Timothy J Nelson, MD, PhD

  • 3163 Citations
  • 29 Scopus h-Index
20022019
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Research Output 2002 2019

  • 3163 Citations
  • 29 Scopus h-Index
  • 84 Article
  • 4 Review article
  • 3 Chapter
  • 1 Comment/debate
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Article
2019
2 Citations (Scopus)

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A. C., Nelson, T. J., Hall-Flavin, D., Heard, K. J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A. T., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonergic Neurons
Neurons
Induced Pluripotent Stem Cells
2 Citations (Scopus)

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonin
Neurons
Synaptic Transmission
Open Access
RNA Sequence Analysis
Induced Pluripotent Stem Cells
Electrophysiology
Cardiac Myocytes
Phenotype
2017
2 Citations (Scopus)

NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis

Wanek Program Genetics Pipeline Group, Apr 1 2017, In : Stem Cells. 35, 4, p. 1106-1119 14 p.

Research output: Contribution to journalArticle

Hypoplastic Left Heart Syndrome
Induced Pluripotent Stem Cells
Nitric Oxide
Phenotype
Cardiac Myocytes
1 Citation (Scopus)

Quantification of Etoposide Hypersensitivity: A Sensitive, Functional Method for Assessing Pluripotent Stem Cell Quality

Secreto, F. J., Li, X., Smith, A. J., Bruinsma, E. S., Perales-Clemente, E., Oommen, S., Hawse, G., Hrstka, S. C. L., Arendt, B. K., Brandt, E. B., Wigle, D. A. & Nelson, T. J., Oct 1 2017, In : Stem cells translational medicine. 6, 10, p. 1829-1839 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Etoposide
Hypersensitivity
Clone Cells
2016
11 Citations (Scopus)

Closure of a recurrent bronchopleural fistula using a matrix seeded with patient-derived mesenchymal stem cells

Aho, J. M., Dietz, A. B., Radel, D. J., Butler, G. W., Thomas, M., Nelson, T. J., Carlsen, B. T., Cassivi, S. D., Resch, Z. T., Faubion, W. A. & Wigle, D. A., Oct 1 2016, In : Stem cells translational medicine. 5, 10, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Fistula
Osteocytes
Abdominal Fat
Pneumonectomy

Hypoplastic left heart syndrome: What's next?

Burkhart, H. M., Thompson, J. L. & Nelson, T. J., Apr 1 2016, In : Journal of Thoracic and Cardiovascular Surgery. 151, 4, p. 909-910 2 p.

Research output: Contribution to journalArticle

Hypoplastic Left Heart Syndrome
Fontan Procedure

Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Li, X., Campbell, K. A., Biendarra, S. M., Terzic, A. & Nelson, T. J., Mar 1 2016, In : Genomics Data. 7, p. 129-130 2 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Transcriptome
Microarrays
Gene expression
34 Citations (Scopus)

Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells

Wyles, S. P., Li, X., Hrstka, S. C., Reyes, S., Oommen, S., Beraldi, R., Edwards, J., Terzic, A., Olson, T. M. & Nelson, T. J., Jan 15 2016, In : Human Molecular Genetics. 25, 2, p. 254-265 12 p., ddv468.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
RNA-Binding Proteins
Cardiac Myocytes
Dilated Cardiomyopathy
Missense Mutation
21 Citations (Scopus)

Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability

Perales-Clemente, E., Cook, A. N., Evans, J. M., Roellinger, S., Secreto, F., Emmanuele, V., Oglesbee, D., Mootha, V. K., Hirano, M., Schon, E. A., Terzic, A. & Nelson, T. J., 2016, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Mitochondrial DNA
Mitochondria
Stem cells
Clone Cells
12 Citations (Scopus)
Induced Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Adrenergic Agents
Homeostasis
2015
19 Citations (Scopus)

Compound heterozygous NOTCH1 mutations underlie impaired cardiogenesis in a patient with hypoplastic left heart syndrome

Theis, J. L., Hrstka, S. C. L., Evans, J. M., O’Byrne, M. M., De Andrade, M., O’Leary, P. W., Nelson, T. J. & Olson, T. M., Sep 10 2015, In : Human Genetics. 134, 9, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

Hypoplastic Left Heart Syndrome
Congenital Heart Defects
Mutation
Induced Pluripotent Stem Cells
Genome
23 Citations (Scopus)

Ebstein anomaly review: What's now, what's next?

