Timothy R DeGrado, PhD

  • 4881 Citations
  • 37 Scopus h-Index
1983 …2020

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2020

Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging

Vandergaast, R., Khongwichit, S., Jiang, H., DeGrado, T. R., Peng, K. W., Smith, D. R., Russell, S. J. & Suksanpaisan, L., Apr 1 2020, In : Cancer Gene Therapy. 27, 3-4, p. 179-188 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Radiation induced oxidation of [18F]fluorothia fatty acids under cGMP manufacturing conditions

Pandey, M. K., Jacobson, M. S., Groth, E. K., Tran, N. G., Lowe, V. J. & DeGrado, T. R., Jan 1 2020, In : Nuclear Medicine and Biology. 80-81, p. 13-23 11 p.

Research output: Contribution to journalArticle

Open Access
2019

Cloning, function, and localization of human, canine, and drosophila ZIP10 (SLC39A10), a Zn2+ transporter

Landry, G. M., Furrow, E., Holmes, H. L., Hirata, T., Kato, A., Williams, P., Strohmaier, K., Gallo, C. J. R., Chang, M. D., Pandey, M. K., Jiang, H., Bansal, A., Franz, M. C., Montalbetti, N., Alexander, M. P., Cabrero, P., Dow, J. A. T., Degrado, T. R. & Romero, M. F., Jan 1 2019, In : American Journal of Physiology - Renal Physiology. 316, 2, p. F263-F273

Research output: Contribution to journalArticle

3 Scopus citations

Cyclotron production of 68Ga in a liquid target: Effects of solution composition and irradiation parameters

Pandey, M. K., Byrne, J. F., Schlasner, K. N., Schmit, N. R. & DeGrado, T. R., Jul 1 2019, In : Nuclear Medicine and Biology. 74-75, p. 49-55 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection

Zhang, L., Suksanpaisan, L., Jiang, H., DeGrado, T. R., Russell, S. J., Zhao, M. & Peng, K. W., Dec 20 2019, In : Molecular Therapy - Oncolytics. 15, p. 178-185 8 p.

Research output: Contribution to journalArticle

Open Access

Noninvasive evaluation of fat-carbohydrate metabolic switching in heart and contracting skeletal muscle

DeGrado, T. R., Pandey, M., Belanger, A. P., Basuli, F., Bansal, A. & Wang, S., Feb 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 2, p. E251-E259

Research output: Contribution to journalArticle

2018

Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models

Nicolas, C. T., Hickey, R., Allen, K. L., Du, Z., Guthman, R. M., Kaiser, R. A., Amiot, B., Bansal, A., Pandey, M., Suksanpaisan, L., DeGrado, T. R., Nyberg, S. & Lillegard, J. B., Jan 1 2018, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

3 Scopus citations

New transgenic NIS reporter rats for longitudinal tracking of fibrogenesis by high-resolution imaging

Brunton, B., Suksanpaisan, L., Li, H., Liu, Q., Yu, Y., Vrieze, A., Zhang, L., Jenks, N., Jiang, H., DeGrado, T. R., Zhao, C. D., Russell, S. J. & Peng, K-W., Dec 1 2018, In : Scientific Reports. 8, 1, 14209.

Research output: Contribution to journalArticle

1 Scopus citations

Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2

Franz, M. C., Pujol-Giménez, J., Montalbetti, N., Fernandez-Tenorio, M., Degrado, T. R., Niggli, E., Romero, M. F. & Hediger, M. A., Jul 3 2018, In : Biochemistry. 57, 26, p. 3976-3986 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
11 Scopus citations
2017

Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

Jiang, H., Schmit, N. R., Koenen, A. R., Bansal, A., Pandey, M. K., Glynn, R. B., Kemp, B. J., Delaney, K. L., Dispenzieri, A., Bakkum-Gamez, J. N., Peng, K. W., Russell, S. J., Gunderson, T. M., Lowe, V. J. & DeGrado, T. R., Jan 1 2017, In : EJNMMI Research. 7, 90.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer

Mather, K. J., Hutchins, G. D., Perry, K., Territo, W., Chisholm, R., Acton, A., Glick-Wilson, B., Considine, R. V., Moberly, S. & DeGrado, T. R., Jan 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 310, 6, p. E452-E460

Research output: Contribution to journalArticle

24 Scopus citations

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R. J., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. C., Peng, K-W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y. H., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S., Jul 27 2016, In : Science Translational Medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

24 Scopus citations

First PET imaging studies with 63Zn-zinc citrate in healthy human participants and patients with Alzheimer disease

DeGrado, T. R., Kemp, B. J., Pandey, M., Jiang, H., Gunderson, T. M., Linscheid, L. R., Woodwick, A. R., McConnell, D. M., Fletcher, J. G., Johnson, G. B., Petersen, R. C., Knopman, D. S. & Lowe, V., 2016, In : Molecular Imaging. 15, p. 1-10 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Imaging of myocardial fatty acid oxidation

Mather, K. J. & DeGrado, T. R., Oct 1 2016, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 10, p. 1535-1543 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Improved production and processing of 89Zr using a solution target

Pandey, M., Bansal, A., Engelbrecht, H. P., Byrne, J. F., Packard, A. B. & DeGrado, T. R., Jan 1 2016, In : Nuclear Medicine and Biology. 43, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Synthesis of 18F-Tetrafluoroborate via radiofluorination of boron trifluoride and evaluation in a murine C6-Glioma tumor model

Jiang, H., Bansal, A., Pandey, M., Peng, K-W., Suksanpaisan, L., Russell, S. J. & DeGrado, T. R., Sep 1 2016, In : Journal of Nuclear Medicine. 57, 9, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tracking and therapeutic value of human adipose tissue-derived mesenchymal stem cell transplantation in reducing venous neointimal hyperplasia associated with arteriovenous fistula

Yang, B., Brahmbhatt, A., Torres, E. N., Thielen, B., McCall, D. L., Engel, S., Bansal, A., Pandey, M., Dietz, A. B., Leof, E. B., DeGrado, T. R., Mukhopadhyay, D. & Misra, S., May 1 2016, In : Radiology. 279, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Novel <sup>89</sup>Zr cell labeling approach for PET-based cell trafficking studies

Bansal, A., Pandey, M., Demirhan, Y. E., Nesbitt, J. J., Crespo-Diaz, R. J., Terzic, A., Behfar, A. & DeGrado, T. R., Dec 1 2015, In : EJNMMI Research. 5, 1

Research output: Contribution to journalArticle

43 Scopus citations

Production and transport of gaseous 18F-synthons: 18F-acyl fluorides

Jiang, H., DiMagno, S. G. & DeGrado, T. R., Dec 1 2015, In : Journal of Fluorine Chemistry. 180, p. 181-185 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

Domingo-Musibay, E., Allen, C., Kurokawa, C., Hardcastle, J. J., Aderca, I., Msaouel, P., Bansal, A., Jiang, H., DeGrado, T. R. & Galanis, E., Sep 11 2014, In : Gene Therapy. 21, 9, p. 483-490 8 p.

Research output: Contribution to journalArticle

Measles edmonston vaccine strain derivatives have potent oncolytic activity against osteosarcoma

Domingo-Musibay, E., Allen, C., Kurokawa, C., Hardcastle, J. J., Aderca, I., Msaouel, P., Bansal, A., Jiang, H., DeGrado, T. R. & Galanis, E., Nov 11 2014, In : Cancer Gene Therapy. 21, 11, p. 483-490 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc

DeGrado, T. R., Pandey, M. K., Byrne, J. F., Engelbrecht, H. P., Jiang, H., Packard, A. B., Thomas, K. A., Jacobson, M. S., Curran, G. L. & Lowe, V. J., Aug 1 2014, In : Journal of Nuclear Medicine. 55, 8, p. 1348-1354 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Production of 89Zr via the 89Y(p,n)89Zr reaction in aqueous solution: Effect of solution composition on in-target chemistry

Pandey, M. K., Engelbrecht, H. P., Byrne, J. P., Packard, A. B. & DeGrado, T. R., Apr 2014, In : Nuclear Medicine and Biology. 41, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl) ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain

Pandey, M. K., DeGrado, T. R., Qian, K., Jacobson, M. S., Hagen, C. E., Duclos, R. I. & Gatley, S. J., Sep 17 2014, In : ACS Chemical Neuroscience. 5, 9, p. 793-802 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

Bansal, A., Harris, R. A. & DeGrado, T. R., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structure dependence of long-chain [18F]fluorothia fatty acids as myocardial fatty acid oxidation probes

Pandey, M. K., Belanger, A. P., Wang, S. & Degrado, T. R., Dec 13 2012, In : Journal of Medicinal Chemistry. 55, 23, p. 10674-10684 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer

Pandey, M. K., Bansal, A. & DeGrado, T. R., Dec 12 2011, In : Heart and Metabolism. 51, p. 15-19 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Microwave-assisted radiosynthesis of [18F]fluorinated fatty acid analogs

Belanger, A. P., Pandey, M. K. & Degrado, T. R., Apr 1 2011, In : Nuclear Medicine and Biology. 38, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Pilot comparison of 18F-fluorocholine and 18F- fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer

Beauregard, J. M., Williams, S. G., Degrado, T. R., Roselt, P. & Hicks, R. J., Aug 1 2010, In : Journal of Medical Imaging and Radiation Oncology. 54, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Synthesis and preliminary evaluation of 18-18F-fluoro-4-thia- oleate as a PET probe of fatty acid oxidation

DeGrado, T. R., Bhattacharyya, F., Pandey, M. K., Belanger, A. P. & Wang, S., Aug 1 2010, In : Journal of Nuclear Medicine. 51, 8, p. 1310-1317 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2009

Use of pressure-hold test for sterilizing filter membrane integrity in radiopharmaceutical manufacturing

Belanger, A. P., Byrne, J. F., Paolino, J. M. & DeGrado, T. R., Nov 1 2009, In : Nuclear Medicine and Biology. 36, 8, p. 955-959 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

Biodisposition and metabolism of [18F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats

Bansal, A., Shuyan, W., Hara, T., Harris, R. A. & DeGrado, T. R., Jun 1 2008, In : European Journal of Nuclear Medicine and Molecular Imaging. 35, 6, p. 1192-1203 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Synthesis and evaluation of near-infrared (NIR) dye-herceptin conjugates as photoacoustic computed tomography (PCT) probes for HER2 expression in breast cancer

Bhattacharyya, S., Wang, S., Reinecke, D., Kiser, W., Kruger, R. A. & DeGrado, T. R., Jun 1 2008, In : Bioconjugate Chemistry. 19, 6, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2007

Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart

Gao, M., Miller, M. A., DeGrado, T. R., Mock, B. H., Lopshire, J. C., Rosenberger, J. G., Dusa, C., Das, M. K., Groh, W. J., Zipes, D. P., Hutchins, G. D. & Zheng, Q. H., Feb 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 3, p. 1289-1297 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Fluoromethylcholine PET in recurrent multifocal hepatoma

Lenzo, N. P., Anderson, J., Campbell, A., Morandeau, L. & De Grado, T. R., Dec 1 2007, In : Australasian Radiology. 51, SUPPL. 4, p. B299-B302

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3

Zheng, Q. H., Gao, M., Mock, B. H., Wang, S., Hara, T., Nazih, R., Miller, M. A., Receveur, T. J., Lopshire, J. C., Groh, W. J., Zipes, D. P., Hutchins, G. D. & DeGrado, T. R., Apr 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 8, p. 2220-2224 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
2006

Choline transporter as a novel target for molecular imaging of cancer

Hara, T., Bansal, A. & DeGrado, T. R., Oct 1 2006, In : Molecular Imaging. 5, 4, p. 498-509 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells

Hara, T., Bansal, A. & DeGrado, T. R., Nov 1 2006, In : Nuclear Medicine and Biology. 33, 8, p. 977-984 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Restoring chemotherapy and hormonetherapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model

