Timothy R DeGrado, PhD

  • 4784 Citations
  • 36 Scopus h-Index
1983 …2019
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Research Output 1983 2019

  • 4784 Citations
  • 36 Scopus h-Index
  • 108 Article
  • 3 Conference contribution
  • 2 Chapter
  • 2 Review article
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Article
1983
17 Citations (Scopus)

Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

Sherratt, H. S. A., Gatley, S. J., DeGrado, T. R., Ng, C. K. & Holden, J. E., Dec 28 1983, In : Biochemical and Biophysical Research Communications. 117, 3, p. 653-657 5 p.

Research output: Contribution to journalArticle

Ethylene Oxide
Metabolism
Iodine
Rats
Fatty Acids
1984
25 Citations (Scopus)

Phosphorylation of glucose analog 3-0-methyl-D-glucose by rat heart

Gatley, S. J., Holden, J. E., Halama, J. R., DeGrado, T. R., Bernstein, D. R. & Ng, C. K., Mar 30 1984, In : Biochemical and Biophysical Research Communications. 119, 3, p. 1008-1014 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Rats
Glucose
Glucose-6-Phosphate
Sugar Phosphates
11 Citations (Scopus)

Validation of 3-deoxy-3-fluoro-D-glucose as a glucose transport analogue in rat heart.

Halama, J. R., Gatley, S. J., DeGrado, T. R., Bernstein, D. R., Ng, C. K. & Holden, J. E., Nov 1984, In : The American journal of physiology. 247, 5 Pt 2

Research output: Contribution to journalArticle

Glucose
3-deoxy-3-fluoro-D-glucose
3-O-Methylglucose
Glucose-6-Phosphate
Hexokinase
1986

**1**8F.

Bosch, A. L., DeGrado, T. R. & Gatley, S. J., 1986, In : Applied Radiation and Isotopes. 37, 4, p. 305-308 4 p.

Research output: Contribution to journalArticle

fluorides
brackets
acetonitrile
synthesis
reaction time
1 Citation (Scopus)

Kinetic studies with F-18 fluoride

Gatley, S. J., Kornguth, M., DeGrado, T. R. & Holden, J. E., 1986, In : Journal of Labelled Compounds and Radiopharmaceuticals. 23, 10-12, p. 1199-1201 3 p.

Research output: Contribution to journalArticle

Fluorides
16 Citations (Scopus)
fluorine
fluorides
preparation
acids
acetonitrile
1988
6 Citations (Scopus)

Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & John Gatley, S., Dec 1988, In : European Journal Of Nuclear Medicine. 14, 12, p. 600-606 7 p.

Research output: Contribution to journalArticle

Acids
Fatty Acids
Ethylene Oxide
Radioactivity
Blood Vessels
10 Citations (Scopus)

Effects of reaction conditions on rates of incorporation of no-carrier added F-18 fluoride into several organic compounds

Korguth, M. L., DeGrado, T. R., Holden, J. E. & Gatley, S. J., 1988, In : Journal of Labelled Compounds and Radiopharmaceuticals. 25, 4, p. 369-381 13 p.

Research output: Contribution to journalArticle

Dinitrofluorobenzene
Tetraethylammonium
Hexoses
Iodides
Dimethyl Sulfoxide
1989

Kinetics of [18F]1-fluoro-2,4-dinitrobenzene, a potential probe for the glutathione detoxification system, in perfused working rat heart

Kornguth, M. L., Holden, J. E., DeGrado, T. R., Ng, C. K., Raffel, D. M. & Gatley, S. J., 1989, In : International Journal of Radiation Applications and Instrumentation.. 16, 5, p. 519-524 6 p.

Research output: Contribution to journalArticle

Dinitrofluorobenzene
Glutathione
Glutathione Transferase
Myocardium
Enzymes
1 Citation (Scopus)

Kinetics of [18F]1-fluoro-2,4-dinitrobenzene, a potential probe for the glutathione detoxification system, in perfused working rat heart

Kornguth, M. L., Holden, J. E., DeGrado, T. R., Ng, C. K., Raffel, D. M. & Gatley, S. J., 1989, In : Nuclear Medicine and Biology. 16, 5, p. 519-524 6 p.

