Timothy Kline, PhD

  • 680 Citations
  • 15 Scopus h-Index
20092019
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Research Output 2009 2019

  • 680 Citations
  • 15 Scopus h-Index
  • 37 Article
  • 6 Conference contribution
  • 2 Chapter
2019
9 Citations (Scopus)

Automated Abdominal Segmentation of CT Scans for Body Composition Analysis Using Deep Learning

Weston, A. D., Korfiatis, P., Kline, T., Philbrick, K. A., Kostandy, P., Sakinis, T., Sugimoto, M., Takahashi, N. M. & Erickson, B. J., Mar 1 2019, In : Radiology. 290, 3, p. 669-679 11 p.

Research output: Contribution to journalArticle

Body Composition
Learning
Hepatocellular Carcinoma
Abdomen
Intra-Abdominal Fat

Automatic Measurement of Kidney and Liver Volumes from MR Images of Patients Affected by Autosomal Dominant Polycystic Kidney Disease

van Gastel, M. D. A., Edwards, M. E., Torres, V., Erickson, B. J., Gansevoort, R. T. & Kline, T., Aug 1 2019, In : Journal of the American Society of Nephrology : JASN. 30, 8, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Kidney
Liver
Growth
Semantics

In vivo magnetic resonance imaging techniques for structural and functional characterization of murine model kidneys

Kline, T., Jan 1 2019, Methods in Cell Biology. Academic Press Inc., (Methods in Cell Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Magnetic Resonance Imaging
Kidney
Polycystic Kidney Diseases
Molecular Biology
Technology

Kidney and cystic volume imaging for disease presentation and progression in the cat autosomal dominant polycystic kidney disease large animal model

Yu, Y., Shumway, K. L., Matheson, J. S., Edwards, M. E., Kline, T. & Lyons, L. A., Jul 12 2019, In : BMC Nephrology. 20, 1, 259.

Research output: Contribution to journalArticle

Open Access
Cystic Kidney Diseases
Autosomal Dominant Polycystic Kidney
Disease Progression
Cats
Animal Models

RIL-Contour: a Medical Imaging Dataset Annotation Tool for and with Deep Learning

Philbrick, K. A., Weston, A. D., Akkus, Z., Kline, T., Korfiatis, P., Sakinis, T., Kostandy, P., Boonrod, A., Zeinoddini, A., Takahashi, N. M. & Erickson, B. J., Jan 1 2019, In : Journal of Digital Imaging.

Research output: Contribution to journalArticle

Open Access
Medical imaging
Diagnostic Imaging
Learning
Software
Datasets
2 Citations (Scopus)

Standardizing total kidney volume measurements for clinical trials of autosomal dominant polycystic kidney disease

Edwards, M. E., Blais, J. D., Czerwiec, F. S., Erickson, B. J., Torres, V. & Kline, T., Jan 1 2019, In : Clinical Kidney Journal. 12, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Open Access
Autosomal Dominant Polycystic Kidney
Clinical Trials
Kidney
Growth
TEMPO
2018
16 Citations (Scopus)

Deep Learning in Radiology: Does One Size Fit All?

Erickson, B. J., Korfiatis, P., Kline, T., Akkus, Z., Philbrick, K. & Weston, A. D., Jan 1 2018, (Accepted/In press) In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Radiology
Learning
Diagnostic Imaging
2 Citations (Scopus)

Evaluation of a deep learning architecture for MR imaging prediction of ATRX in glioma patients

Korfiatis, P., Kline, T. & Erickson, B. J., Jan 1 2018, Medical Imaging 2018: Computer-Aided Diagnosis. SPIE, Vol. 10575. 105752G

Research output: Chapter in Book/Report/Conference proceedingConference contribution

mutations
Glioma
learning
Tumors
tumors
3 Citations (Scopus)

Long-term administration of tolvaptan in autosomal dominant polycystic kidney disease

Edwards, M. E., Chebib, F., Irazabal Mira, M., Ofstie, T. G., Bungum, L. A., Metzger, A. J., Senum, S. R., Hogan, M. C., El-Zoghby, Z. M., Kline, T., Harris, P. C., Czerwiec, F. S. & Torres, V., Aug 7 2018, In : Clinical Journal of the American Society of Nephrology. 13, 8, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Odds Ratio
Confidence Intervals
Safety
Safety Management
11 Citations (Scopus)

Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)

