• 28943 Citations
  • 91 Scopus h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
1991

Cleavage of a smooth muscle myosin heavy chain near its c terminus by α-chymotrypsin: Effect on the properties of myosin

Ikebe, M., Hewett, T., Martin, A. F., Chen, M. & Hartshorne, D. J., 1991, In : Journal of Biological Chemistry. 266, 11, p. 7030-7036 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
1993

Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations

Grupp, I. L., Subramaniam, A., Hewett, T. E., Robbins, J. & Grupp, G., 1993, In : American Journal of Physiology - Heart and Circulatory Physiology. 265, 4 34-4, p. H1401-H1410

Research output: Contribution to journalArticle

121 Scopus citations

Correlations between myosin heavy chain isoforms and mechanical parameters in rat myometrium.

Hewett, T., Martin, A. F. & Paul, R. J., Jan 1 1993, In : Journal of Physiology. 460, 1, p. 351-364 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
1994

α-Skeletal actin is associated with increased contractility in the mouse heart

Hewett, T., Grupp, I. L., Grupp, G. & Robbins, J., Apr 1994, In : Circulation Research. 74, 4, p. 740-746 7 p.

Research output: Contribution to journalArticle

114 Scopus citations
1996

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T., Grupp, G., Osinska, H., Hewett, T. E., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

Open Access
154 Scopus citations

Knee hyperextension gait abnormalities in unstable knees: Recognition and preoperative gait retraining

Noyes, F. R., Dunworth, L. A., Andriacchi, T. P., Andrews, M. & Hewett, T., Jan 1996, In : American Journal of Sports Medicine. 24, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

Lower limb alignment and foot angle are related to stance phase knee adduction in normal subjects: A critical analysis of the reliability of gait analysis data

Andrews, M., Noyes, F. R., Hewett, T. & Andriacchi, T. P., Mar 1996, In : Journal of Orthopaedic Research. 14, 2, p. 289-295 7 p.

Research output: Contribution to journalArticle

193 Scopus citations

Plyometric training in female athletes: Decreased impact forces and increased hamstring torques

Hewett, T., Stroupe, A. L., Nance, T. A. & Noyes, F. R., Nov 1996, In : American Journal of Sports Medicine. 24, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

694 Scopus citations
1997

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice

Colbert, M. C., Hall, D. G., Kimball, T. R., Witt, S. A., Lorenz, J. N., Kirby, M. L., Hewett, T. E., Klevitsky, R. & Robbins, J., Oct 15 1997, In : Journal of Clinical Investigation. 100, 8, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

Open Access
84 Scopus citations
125 Scopus citations

Joint loading with valgus bracing in patients with varus gonarthrosis

Lindenfeld, T. N., Hewett, T. E. & Andriacchi, T. P., Jan 1 1997, In : Clinical orthopaedics and related research. 344, p. 290-297 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Lethal cardiomyopathy in juvenile mice caused by tropomodulin overexpression

Sussman, M. A., Cambon, N., Hewett, T., Klevitsky, R., Osinska, H. & Welch, S., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Transgenic remodeling of the regulatory myosin light chains in the mammalian heart

Gulick, J., Hewett, T., Klevitsky, R., Buck, S. H., Moss, R. L. & Robbins, J., 1997, In : Circulation Research. 80, 5, p. 655-664 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
1998

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy

Yang, Q., Sanbe, A., Osinska, H., Hewett, T. E., Klevitsky, R. & Robbins, J., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

Open Access
144 Scopus citations

Association between the menstrual cycle and anterior cruciate ligament injuries in female athletes

Wojtys, E. M., Huston, L. J., Lindenfeld, T. N., Hewett, T. & Greenfield, M. L. V. H., Sep 1998, In : American Journal of Sports Medicine. 26, 5, p. 614-619 6 p.

Research output: Contribution to journalArticle

245 Scopus citations

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy

Tardiff, J. C., Factor, S. M., Tompkins, B. D., Hewett, T. E., Palmer, B. M., Moore, R. L., Schwartz, S., Robbins, J. & Leinwand, L. A., Jun 15 1998, In : Journal of Clinical Investigation. 101, 12, p. 2800-2811 12 p.

