• 24271 Citations
  • 68 Scopus h-Index
1980 …2019

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2019

Classification of melanocytic lesions in selected and whole-slide images via convolutional neural networks

Hart, S., Flotte, W., Norgan, A. P., Shah, K. K., Buchan, Z. R., Mounajjed, T. & Flotte, T. J., Jan 1 2019, In : Journal of Pathology Informatics. 10, 1, 5.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma

Maus, R. L. G., Jakub, J. W., Hieken, T. J., Nevala, W. K., Christensen, T. A., Sutor, S. L., Flotte, T. J. & Markovic, S. N., Dec 2 2019, In : OncoImmunology. 8, 12, e1667742.

Research output: Contribution to journalArticle

Open Access

Robust hierarchical density estimation and regression for re-stained histological whole slide image co-registration

Jiang, J., Larson, N., Prodduturi, N., Flotte, T. J. & Hart, S., Jan 1 2019, In : PloS one. 14, 7, e0220074.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Understanding heterogeneous tumor microenvironment in metastatic melanoma

Yan, Y., Leontovich, A. A., Gerdes, M. J., Desai, K., Dong, J., Sood, A., Santamaria-Pang, A., Mansfield, A., Chadwick, C., Zhang, R., Nevala, W. K., Flotte, T. J., Ginty, F. & Markovic, S. N., Jun 1 2019, In : PloS one. 14, 6, e0216485.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

77 Scopus citations

Anatomical pathology is at a crossroads

Flotte, T. J. & Bell, D. A., Jan 1 2018, (Accepted/In press) In : Pathology.

Research output: Contribution to journalArticle

4 Scopus citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

192 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

40 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

20 Scopus citations

CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment

Enninga, E. A. L., Chatzopoulos, K., Butterfield, J. T., Sutor, S. L., Leontovich, A. A., Nevala, W. K., Flotte, T. J. & Markovic, S. N., Aug 1 2018, In : Journal of Pathology. 245, 4, p. 468-477 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

215 Scopus citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

57 Scopus citations
2 Scopus citations

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer Cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

83 Scopus citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

235 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

24 Scopus citations

Cytotechnologists as coinvestigators in anatomical pathology research

Kopp, K. J., Passow, M. R., Del Rosario, K. M., Christensen, M. R., O'Shaughnessy, J. W., Bartholet, M. K., Francis, M. E. & Flotte, T. J., Jan 1 2018, (Accepted/In press) In : Cancer cytopathology.

Research output: Contribution to journalArticle

3 Scopus citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

70 Scopus citations

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

44 Scopus citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

76 Scopus citations

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

111 Scopus citations

Histological features and outcome of inverted type-A melanocytic nevi

Dadras, S. S., Lu, J., Zembowicz, A., Flotte, T. J. & Mihm, M. C., Apr 1 2018, In : Journal of Cutaneous Pathology. 45, 4, p. 254-262 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

17 Scopus citations

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

110 Scopus citations

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

23 Scopus citations

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 338-354.e15

Research output: Contribution to journalArticle

111 Scopus citations

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

23 Scopus citations

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

264 Scopus citations

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

The Cancer Genome Atlas Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 282-300.e2

Research output: Contribution to journalArticle

42 Scopus citations

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

73 Scopus citations

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

106 Scopus citations

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 305-320.e10

Research output: Contribution to journalArticle

58 Scopus citations

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 271-281.e7

Research output: Contribution to journalArticle

83 Scopus citations

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

57 Scopus citations

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

85 Scopus citations

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 270-281.e3

Research output: Contribution to journalArticle

36 Scopus citations

Targeting the cyclin dependent kinase and retinoblastoma axis overcomes standard of care resistance in BRAFV600E-mutant melanoma

Harris, A. L., Lee, S. E., Dawson, L. K., Marlow, L. A., Edenfield, B. H., Durham, W. F., Flotte, T. J., Thompson, M., Small, D. L., Synnott, A. J., Markovic, S. N. & Copland, J. A. III., Jan 1 2018, In : Oncotarget. 9, 13, p. 10905-10919 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Immune Landscape of Cancer

The Cancer Genome Atlas Research Network, Apr 17 2018, In : Immunity. 48, 4, p. 812-830.e14