Shanmugam, R., Jayaprakasan, V., Gokmen-Polar, Y., Kelich, S., Miller, K. D., Yip-Schneider, M., Cheng, L., Bhat-Nakshatri, P., Sledge, G. W., Nakshatri, H., Zheng, Q. H., Miller, M. A., DeGrado, T., Hutchins, G. D. & Sweeney, C. J., Oct 1 2006, In : Prostate. 66, 14, p. 1498-1511 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: Effects of hypoxia and composition of exogenous fatty acids

DeGrado, T. R., Kitapci, M. T., Wang, S., Ying, J. & Lopaschuk, G. D., Jan 1 2006, In : Journal of Nuclear Medicine. 47, 1, p. 173-181 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2005

A facile synthesis of [11C]acetylene

Nazih, R., Blauser, J. P., Mock, B. H. & DeGrado, T. R., Sep 1 2005, In : Applied Radiation and Isotopes. 63, 3, p. 305-309 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2004

An improved synthesis of PET dopamine D2 receptors radioligand [11c]raclopride

Fei, X., Mock, B. H., DeGrado, T. R., Wang, J. Q., Glick-Wilson, B. E., Sullivan, M. L., Hutchins, G. D. & Zheng, Q. H., Jun 18 2004, In : Synthetic Communications. 34, 10, p. 1897-1907 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Regional Cardiac Sympathetic Innervation Early and Late after Transmyocardial Laser Revascularization

Hughes, G. C., Baklanov, D. V., Biswas, S. S., Pippen, A. M., DeGrado, T. R., Coleman, R. E., Landolfo, C. K., Lowe, J. E., Annex, B. H. & Landolfo, K. P., Jan 1 2004, In : Journal of Cardiac Surgery. 19, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Therapeutic angiogenesis in chronically ischemic porcine myocardium: Comparative effects of bFGF and VEGF

Hughes, G. C., Biswas, S. S., Yin, B., Coleman, R. E., DeGrado, T. R., Landolfo, C. K., Lowe, J. E., Annex, B. H. & Landolfo, K. P., Mar 2004, In : Annals of Thoracic Surgery. 77, 3, p. 812-818 7 p.

Research output: Contribution to journalArticle

85 Scopus citations
2003

Synthesis, biodistribution and micro-PET imaging of a potential cancer biomarker carbon-11 labeled MMP inhibitor (2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [ 11C]methyl ester

Zheng, Q. H., Fei, X., DeGrado, T. R., Wang, J. Q., Stone, K. L., Martinez, T. D., Gay, D. J., Baity, W. L., Mock, B. H., Glick-Wilson, B. E., Sullivan, M. L., Miller, K. D., Sledge, G. W. & Hutchins, G. D., Oct 2003, In : Nuclear Medicine and Biology. 30, 7, p. 753-760 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2002

A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardium

Hughes, G. C., Biswas, S. S., Yin, B., Baklanov, D. V., Annex, B. H., Coleman, R. E., DeGrado, T. R., Landolfo, C. K., Landolfo, K. P. & Lowe, J. E., Apr 3 2002, In : Journal of the American College of Cardiology. 39, 7, p. 1220-1228 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Comparison of [18F]fluorocholine and [18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer

Price, D. T., Coleman, R. E., Liao, R. P., Robertson, C. N., Polascik, T. J. & DeGrado, T. R., Jan 1 2002, In : Journal of Urology. 168, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

201 Scopus citations

Imaging of pheochromocytoma in 2 dogs using p-[18F]fluorobenzylguanidine

Berry, C. R., DeGrado, T. R., Nutter, F., Garg, P. K., Breitschwerdt, E. B., Spaulding, K., Concannon, K. D., Zalutsky, M. R. & Coleman, R. E., Mar 1 2002, In : Veterinary Radiology and Ultrasound. 43, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

Pharmacokinetics and radiation dosimetry of 18F-fluorocholine

DeGrado, T. R., Reiman, R. E., Price, D. T., Wang, S. & Coleman, R. E., Feb 7 2002, In : Journal of Nuclear Medicine. 43, 1, p. 92-96 5 p.

Research output: Contribution to journalArticle

150 Scopus citations