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Decrease in knee joint pain and increase in function in patients with medial compartment arthrosis: A prospective analysis of valgus bracing

Hewett, T., Noyes, F. R., Barber-Westin, S. D. & Heckmann, T. P., Feb 1998, In : Orthopedics. 21, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice

Fewell, J. G., Hewett, T. E., Sanbe, A., Klevitsky, R., Hayes, E., Warshaw, D., Maughan, D. & Robbins, J., Jun 15 1998, In : Journal of Clinical Investigation. 101, 12, p. 2630-2639 10 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Molecular and physiological effects of α-tropomyosin ablation in the mouse

Rethinasamy, P., Muthuchamy, M., Hewett, T., Boivin, G., Wolska, B. M., Evans, C., Solaro, R. J. & Wieczorek, D. F., 1998, In : Circulation Research. 82, 1, p. 116-123 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice

Sussman, M. A., Welch, S., Cambon, N., Klevitsky, R., Hewett, T. E., Price, R., Witt, S. A. & Kimball, T. R., Jan 1 1998, In : Journal of Clinical Investigation. 101, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Open Access
129 Scopus citations
1999

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy

Tardiff, J. C., Hewett, T. E., Palmer, B. M., Olsson, C., Factor, S. M., Moore, R. L., Robbins, J. & Leinwand, L. A., Aug 1999, In : Journal of Clinical Investigation. 104, 4, p. 469-481 13 p.

Research output: Contribution to journalArticle

Open Access
162 Scopus citations

In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy

Yang, Q., Sanbe, A., Osinska, H., Hewett, T. E., Klevitsky, R. & Robbins, J., Oct 29 1999, In : Circulation research. 85, 9, p. 841-847 7 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

The effect of neuromuscular training on the incidence of knee injury in female athletes. A prospective study

Hewett, T. E., Lindenfeld, T. N., Riccobene, J. V. & Noyes, F. R., Jan 1 1999, In : American Journal of Sports Medicine. 27, 6, p. 699-706 8 p.

Research output: Contribution to journalArticle

1053 Scopus citations

Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology

James, J., Osinska, H., Hewett, T. E., Kimball, T., Klevitsky, R., Witt, S., Hall, D. G., Gulicki, J. & Robbins, J., Feb 1 1999, In : Transgenic Research. 8, 1, p. 9-22 14 p.

Research output: Contribution to journalArticle

30 Scopus citations
2000

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

Sussman, M. A., Welch, S., Walker, A., Klevitsky, R., Hewett, T. E., Price, R. L., Schaefer, E. & Yager, K., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 875-886 12 p.

Research output: Contribution to journalArticle

Open Access
140 Scopus citations

A prospective study of high school wrestling injuries

Pasque, C. B. & Hewett, T. E., Jan 1 2000, In : American Journal of Sports Medicine. 28, 4, p. 509-515 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects

Tardiff, J. C., Hewett, T. E., Factor, S. M., Vikstrom, K. L., Robbins, J. & Leinwand, L. A., Feb 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 2 47-2, p. H412-H419

Research output: Contribution to journalArticle

119 Scopus citations

High tibial osteotomy and ligament reconstruction for varus angulated anterior cruciate ligament-deficient knees

Noyes, F. R., Barber-Westin, S. D. & Hewett, T. E., Jan 1 2000, In : American Journal of Sports Medicine. 28, 3, p. 282-296 15 p.

Research output: Contribution to journalArticle

236 Scopus citations

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice

Sussman, M. A., Welch, S., Walker, A., Klevitsky, R., Hewett, T. E., Witt, S. A., Kimball, T. R., Price, R., Lim, H. W. & Molkentin, J. D., Apr 1 2000, In : Cardiovascular research. 46, 1, p. 90-101 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy

Sanbe, A., Nelson, D., Gulick, J., Setser, E., Osinska, H., Wang, X., Hewett, T. E., Klevitsky, R., Hayes, E., Warshaw, D. M. & Robbins, J., Aug 18 2000, In : Circulation research. 87, 4, p. 296-302 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C. F., Kitsis, R. N. & Molkentin, J. D., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6341-6350 10 p.

Research output: Contribution to journalArticle

578 Scopus citations

Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy

James, J., Zhang, Y., Osinska, H., Sanbe, A., Klevitsky, R., Hewett, T. E. & Robbins, J., Oct 27 2000, In : Circulation research. 87, 9, p. 805-811 7 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations
2001

ACL Injury Prevention Starts Young

Hewett, T., Mar 1 2001, In : Physician and Sportsmedicine. 29, 3, p. 5-92 88 p.

Research output: Contribution to journalArticle

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, X. & Robbins, J., Jun 21 2001, In : Cardiovascular research. 51, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains

Lerman, I., Harrison, B. C., Freeman, K., Hewett, T. E., Allen, D. L., Robbins, J. & Leinwand, L. A., Jan 1 2002, In : Journal of applied physiology. 92, 6, p. 2245-2255 11 p.

Research output: Contribution to journalArticle

192 Scopus citations

Strategies for enhancing proprioception and neuromuscular control of the knee

Hewett, T. E., Paterno, M. V. & Myer, G. D., Sep 2002, In : Clinical orthopaedics and related research. 402, p. 76-94 19 p.