Research output: Contribution to journalArticle

Dinitrofluorobenzene
Glutathione
Glutathione Transferase
Myocardium
Enzymes
2 Citations (Scopus)

Measurement of O2 consumption in isolated organs without venous cannulation

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., 1989, In : Journal of Applied Physiology. 66, 3, p. 1316-1320 5 p.

Research output: Contribution to journalArticle

Catheterization
Pulmonary Artery
21 Citations (Scopus)

Quantitative analysis of myocardial kinetics of 15-p-[iodine-125]iodophenylpentadecanoic acid

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., 1989, In : Journal of Nuclear Medicine. 30, 7, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Iodine
Fatty Acids
Acids
Radioactivity
Carnitine O-Palmitoyltransferase
19 Citations (Scopus)

β-Methyl-15-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart

DeGrado, T. R., Holden, J. E., Ng, C. K., Raffel, D. M. & Gatley, S. J., Feb 1989, In : European Journal Of Nuclear Medicine. 15, 2, p. 78-80 3 p.

Research output: Contribution to journalArticle

Acids
Fatty Acids
Ethylene Oxide
Carnitine O-Palmitoyltransferase
Nuclear Medicine
1990
1 Citation (Scopus)

Catabolism of 15-(p-iodophenyl)-R,S-β-methylpentadecanoic acid (BMIPP) by isolated rat hearts

DeGrado, T. R., Holden, J. E. & Gatley, S. J., 1990, In : European Journal Of Nuclear Medicine. 17, 3-4, p. 188-189 2 p.

Research output: Contribution to journalArticle

Iodobenzenes
Iodine Radioisotopes
Acids
iodofiltic acid
4 Citations (Scopus)
Biochemical Phenomena
Radiopharmaceuticals
Positron-Emission Tomography
Glucose
Fluorodeoxyglucose F18
1991
97 Citations (Scopus)
Fatty Acids
Ethylene Oxide
Myocardium
Carnitine O-Palmitoyltransferase
Hairless Mouse
58 Citations (Scopus)

Sensitivity of myocardial fluorodeoxyglucose lumped constant to glucose and insulin

Ng, C. K., Holden, J. E., DeGrado, T. R., Raffel, D. M., Kornguth, M. L. & Gatley, S. J., 1991, In : American Journal of Physiology - Heart and Circulatory Physiology. 260, 2 29-2

Research output: Contribution to journalArticle

Insulin
Glucose
Phosphorylation
formic acid
Gamma Rays
35 Citations (Scopus)
Anions
Esters
Fatty Acids
Chemical activation
High Pressure Liquid Chromatography
1992
35 Citations (Scopus)

Comparison of technetium-99m sestamibi and thallium-201 retention characteristics in canine myocardium

Melon, P. G., Beanlands, R. S., DeGrado, T. R., Nguyen, N., Petry, N. A. & Schwaiger, M., Nov 1 1992, In : Journal of the American College of Cardiology. 20, 5, p. 1277-1283 7 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Thallium
Canidae
Myocardium
Injections
17 Citations (Scopus)
Cytochrome P-450 Enzyme System
Fatty Acids
NADP
Bone and Bones
Subcellular Fractions
1993
114 Citations (Scopus)

Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans

Allman, K. C., Wieland, D. M., Muzik, O., DeGrado, T. R., Wolfe, E. R. & Schwaiger, M., 1993, In : Journal of the American College of Cardiology. 22, 2, p. 368-375 8 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Adrenergic Agents
Carbon
Myocardial Infarction
Infarction
101 Citations (Scopus)

Myocardial kinetics of carbon-11-meta-hydroxyephedrine: Retention mechanisms and effects of norepinephrine

DeGrado, T. R., Hutchins, G. D., Toorongian, S. A., Wieland, D. M. & Schwaiger, M., 1993, In : Journal of Nuclear Medicine. 34, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

Catecholamines
Norepinephrine
Carbon
Myocardium
Metaraminol

Reply

Melon, P. G., DeGrado, T. R., Petry, N. A., Beanlands, R. S., Nguyen, N. & Schwaiger, M., 1993, In : Journal of the American College of Cardiology. 22, 2, p. 632 1 p.

