• 27605 Citations
  • 88 Scopus h-Index
1991 …2020
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Research Output 1991 2020

2004
20 Citations (Scopus)

Charged residue changes in the carboxy-terminus of α-tropomyosin alter mouse cardiac muscle contractility

Gaffin, R. D., Gokulan, K., Sacchettini, J. C., Hewett, T., Klevitsky, R., Robbins, J. & Muthuchamy, M., Apr 15 2004, In : Journal of Physiology. 556, 2, p. 531-543 13 p.

Research output: Contribution to journalArticle

Tropomyosin
Myocardium
Myofibrils
Calcium
Striated Muscle
284 Citations (Scopus)

Decrease in neuromuscular control about the knee with maturation in female athletes

Hewett, T., Myer, G. D. & Ford, K. R., Aug 2004, In : Journal of Bone and Joint Surgery - Series A. 86, 8, p. 1601-1608 8 p.

Research output: Contribution to journalArticle

Athletes
Knee
Knee Joint
Lower Extremity
Torque
34 Citations (Scopus)

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

Wei, L., Taffet, G. E., Khoury, D. S., Bo, J., Li, Y., Yatani, A., Delaughter, M. C., Klevitsky, R., Hewett, T., Robbins, J., Michael, L. H., Schneider, M. D., Entman, M. L. & Schwartz, R. J., 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 7, p. 857-859 3 p.

Research output: Contribution to journalArticle

rho Guanine Nucleotide Dissociation Inhibitor alpha
Ventricular Function
Cardiomegaly
rho GTP-Binding Proteins
Atrioventricular Block
53 Citations (Scopus)

Methodological approaches and rationale for training to prevent anterior cruciate ligament injuries in female athletes

Myer, G. D., Ford, K. R. & Hewett, T., Oct 2004, In : Scandinavian Journal of Medicine and Science in Sports. 14, 5, p. 275-285 11 p.

Research output: Contribution to journalReview article

Athletes
Wounds and Injuries
Sports
Incidence
Teaching
219 Citations (Scopus)

Neuromuscular training improves single-limb stability in young female athletes

Paterno, M. V., Myer, G. D., Ford, K. R. & Hewett, T., Jun 2004, In : Journal of Orthopaedic and Sports Physical Therapy. 34, 6, p. 305-316 12 p.

Research output: Contribution to journalArticle

Athletes
Extremities
Education
Lower Extremity
Anterior Cruciate Ligament Reconstruction
442 Citations (Scopus)

PKC-α regulates cardiac contractility and propensity toward heart failure

Braz, J. C., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T. F., Lorenz, J. N., Nairn, A. C., Liggett, S. B., Bodi, I., Wang, S., Schwartz, A., Lakatta, E. G., DePaoli-Roach, A. A., Robbins, J., Hewett, T., Bibb, J. A., Westfall, M. V., Kranias, E. G. & 1 others, Molkentin, J. D., Mar 2004, In : Nature Medicine. 10, 3, p. 248-254 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Heart Failure
Protein Phosphatase 1
Signal transduction
Sarcoplasmic Reticulum
167 Citations (Scopus)

Rationale and clinical techniques for anterior cruciate ligament injury prevention among female athletes

Myer, G. D., Ford, K. R. & Hewett, T., Oct 2004, In : Journal of Athletic Training. 39, 4, p. 352-364 13 p.

Research output: Contribution to journalArticle

Athletes
Sports
Anterior Cruciate Ligament Injuries
Population Dynamics
Puberty

Taking the load off.

Divine, J. G. & Hewett, T., 2004, In : Rehab management. 17, 6, p. 28-29 2 p.

Research output: Contribution to journalReview article

Braces
Knee Osteoarthritis
Weight-Bearing
2003
80 Citations (Scopus)

Analysis of myosin heavy chain functionality in the heart

Krenz, M., Sanbe, A., Bouyer-Dalloz, F., Gulick, J., Klevitsky, R., Hewett, T., Osinska, H. E., Lorenz, J. N., Brosseau, C., Federico, A., Alpert, N. R., Warshaw, D. M., Perryman, M. B., Helmke, S. M. & Robbins, J., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 17466-17474 9 p.