Research output: Contribution to journalArticle

370 Scopus citations
2015

Acute cutaneous graft-vs.-host disease compared to drug hypersensitivity reaction with vacuolar interface changes: A blinded study of microscopic and immunohistochemical features

Lehman, J., Gibson, L. E., El-Azhary, R. A., Chavan, R. N., Hashmi, S. K., Lohse, C. M. & Flotte, T. J., Jan 1 2015, In : Journal of Cutaneous Pathology. 42, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expression of the chemokine receptor gene, CCR8, is associated with DUSP22 rearrangements in anaplastic large cell lymphoma

Xing, X., Flotte, T. J., Law, M. E., Blahnik, A. J., Chng, W. J., Huang, G., Knudson, R. A., Ketterling, R. P., Porcher, J. C., Ansell, S. M., Sidhu, J., Dogan, A. & Feldman, A. L., Sep 23 2015, In : Applied Immunohistochemistry and Molecular Morphology. 23, 8, p. 580-589 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Dendritic cells are prominent in granuloma annulare

Chavan, R. N., Lehman, J. & Flotte, T. J., 2014, In : Journal of the American Academy of Dermatology. 71, 5, p. 1020-1022 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Preappointment testing for BRAF/KIT mutation in advanced melanoma: A model in molecular data delivery for individualized medicine

Mounajjed, T., Brown, C. L., Stern, T. K., Bjorheim, A. M., Bridgeman, A. J., Rumilla, K. M., Mc Williams, R. R. & Flotte, T. J., Nov 1 2014, In : Human Pathology. 45, 11, p. 2240-2246 7 p.

Research output: Contribution to journalArticle

2013

Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

Pulido, J. S., Flotte, T. J., Raja, H., Miles, S., Winters, J. L., Niles, R., Jaben, E. A., Markovic, S. N., Davies, J., Kalli, K. R., Vile, R. G., Garcia, J. J. & Salomao, D. R., Sep 2013, In : Eye (Basingstoke). 27, 9, p. 1058-1062 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mass spectrometry-based proteomic analysis of cutaneous cryoglobulinaemia in formalin-fixed tissues

Shon, W., Dogan, A., Camilleri, M. J., Erickson, L. A. & Flotte, T. J., May 2013, In : British Journal of Dermatology. 168, 5, p. 1128-1130 3 p.

Research output: Contribution to journalArticle

2012

Increased diagnosis of thin superficial spreading melanomas: A 20-year study

Frangos, J. E., Duncan, L. M., Piris, A., Nazarian, R. M., Mihm, M. C., Hoang, M. P., Gleason, B., Flotte, T. J., Byers, H. R., Barnhill, R. L. & Kimball, A. B., Sep 2012, In : Journal of the American Academy of Dermatology. 67, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification

Hipp, J., Monaco, J., Kunju, L. P., Cheng, J., Yagi, Y., Rodriguez-Canales, J., Emmert-Buck, M. R., Hewitt, S., Feldman, M. D., Tomaszewski, J. E., Toner, M., Tompkins, R. G., Flotte, T. J., Lucas, D., Gilbertson, J. R., Madabhushi, A. & Balis, U., 2012, In : Analytical Cellular Pathology. 35, 4, p. 251-265 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: An immunohistochemical and ultrastructural study

Shon, W., Wada, D. A., Gibson, L. E., Flotte, T. J. & Scheithauer, B. W., Nov 2011, In : Journal of Cutaneous Pathology. 38, 11, p. 865-870 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Long-term outcome of spitz-type melanocytic tumors

Sepehr, A., Chao, E., Trefrey, B., Blackford, A., Duncan, L. M., Flotte, T. J., Sober, A., Mihm, M. C. & Tsao, H., Oct 2011, In : Archives of Dermatology. 147, 10, p. 1173-1179 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background

Geyer, J. T., Ferry, J. A., Longtine, J. A., Flotte, T. J., Harris, N. L. & Zukerberg, L. R., Jan 2010, In : American Journal of Clinical Pathology. 133, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

Goel, V. K., Ibrahim, N., Jiang, G., Singhal, M., Fee, S., Flotte, T. J., Westmoreland, S., Haluska, F. S., Hinds, P. W. & Haluska, F. G., Jun 11 2009, In : Oncogene. 28, 23, p. 2289-2298 10 p.

Research output: Contribution to journalArticle

99 Scopus citations