Wong, A. T. Y., Mannix, C., Grantham, J. J., Allman-Farinelli, M., Badve, S. V., Boudville, N., Byth, K., Chan, J., Coulshed, S., Edwards, M. E., Erickson, B. J., Fernando, M., Foster, S., Haloob, I., Harris, D. C. H., Hawley, C. M., Hill, J., Howard, K., Howell, M., Jiang, S. H. & 14 others, Johnson, D. W., Kline, T., Kumar, K., Lee, V. W., Lonergan, M., Mai, J., McCloud, P., Peduto, A., Rangan, A., Roger, S. D., Sud, K., Torres, V., Vliayuri, E. & Rangan, G. K., Jan 1 2018, In : BMJ Open. 8, 1, e018794.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Drinking
Renal Insufficiency
Randomized Controlled Trials
Kidney
1 Citation (Scopus)

Three-dimensional NMR microscopy of zebrafish specimens

Kline, T., Sussman, C. R., Irazabal Mira, M., Mishra, P. K., Pearson, E. A., Torres, V. & Macura, S. I., Jan 1 2018, (Accepted/In press) In : NMR in Biomedicine. e4031.

Research output: Contribution to journalArticle

Zebrafish
Formaldehyde
Microscopy
Microscopic examination
Nuclear magnetic resonance
6 Citations (Scopus)

What does deep learning see? Insights from a classifier trained to predict contrast enhancement phase from CT images

Philbrick, K. A., Yoshida, K., Inoue, D., Akkus, Z., Kline, T., Weston, A. D., Korfiatis, P., Takahashi, N. M. & Erickson, B. J., Dec 1 2018, In : American Journal of Roentgenology. 211, 6, p. 1184-1193 10 p.

Research output: Contribution to journalArticle

Learning
2017
112 Citations (Scopus)

Machine learning for medical imaging

Erickson, B. J., Korfiatis, P., Akkus, Z. & Kline, T., Mar 1 2017, In : Radiographics. 37, 2, p. 505-515 11 p.

Research output: Contribution to journalArticle

Diagnostic Imaging
Learning
Machine Learning
18 Citations (Scopus)

Noninvasive assessment of renal fibrosis with magnetization transfer MR imaging: Validation and evaluation in murine renal artery stenosis

Jiang, K., Ferguson, C. M., Ebrahimi, B., Tang, H., Kline, T., Burningham, T. A., Mishra, P. K., Grande, J. P., Macura, S. I. & Lerman, L. O., Apr 1 2017, In : Radiology. 283, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Renal Artery Obstruction
Fibrosis
Kidney
Hydroxyproline
Blood Volume
21 Citations (Scopus)

Performance of an Artificial Multi-observer Deep Neural Network for Fully Automated Segmentation of Polycystic Kidneys

Kline, T., Korfiatis, P., Edwards, M. E., Blais, J. D., Czerwiec, F. S., Harris, P. C., King, B. F., Torres, V. & Erickson, B. J., May 26 2017, (Accepted/In press) In : Journal of Digital Imaging. p. 1-7 7 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Kidney
Learning
Imaging techniques
Medical imaging
10 Citations (Scopus)

Quantitative MRI of kidneys in renal disease

Kline, T., Edwards, M. E., Garg, I., Irazabal Mira, M., Korfiatis, P., Harris, P. C., King, B. F., Torres, V., Venkatesh, S. K. & Erickson, B. J., Jun 28 2017, (Accepted/In press) In : Abdominal Radiology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Magnetic Resonance Imaging
Kidney
Elasticity Imaging Techniques
Oxygen
26 Citations (Scopus)
Methylation
Methyltransferases
Tumors
Neural networks
Biomarkers
28 Citations (Scopus)

Toolkits and Libraries for Deep Learning

Erickson, B. J., Korfiatis, P., Akkus, Z., Kline, T. & Philbrick, K., Mar 17 2017, (Accepted/In press) In : Journal of Digital Imaging. p. 1-6 6 p.

Research output: Contribution to journalArticle

Libraries
Learning
Network architecture
Learning systems
Neural networks
2016
25 Citations (Scopus)
Autosomal Dominant Polycystic Kidney
Disease Progression
Magnetic Resonance Spectroscopy
Kidney
Biomarkers
11 Citations (Scopus)

Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease

Kline, T., Korfiatis, P., Edwards, M. E., Bae, K. T., Yu, A., Chapman, A. B., Mrug, M., Grantham, J. J., Landsittel, D., Bennett, W. M., King, B. F., Harris, P. C., Torres, V. & Erickson, B. J., Jul 12 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Glomerular Filtration Rate
Kidney
Linear Models
Biomarkers
50 Citations (Scopus)
Methyltransferases
Glioblastoma
Methylation
Biomarkers
ROC Curve
16 Citations (Scopus)

