Timothy R DeGrado, PhD

  • 4820 Citations
  • 36 Scopus h-Index
1983 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter

Landry, G. M., Furrow, E., Holmes, H. L., Hirata, T., Kato, A., Williams, P., Strohmaier, K., Gallo, C. J. R., Chang, M., Pandey, M., Jiang, H., Bansal, A., Franz, M. C., Montalbetti, N., Alexander, M. P., Cabrero, P., Dow, J. A. T., DeGrado, T. R. & Romero, M. F., Feb 1 2019, In : American journal of physiology. Renal physiology. 316, 2, p. F263-F273

Research output: Contribution to journalArticle

3 Scopus citations

Cyclotron production of 68 Ga in a liquid target: Effects of solution composition and irradiation parameters

Pandey, M., Byrne, J. F., Schlasner, K. N., Schmit, N. R. & DeGrado, T. R., Jan 1 2019, In : Nuclear Medicine and Biology.

Research output: Contribution to journalArticle

6 Scopus citations

Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection

Zhang, L., Suksanpaisan, L., Jiang, H., DeGrado, T. R., Russell, S. J., Zhao, M. & Peng, K. W., Dec 20 2019, In : Molecular Therapy - Oncolytics. 15, p. 178-185 8 p.

Research output: Contribution to journalArticle

Open Access

Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging

Vandergaast, R., Khongwichit, S., Jiang, H., DeGrado, T. R., Peng, K-W., Smith, D. R., Russell, S. J. & Suksanpaisan, L., Jan 1 2019, (Accepted/In press) In : Cancer Gene Therapy.

Research output: Contribution to journalArticle

1 Scopus citations

Noninvasive evaluation of fat-carbohydrate metabolic switching in heart and contracting skeletal muscle

DeGrado, T. R., Pandey, M., Belanger, A. P., Basuli, F., Bansal, A. & Wang, S., Feb 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 2, p. E251-E259

Research output: Contribution to journalArticle

2018

[18F]Tetrafluoroborate ([18F]TFB) and its analogs for PET imaging of the sodium/iodide symporter

Jiang, H. & DeGrado, T. R., Jan 1 2018, In : Theranostics. 8, 14, p. 3918-3931 14 p.

Research output: Contribution to journalReview article

6 Scopus citations

Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models

Nicolas, C. T., Hickey, R., Allen, K. L., Du, Z., Guthman, R. M., Kaiser, R. A., Amiot, B., Bansal, A., Pandey, M., Suksanpaisan, L., DeGrado, T. R., Nyberg, S. & Lillegard, J. B., Jan 1 2018, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

3 Scopus citations

New transgenic NIS reporter rats for longitudinal tracking of fibrogenesis by high-resolution imaging

Brunton, B., Suksanpaisan, L., Li, H., Liu, Q., Yu, Y., Vrieze, A., Zhang, L., Jenks, N., Jiang, H., DeGrado, T. R., Zhao, C. D., Russell, S. J. & Peng, K-W., Dec 1 2018, In : Scientific Reports. 8, 1, 14209.

Research output: Contribution to journalArticle

1 Scopus citations

Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2

Franz, M. C., Pujol-Giménez, J., Montalbetti, N., Fernandez-Tenorio, M., DeGrado, T. R., Niggli, E., Romero, M. F. & Hediger, M. A., Jul 3 2018, In : Biochemistry. 57, 26, p. 3976-3986 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
8 Scopus citations
2017

Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

Jiang, H., Schmit, N. R., Koenen, A. R., Bansal, A., Pandey, M., Glynn, R. B., Kemp, B. J., Delaney, K. L., Dispenzieri, A., Bakkum-Gamez, J. N., Peng, K-W., Russell, S. J., Gunderson, T. M., Lowe, V. & DeGrado, T. R., 2017, In : EJNMMI Research. 7, 90.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer

Mather, K. J., Hutchins, G. D., Perry, K., Territo, W., Chisholm, R., Acton, A., Glick-Wilson, B., Considine, R. V., Moberly, S. & DeGrado, T. R., 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 310, 6, p. E452-E460

Research output: Contribution to journalArticle

23 Scopus citations

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R. J., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. C., Peng, K-W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y. H., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S., Jul 27 2016, In : Science Translational Medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

22 Scopus citations

First PET imaging studies with 63Zn-zinc citrate in healthy human participants and patients with Alzheimer disease

DeGrado, T. R., Kemp, B. J., Pandey, M., Jiang, H., Gunderson, T. M., Linscheid, L. R., Woodwick, A. R., McConnell, D. M., Fletcher, J. G., Johnson, G. B., Petersen, R. C., Knopman, D. S. & Lowe, V., 2016, In : Molecular Imaging. 15, p. 1-10 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging

Pandey, M. & DeGrado, T. R., 2016, In : Theranostics. 6, 4, p. 571-593 23 p.