Research output: Contribution to journalArticle

199 Scopus citations
2003

Analysis of myosin heavy chain functionality in the heart

Krenz, M., Sanbe, A., Bouyer-Dalloz, F., Gulick, J., Klevitsky, R., Hewett, T. E., Osinska, H. E., Lorenz, J. N., Brosseau, C., Federico, A., Alpert, N. R., Warshaw, D. M., Perryman, M. B., Helmke, S. M. & Robbins, J., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 17466-17474 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

Braz, J. C., Bueno, O. F., Liang, Q., Wilkins, B. J., Dai, Y. S., Parsons, S., Braunwart, J., Glascock, B. J., Klevitsky, R., Kimball, T. F., Hewett, T. E. & Molkentin, J. D., May 1 2003, In : Journal of Clinical Investigation. 111, 10, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

251 Scopus citations

Valgus knee motion during landing in high school female and male basketball players

Ford, K. R., Myer, G. D. & Hewett, T. E., Oct 1 2003, In : Medicine and science in sports and exercise. 35, 10, p. 1745-1750 6 p.

Research output: Contribution to journalArticle

556 Scopus citations
2004

Calcineurin Aβ Gene Targeting Predisposes the Myocardium to Acute Ischemia-Induced Apoptosis and Dysfunction

Bueno, O. F., Lips, D. J., Kaiser, R. A., Wilkins, B. J., Dai, Y. S., Glascock, B. J., Klevitsky, R., Hewett, T. E., Kimball, T. R., Aronow, B. J., Doevendans, P. A. & Molkentin, J. D., Jan 9 2004, In : Circulation research. 94, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Charged residue alterations in the inner-core domain and carboxy-terminus of α-tropomyosin differentially affect mouse cardiac muscle contractility

Gaffin, R. D., Tong, C. W., Zawieja, D. C., Hewett, T. E., Klevitsky, R., Robbins, J. & Muthuchamy, M., Dec 15 2004, In : Journal of Physiology. 561, 3, p. 777-791 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Charged residue changes in the carboxy-terminus of α-tropomyosin alter mouse cardiac muscle contractility

Gaffin, R. D., Gokulan, K., Sacchettini, J. C., Hewett, T., Klevitsky, R., Robbins, J. & Muthuchamy, M., Apr 15 2004, In : Journal of Physiology. 556, 2, p. 531-543 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Decrease in neuromuscular control about the knee with maturation in female athletes

Hewett, T. E., Myer, G. D. & Ford, K. R., Aug 2004, In : Journal of Bone and Joint Surgery - Series A. 86, 8, p. 1601-1608 8 p.

Research output: Contribution to journalArticle

289 Scopus citations

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

Wei, L., Taffet, G. E., Khoury, D. S., Bo, J., Li, Y., Yatani, A., Delaughter, M. C., Klevitsky, R., Hewett, T. E., Robbins, J., Michael, L. H., Schneider, M. D., Entman, M. L. & Schwartz, R. J., May 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 7, p. 857-859 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Neuromuscular training improves single-limb stability in young female athletes

Paterno, M. V., Myer, G. D., Ford, K. R. & Hewett, T. E., Jun 2004, In : Journal of Orthopaedic and Sports Physical Therapy. 34, 6, p. 305-316 12 p.

Research output: Contribution to journalArticle

224 Scopus citations

PKC-α regulates cardiac contractility and propensity toward heart failure

Braz, J. C., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T. F., Lorenz, J. N., Nairn, A. C., Liggett, S. B., Bodi, I., Wang, S., Schwartz, A., Lakatta, E. G., DePaoli-Roach, A. A., Robbins, J., Hewett, T. E., Bibb, J. A., Westfall, M. V., Kranias, E. G. & 1 others, Molkentin, J. D., Mar 1 2004, In : Nature Medicine. 10, 3, p. 248-254 7 p.

Research output: Contribution to journalArticle

449 Scopus citations

Rationale and clinical techniques for anterior cruciate ligament injury prevention among female athletes

Myer, G. D., Ford, K. R. & Hewett, T. E., Oct 1 2004, In : Journal of athletic training. 39, 4, p. 352-364 13 p.

Research output: Contribution to journalArticle

170 Scopus citations
2005

Biomechanical measures of neuromuscular control and valgus loading of the knee predict anterior cruciate ligament injury risk in female athletes: A prospective study

Hewett, T. E., Myer, G. D., Ford, K. R., Heidt, R. S., Colosimo, A. J., McLean, S. G., Van Den Bogert, A. J., Paterno, M. V. & Succop, P., Apr 1 2005, In : American Journal of Sports Medicine. 33, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

1635 Scopus citations

Evaluation of a two dimensional analysis method as a screening and evaluation tool for anterior cruciate ligament injury

McLean, S. G., Walker, K., Ford, K. R., Myer, G. D., Hewett, T. E. & Van Den Bogert, A. J., Jun 2005, In : British journal of sports medicine. 39, 6, p. 355-362 8 p.

Research output: Contribution to journalArticle

142 Scopus citations