Timothy J Nelson, MD, PhD

  • 3365 Citations
  • 30 Scopus h-Index
20022020

Research output per year

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Research Output

2020

Addressing Variability and Heterogeneity of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Biendarra-Tiegs, S. M., Secreto, F. J. & Nelson, T. J., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 1-29 29 p. (Advances in Experimental Medicine and Biology; vol. 1212).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Human Induced Pluripotent Stem Cell-Derived Non-Cardiomyocytes Modulate Cardiac Electrophysiological Maturation through Connexin 43-Mediated Cell-Cell Interactions

Biendarra-Tiegs, S. M., Clemens, D. J., Secreto, F. J. & Nelson, T. J., Jan 15 2020, In : Stem Cells and Development. 29, 2, p. 75-89 15 p.

Research output: Contribution to journalArticle

Open Access

m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity

Klein Gunnewiek, T. M., Van Hugte, E. J. H., Frega, M., Guardia, G. S., Foreman, K., Panneman, D., Mossink, B., Linda, K., Keller, J. M., Schubert, D., Cassiman, D., Rodenburg, R., Vidal Folch, N., Oglesbee, D., Perales-Clemente, E., Nelson, T. J., Morava, E., Nadif Kasri, N. & Kozicz, T., Apr 21 2020, In : Cell reports. 31, 3, 107538.

Research output: Contribution to journalArticle

Open Access
2019

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A. C., Nelson, T. J., Hall-Flavin, D., Heard, K. J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A. T., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

5 Scopus citations

Hypoplastic left heart syndrome: From bedside to bench and back

Saraf, A., Book, W. M., Nelson, T. J. & Xu, C., Oct 1 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 109-118 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

5 Scopus citations
Open Access
2 Scopus citations

Studying treatment resistance in depression using patient derived neurons in vitro

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jun 1 2019, In : Molecular Psychiatry. 24, 6, 1 p.

Research output: Contribution to journalComment/debate

2017

Current Interventional and Surgical Management of Congenital Heart Disease: Specific Focus on Valvular Disease and Cardiac Arrhythmias

Holst, K. A., Said, S. M., Nelson, T. J., Cannon, B. C. & Dearani, J. A., Mar 17 2017, In : Circulation Research. 120, 6, p. 1027-1044 18 p.

Research output: Contribution to journalReview article

16 Scopus citations

Disease modeling studies using induced pluripotent stem cells: Are we using enough controls?

Johnson, A. A., Andrews-Pfannkoch, C., Nelson, T. J., Pulido, J. S. & Marmorstein, A. D., Dec 1 2017, In : Regenerative Medicine. 12, 8, p. 899-903 5 p.

Research output: Contribution to journalReview article

6 Scopus citations

NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis

Wanek Program Genetics Pipeline Group, Apr 1 2017, In : Stem Cells. 35, 4, p. 1106-1119 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Quantification of Etoposide Hypersensitivity: A Sensitive, Functional Method for Assessing Pluripotent Stem Cell Quality

Secreto, F. J., Li, X., Smith, A. J., Bruinsma, E. S., Perales-Clemente, E., Oommen, S., Hawse, G., Hrstka, S. C. L., Arendt, B. K., Brandt, E. B., Wigle, D. A. & Nelson, T. J., Oct 1 2017, In : Stem cells translational medicine. 6, 10, p. 1829-1839 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Closure of a recurrent bronchopleural fistula using a matrix seeded with patient-derived mesenchymal stem cells

Aho, J. M., Dietz, A. B., Radel, D. J., Butler, G. W., Thomas, M., Nelson, T. J., Carlsen, B. T., Cassivi, S. D., Resch, Z. T., Faubion, W. A. & Wigle, D. A., Oct 1 2016, In : Stem cells translational medicine. 5, 10, p. 1375-1379 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Hypoplastic left heart syndrome: What's next?

Burkhart, H. M., Thompson, J. L. & Nelson, T. J., Apr 1 2016, In : Journal of Thoracic and Cardiovascular Surgery. 151, 4, p. 909-910 2 p.

Research output: Contribution to journalEditorial

Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Li, X., Campbell, K. A., Biendarra, S. M., Terzic, A. & Nelson, T. J., Mar 1 2016, In : Genomics Data. 7, p. 129-130 2 p.