Research output: Contribution to journalReview article

60 Scopus citations

Imaging of myocardial fatty acid oxidation

Mather, K. J. & DeGrado, T. R., Jan 21 2016, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

12 Scopus citations

Improved production and processing of 89Zr using a solution target

Pandey, M., Bansal, A., Engelbrecht, H. P., Byrne, J. F., Packard, A. B. & DeGrado, T. R., Jan 1 2016, In : Nuclear Medicine and Biology. 43, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Synthesis of 18F-Tetrafluoroborate via radiofluorination of boron trifluoride and evaluation in a murine C6-Glioma tumor model

Jiang, H., Bansal, A., Pandey, M., Peng, K-W., Suksanpaisan, L., Russell, S. J. & DeGrado, T. R., Sep 1 2016, In : Journal of Nuclear Medicine. 57, 9, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tracking and therapeutic value of human adipose tissue-derived mesenchymal stem cell transplantation in reducing venous neointimal hyperplasia associated with arteriovenous fistula

Yang, B., Brahmbhatt, A., Torres, E. N., Thielen, B., McCall, D. L., Engel, S., Bansal, A., Pandey, M., Dietz, A. B., Leof, E. B., DeGrado, T. R., Mukhopadhyay, D. & Misra, S., May 1 2016, In : Radiology. 279, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Novel <sup>89</sup>Zr cell labeling approach for PET-based cell trafficking studies

Bansal, A., Pandey, M., Demirhan, Y. E., Nesbitt, J. J., Crespo-Diaz, R. J., Terzic, A., Behfar, A. & DeGrado, T. R., Dec 1 2015, In : EJNMMI Research. 5, 1

Research output: Contribution to journalArticle

37 Scopus citations

Production and transport of gaseous 18F-synthons: 18F-acyl fluorides

Jiang, H., DiMagno, S. G. & DeGrado, T. R., Dec 1 2015, In : Journal of Fluorine Chemistry. 180, p. 181-185 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

Domingo-Musibay, E., Allen, C., Kurokawa, C., Hardcastle, J. J., Aderca, I., Msaouel, P., Bansal, A., Jiang, H., DeGrado, T. R. & Galanis, E., Sep 11 2014, In : Gene Therapy. 21, 9, p. 483-490 8 p.

Research output: Contribution to journalArticle

Measles edmonston vaccine strain derivatives have potent oncolytic activity against osteosarcoma

Domingo-Musibay, E., Allen, C., Kurokawa, C., Hardcastle, J. J., Aderca, I., Msaouel, P., Bansal, A., Jiang, H., DeGrado, T. R. & Galanis, E., Nov 11 2014, In : Cancer Gene Therapy. 21, 11, p. 483-490 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc

DeGrado, T. R., Pandey, M. K., Byrne, J. F., Engelbrecht, H. P., Jiang, H., Packard, A. B., Thomas, K. A., Jacobson, M. S., Curran, G. L. & Lowe, V. J., Aug 1 2014, In : Journal of Nuclear Medicine. 55, 8, p. 1348-1354 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Production of 89Zr via the 89Y(p,n)89Zr reaction in aqueous solution: Effect of solution composition on in-target chemistry

Pandey, M. K., Engelbrecht, H. P., Byrne, J. P., Packard, A. B. & DeGrado, T. R., Apr 2014, In : Nuclear Medicine and Biology. 41, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Radionuclide imaging of human epidermal receptors

Bhattacharyya, S., Bansal, A., Dixit, M. & DeGrado, T. R., Sep 4 2014, Nuclear Oncology. Wolters Kluwer Health, p. 598-615 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl) ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain

Pandey, M. K., DeGrado, T. R., Qian, K., Jacobson, M. S., Hagen, C. E., Duclos, R. I. & Gatley, S. J., Sep 17 2014, In : ACS Chemical Neuroscience. 5, 9, p. 793-802 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

Bansal, A., Harris, R. A. & DeGrado, T. R., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

PET and SPECT imaging of tumor metabolism

DeGrado, T. R., Jan 1 2012, Molecular Imaging Probes for Cancer Research. World Scientific Publishing Co., p. 197-218 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Structure dependence of long-chain [18F]fluorothia fatty acids as myocardial fatty acid oxidation probes

Pandey, M. K., Belanger, A. P., Wang, S. & Degrado, T. R., Dec 13 2012, In : Journal of Medicinal Chemistry. 55, 23, p. 10674-10684 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Fluorine-18 labeled thia fatty acids for PET imaging of fatty acid oxidation in heart and cancer

Pandey, M. K., Bansal, A. & DeGrado, T. R., Dec 12 2011, In : Heart and Metabolism. 51, p. 15-19 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Microwave-assisted radiosynthesis of [18F]fluorinated fatty acid analogs

Belanger, A. P., Pandey, M. K. & Degrado, T. R., Apr 1 2011, In : Nuclear Medicine and Biology. 38, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Pilot comparison of 18F-fluorocholine and 18F- fluorodeoxyglucose PET/CT with conventional imaging in prostate cancer

Beauregard, J. M., Williams, S. G., Degrado, T. R., Roselt, P. & Hicks, R. J., Aug 1 2010, In : Journal of Medical Imaging and Radiation Oncology. 54, 4, p. 325-332 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Synthesis and preliminary evaluation of 18-18F-fluoro-4-thia- oleate as a PET probe of fatty acid oxidation

