Timothy J Nelson, MD, PhD

  • 3087 Citations
  • 29 Scopus h-Index
20022019
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Research Output 2002 2019

  • 3087 Citations
  • 29 Scopus h-Index
  • 84 Article
  • 4 Review article
  • 3 Chapter
  • 1 Comment/debate
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Article
2011
10 Citations (Scopus)

Regenerative medicine: a reality of stem cell technology.

Terzic, A., Edwards, B. S., McKee, K. C. & Nelson, T. J., May 2011, In : Minnesota Medicine. 94, 5, p. 44-47 4 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Stem Cells
Technology
Organ Transplantation
Homeostasis
468 Citations (Scopus)

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y. H., Terzic, C. M. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

Glycolysis
Energy Metabolism
Electron Transport Complex I
Induced Pluripotent Stem Cells
Metabolomics
30 Citations (Scopus)

The science and ethics of induced pluripotency: What will become of embryonic stem cells?

Zacharias, D. G., Nelson, T. J., Mueller, P. & Hook, C. C., 2011, In : Mayo Clinic Proceedings. 86, 7, p. 634-640 7 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Ethics
Stem Cell Research
Induced Pluripotent Stem Cells
Stem Cells
2010
14 Citations (Scopus)

ATP-sensitive K+ channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy

Zlatkovic-Lindor, J., Arrell, D. K., Yamada, S., Nelson, T. J. & Terzic, A., Aug 2010, In : Stem Cells. 28, 8, p. 1355-1367 13 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Proteome
Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Stem Cells
20 Citations (Scopus)

Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network

Chiriac, A., Nelson, T. J., Faustino, R. S., Behfar, A. & Terzic, A., 2010, In : PLoS One. 5, 4, e9943.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Transcriptome
transcriptome
Vascular Endothelial Growth Factor A
50 Citations (Scopus)

C-MYC-Independent Nuclear Reprogramming Favors Cardiogenic Potential of Induced Pluripotent Stem Cells

Martinez-Fernandez, A., Nelson, T. J., Ikeda, Y. H. & Terzic, A., Feb 2010, In : Journal of Cardiovascular Translational Research. 3, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Clone Cells
Fibroblasts
Pluripotent Stem Cells
Sarcomeres
18 Citations (Scopus)

Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype

Faustino, R. S., Chiriac, A., Niederlander, N. J., Nelson, T. J., Behfar, A., Mishra, P. K., Macura, S. I., Michalak, M., Terzic, A. & Terzic, C. M., Jul 2010, In : Stem Cells. 28, 7, p. 1281-1291 11 p.

Research output: Contribution to journalArticle

Calreticulin
Embryonic Stem Cells
Transcriptome
Stem Cells
Computational Biology
28 Citations (Scopus)

Induced pluripotent stem cells: Advances to applications

Nelson, T. J., Martinez-Fernandez, A., Yamada, S., Ikeda, Y. H., Terzic, C. M. & Terzic, A., 2010, In : Stem Cells and Cloning: Advances and Applications. 3, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Regenerative Medicine
Stem Cells
Pluripotent Stem Cells
Hemophilia A
107 Citations (Scopus)

Induced pluripotent stem cells: Developmental biology to regenerative medicine

Nelson, T. J., Martinez-Fernandez, A. & Terzic, A., Dec 2010, In : Nature Reviews Cardiology. 7, 12, p. 700-710 11 p.

Research output: Contribution to journalArticle

Developmental Biology
Induced Pluripotent Stem Cells
Regenerative Medicine
Cell Biology
Stem Cells
32 Citations (Scopus)

Regenerative Medicine. Advancing Health Care 2020

Terzic, A. & Nelson, T. J., May 18 2010, In : Journal of the American College of Cardiology. 55, 20, p. 2254-2257 4 p.

Research output: Contribution to journalArticle

Rejuvenation
Precision Medicine
Regenerative Medicine
Stem Cell Transplantation
Tissue Engineering
12 Citations (Scopus)

SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells

Chiriac, A., Terzic, A., Park, S., Ikeda, Y. H., Faustino, R. & Nelson, T. J., 2010, In : Journal of Cardiovascular Translational Research. 3, 6, p. 674-682 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem Cells
CXCR4 Receptors
Gene Knockdown Techniques
Embryoid Bodies
11 Citations (Scopus)

Stem cells: Clinical trials results the end of the beginning or the beginning of the end?

