citations

Estimation of myocardial blood flow for longitudinal studies with13N-labeled ammonia and positron emission tomography

DeGrado, T. R., Hanson, M. W., Turkington, T. G., Delong, D. M., Brezinski, D. A., Vallée, J. P., Hedlund, L. W., Zhang, J., Cobb, F., Sullivan, M. J. & Coleman, R. E., Dec 1 1996, In : Journal of Nuclear Cardiology. 3, 6 PART I, p. 494-507 14 p.

Research output: Contribution to journalArticle

69 Scopus citations

Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model

Berry, C. R., Garg, P. K., DeGrado, T. R., Hellyer, P., Weber, W., Garg, S., Hansen, B., Zalutsky, M. R. & Coleman, R. E., Jan 1 1996, In : Journal of Nuclear Cardiology. 3, 2, p. 119-129 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart

Berry, C. R., Garg, P. K., Zalutsky, M. R., Coleman, R. E. & DeGrado, T. R., Dec 1 1996, In : Journal of Nuclear Medicine. 37, 12, p. 2011-2016 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
1995

Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart

DeGrado, T. R., Zalutsky, M. R. & Vaidyanathan, G., Jan 1995, In : Nuclear Medicine and Biology. 22, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
1994

Evaluation of ( - )[18F]fluoroethoxybenzovesamicol as a new PET tracer of cholinergic neurons of the heart

DeGrado, T. R., Mulholland, G. K., Wieland, D. M. & Schwaiger, M., Feb 1994, In : Nuclear Medicine and Biology. 21, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Imaging of cardiac neuronal function after cocaine exposure using Carbon-11 hydroxyephedrine and positron emission tomography

Melon, P. G., Nguyen, N., DeGrado, T. R., Mangner, T. J., Wieland, D. M. & Schwaiger, M., Jun 1994, In : Journal of the American College of Cardiology. 23, 7, p. 1693-1699 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes

Sun, D. Q., Nguyen, N., DeGrado, T. R., Schwaiger, M. & Brosius, F. C., Feb 1994, In : Circulation. 89, 2, p. 793-798 6 p.

Research output: Contribution to journalArticle

Open Access
206 Scopus citations

Kinetics of 14(R,S)-fluorine-18-fluoro-6-thia-heptadecanoic acid in normal human hearts at rest, during exercise and after dipyridamole injection

Ebert, A., Herzog, H., Stocklin, G. L., Henrich, M. M., DeGrado, T. R., Coenen, H. H. & Feinendegen, L. E., Jan 1 1994, In : Journal of Nuclear Medicine. 35, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Performance characteristics of a whole-body PET scanner

DeGrado, T. R., Turkington, T. G., Williams, J. J., Stearns, C. W., Hoffman, J. M. & Coleman, R. E., Jan 1 1994, In : Journal of Nuclear Medicine. 35, 8, p. 1398-1406 9 p.

Research output: Contribution to journalArticle

446 Scopus citations
1993

Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans

Allman, K. C., Wieland, D. M., Muzik, O., Degrado, T. R., Wolfe, E. R. & Schwaiger, M., Aug 1993, In : Journal of the American College of Cardiology. 22, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Myocardial kinetics of carbon-11-meta-hydroxyephedrine: Retention mechanisms and effects of norepinephrine

DeGrado, T. R., Hutchins, G. D., Toorongian, S. A., Wieland, D. M. & Schwaiger, M., Jan 1 1993, In : Journal of Nuclear Medicine. 34, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

102 Scopus citations
1992

Comparison of technetium-99m sestamibi and thallium-201 retention characteristics in canine myocardium

Melon, P. G., Beanlands, R. S., DeGrado, T. R., Nguyen, N., Petry, N. A. & Schwaiger, M., Nov 1 1992, In : Journal of the American College of Cardiology. 20, 5, p. 1277-1283 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
17 Scopus citations
1991

14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid (FTHA): Evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids

DeGrado, T. R., Coenen, H. H. & Stocklin, G., Jan 1 1991, In : Journal of Nuclear Medicine. 32, 10, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

Sensitivity of myocardial fluorodeoxyglucose lumped constant to glucose and insulin

Ng, C. K., Holden, J. E., DeGrado, T. R., Raffel, D. M., Kornguth, M. L. & Gatley, S. J., Jan 1 1991, In : American Journal of Physiology - Heart and Circulatory Physiology. 260, 2 29-2, p. H593-H603

Research output: Contribution to journalArticle

58 Scopus citations
35 Scopus citations
1989

Kinetics of [18F]1-fluoro-2,4-dinitrobenzene, a potential probe for the glutathione detoxification system, in perfused working rat heart

Kornguth, M. L., Holden, J. E., Degrado, T. R., Ng, C. K., Raffel, D. M. & Gatley, S. J., 1989, In : International Journal of Radiation Applications and Instrumentation.. 16, 5, p. 519-524 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Measurement of O2 consumption in isolated organs without venous cannulation

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., Jan 1 1989, In : Journal of applied physiology. 66, 3, p. 1316-1320 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Quantitative analysis of myocardial kinetics of 15-p-[iodine-125]iodophenylpentadecanoic acid

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., Jan 1 1989, In : Journal of Nuclear Medicine. 30, 7, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

β-Methyl-15-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., Feb 1 1989, In : European Journal of Nuclear Medicine. 15, 2, p. 78-80 3 p.

Research output: Contribution to journalArticle

19 Scopus citations
1988

Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & John Gatley, S., Dec 1 1988, In : European Journal of Nuclear Medicine. 14, 12, p. 600-606 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of reaction conditions on rates of incorporation of no‐carrier added F‐18 fluoride into several organic compounds

Korguth, M., Degrado, T., Holden, J. & Gatley, S., Apr 1988, In : Journal of Labelled Compounds and Radiopharmaceuticals. 25, 4, p. 369-381 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
1986

**1**8F.

Bosch, A. L., DeGrado, T. R. & Gatley, S. J., 1986, In : Applied Radiation and Isotopes. 37, 4, p. 305-308 4 p.

Research output: Contribution to journalArticle

Kinetic studies with F-18 fluoride

Gatley, S. J., Kornguth, M., DeGrado, T. R. & Holden, J. E., Jan 1 1986, In : Journal of Labelled Compounds and Radiopharmaceuticals. 23, 10-12, p. 1199-1201 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
16 Scopus citations
1984

Phosphorylation of glucose analog 3-0-methyl-D-glucose by rat heart

Gatley, S. J., Holden, J. E., Halama, J. R., DeGrado, T. R., Bernstein, D. R. & Ng, C. K., Mar 30 1984, In : Biochemical and Biophysical Research Communications. 119, 3, p. 1008-1014 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Validation of 3-deoxy-3-fluoro-D-glucose as a glucose transport analogue in rat heart

Halama, J. R., Gatley, S. J. & DeGrado, T. R., Jan 1 1984, In : American Journal of Physiology - Heart and Circulatory Physiology. 16, 5, p. H754-H759

Research output: Contribution to journalArticle

11 Scopus citations