DeGrado, T. R., Bhattacharyya, F., Pandey, M. K., Belanger, A. P. & Wang, S., Aug 1 2010, In : Journal of Nuclear Medicine. 51, 8, p. 1310-1317 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2009

Use of pressure-hold test for sterilizing filter membrane integrity in radiopharmaceutical manufacturing

Belanger, A. P., Byrne, J. F., Paolino, J. M. & DeGrado, T. R., Nov 1 2009, In : Nuclear Medicine and Biology. 36, 8, p. 955-959 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

Biodisposition and metabolism of [18F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats

Bansal, A., Shuyan, W., Hara, T., Harris, R. A. & DeGrado, T. R., Jun 1 2008, In : European Journal of Nuclear Medicine and Molecular Imaging. 35, 6, p. 1192-1203 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Prostate biopsy guided by 18F-fluorocholine PET in men with persistently elevated PSA levels

Kwee, S. A. & DeGrado, T., Aug 1 2008, In : European Journal of Nuclear Medicine and Molecular Imaging. 35, 8, p. 1567-1569 3 p.

Research output: Contribution to journalLetter

17 Scopus citations

Synthesis and evaluation of near-infrared (NIR) dye-herceptin conjugates as photoacoustic computed tomography (PCT) probes for HER2 expression in breast cancer

Bhattacharyya, S., Wang, S., Reinecke, D., Kiser, W., Kruger, R. A. & DeGrado, T. R., Jun 1 2008, In : Bioconjugate Chemistry. 19, 6, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
2007

Cancer Imaging With Fluorine-18-Labeled Choline Derivatives

Kwee, S. A., DeGrado, T. R., Talbot, J. N., Gutman, F. & Coel, M. N., Nov 1 2007, In : Seminars in Nuclear Medicine. 37, 6, p. 420-428 9 p.

Research output: Contribution to journalReview article

92 Scopus citations

Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart

Gao, M., Miller, M. A., DeGrado, T. R., Mock, B. H., Lopshire, J. C., Rosenberger, J. G., Dusa, C., Das, M. K., Groh, W. J., Zipes, D. P., Hutchins, G. D. & Zheng, Q. H., Feb 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 3, p. 1289-1297 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Fluoromethylcholine PET in recurrent multifocal hepatoma

Lenzo, N. P., Anderson, J., Campbell, A., Morandeau, L. & De Grado, T. R., Dec 1 2007, In : Australasian Radiology. 51, SUPPL. 4, p. B299-B302

Research output: Contribution to journalArticle

7 Scopus citations

Photoacoustic molecular imaging

Kiser, W. L., Reinecke, D., Degrado, T., Bhattacharyya, S. & Kruger, R. A., Apr 30 2007, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. 643721. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6437).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3

Zheng, Q. H., Gao, M., Mock, B. H., Wang, S., Hara, T., Nazih, R., Miller, M. A., Receveur, T. J., Lopshire, J. C., Groh, W. J., Zipes, D. P., Hutchins, G. D. & DeGrado, T. R., Apr 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 8, p. 2220-2224 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

The impact of urinary excretion of 18F-labeled choline analogs

DeGrado, T. R., Kwee, S. A., Coel, M. N. & Coleman, R. E., Jul 1 2007, In : Journal of Nuclear Medicine. 48, 7, 1 p.

Research output: Contribution to journalLetter

7 Scopus citations
2006

Choline transporter as a novel target for molecular imaging of cancer

Hara, T., Bansal, A. & DeGrado, T. R., Oct 1 2006, In : Molecular Imaging. 5, 4, p. 498-509 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells

Hara, T., Bansal, A. & DeGrado, T. R., Nov 1 2006, In : Nuclear Medicine and Biology. 33, 8, p. 977-984 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Restoring chemotherapy and hormonetherapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model

Shanmugam, R., Jayaprakasan, V., Gokmen-Polar, Y., Kelich, S., Miller, K. D., Yip-Schneider, M., Cheng, L., Bhat-Nakshatri, P., Sledge, G. W., Nakshatri, H., Zheng, Q. H., Miller, M. A., DeGrado, T., Hutchins, G. D. & Sweeney, C. J., Oct 1 2006, In : Prostate. 66, 14, p. 1498-1511 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: Effects of hypoxia and composition of exogenous fatty acids

DeGrado, T. R., Kitapci, M. T., Wang, S., Ying, J. & Lopaschuk, G. D., Jan 1 2006, In : Journal of Nuclear Medicine. 47, 1, p. 173-181 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2005

A facile synthesis of [11C]acetylene

Nazih, R., Blauser, J. P., Mock, B. H. & DeGrado, T. R., Sep 1 2005, In : Applied Radiation and Isotopes. 63, 3, p. 305-309 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2004

An improved synthesis of PET dopamine D2 receptors radioligand [11c]raclopride

Fei, X., Mock, B. H., DeGrado, T. R., Wang, J. Q., Glick-Wilson, B. E., Sullivan, M. L., Hutchins, G. D. & Zheng, Q. H., Jun 18 2004, In : Synthetic Communications. 34, 10, p. 1897-1907 11 p.

Research output: Contribution to journalArticle

34 Scopus citations