Research output: Contribution to journalArticle

Myosin Heavy Chains
Myosins
Protein Isoforms
Cardiac Myosins
Gene Transfer Techniques
249 Citations (Scopus)

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

Braz, J. C., Bueno, O. F., Liang, Q., Wilkins, B. J., Dai, Y. S., Parsons, S., Braunwart, J., Glascock, B. J., Klevitsky, R., Kimball, T. F., Hewett, T. & Molkentin, J. D., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Calcineurin
Hypertrophic Cardiomyopathy
p38 Mitogen-Activated Protein Kinases
Up-Regulation
546 Citations (Scopus)

Valgus knee motion during landing in high school female and male basketball players

Ford, K. R., Myer, G. D. & Hewett, T., Oct 1 2003, In : Medicine and Science in Sports and Exercise. 35, 10, p. 1745-1750 6 p.

Research output: Contribution to journalArticle

Basketball
Athletes
Knee
Knee Joint
Biomechanical Phenomena
2002
187 Citations (Scopus)

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains

Lerman, I., Harrison, B. C., Freeman, K., Hewett, T., Allen, D. L., Robbins, J. & Leinwand, L. A., 2002, In : Journal of Applied Physiology. 92, 6, p. 2245-2255 11 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Myosin Heavy Chains
Atrial Natriuretic Factor
Hypertrophy
Myocardium
190 Citations (Scopus)

Strategies for enhancing proprioception and neuromuscular control of the knee

Hewett, T., Paterno, M. V. & Myer, G. D., Sep 2002, In : Clinical Orthopaedics and Related Research. 402, p. 76-94 19 p.

Research output: Contribution to journalArticle

Proprioception
Knee
Athletes
Sports
Wounds and Injuries
2001

ACL Injury Prevention Starts Young

Hewett, T., Mar 1 2001, In : Physician and Sportsmedicine. 29, 3, p. 5-92 88 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament Injuries
229 Citations (Scopus)

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation Research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Crystallins
Desmin
Cardiomyopathies
Mutation
Cardiac Myocytes
17 Citations (Scopus)

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Yang, Q., Hewett, T., Klevitsky, R., Sanbe, A., Wang, X. & Robbins, J., 2001, In : Cardiovascular Research. 51, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Cyclic AMP-Dependent Protein Kinases
Transgenic Mice
Phosphorylation
Exercise
81 Citations (Scopus)

Prevention of anterior cruciate ligament injuries.

Hewett, T., Myer, G. D. & Ford, K. R., Dec 2001, In : Current women"s health reports. 1, 3, p. 218-224 7 p.

Research output: Contribution to journalReview article

Knee Injuries
Athletes
Sports
Ligaments
Knee
2000
140 Citations (Scopus)

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

Sussman, M. A., Welch, S., Walker, A., Klevitsky, R., Hewett, T., Price, R. L., Schaefer, E. & Yager, K., Apr 2000, In : Journal of Clinical Investigation. 105, 7, p. 875-886 12 p.

Research output: Contribution to journalArticle

Focal Adhesions
Cardiomyopathies
Phenotype
rac1 GTP-Binding Protein
p21-Activated Kinases
83 Citations (Scopus)

A prospective study of high school wrestling injuries

Pasque, C. B. & Hewett, T., 2000, In : American Journal of Sports Medicine. 28, 4, p. 509-515 7 p.