Semiautomated segmentation of polycystic kidneys in T2-weighted MR images

Kline, T., Edwards, M. E., Korfiatis, P., Akkus, Z., Torres, V. & Erickson, B. J., Sep 1 2016, In : American Journal of Roentgenology. 207, 3, p. 605-613 9 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Kidney
Autosomal Dominant Polycystic Kidney
Organ Size
Software
2015
3 Citations (Scopus)

Coronary microcirculation changes in non-ischemic dilated cardiomyopathy identified by novel perfusion CT

Miller, W. L., Behrenbeck, T. R., McCollough, C. H., Williamson, E. E., Leng, S., Kline, T. & Ritman, E. L., Feb 25 2015, (Accepted/In press) In : International Journal of Cardiovascular Imaging.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Microcirculation
Perfusion
Tomography
Microvessels
6 Citations (Scopus)

MIRMAID: A content management system for medical image analysis research

Korfiatis, P., Kline, T., Blezek, D. J., Langer, S. G., Ryan, W. J. & Erickson, B. J., Sep 1 2015, In : Radiographics. 35, 5, p. 1461-1468 8 p.

Research output: Contribution to journalArticle

Information Management
Diagnostic Imaging
Biomedical Research
Databases
Research
10 Citations (Scopus)

Semi-automated segmentation of pre-operative low grade gliomas in magnetic resonance imaging

Akkus, Z., Sedlar, J., Coufalova, L., Korfiatis, P., Kline, T., Warner, J. D., Agrawal, J. & Erickson, B. J., Aug 14 2015, In : Cancer Imaging. 15, 1, 12.

Research output: Contribution to journalArticle

Glioma
Magnetic Resonance Imaging
Atlases
Neoplasms
Gadolinium
15 Citations (Scopus)
Autosomal Dominant Polycystic Kidney
Kidney
Polycystic Kidney Diseases
Pathology
Disease Progression
2014
9 Citations (Scopus)

Anatomy of hepatic arteriolo-portal venular shunts evaluated by 3D micro-CT imaging

Kline, T., Knudsen, B. E., Anderson, J. L., Vercnocke, A. J., Jorgensen, S. M. & Ritman, E. L., 2014, In : Journal of Anatomy. 224, 6, p. 724-731 8 p.

Research output: Contribution to journalArticle

micro-computed tomography
hepatic artery
portal vein
Portal Vein
Hepatic Artery
6 Citations (Scopus)

Early changes in myocardial microcirculation in asymptomatic hypercholesterolemic subjects: As detected by perfusion CT

Behrenbeck, T. R., McCollough, C. H., Miller, W. L., Williamson, E. E., Leng, S., Kline, T. & Ritman, E. L., 2014, In : Annals of Biomedical Engineering. 42, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

Microcirculation
Blood
Microcirculation
Biomedical engineering
2012
3 Citations (Scopus)

Characterization of the pore labyrinth geometry of sea sponges imaged by micro-CT

Kline, T. & Ritman, E. L., Apr 2012, In : Journal of Porous Materials. 19, 2, p. 141-151 11 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Fluids
Geometry
Linings
Nutrients
11 Citations (Scopus)

IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall

Moritz, R., Eaker, D. R., Anderson, J. L., Kline, T., Jorgensen, S. M., Lerman, A. & Ritman, E. L., Sep 2012, In : JACC: Cardiovascular Imaging. 5, 9, p. 935-940 6 p.

Research output: Contribution to journalArticle

Vasa Vasorum
Coronary Vessels
Acute Coronary Syndrome
Blood Vessels
Atherosclerosis
4 Citations (Scopus)

Studying Microcirculation with Micro-CT

Kline, T. & Ritman, E. L., Apr 23 2012, Microcirculation Imaging. Wiley-VCH, p. 313-347 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microcirculation
Tissue
Blood Vessels
Contrast Media
Shear stress
2011
108 Citations (Scopus)

Algorithm-enabled low-dose micro-CT imaging

Han, X., Bian, J., Eaker, D. R., Kline, T., Sidky, E. Y., Ritman, E. L. & Pan, X., Mar 2011, In : IEEE Transactions on Medical Imaging. 30, 3, p. 606-620 15 p., 5609203.

Research output: Contribution to journalArticle

Tomography
Imaging techniques
Animals
Animal Structures
Image quality
9 Citations (Scopus)

Relating function to branching geometry: A micro-CT study of the hepatic artery, portal vein, and biliary tree

Kline, T., Zamir, M. & Ritman, E. L., Oct 2011, In : Cells Tissues Organs. 194, 5, p. 431-442 12 p.