Research output: Contribution to journalArticle

1994
26 Citations (Scopus)

Evaluation of ( - )[18F]fluoroethoxybenzovesamicol as a new PET tracer of cholinergic neurons of the heart

DeGrado, T. R., Mulholland, G. K., Wieland, D. M. & Schwaiger, M., 1994, In : Nuclear Medicine and Biology. 21, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Cholinergic Neurons
Myocardium
Vesicular Acetylcholine Transport Proteins
Stereoisomerism
Structure-Activity Relationship
15 Citations (Scopus)

Imaging of cardiac neuronal function after cocaine exposure using Carbon-11 hydroxyephedrine and positron emission tomography

Melon, P. G., Nguyen, N., DeGrado, T. R., Mangner, T. J., Wieland, D. M. & Schwaiger, M., 1994, In : Journal of the American College of Cardiology. 23, 7, p. 1693-1699 7 p.

Research output: Contribution to journalArticle

Cocaine
Positron-Emission Tomography
Carbon
Norepinephrine
Hemodynamics
206 Citations (Scopus)

Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes

Sun, D., Nguyen, N., DeGrado, T. R., Schwaiger, M. & Brosius, F. C., Feb 1994, In : Circulation. 89, 2, p. 793-798 6 p.

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Cardiac Myocytes
Ischemia
Cell Membrane
Insulin
39 Citations (Scopus)

Kinetics of 14(R,S)-fluorine-18-fluoro-6-thia-heptadecanoic acid in normal human hearts at rest, during exercise and after dipyridamole injection

Ebert, A., Herzog, H., Stocklin, G. L., Henrich, M. M., DeGrado, T. R., Coenen, H. H. & Feinendegen, L. E., 1994, In : Journal of Nuclear Medicine. 35, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Dipyridamole
Fluorine
Injections
Pressure
Fasting
446 Citations (Scopus)

Performance characteristics of a whole-body PET scanner

DeGrado, T. R., Turkington, T. G., Williams, J. J., Stearns, C. W., Hoffman, J. M. & Coleman, R. E., 1994, In : Journal of Nuclear Medicine. 35, 8, p. 1398-1406 9 p.

Research output: Contribution to journalArticle

Radioactivity
Noise
Tungsten
Research
bismuth germanium oxide
1995
57 Citations (Scopus)

Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart

DeGrado, T. R., Zalutsky, M. R. & Vaidyanathan, G., 1995, In : Nuclear Medicine and Biology. 22, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

3-Iodobenzylguanidine
2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-ol
Desipramine
Pulse
Heart Rate
1996
98 Citations (Scopus)

Adult age differences in regional cerebral blood flow during visual word identification: Evidence from H215O PET

Madden, D. J., Turkington, T. G., Coleman, R. E., Provenzale, J. M., DeGrado, T. R. & Hoffman, J. M., Apr 1996, In : NeuroImage. 3, 2, p. 127-142 16 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Regional Blood Flow
Semantics
Young Adult
Information Storage and Retrieval
69 Citations (Scopus)

Estimation of myocardial blood flow for longitudinal studies with 13N-labeled ammonia and positron emission tomography

DeGrado, T. R., Hanson, M. W., Turkington, T. G., Delong, D. M., Brezinski, D. A., Vallée, J. P., Hedlund, L. W., Zhang, J., Cobb, F., Sullivan, M. J. & Coleman, R. E., Nov 1996, In : Journal of Nuclear Cardiology. 3, 6, p. 494-507 14 p.

Research output: Contribution to journalArticle

Ammonia
Positron-Emission Tomography
Longitudinal Studies
Microspheres
Electrons
11 Citations (Scopus)

Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model

Berry, C. R., Garg, P. K., DeGrado, T. R., Hellyer, P., Weber, W., Garg, S., Hansen, B., Zalutsky, M. R. & Edward Coleman, R., Mar 1996, In : Journal of Nuclear Cardiology. 3, 2, p. 119-129 11 p.