Dearani, J. A., Mora, B. N., Nelson, T. J., Haile, D. T. & O'Leary, P. W., Oct 3 2015, In : Expert Review of Cardiovascular Therapy. 13, 10, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

Ebstein Anomaly
Tricuspid Valve
Right Ventricular Function
Tricuspid Valve Insufficiency
Mortality
12 Citations (Scopus)
Ventricular Function
Ventricular Pressure
Fetal Blood
Blood
Heart Ventricles
2 Citations (Scopus)
Induced Pluripotent Stem Cells
Stem cells
Cardiovascular Diseases
Blueprints
Biotechnology
2 Citations (Scopus)

Nos3<sup>-/-</sup> iPSCs model concordant signatures of in utero cardiac pathogenesis

Campbell, K. A., Li, X., Biendarra, S. M., Terzic, A. & Nelson, T. J., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 228-236 9 p., 8180.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Benchmarking
Systems Biology
Energy Metabolism
Up-Regulation
28 Citations (Scopus)
Cord Blood Stem Cell Transplantation
Prenatal Ultrasonography
Hypoplastic Left Heart Syndrome
Fontan Procedure
Right Ventricular Function
7 Citations (Scopus)

Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy

Yamada, S., Arrell, D. K., Martinez-Fernandez, A., Behfar, A., Kane, G. M., Terzic, C. M., Crespo-Diaz, R. J., McDonald, R., Wyles, S. P., Zlatkovic-Lindor, J., Nelson, T. J. & Terzic, A., May 11 2015, In : Journal of the American Heart Association. 4, 5

Research output: Contribution to journalArticle

Cardiomyopathies
Heart Failure
Stem Cells
Equipment and Supplies
Cardiac Resynchronization Therapy
11 Citations (Scopus)
Fetal Blood
Regeneration
Blood Cells
Swine
Cell- and Tissue-Based Therapy
1 Citation (Scopus)

Systems-Based Technologies in Profiling the Stem Cell Molecular Framework for Cardioregenerative Medicine

Wyles, S. P., Faustino, R. S., Li, X., Terzic, A. & Nelson, T. J., Jun 4 2015, In : Stem Cell Reviews and Reports. 11, 3, p. 501-510 10 p.

Research output: Contribution to journalArticle

Stem Cells
Medicine
Systems Biology
Technology
Metabolomics
Cardiomyopathy
Induced Pluripotent Stem Cells
Stem Cells
Dilated Cardiomyopathy
Gene Expression Profiling
2014
8 Citations (Scopus)
Zebrafish
Cardiac Myocytes
Embryonic Structures
Myosin Type II
Sarcomeres
13 Citations (Scopus)

Inhibition of DNA topoisomerase ii selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy

Wyles, S. P., Yamada, S., Oommen, S., Maleszewski, J., Beraldi, R., Martinez-Fernandez, A., Terzic, A. & Nelson, T. J., Oct 1 2014, In : Stem Cells and Development. 23, 19, p. 2274-2282 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Type I DNA Topoisomerase
Etoposide
Pluripotent Stem Cells
Teratoma
5 Citations (Scopus)

Ips cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes

Martinez-Fernandez, A., Nelson, T. J., Reyes, S., Alekseev, A. E., Secreto, F., Terzic, C. M., Beraldi, R., Sung, H. K., Nagy, A. & Terzic, A., Oct 1 2014, In : Circulation: Cardiovascular Genetics. 7, 5, p. 667-676 10 p.

Research output: Contribution to journalArticle

Transgenes
Induced Pluripotent Stem Cells
Transposases
Actinin
Excitation Contraction Coupling
26 Citations (Scopus)

Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy

Beraldi, R., Li, X., Fernandez, A. M., Reyes, S., Secreto, F., Terzic, A., Olson, T. M. & Nelson, T. J., 2014, In : Human Molecular Genetics. 23, 14, p. 3779-3791 13 p., ddu091.