Behfar, A., Crespo-Diaz, R., Nelson, T. J., Terzic, A. & Gersh, B. J., 2010, In : Cardiovascular and Hematological Disorders - Drug Targets. 10, 3, p. 186-201 16 p.

Research output: Contribution to journalArticle

Stem Cells
Clinical Trials
Cell- and Tissue-Based Therapy
Heart Diseases
Adult Stem Cells
2009
9 Citations (Scopus)

Clinical pharmacology: A paradigm for individualized medicine

Waldman, S. A., Kraft, W. K., Nelson, T. J. & Terzic, A., 2009, In : Biomarkers in Medicine. 3, 6, p. 679-684 6 p.

Research output: Contribution to journalArticle

Precision Medicine
Clinical Pharmacology
Medicine
Therapeutics
Pharmaceutical Preparations
6 Citations (Scopus)

Experimental therapeutics: A paradigm for personalized medicine

Waldman, S. A., Kraft, W. K., Nelson, T. J. & Terzic, A., Dec 2009, In : Clinical and Translational Science. 2, 6, p. 436-438 3 p.

Research output: Contribution to journalArticle

Medicine
Pharmaceutical Preparations
Drug Discovery
26 Citations (Scopus)

Induced pluripotent reprogramming from promiscuous human sternness-related factors

Nelson, T. J., Martinez-Fernandez, A., Yamada, S., Mael, A. A., Terzic, A. & Ikeda, Y. H., 2009, In : Clinical and Translational Science. 2, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Genes
Fibroblasts
Stem cells
Viruses
Embryonic Structures
10 Citations (Scopus)

Induced pluripotent stem cells: Reprogrammed without a trace

Nelson, T. J. & Terzic, A., 2009, In : Regenerative Medicine. 4, 3, p. 333-335 3 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Regenerative Medicine
Stem cells
Cell Differentiation
96 Citations (Scopus)

IPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism

Martinez-Fernandez, A., Nelson, T. J., Yamada, S., Reyes, S., Alekseev, A. E., Terzic, C. M., Ikeda, Y. H. & Terzic, A., Sep 2009, In : Circulation Research. 105, 7, p. 648-656 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Chimerism
Fibroblasts
Embryoid Bodies
Actinin
17 Citations (Scopus)

KCNJ11 knockout morula re-engineered by stem cell diploid aggregation

Nelson, T. J., Martinez-Fernandez, A. & Terzic, A., 2009, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 364, 1514, p. 269-276 8 p.

Research output: Contribution to journalArticle

Morula
KATP Channels
Cell Aggregation
chimerism
morula
18 Citations (Scopus)

Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis

Nelson, T. J., Chiriac, A., Faustino, R. S., Crespo-Diaz, R. J., Behfar, A. & Terzic, A., Mar 2009, In : Differentiation. 77, 3, p. 248-255 8 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
GATA4 Transcription Factor
Transcription Factors
Vascular Endothelial Growth Factor Receptor-1
Gene Expression
355 Citations (Scopus)

Repair of acute myocardial infarction with induced pluripotent stem cells induced by human stemness factors

Nelson, T. J., Martinez-Fernandez, A., Yamada, S., Terzic, C. M., Ikeda, Y. H. & Terzic, A., Aug 2009, In : Circulation. 120, 5, p. 408-416 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Myocardial Infarction
Fibroblasts
Heart Diseases
Morula
54 Citations (Scopus)

Stem cell platforms for regenerative medicine

Nelson, T. J., Behfar, A., Yamada, S., Martinez-Fernandez, A. & Terzic, A., 2009, In : Clinical and Translational Science. 2, 3, p. 222-227 6 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Stem cells
Stem Cells
Repair
Regeneration
21 Citations (Scopus)

Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype

Yamada, S., Nelson, T. J., Behfar, A., Crespo-Diaz, R. J., Fraidenraich, D. & Terzic, A., Jul 2009, In : Stem Cells. 27, 7, p. 1697-1705 9 p.

Research output: Contribution to journalArticle

Blastocyst
Stem Cells
Myocardial Infarction
Transplants
Phenotype
2008
88 Citations (Scopus)

CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells

Nelson, T. J., Faustino, R. S., Chiriac, A., Crespo-Diaz, R., Behfar, A. & Terzic, A., Jun 2008, In : Stem Cells. 26, 6, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Mesoderm
Biomarkers
Pluripotent Stem Cells
Genes
59 Citations (Scopus)

Embryonic stem cell therapy of heart failure in genetic cardiomyopathy

Yamada, S., Nelson, T. J., Crespo-Diaz, R. J., Terzic, C. M., Liu, X. K., Miki, T., Seino, S., Behfar, A. & Terzic, A., Oct 2008, In : Stem Cells. 26, 10, p. 2644-2653 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Cardiomyopathies
Heart Failure
KATP Channels
38 Citations (Scopus)

Stem cells: Biologics for regeneration

Nelson, T. J., Behfar, A. & Terzic, A., Nov 2008, In : Clinical Pharmacology and Therapeutics. 84, 5, p. 620-623 4 p.