Research output: Contribution to journalArticle

Wrestling
Prospective Studies
Wounds and Injuries
Mandrillus
118 Citations (Scopus)

Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects

Tardiff, J. C., Hewett, T., Factor, S. M., Vikstrom, K. L., Robbins, J. & Leinwand, L. A., Feb 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 2 47-2

Research output: Contribution to journalArticle

Myosin Heavy Chains
Protein Isoforms
Myosins
Calcium-Transporting ATPases
Transgenes
232 Citations (Scopus)

High tibial osteotomy and ligament reconstruction for varus angulated anterior cruciate ligament-deficient knees

Noyes, F. R., Barber-Westin, S. D. & Hewett, T., 2000, In : American Journal of Sports Medicine. 28, 3, p. 282-296 15 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament
Osteotomy
Ligaments
Knee
Tibial Meniscus
11 Citations (Scopus)

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice

Sussman, M. A., Welch, S., Walker, A., Klevitsky, R., Hewett, T., Witt, S. A., Kimball, T. R., Price, R., Lim, H. W. & Molkentin, J. D., Apr 2000, In : Cardiovascular Research. 46, 1, p. 90-101 12 p.

Research output: Contribution to journalArticle

Tropomodulin
Calcineurin
Transgenic Mice
Dilatation
Hypertrophy
37 Citations (Scopus)

In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy

Sanbe, A., Nelson, D., Gulick, J., Setser, E., Osinska, H., Wang, X., Hewett, T., Klevitsky, R., Hayes, E., Warshaw, D. M. & Robbins, J., Aug 18 2000, In : Circulation Research. 87, 4, p. 296-302 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Myosin Light Chains
Myofibrils
Hypertrophic Cardiomyopathy
Hypertrophy
169 Citations (Scopus)

Neuromuscular and hormonal factors associated with knee injuries in female athletes: Strategies for intervention

Hewett, T., 2000, In : Sports Medicine. 29, 5, p. 313-327 15 p.

Research output: Contribution to journalReview article

Knee Injuries
Athletes
Knee
Sports
Menstrual Cycle
825 Citations (Scopus)

Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies.

Griffin, L. Y., Agel, J., Albohm, M. J., Arendt, E. A., Dick, R. W., Garrett, W. E., Garrick, J. G., Hewett, T., Huston, L., Ireland, M. L., Johnson, R. J., Kibler, W. B., Lephart, S., Lewis, J. L., Lindenfeld, T. N., Mandelbaum, B. R., Marchak, P., Teitz, C. C. & Wojtys, E. M., May 2000, In : The Journal of the American Academy of Orthopaedic Surgeons. 8, 3, p. 141-150 10 p.

Research output: Contribution to journalReview article

Sports
Education
Costs and Cost Analysis
Anterior Cruciate Ligament Injuries
Incidence
568 Citations (Scopus)

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T., Jones, S. P., Lefer, D. J., Peng, C. F., Kitsis, R. N. & Molkentin, J. D., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6341-6350 10 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
JNK Mitogen-Activated Protein Kinases
Cardiomegaly
Mitogen-Activated Protein Kinases
Transgenic Mice
112 Citations (Scopus)

Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy

James, J., Zhang, Y., Osinska, H., Sanbe, A., Klevitsky, R., Hewett, T. & Robbins, J., Oct 27 2000, In : Circulation Research. 87, 9, p. 805-811 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin I
Mutation
Calcium
Phenotype
1999
160 Citations (Scopus)

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy

Tardiff, J. C., Hewett, T., Palmer, B. M., Olsson, C., Factor, S. M., Moore, R. L., Robbins, J. & Leinwand, L. A., Aug 1999, In : Journal of Clinical Investigation. 104, 4, p. 469-481 13 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin T
Hypertrophic Cardiomyopathy
Alleles
Phenotype
74 Citations (Scopus)

In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy

Yang, Q., Sanbe, A., Osinska, H., Hewett, T., Klevitsky, R. & Robbins, J., Oct 29 1999, In : Circulation Research. 85, 9, p. 841-847 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Myosins
Connectin
Binding Sites
Transgenic Mice
1033 Citations (Scopus)

The effect of neuromuscular training on the incidence of knee injury in female athletes. A prospective study

Hewett, T., Lindenfeld, T. N., Riccobene, J. V. & Noyes, F. R., 1999, In : American Journal of Sports Medicine. 27, 6, p. 699-706 8 p.