Research output: Contribution to journalArticle

Coronary Occlusion
Canidae
Coronary Vessels
Infarction
Positron-Emission Tomography
20 Citations (Scopus)

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart

Berry, C. R., Garg, P. K., Zalutsky, M. R., Coleman, R. E. & DeGrado, T. R., Dec 1996, In : Journal of Nuclear Medicine. 37, 12, p. 2011-2016 6 p.

Research output: Contribution to journalArticle

Fluorine
Desipramine
2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-ol
Radioactivity
Perfusion
1997
23 Citations (Scopus)

Alignment of dynamic cardiac PET images for correction of motion

Turkington, T. G., DeGrado, T. R., Hanson, M. W. & Edward Coleman, R., 1997, In : IEEE Transactions on Nuclear Science. 44, 2, p. 235-242 8 p.

Research output: Contribution to journalArticle

Positron emission tomography
positrons
Blood
templates
tomography
97 Citations (Scopus)

Marijuana intoxication and brain activation in marijuana smokers

Mathew, R. J., Wilson, W. H., Coleman, R. E., Turkington, T. G. & DeGrado, T. R., May 2 1997, In : Life Sciences. 60, 23, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

Dronabinol
Cannabis
Cerebrovascular Circulation
Brain
Chemical activation
1998
21 Citations (Scopus)

Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia

Renstrom, B., Rommelfanger, S., Stone, C. K., DeGrado, T. R., Carlson, K. J., Scarbrough, E., Nickles, R. J., Liedtke, A. J. & Holden, J. E., Oct 1998, In : Journal of Nuclear Medicine. 39, 10, p. 1684-1689 6 p.

Research output: Contribution to journalArticle

Myocardial Ischemia
Fatty Acids
Arteries
Perfusion
Ischemia
8 Citations (Scopus)

Effects of specific activity on meta-[131I]iodobenzylguanidine kinetics in isolated rat heart

DeGrado, T. R., Zalutsky, M. R., Coleman, R. E. & Vaidyanathan, G., Jan 1998, In : Nuclear Medicine and Biology. 25, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

3-Iodobenzylguanidine
Isotopes
Pulse
8 Citations (Scopus)

Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: Application to m-iodobenzylguanidine

Vaidyanathan, G., Zalutsky, M. R. & DeGrado, T. R., Nov 1998, In : Bioconjugate Chemistry. 9, 6, p. 758-764 7 p.

Research output: Contribution to journalArticle

3-Iodobenzylguanidine
Radiopharmaceuticals
Benzene
Pyridine
Tumors
26 Citations (Scopus)

Myocardial uptake of the fatty acid analog 14-fluorine-18-fluoro-6- thia-heptadecanoic acid in comparison to beta-oxidation rates by tritiated palmitate

Stone, C. K., Pooley, R. A., DeGrado, T. R., Renstrom, B., Nickles, R. J., Nellis, S. H., Liedtke, A. J. & Holden, J. E., Oct 1998, In : Journal of Nuclear Medicine. 39, 10, p. 1690-1696 7 p.

Research output: Contribution to journalArticle

Fluorine
Palmitates
Fatty Acids
Lactic Acid
Perfusion
72 Citations (Scopus)

Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia

Hughes, G. C., Lowe, J. E., Kypson, A. P., St Louis, J. D., Pippen, A. M., Peters, K. G., Coleman, R. E., DeGrado, T. R., Donovan, C. L., Annex, B. H. & Landolfo, K. P., 1998, In : Annals of Thoracic Surgery. 66, 6, p. 2029-2036 8 p.

Research output: Contribution to journalArticle

Transmyocardial Laser Revascularization
Ischemia
Myocardium
Swine
Stress Echocardiography
45 Citations (Scopus)

Quantification of myocardial perfusion by MRI after coronary occlusion

Vallée, J. P. M., Sostman, H. D., MacFall, J. R., DeGrado, T. R., Zhang, J., Sebbag, L., Cobb, F. R., Wheeler, T., Hedlund, L. W., Turkington, T. G., Spritzer, C. E. & Coleman, R. E., Aug 1998, In : Magnetic Resonance in Medicine. 40, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

Coronary Occlusion
Positron-Emission Tomography
Perfusion
Gadolinium DTPA
Microspheres
4 Citations (Scopus)

Transcapillary transport of metaiodobenzylguanidine (MIBG) in isolated rat heart

DeGrado, T. R. & Wang, S., Jul 1998, In : Nuclear Medicine and Biology. 25, 5, p. 455-465 11 p.