Research output: Contribution to journalArticle

Hepatic Artery
Biliary Tract
Portal Vein
Hepatic Veins
Blood Vessels

SU‐E‐I‐40: Reconstruction of Sparse Images from Few‐View Cone‐Beam Data

Han, X., Bian, J., Eaker, D., Kline, T., Sidky, E., Ritman, E. & Pan, X., Jan 1 2011, In : Medical Physics. 38, 6, p. 3404-3405 2 p.

Research output: Contribution to journalArticle

Computer-Assisted Image Processing
Coronary Vessels
Radiation
X-Ray Microtomography
Arteries
2010
23 Citations (Scopus)

Accuracy of microvascular measurements obtained from micro-CT images

Kline, T., Zamir, M. & Ritman, E. L., Sep 2010, In : Annals of Biomedical Engineering. 38, 9, p. 2851-2864 14 p.

Research output: Contribution to journalArticle

Geometry
Optical transfer function
Image segmentation
Image analysis
Microscopes
5 Citations (Scopus)

Erode/dilate analysis of micro-CT images of porcine myocardial microvasculature

Kline, T., Dong, Y., Zamir, M. & Ritman, E. L., 2010, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7626. 762620

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biopsy
Microvessels
Swine
Blood Vessels
Microspheres
1 Citation (Scopus)

Image reconstruction from a reduced number of projections in Micro-CT specimen imaging

Han, X., Bian, J., Eaker, D. R., Kline, T., Sidky, E. Y., Ritman, E. L. & Pan, X., 2010, IEEE Nuclear Science Symposium Conference Record. p. 3466-3469 4 p. 5874450

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Computer-Assisted Image Processing
image reconstruction
projection
descent
Three-Dimensional Imaging
26 Citations (Scopus)

Synchrotron-based micro-CT imaging of the human lung acinus

Litzlbauer, H. D., Korbel, K., Kline, T., Jorgensen, S. M., Eaker, D. R., Bohle, R. M., Ritman, E. L. & Langheinrich, A. C., 2010, In : Anatomical Record. 293, 9, p. 1607-1614 8 p.

Research output: Contribution to journalArticle

micro-computed tomography
Synchrotrons
lungs
image analysis
Lung
2009
46 Citations (Scopus)

Biocompatible high-moment FeCo-Au magnetic nanoparticles for magnetic hyperthermia treatment optimization

Kline, T., Xu, Y. H., Jing, Y. & Wang, J. P., May 1 2009, In : Journal of Magnetism and Magnetic Materials. 321, 10, p. 1525-1528 4 p.

Research output: Contribution to journalArticle

hyperthermia
Nanoparticles
moments
nanoparticles
optimization
15 Citations (Scopus)

Experimental and theoretical investigation of cubic FeCo nanoparticles for magnetic hyperthermia

Jing, Y., Sohn, H., Kline, T., Victora, R. H. & Wang, J. P., Apr 27 2009, In : Journal of Applied Physics. 105, 7, 07B305.

Research output: Contribution to journalArticle

hyperthermia
nanoparticles
heating
hematite
magnetite
4 Citations (Scopus)

High-magnetic-moment nanoparticles for biomedicine

Jing, Y., He, S., Kline, T., Xu, Y. & Wang, J. P., Jan 1 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 4483-4486 4 p. 5333679

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Magnetic moments
Nanoparticles
Drug delivery
Condensation
Magnetic properties
2 Citations (Scopus)

Micro-CT analysis of sea sponge pore architecture as a model of a cell-populated synthetic tissue scaffold

Plath, A. S., Kline, T., Eaker, D. R., Beighley, P. E., Vercnocke, A. J. & Ritman, E. L., 2009, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7262. 72622K

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tissue Scaffolds
Artificial Cells
Porifera
Oceans and Seas
Erosion
3 Citations (Scopus)

Paths of least flow-resistance: Characterization for the optimization of synthetic tissue scaffold design

Kline, T. & Ritman, E. L., 2009, Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009. p. 606-609 4 p. 5193120

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tissue Scaffolds
Scaffolds
Waste Products
Porifera
Oceans and Seas
4 Citations (Scopus)

Thermal response of superparamagnetic particles suspended in liquid and solid media

Zeng, P., Kline, T., Wang, J. P. & Wiedmann, T. S., Mar 1 2009, In : Journal of Magnetism and Magnetic Materials. 321, 5, p. 373-376 4 p.

Research output: Contribution to journalArticle

Nanoparticles
nanoparticles
Lipids
Liquids
liquids