Research output: Contribution to journalArticle

Knee Injuries
Athletes
Prospective Studies
Incidence
Plyometric Exercise
30 Citations (Scopus)

Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology

James, J., Osinska, H., Hewett, T., Kimball, T., Klevitsky, R., Witt, S., Hall, D. G., Gulicki, J. & Robbins, J., Feb 1999, In : Transgenic Research. 8, 1, p. 9-22 14 p.

Research output: Contribution to journalArticle

contractile proteins
Contractile Proteins
genetically modified organisms
Pathology
Phenotype
1998
144 Citations (Scopus)

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy

Yang, Q., Sanbe, A., Osinska, H., Hewett, T., Klevitsky, R. & Robbins, J., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Sarcomeres
Cardiac Myosins
Connectin
Mutation
237 Citations (Scopus)

Association between the menstrual cycle and anterior cruciate ligament injuries in female athletes

Wojtys, E. M., Huston, L. J., Lindenfeld, T. N., Hewett, T. & Greenfield, M. L. V. H., Sep 1998, In : American Journal of Sports Medicine. 26, 5, p. 614-619 6 p.

Research output: Contribution to journalArticle

Menstrual Cycle
Athletes
Wounds and Injuries
Knee Injuries
Follicular Phase
159 Citations (Scopus)

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy

Tardiff, J. C., Factor, S. M., Tompkins, B. D., Hewett, T., Palmer, B. M., Moore, R. L., Schwartz, S., Robbins, J. & Leinwand, L. A., Jun 15 1998, In : Journal of Clinical Investigation. 101, 12, p. 2800-2811 12 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Troponin T
Transgenic Mice
Sudden Death
Mutation
145 Citations (Scopus)

Cardiac physiology in transgenic mice

James, J. F., Hewett, T. & Robbins, J., Mar 9 1998, In : Circulation Research. 82, 4, p. 407-415 9 p.

Research output: Contribution to journalShort survey

Transgenic Mice
Animal Structures
Gene Transfer Techniques
Gene Targeting
Animal Models
84 Citations (Scopus)

Decrease in knee joint pain and increase in function in patients with medial compartment arthrosis: A prospective analysis of valgus bracing

Hewett, T., Noyes, F. R., Barber-Westin, S. D. & Heckmann, T. P., Feb 1998, In : Orthopedics. 21, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

Braces
Joint Diseases
Arthralgia
Knee Joint
Pain
69 Citations (Scopus)

Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice

Fewell, J. G., Hewett, T., Sanbe, A., Klevitsky, R., Hayes, E., Warshaw, D., Maughan, D. & Robbins, J., Jun 15 1998, In : Journal of Clinical Investigation. 101, 12, p. 2630-2639 10 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosin Light Chains
Transgenic Mice
Protein Isoforms
Gene Transfer Techniques
86 Citations (Scopus)

Molecular and physiological effects of α-tropomyosin ablation in the mouse

Rethinasamy, P., Muthuchamy, M., Hewett, T., Boivin, G., Wolska, B. M., Evans, C., Solaro, R. J. & Wieczorek, D. F., 1998, In : Circulation Research. 82, 1, p. 116-123 8 p.

Research output: Contribution to journalArticle

Tropomyosin
Messenger RNA
Striated Muscle
Myofibrils
Recombinant DNA
128 Citations (Scopus)

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice

Sussman, M. A., Welch, S., Cambon, N., Klevitsky, R., Hewett, T., Price, R., Witt, S. A. & Kimball, T. R., Jan 1 1998, In : Journal of Clinical Investigation. 101, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Tropomodulin
Myofibrils
Dilated Cardiomyopathy
Transgenic Mice
Parturition
35 Citations (Scopus)

Physical and arthroscopic examination techniques of the patellofemoral joint

Nissen, C. W., Cullen, M. C., Hewett, T. & Noyes, F. R., Nov 1998, In : Journal of Orthopaedic and Sports Physical Therapy. 28, 5, p. 277-285 9 p.