Research output: Contribution to journalArticle

Biological Products
Regeneration
Stem Cells
Therapeutics
Pharmacology
46 Citations (Scopus)
Regenerative Medicine
Repair
Stem cells
Regeneration
Stem Cells
2007
33 Citations (Scopus)

A definitive example of a geometric "entatic state" effect: Electron-transfer kinetics for a copper(ll/l) complex involving a quinquedentate macrocyclic trithiaether - Bipyridine ligand

Chaka, G., Sonnenberg, J. L., Schlegel, H. B., Heeg, M. J., Jaeger, G., Nelson, T. J., Ochrymowycz, L. A. & Rorabacher, D. B., Apr 25 2007, In : Journal of the American Chemical Society. 129, 16, p. 5217-5227 11 p.

Research output: Contribution to journalArticle

Sulfur
Oxidation-Reduction
Copper
Ligands
Electrons
36 Citations (Scopus)

Nuclear transport: Target for therapy

Faustino, R. S., Nelson, T. J., Terzic, A. & Terzic, C. M., Jun 2007, In : Clinical Pharmacology and Therapeutics. 81, 6, p. 880-886 7 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Clinical Pharmacology
Nuclear Envelope
Cell Communication
Cytosol
2006
48 Citations (Scopus)

Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells

Nelson, T. J., Ge, Z. D., Van Orman, J., Barron, M., Rudy-Reil, D., Hacker, T. A., Misra, R., Duncan, S. A., Auchamdpach, J. A. & Lough, J. W., Nov 2006, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 288, 11, p. 1216-1224 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
embryonic stem cells
cardiac output
Embryonic Stem Cells
stem
2005
66 Citations (Scopus)

SRF-dependent gene expression in isolated cardiomyocytes: Regulation of genes involved in cardiac hypertrophy

Nelson, T. J., Balza, R., Xiao, Q. & Misra, R. P., Sep 2005, In : Journal of Molecular and Cellular Cardiology. 39, 3, p. 479-489 11 p.

Research output: Contribution to journalArticle

Serum Response Factor
Cardiomegaly
Cardiac Myocytes
Gene Expression
Genes
2004
14 Citations (Scopus)

Conserved Enhancer in the Serum Response Factor Promoter Controls Expression during Early Coronary Vasculogenesis

Nelson, T. J., Duncan, S. A. & Misra, R. P., Apr 30 2004, In : Circulation Research. 94, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

Serum Response Factor
Embryonic Structures
Embryonic Stem Cells
Transgenes
Tetraploidy
60 Citations (Scopus)

Identification and Characterization of a Glycosaminoglycan Recognition Element of the C Chemokine Lymphotactin

Peterson, F. C., Elgin, E. S., Nelson, T. J., Zhang, F., Hoeger, T. J., Linhardt, R. J. & Volkman, B. F., Mar 26 2004, In : Journal of Biological Chemistry. 279, 13, p. 12598-12604 7 p.

Research output: Contribution to journalArticle

C Chemokines
Glycosaminoglycans
Chemokines
Heparin
Arginine
2002
4 Citations (Scopus)

Electron-transfer kinetics and equilibria of copper(II/I) complexes with 1,4,7-trithiacyclononane. a square scheme mechanism involving ligand addition

Kandegedara, A., Krylova, K., Nelson, T. J., Schroeder, R. R., Ochrymowycz, L. A. & Rorabacher, D. B., 2002, In : Dalton Transactions. 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Copper
Ligands
Kinetics
Electrons
Water
11 Citations (Scopus)

Electron-transfer kinetics and equilibria of copper(II/I) complexes with 1,4,7-trithiacyclononane. A square scheme mechanism involving ligand addition

Kandegedara, A., Krylova, K., Nelson, T. J., Schroeder, R. R., Ochrymowycz, L. A. & Rorabacher, D. B., 2002, In : Journal of the Chemical Society, Dalton Transactions. 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Copper
Ligands
Kinetics
Electrons
Water