Research output: Contribution to journalArticle

Sarcomeres
Dilated Cardiomyopathy
Pluripotent Stem Cells
RNA
Genes
8 Citations (Scopus)

Selection via pluripotency-related transcriptional screen minimizes the influence of somatic origin on iPSC differentiation propensity

Hartjes, K. A., Li, X., Martinez-Fernandez, A., Roemmich, A. J., Larsen, B., Terzic, A. & Nelson, T. J., 2014, In : Stem Cells. 32, 9, p. 2350-2359 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cell Differentiation
Doxycycline
Gene Expression
Genotype
9 Citations (Scopus)

Stem cells: The pursuit of genomic stability

Wyles, S. P., Brandt, E. B. & Nelson, T. J., Nov 14 2014, In : International Journal of Molecular Sciences. 15, 11, p. 20948-20967 20 p.

Research output: Contribution to journalArticle

stem cells
Genomic Instability
Stem cells
DNA Repair
DNA Damage
9 Citations (Scopus)

The inferred cardiogenic gene regulatory network in the mammalian heart

Bazil, J. N., Stamm, K. D., Li, X., Thiagarajan, R., Nelson, T. J., Tomita-Mitchell, A. & Beard, D. A., Jun 27 2014, In : PLoS One. 9, 6, e100842.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
heart
genes
gene interaction
26 Citations (Scopus)

Transcriptional atlas of cardiogenesis maps congenital heart disease interactome

Li, X., Martinez-Fernandez, A., Hartjes, K. A., Kocher, J-P., Olson, T. M., Terzic, A. & Nelson, T. J., Jul 1 2014, In : Physiological Genomics. 46, 13, p. 482-495 14 p.

Research output: Contribution to journalArticle

Atlases
Heart Diseases
Epithelial-Mesenchymal Transition
Spatio-Temporal Analysis
Gene Expression Profiling
31 Citations (Scopus)
Transcriptome
Myocardial Infarction
Genes
Genome
Gene Expression
2013
5 Citations (Scopus)
Myocardial Infarction
Left Ventricular Function
Myocardial Ischemia
Stroke Volume
Echocardiography
74 Citations (Scopus)

Disease-causing mitochondrial Heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS

Folmes, C., Martinez-Fernandez, A., Perales-Clemente, E., Li, X., McDonald, A., Oglesbee, D., Hrstka, S. C., Terzic, C. M., Terzic, A. & Nelson, T. J., Jul 2013, In : Stem Cells. 31, 7, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

MELAS Syndrome
Induced Pluripotent Stem Cells
Mitochondrial Diseases
Mitochondrial DNA
Clone Cells
18 Citations (Scopus)

Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction

Yamada, S., Nelson, T. J., Kane, G. M., Martinez-Fernandez, A., Crespo-Diaz, R. J., Ikeda, Y. H., Terzic, C. M. & Terzic, A., Sep 2013, In : Journal of Physiology. 591, 17, p. 4335-4349 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cardiac Resynchronization Therapy
Infarction
Stem Cell Transplantation
Cicatrix
8 Citations (Scopus)

Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K+ channel-deficient dilated cardiomyopathy.

Yamada, S., Arrell, D. K., Kane, G. M., Nelson, T. J., Terzic, C. M., Behfar, A., Purushothaman, S., Prinzen, F. W., Auricchio, A. & Terzic, A., 2013, In : Journal of the American Heart Association. 2, 6

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Adenosine Triphosphate
Heart Failure
Asymptomatic Diseases
Cardiomyopathies
18 Citations (Scopus)

Metabolome and metaboproteome remodeling in nuclear reprogramming

Folmes, C., Kent Arrell, D., Zlatkovic-Lindor, J., Martinez-Fernandez, A., Terzic, C. M., Nelson, T. J. & Terzic, A., Aug 1 2013, In : Cell Cycle. 12, 15, p. 2355-2365 11 p.