Research output: Contribution to journalArticle

Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells

Wyles, S. P., Li, X., Hrstka, S. C., Reyes, S., Oommen, S., Beraldi, R., Edwards, J., Terzic, A., Olson, T. M. & Nelson, T. J., Jan 15 2016, In : Human Molecular Genetics. 25, 2, p. 254-265 12 p., ddv468.

Research output: Contribution to journalArticle

40 Scopus citations

Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability

Perales-Clemente, E., Cook, A. N., Evans, J. M., Roellinger, S., Secreto, F., Emmanuele, V., Oglesbee, D., Mootha, V. K., Hirano, M., Schon, E. A., Terzic, A. & Nelson, T. J., 2016, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

23 Scopus citations
15 Scopus citations

Regenerative chimerism bioengineered through stem cell reprogramming

Nelson, T. J., Martinez-Fernandez, A., Yamada, S. & Terzic, A., Apr 12 2016, Regenerative Medicine - from Protocol to Patient: 3. Tissue Engineering, Biomaterials and Nanotechnology: Third Edition. Springer International Publishing, p. 41-64 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regenerative medicine - From stem cell biology to clinical trials for pediatric heart failure

Cantero Peral, S., Bernstein, D. & Nelson, T. J., Dec 1 2016, In : Progress in Pediatric Cardiology. 43, p. 87-89 3 p.

Research output: Contribution to journalReview article

2015

Compound heterozygous NOTCH1 mutations underlie impaired cardiogenesis in a patient with hypoplastic left heart syndrome

Theis, J. L., Hrstka, S. C. L., Evans, J. M., O’Byrne, M. M., De Andrade, M., O’Leary, P. W., Nelson, T. J. & Olson, T. M., Sep 10 2015, In : Human Genetics. 134, 9, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Ebstein anomaly review: What's now, what's next?

Dearani, J. A., Mora, B. N., Nelson, T. J., Haile, D. T. & O'Leary, P. W., Oct 3 2015, In : Expert Review of Cardiovascular Therapy. 13, 10, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
13 Scopus citations
3 Scopus citations

Nos3<sup>-/-</sup> iPSCs model concordant signatures of in utero cardiac pathogenesis

Campbell, K. A., Li, X., Biendarra, S. M., Terzic, A. & Nelson, T. J., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 228-236 9 p., 8180.

Research output: Contribution to journalArticle

3 Scopus citations

Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy

Yamada, S., Arrell, D. K., Martinez-Fernandez, A., Behfar, A., Kane, G. M., Terzic, C. M., Crespo-Diaz, R. J., McDonald, R., Wyles, S. P., Zlatkovic-Lindor, J., Nelson, T. J. & Terzic, A., May 11 2015, In : Journal of the American Heart Association. 4, 5

Research output: Contribution to journalArticle

11 Scopus citations
13 Scopus citations

Systems-Based Technologies in Profiling the Stem Cell Molecular Framework for Cardioregenerative Medicine

Wyles, S. P., Faustino, R. S., Li, X., Terzic, A. & Nelson, T. J., Jun 4 2015, In : Stem Cell Reviews and Reports. 11, 3, p. 501-510 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis

Yang, J., Hartjes, K. A., Nelson, T. J. & Xu, X., Feb 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 3, p. H382-H395

Research output: Contribution to journalArticle

8 Scopus citations

Heart Regeneration. The Developmental and Stem Cell Biology Approach.

Martinez-Fernandez, A., Beraldi, R., Cantero Peral, S., Terzic, A. & Nelson, T. J., Jan 1 2014, Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., p. 457-477 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inhibition of DNA topoisomerase ii selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy

Wyles, S. P., Yamada, S., Oommen, S., Maleszewski, J. J., Beraldi, R., Martinez-Fernandez, A., Terzic, A. & Nelson, T. J., Oct 1 2014, In : Stem Cells and Development. 23, 19, p. 2274-2282 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ips cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes

Martinez-Fernandez, A., Nelson, T. J., Reyes, S., Alekseev, A. E., Secreto, F., Perez-Terzic, C., Beraldi, R., Sung, H. K., Nagy, A. & Terzic, A., Oct 1 2014, In : Circulation: Cardiovascular Genetics. 7, 5, p. 667-676 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy

Beraldi, R., Li, X., Fernandez, A. M., Reyes, S., Secreto, F., Terzic, A., Olson, T. M. & Nelson, T. J., Jul 2014, In : Human molecular genetics. 23, 14, p. 3779-3791 13 p., ddu091.