Research output: Contribution to journalReview article

Patellofemoral Joint
Physical Examination
Cartilage
Patella
Thigh
1997
84 Citations (Scopus)

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice

Colbert, M. C., Hall, D. G., Kimball, T. R., Witt, S. A., Lorenz, J. N., Kirby, M. L., Hewett, T., Klevitsky, R. & Robbins, J., Oct 15 1997, In : Journal of Clinical Investigation. 100, 8, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Myosin Heavy Chains
Dilated Cardiomyopathy
Transgenic Mice
Heart Failure
122 Citations (Scopus)
Posterior Cruciate Ligament
Radiography
Rupture
Knee
Tears
6 Citations (Scopus)

Gait characteristics of the anterior cruciate ligament-deficient varus knee.

Hewett, T., Blum, K. R. & Noyes, F. R., 1997, In : The American journal of knee surgery. 10, 4, p. 246-254 9 p.

Research output: Contribution to journalReview article

Joint Instability
Anterior Cruciate Ligament
Knee Joint
Osteotomy
Tibia
125 Citations (Scopus)

Joint loading with valgus bracing in patients with varus gonarthrosis

Lindenfeld, T. N., Hewett, T. & Andriacchi, T. P., 1997, In : Clinical Orthopaedics and Related Research. 344, p. 290-297 8 p.

Research output: Contribution to journalArticle

Braces
Joints
Knee
Body Weight
Pain

Lethal cardiomyopathy in juvenile mice caused by tropomodulin overexpression

Sussman, M. A., Cambon, N., Hewett, T., Klevitsky, R., Osinska, H. & Welch, S., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Tropomodulin
Myofibrils
cardiomyopathy
Cardiomyopathies
lethal genes
79 Citations (Scopus)

Transgenic remodeling of the regulatory myosin light chains in the mammalian heart

Gulick, J., Hewett, T., Klevitsky, R., Buck, S. H., Moss, R. L. & Robbins, J., 1997, In : Circulation Research. 80, 5, p. 655-664 10 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Protein Isoforms
Transgenes
Light
Gene Transfer Techniques
1996
152 Citations (Scopus)

Ablation of the murine α myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Jones, W. K., Grupp, I. L., Doetschman, T., Grupp, G., Osinska, H., Hewett, T., Boivin, G., Gulick, J., Ng, W. A. & Robbins, J., Oct 15 1996, In : Journal of Clinical Investigation. 98, 8, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

Myosin Heavy Chains
Alleles
Genes
Contractile Proteins
Homologous Recombination
62 Citations (Scopus)

Knee hyperextension gait abnormalities in unstable knees: Recognition and preoperative gait retraining

Noyes, F. R., Dunworth, L. A., Andriacchi, T. P., Andrews, M. & Hewett, T., Jan 1996, In : American Journal of Sports Medicine. 24, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

Gait
Knee
Ankle
Hip
Ligaments
186 Citations (Scopus)

Lower limb alignment and foot angle are related to stance phase knee adduction in normal subjects: A critical analysis of the reliability of gait analysis data

Andrews, M., Noyes, F. R., Hewett, T. & Andriacchi, T. P., Mar 1996, In : Journal of Orthopaedic Research. 14, 2, p. 289-295 7 p.

Research output: Contribution to journalArticle

Gait
Foot
Lower Extremity
Knee
Knee Joint
684 Citations (Scopus)

Plyometric training in female athletes: Decreased impact forces and increased hamstring torques

Hewett, T., Stroupe, A. L., Nance, T. A. & Noyes, F. R., Nov 1996, In : American Journal of Sports Medicine. 24, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

Plyometric Exercise
Torque
Athletes
Knee
Lower Extremity