Research output: Contribution to journalArticle

Metabolome
Induced Pluripotent Stem Cells
Glycolysis
Energy Metabolism
Down-Regulation
13 Citations (Scopus)

Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines

Martinez-Fernandez, A., Li, X., Hartjes, K. A., Terzic, A. & Nelson, T. J., Oct 2013, In : Circulation: Cardiovascular Genetics. 6, 5, p. 462-471 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cell Line
Transcriptome
Genes
Developmental Genes
30 Citations (Scopus)

New and TALENted genome engineering toolbox

Campbell, J. M., Hartjes, K. A., Nelson, T. J., Xu, X. H. & Ekker, S. C., Aug 16 2013, In : Circulation Research. 113, 5, p. 571-587 17 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Genome
Precision Medicine
Phenotype
Genes
34 Citations (Scopus)
Induced Pluripotent Stem Cells
Metabolomics
Cellular Reprogramming
Energy Metabolism
Mitochondria
45 Citations (Scopus)

Patients with heart failure have an increased risk of incident cancer

Hasin, T., Gerber, Y., McNallan, S. M., Weston, S. A., Kushwaha, S. S., Nelson, T. J., Cerhan, J. R. & Roger, V. L., Sep 3 2013, In : Journal of the American College of Cardiology. 62, 10, p. 881-886 6 p.

Research output: Contribution to journalArticle

Heart Failure
Neoplasms
Confidence Intervals
Comorbidity
Morbidity
25 Citations (Scopus)

Regenerative medicine primer

Terzic, A. & Nelson, T. J., 2013, In : Mayo Clinic Proceedings. 88, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Tissue Engineering
Transplants
Organogenesis
Pandemics
2012
29 Citations (Scopus)

Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk

Smith, A. J., Nelson, N. G., Oommen, S., Hartjes, K. A., Folmes, C., Terzic, A. & Nelson, T. J., 2012, In : Stem cells translational medicine. 1, 10, p. 709-718 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Teratoma
DNA Damage
Induced Pluripotent Stem Cells
Hypersensitivity
61 Citations (Scopus)

Energy metabolism plasticity enables stemness programs

Folmes, C., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Energy Metabolism
Plasticity
Tissue
Organelle Biogenesis
Glycolysis

Impedance of Novel Therapeutic Technologies: The Case of Stem Cells

Zacharias, D. G., Nelson, T. J., Mueller, P. & Hook, C. C., Oct 2012, In : Clinical and Translational Science. 5, 5, p. 422-427 6 p.

Research output: Contribution to journalArticle

Stem cells
Electric Impedance
Stem Cells
Technology
Regenerative Medicine
300 Citations (Scopus)

Metabolic plasticity in stem cell homeostasis and differentiation

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

Cell Differentiation
Homeostasis
Stem Cells
Epigenomics
Energy Metabolism
46 Citations (Scopus)

Mitochondria in control of cell fate

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation Research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

Cell Lineage
Cardiac Myocytes
Mitochondria
Stem Cells
Embryonic Structures
2011
41 Citations (Scopus)

Energy metabolism in nuclear reprogramming

Folmes, C., Nelson, T. J. & Terzic, A., Dec 2011, In : Biomarkers in Medicine. 5, 6, p. 715-729 15 p.

Research output: Contribution to journalArticle

Energy Metabolism
Induced Pluripotent Stem Cells
Metabolomics
Biomarkers
Organelle Biogenesis
71 Citations (Scopus)

Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny

Thatava, T., Nelson, T. J., Edukulla, R., Sakuma, T., Ohmine, S., Tonne, J. M., Yamada, S., Kudva, Y. C., Terzic, A. & Ikeda, Y. H., Mar 2011, In : Gene Therapy. 18, 3, p. 283-293 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Glucagon-Like Peptide 1
Insulin
Glucose
Endoderm
35 Citations (Scopus)

Induced pluripotent stem cells: An emerging theranostics platform

Nelson, T. J. & Terzic, A., May 2011, In : Clinical Pharmacology and Therapeutics. 89, 5, p. 648-650 3 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Molecular Dynamics Simulation
Cell Biology
Stem Cells
Therapeutics
21 Citations (Scopus)

Nuclear reprogramming strategy modulates differentiation potential of induced pluripotent stem cells

Martinez-Fernandez, A., Nelson, T. J. & Terzic, A., Apr 2011, In : Journal of Cardiovascular Translational Research. 4, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Epigenomics
Dissection
Population
Cellular Reprogramming