Research output: Contribution to journalArticle

31 Scopus citations

Selection via pluripotency-related transcriptional screen minimizes the influence of somatic origin on iPSC differentiation propensity

Hartjes, K. A., Li, X., Martinez-Fernandez, A., Roemmich, A. J., Larsen, B. T., Terzic, A. & Nelson, T. J., Sep 2014, In : Stem Cells. 32, 9, p. 2350-2359 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Stem cells: The pursuit of genomic stability

Wyles, S. P., Brandt, E. B. & Nelson, T. J., Nov 14 2014, In : International journal of molecular sciences. 15, 11, p. 20948-20967 20 p.

Research output: Contribution to journalReview article

11 Scopus citations

The inferred cardiogenic gene regulatory network in the mammalian heart

Bazil, J. N., Stamm, K. D., Li, X., Thiagarajan, R., Nelson, T. J., Tomita-Mitchell, A. & Beard, D. A., Jun 27 2014, In : PloS one. 9, 6, e100842.

Research output: Contribution to journalArticle

9 Scopus citations

Transcriptional atlas of cardiogenesis maps congenital heart disease interactome

Li, X., Martinez-Fernandez, A., Hartjes, K. A., Kocher, J. P. A., Olson, T. M., Terzic, A. & Nelson, T. J., Jul 1 2014, In : Physiological Genomics. 46, 13, p. 482-495 14 p.

Research output: Contribution to journalArticle

28 Scopus citations
32 Scopus citations
2013
5 Scopus citations

Disease-causing mitochondrial Heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS

Folmes, C. D. L., Martinez-Fernandez, A., Perales-Clemente, E., Li, X., McDonald, A., Oglesbee, D., Hrstka, S. C., Perez-Terzic, C., Terzic, A. & Nelson, T. J., Jul 1 2013, In : Stem Cells. 31, 7, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction

Yamada, S., Nelson, T. J., Kane, G. C., Martinez-Fernandez, A., Crespo-Diaz, R. J., Ikeda, Y., Perez-Terzic, C. & Terzic, A., Sep 1 2013, In : Journal of Physiology. 591, 17, p. 4335-4349 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K + channel-deficient dilated cardiomyopathy.

Yamada, S., Arrell, D. K., Kane, G. C., Nelson, T. J., Perez-Terzic, C. M., Behfar, A., Purushothaman, S., Prinzen, F. W., Auricchio, A. & Terzic, A., 2013, In : Journal of the American Heart Association. 2, 6, p. e000410

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Metabolome and metaboproteome remodeling in nuclear reprogramming

Folmes, C. D. L., Kent Arrell, D., Zlatkovic-Lindor, J., Martinez-Fernandez, A., Perez-Terzic, C., Nelson, T. J. & Terzic, A., Aug 1 2013, In : Cell Cycle. 12, 15, p. 2355-2365 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines

Martinez-Fernandez, A., Li, X., Hartjes, K. A., Terzic, A. & Nelson, T. J., Oct 1 2013, In : Circulation: Cardiovascular Genetics. 6, 5, p. 462-471 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

New and TALENted genome engineering toolbox

Campbell, J. M., Hartjes, K. A., Nelson, T. J., Xu, X. & Ekker, S. C., Aug 16 2013, In : Circulation research. 113, 5, p. 571-587 17 p.

Research output: Contribution to journalReview article

30 Scopus citations
37 Scopus citations

Patients with heart failure have an increased risk of incident cancer

Hasin, T., Gerber, Y., McNallan, S. M., Weston, S. A., Kushwaha, S. S., Nelson, T. J., Cerhan, J. R. & Roger, V. L., Sep 3 2013, In : Journal of the American College of Cardiology. 62, 10, p. 881-886 6 p.

Research output: Contribution to journalArticle

53 Scopus citations