Research output: Contribution to journalArticle

Permeability
Injections
Capillary Permeability
Radioactivity
Lactic Acid
1999
43 Citations (Scopus)

Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium

Hughes, G. C., Kypson, A. P., St. Louis, J. D., Annex, B. H., Coleman, R. E., DeGrado, T. R., Donovan, C. L., Lowe, J. E. & Landolfo, K. P., Jun 1999, In : Annals of Thoracic Surgery. 67, 6, p. 1714-1720 7 p.

Research output: Contribution to journalArticle

Transmyocardial Laser Revascularization
Myocardium
Perfusion
Stress Echocardiography
Positron-Emission Tomography
86 Citations (Scopus)

Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

Mathew, R. J., Wilson, W. H., Chiu, N. Y., Turkington, T. G., DeGrado, T. R. & Coleman, R. E., 1999, In : Acta Psychiatrica Scandinavica. 100, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Depersonalization
Dronabinol
Regional Blood Flow
Gyrus Cinguli
2000
41 Citations (Scopus)

An experimental model of chronic myocardial hibernation

St. Louis, J. D., Chad Hughes, G., Kypson, A. P., DeGrado, T. R., Donovan, C. L., Edward Coleman, R., Yin, B., Steenbergen, C., Landolfo, K. P. & Lowe, J. E., May 2000, In : Annals of Thoracic Surgery. 69, 5, p. 1351-1357 7 p.

Research output: Contribution to journalArticle

Myocardial Stunning
Myocardium
Theoretical Models
Stress Echocardiography
Positron-Emission Tomography
58 Citations (Scopus)

Induction of angiogenesis after TMR: A comparison of holmium: YAG, CO2, and excimer lasers

Hughes, G. C., Kypson, A. P., Annex, B. H., Yin, B., St. Louis, J. D., Biswas, S. S., Coleman, R. E., DeGrado, T. R., Donovan, C. L., Landolfo, K. P. & Lowe, J. E., 2000, In : Annals of Thoracic Surgery. 70, 2, p. 504-509 6 p.

Research output: Contribution to journalArticle

Transmyocardial Laser Revascularization
Excimer Lasers
Gas Lasers
Solid-State Lasers
Holmium
8 Citations (Scopus)

Preliminary evaluation of 15-[18F]fluoro-3-oxa-pentadecanoate as a PET tracer of hepatic fatty acid oxidation

DeGrado, T. R., Wang, S. & Rockey, D. C., 2000, In : Journal of Nuclear Medicine. 41, 10, p. 1727-1736 10 p.

Research output: Contribution to journalArticle

Fatty Acids
Liver
Palmitates
Carnitine O-Palmitoyltransferase
15-fluoro-3-oxa-pentadecanoate
36 Citations (Scopus)

Preliminary evaluation of F-18 fluorocholine (FCH) as a PET tumor imaging agent

Coleman, R. E., DeGrado, T. R., Wang, S., Baldwin, S. W., Orr, M. D., Reiman, R. E. & Price, D. T., 2000, In : Clinical Positron Imaging (Netherlands). 3, 4, p. 147 1 p.

Research output: Contribution to journalArticle

Neoplasms
Brain Neoplasms
Prostatic Neoplasms
Choline
fluorocholine
42 Citations (Scopus)

Synthesis and preliminary evaluation of 18F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation

DeGrado, T. R., Wang, S., Holden, J. E., Nickles, R. J., Taylor, M. & Stone, C. K., Apr 2000, In : Nuclear Medicine and Biology. 27, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

Palmitates
Positron-Emission Tomography
Fatty Acids
Radioactivity
Myocardium
17 Citations (Scopus)

Tracer kinetic modeling in nuclear cardiology

DeGrado, T. R., Bergmann, S. R., Ng, C. K. & Raffel, D. M., 2000, In : Journal of Nuclear Cardiology. 7, 6, p. 686-700 15 p.

Research output: Contribution to journalArticle

Cardiology
Process Assessment (Health Care)
Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography