Thai H Ho, MD, PhD

  • 3246 Citations
  • 24 Scopus h-Index
20022019
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Research Output 2002 2019

2019

Erratum: Germ cell tumors with malignant somatic transformation: A mayo clinic experience (Oncology Research and Treatment (2019) 42 (95-100) DOI: 10.1159/000495802)

Scheckel, C. J., Kosiorek, H. E., Butterfield, R., Ho, T. H. & Hilal, T., Jun 1 2019, In : Oncology Research and Treatment. 42, 6, 1 p.

Research output: Contribution to journalComment/debate

Germ Cell and Embryonal Neoplasms
alpha-Fetoproteins
Research
Chorionic Gonadotropin
Sarcoma
1 Citation (Scopus)

Germ Cell Tumors with Malignant Somatic Transformation: A Mayo Clinic Experience

Scheckel, C. J., Kosiorek, H. E., Butterfield, R., Ho, T. H. & Hilal, T., Mar 1 2019, In : Oncology Research and Treatment. 42, 3, p. 95-100 6 p.

Research output: Contribution to journalArticle

Germ Cell and Embryonal Neoplasms
Confidence Intervals
Survival
Research Ethics Committees
alpha-Fetoproteins

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

Yang, M., Hlady, R. A., Zhou, D., Ho, T. H. & Robertson, K. D., Sep 1 2019, In : Cancer medicine. 8, 12, p. 5760-5768 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Renal Cell Carcinoma
Computer Simulation
Biomarkers
Methylation
2 Citations (Scopus)

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D. F., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Renal Cell Carcinoma
Cells
Switches
Cell Line

Role of robot-assisted retroperitoneal lymph node dissection in malignant mesothelioma of the tunica vaginalis: case series and review of the literature

Faraj, K. S., Abdul-Muhsin, H. M., Navaratnam, A. K., Rose, K. M., Stagg, J., Ho, T. H., Bryce, A. H., Cheney, S. M., Tyson, M. D. & Castle, E. P., Jun 1 2019, In : The Canadian journal of urology. 26, 3, p. 9752-9757 6 p.

Research output: Contribution to journalArticle

Lymph Node Excision
Lymph Nodes
Malignant Mesothelioma
Epididymitis
Orchiectomy
2018
1 Citation (Scopus)

Adjuvant Antiangiogenic Agents in Post-nephrectomy Renal Cell Carcinoma: A Systematic Review and Meta-analysis

Sonbol, M. B., Firwana, B., Hilal, T., Wang, Z., Almader-Douglas, D., Joseph, R. W. & Ho, T. H., Jun 1 2018, In : European Urology Oncology. 1, 2, p. 101-108 8 p.

Research output: Contribution to journalReview article

Angiogenesis Inhibitors
Nephrectomy
Renal Cell Carcinoma
Meta-Analysis
Disease-Free Survival
11 Citations (Scopus)

A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone

Wang, L., Dehm, S. M., Hillman, D. W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R. E., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B., Pitot, H. C., Ho, T. H., Bryce, A. H., Ye, Z., Li, Y., Eiken, P., Vedell, P. T. & 16 others, Barman, P., McMenomy, B. P., Atwell, T. D., Carlson, R. E., Ellingson, M., Eckloff, B. W., Qin, R., Ou, F., Hart, S., Huang, H., Jen, J., Wieben, E. D., Kalari, K. R., Weinshilboum, R. M., Wang, L. & Kohli, M., Feb 1 2018, In : Annals of Oncology. 29, 2, p. 352-360 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Prednisone
Prostatic Neoplasms
Cell Cycle
Cell Proliferation
3 Citations (Scopus)

Behavior of blood plasma glycan features in bladder cancer

Ferdosi, S., Ho, T. H., Castle, E. P., Stanton, M. L. & Borges, C. R., Jul 1 2018, In : PLoS One. 13, 7, e0201208.

Research output: Contribution to journalArticle

blood plasma
Urinary Bladder Neoplasms
Polysaccharides
Blood
polysaccharides
6 Citations (Scopus)

Chromosome 3p loss–orchestrated VHL, HIF, and epigenetic deregulation in clear cell renal cell carcinoma

Hsieh, J. J., Le, V. H., Oyama, T., Ricketts, C. J., Ho, T. H. & Cheng, E. H., Dec 20 2018, In : Journal of Clinical Oncology. 36, 36, p. 3533-3539 7 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Epigenomics
Chromosomes
Vascular Endothelial Growth Factor Receptor
Tumor Suppressor Genes
50 Citations (Scopus)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer Cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

Alternative Splicing
Neoplasms
Exons
Exome
Peptides
12 Citations (Scopus)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

Genes
Neoplasms
Squamous Cell Neoplasms
Tumors
Atlases
13 Citations (Scopus)

Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))

The Cancer Genome Atlas Research Network & The Cancer Genome Atlas Research Network, Jun 19 2018, In : Cell Reports. 23, 12, 1 p.

Research output: Contribution to journalComment/debate

Atlases
Renal Cell Carcinoma
Names
Emotions
Genes
32 Citations (Scopus)

Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

The MC3 Working Group & The Cancer Genome Atlas Research Network, Aug 9 2018, In : Cell. 174, 4, p. 1034-1035 2 p.

Research output: Contribution to journalComment/debate

Neoplasm Genes
Adenocarcinoma
Genes
Mutation
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
83 Citations (Scopus)

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Atlases
DNA Damage
Repair
Genes
160 Citations (Scopus)

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bossé, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., Tracy, A., Giannakis, M., Hodi, F. S., Drake, C. G., Allaf, M. E., Snyder, A., Hellmann, M. D., Ho, T. & 5 others, Ho, T. H., Signoretti, S., Kaelin, W. G., Choueiri, T. K. & Van Allen, E. M., Jan 4 2018, (Accepted/In press) In : Science. p. 1-10 10 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Programmed Cell Death 1 Receptor
Exome
Therapeutics
Chromatin Assembly and Disassembly
14 Citations (Scopus)

Quantitative spatial profiling of PD-1/PD-L1 interaction and HLA-DR/IDO-1 predicts improved outcomes of anti-PD-1 therapies in metastatic melanoma

Johnson, D. B., Bordeaux, J., Kim, J. Y., Vaupel, C., Rimm, D. L., Ho, T. H., Joseph, R. W., Daud, A. I., Conry, R. M., Gaughan, E. M., Hernandez-Aya, L. F., Dimou, A., Funchain, P., Smithy, J., Witte, J. S., McKee, S. B., Ko, J., Wrangle, J. M., Dabbas, B., Tangri, S. & 5 others, Lameh, J., Hall, J., Markowitz, J., Balko, J. M. & Dakappagari, N., Nov 1 2018, In : Clinical Cancer Research. 24, 21, p. 5250-5260 11 p.

Research output: Contribution to journalArticle

HLA-DR Antigens
Melanoma
Biomarkers
Survival
Therapeutics
4 Citations (Scopus)

Stage Dependence, Cell-Origin Independence, and Prognostic Capacity of Serum Glycan Fucosylation, β1-4 Branching, β1-6 Branching, and α2-6 Sialylation in Cancer

Ferdosi, S., Rehder, D. S., Maranian, P., Castle, E. P., Ho, T. H., Pass, H. I., Cramer, D. W., Anderson, K. S., Fu, L., Cole, D. E. C., Le, T., Wu, X. & Borges, C. R., Jan 5 2018, In : Journal of Proteome Research. 17, 1, p. 543-558 16 p.

Research output: Contribution to journalArticle

Polysaccharides
Plasmas
Serum
Neoplasms
Lung Neoplasms
61 Citations (Scopus)

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 313-326.e5

Research output: Contribution to journalArticle

Atlases
Renal Cell Carcinoma
Genes
Cells
Genome
3 Citations (Scopus)

The Impact of Pazopanib on the Cardiovascular System

Justice, C. N., Derbala, M. H., Baich, T. M., Kempton, A. N., Guo, A. S., Ho, T. H. & Smith, S. A., Sep 1 2018, In : Journal of Cardiovascular Pharmacology and Therapeutics. 23, 5, p. 387-398 12 p.

Research output: Contribution to journalReview article

Cardiovascular System
Protein-Tyrosine Kinases
Vascular Endothelial Growth Factor Receptor
Therapeutics
Renal Cell Carcinoma
9 Citations (Scopus)

Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study

Saad, A. M., Gad, M. M., Al-Husseini, M. J., Ruhban, I. A., Sonbol, M. B. & Ho, T. H., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Epidemiology
Mortality
Incidence
Confidence Intervals
2017
34 Citations (Scopus)

Androgen receptor variant AR-V9 is coexpressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance

Kohli, M., Ho, Y., Hillman, D. W., Van Etten, J. L., Henzler, C., Yang, R., Sperger, J. M., Li, Y., Tseng, E., Hon, T., Clark, T., Tan, W., Carlson, R. E., Wang, L., Sicotte, H., Ho, T. H., Jimenez, R. E., Huang, H., Vedell, P. T., Eckloff, B. W. & 9 others, Quevedo, J. F., Pitot, H. C., Costello, B., Jen, J., Wieben, E. D., Silverstein, K. A. T., Lang, J. M., Wang, L. M. & Dehm, S. M., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4704-4715 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Neoplasm Metastasis
Castration
abiraterone
9 Citations (Scopus)

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

Eckel-Passow, J. E., Serie, D. J., Cheville, J. C., Ho, T. H., Kapur, P., Brugarolas, J., Thompson, R. H., Leibovich, B. C., Kwon, E. D., Joseph, R. W. & Parker, A., Mar 21 2017, In : BMC Urology. 17, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Neoplasms
Renal Cell Carcinoma
Clear-cell metastatic renal cell carcinoma
Mutation
Immunohistochemistry
346 Citations (Scopus)

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

Robertson, A. G., Kim, J., Al-Ahmadie, H., Bellmunt, J., Guo, G., Cherniack, A. D., Hinoue, T., Laird, P. W., Hoadley, K. A., Akbani, R., Castro, M. A. A., Gibb, E. A., Kanchi, R. S., Gordenin, D. A., Shukla, S. A., Sanchez-Vega, F., Hansel, D. E., Czerniak, B. A., Reuter, V. E., Su, X. & 193 others, de Sa Carvalho, B., Chagas, V. S., Mungall, K. L., Sadeghi, S., Pedamallu, C. S., Lu, Y., Klimczak, L. J., Zhang, J., Choo, C., Ojesina, A. I., Bullman, S., Leraas, K. M., Lichtenberg, T. M., Wu, C. J., Schultz, N., Getz, G., Meyerson, M., Mills, G. B., McConkey, D. J., Akbani, R., Al-Ahmadie, H., Albert, M., Alexopoulou, I., Ally, A., Antic, T., Aron, M., Balasundaram, M., Bartlett, J., Baylin, S. B., Stanton, M. L., Bellmunt, J., Birol, I., Boice, L., Bootwalla, M. S., Bowen, J., Bowlby, R., Brooks, D., Broom, B. M., Bshara, W., Bullman, S., Burks, E., Castle, E. P., Carlsen, R., Carvalho, B. S., Carvalho, A. L., Castle, E. P., Castro, M. A. A., Castro, P., Catto, J. W., Chagas, V. S., Cherniack, A. D., Chesla, D. W., Choo, C., Chuah, E., Chudamani, S., Cortessis, V. K., Cottingham, S. L., Crain, D., Curley, E., Czerniak, B. A., Daneshmand, S., Demchok, J. A., Dhalla, N., Djaladat, H., Eckman, J., Egea, S. C., Engel, J., Ho, T. H., Ferguson, M. L., Gardner, J., Gastier-Foster, J. M., Gerken, M., Getz, G., Gibb, E. A., Gomez-Fernandez, C. R., Gordenin, D. A., Guo, G., Hansel, D. E., Harr, J., Hartmann, A., Herbert, L. M., Hinoue, T., Ho, T. H., Hoadley, K. A., Holt, R. A., Hutter, C. M., Jones, S. J. M., Jorda, M., Kahnoski, R. J., Kanchi, R. S., Kasaian, K., Kim, J., Klimczak, L. J., Kwiatkowski, D. J., Lai, P. H., Laird, P. W., Lane, B. R., Leraas, K. M., Lerner, S. P., Lichtenberg, T. M., Liu, J., Lolla, L., Lotan, Y., Lu, Y., Lucchesi, F. R., Ma, Y., Machado, R. D., Maglinte, D. T., Mallery, D., Marra, M. A., Martin, S. E., Mayo, M., McConkey, D. J., Meraney, A., Meyerson, M., Mills, G. B., Moinzadeh, A., Moore, R. A., Mora Pinero, E. M., Singh, P., Morrison, C., Mungall, K. L., Mungall, A. J., Myers, J. B., Naresh, R., O'Donnell, P. H., Ojesina, A. I., Parekh, D. J., Parfitt, J., Paulauskis, J. D., Sekhar Pedamallu, C., Penny, R. J., Pihl, T., Porten, S., Quintero-Aguilo, M. E., Ramirez, N. C., Rathmell, W. K., Reuter, V. E., Rieger-Christ, K., Robertson, A. G., Sadeghi, S., Saller, C., Salner, A., Sanchez-Vega, F., Sandusky, G., Scapulatempo-Neto, C., Schein, J. E., Schuckman, A. K., Schultz, N., Shelton, C., Shelton, T., Shukla, S. A., Simko, J., Singh, P., Sipahimalani, P., Smith, N. D., Sofia, H. J., Sorcini, A., Stanton, M. L., Steinberg, G. D., Stoehr, R., Su, X., Sullivan, T., Sun, Q., Tam, A., Tarnuzzer, R., Tarvin, K., Taubert, H., Thiessen, N., Thorne, L., Tse, K., Tucker, K., Van Den Berg, D. J., van Kessel, K. E., Wach, S., Wan, Y., Wang, Z., Weinstein, J. N., Weisenberger, D. J., Wise, L., Wong, T., Wu, Y., Wu, C. J., Yang, L., Zach, L. A., Zenklusen, J. C., Zhang, J. J., Zhang, J., Zmuda, E., Zwarthoff, E. C., Weinstein, J. N., Kwiatkowski, D. J. & Lerner, S. P., Oct 19 2017, In : Cell. 171, 3, p. 540-556.e25

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cluster Analysis
Muscle
Tumors
Long Noncoding RNA
16 Citations (Scopus)

Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes

Ho, T. H., Serie, D. J., Parasramka, M., Cheville, J. C., Bot, B. M., Tan, W., Wang, L. M., Joseph, R. W., Hilton, T., Leibovich, B. C., Parker, A. & Eckel-Passow, J. E., 2017, In : Annals of Oncology. 28, 3, p. 604-610 7 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Renal Cell Carcinoma
Extracellular Matrix
Up-Regulation
Neoplasm Metastasis
15 Citations (Scopus)

Factors Associated With Survival Following Radium-223 Treatment for Metastatic Castration-resistant Prostate Cancer

Wong, W. W., Anderson, E. M., Mohammadi, H., Daniels, T. B., Schild, S. E., Keole, S. R., Choo, C. R., Tzou, K. S., Bryce, A. H., Ho, T. H., Quevedo, F. J. & Vora, S. A., Feb 27 2017, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Radium
Castration
Prostatic Neoplasms
Alkaline Phosphatase
Survival
13 Citations (Scopus)

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

Zhang, X., Saarinen, A. M., Hitosugi, T. D., Wang, Z., Wang, L., Ho, T. H. & Liu, J. D., Dec 19 2017, In : eLife. 6, e31132.

Research output: Contribution to journalArticle

Lipolysis
Lipase
Cells
Genes
Lipids
12 Citations (Scopus)

Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma

Ho, T. H., Eckel-Passow, J. E., Cheville, J., Christie, A., Joseph, R. W., Serie, D. J., Cheville, J. C., Thompson, R. H., Homayoun, F., Joseph, R. W., Brugarolas, J. & Parker, A., Nov 10 2017, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35, 32, p. 3706-3713 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Necrosis
Atlases
Neoplasms
Enhancer of Zeste Homolog 2 Protein

Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model

Kempton, A., Justice, C., Guo, A., Cefalu, M., Makara, M., Janssen, P., Ho, T. H. & Smith, S. A., Nov 27 2017, (Accepted/In press) In : Clinical and Experimental Hypertension. p. 1-10 10 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Arterial Pressure
Blood Pressure
Cardiac Output
Myocardial Ischemia
2016
2 Citations (Scopus)

A Study of Combination Bicalutamide and Raloxifene for Patients With Castration-Resistant Prostate Cancer

Ho, T. H., Nunez-Nateras, R., Hou, Y. X., Bryce, A. H., Northfelt, D. W., Dueck, A., Wong, B., Stanton, M. L., Joseph, R. W. & Castle, E. P., Jul 8 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Estrogen Receptors
Quality of Life
Therapeutics
56 Citations (Scopus)

Clear Cell Renal Cell Carcinoma Subtypes Identified by BAP1 and PBRM1 Expression

Joseph, R. W., Kapur, P., Serie, D. J., Parasramka, M., Ho, T. H., Cheville, J. C., Frenkel, E., Parker, A. & Brugarolas, J., Jan 1 2016, In : Journal of Urology. 195, 1, p. 180-187 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Proportional Hazards Models
Necrosis
Immunohistochemistry
14 Citations (Scopus)

Clear Cell Type A and B Molecular Subtypes in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Aggressiveness

Serie, D. J., Joseph, R. W., Cheville, J. C., Ho, T. H., Parasramka, M., Hilton, T., Thompson, R. H., Leibovich, B. C., Parker, A. & Eckel-Passow, J. E., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Neoplasms
Renal Cell Carcinoma
Clear-cell metastatic renal cell carcinoma
Kidney Neoplasms
Confidence Intervals
10 Citations (Scopus)

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
DNA Fingerprinting
Patient Preference
Pharmaceutical Preparations

Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib

Bryce, A. H., Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., McCullough, A. E., Hunt, K. S., Ritacca, N. R., Barrett, M., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Stanton, M. L., Cheville, J., Swanson, S., Schneider, D. E., Mc Williams, R. R. & 16 others, Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Von Hoff, D. D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Nov 3 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

393 Citations (Scopus)

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

Linehan, W. M., Spellman, P. T., Ricketts, C. J., Creighton, C. J., Fei, S. S., Davis, C., Wheeler, D. A., Murray, B. A., Schmidt, L., Vocke, C. D., Peto, M., Al Mamun, A. A. M., Shinbrot, E., Sethi, A., Brooks, S., Rathmell, W. K., Brooks, A. N., Hoadley, K. A., Robertson, A. G., Brooks, D. & 208 others, Bowlby, R., Sadeghi, S., Shen, H., Weisenberger, D. J., Bootwalla, M., Baylin, S. B., Laird, P. W., Cherniack, A. D., Saksena, G., Haake, S., Li, J., Liang, H., Lu, Y., Mills, G. B., Akbani, R., Leiserson, M. D. M., Raphael, B. J., Anur, P., Bottaro, D., Albiges, L., Barnabas, N., Choueiri, T. K., Czerniak, B., Godwin, A. K., Hakimi, A. A., Ho, T. H., Hsieh, J., Ittmann, M., Kim, W. Y., Krishnan, B., Merino, M. J., Shaw, K. R. M., Reuter, V. E., Reznik, E., Shelley, C. S., Shuch, B., Signoretti, S., Srinivasan, R., Tamboli, P., Thomas, G., Tickoo, S., Burnett, K., Crain, D., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J. D., Penny, R. J., Shelton, C., Shelton, W. T., Sherman, M. E., Thompson, E., Yena, P., Avedon, M. T., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Santos, T., Wise, L., Zmuda, E., Demchok, J. A., Felau, I., Hutter, C. M., Sheth, M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J., Ayala, B., Baboud, J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Ally, A., Balasundaram, M., Balu, S., Beroukhim, R., Bodenheimer, T., Buhay, C., Butterfield, Y. S. N., Carlsen, R., Carter, S. L., Chao, H., Chuah, E., Clarke, A., Covington, K. R., Dahdouli, M., Dewal, N., Dhalla, N., Doddapaneni, H. V., Drummond, J. A., Gabriel, S. B., Gibbs, R. A., Guin, R., Hale, W., Hawes, A., Hayes, D. N., Holt, R. A., Hoyle, A. P., Jefferys, S. R., Jones, S. J. M., Jones, C. D., Kalra, D., Kovar, C., Lewis, L., Li, J., Ma, Y., Marra, M. A., Mayo, M., Meng, S., Meyerson, M., Mieczkowski, P. A., Moore, R. A., Morton, D., Mose, L. E., Mungall, A. J., Muzny, D., Parker, J. S., Perou, C. M., Roach, J., Schein, J. E., Schumacher, S. E., Shi, Y., Simons, J. V., Sipahimalani, P., Skelly, T., Soloway, M. G., Sougnez, C., Tam, A., Tan, D., Thiessen, N., Veluvolu, U., Wang, M., Wilkerson, M. D., Wong, T., Wu, J., Xi, L., Zhou, J., Bedford, J., Chen, F., Fu, Y., Gerstein, M., Haussler, D., Kasaian, K., Lai, P., Ling, S., Radenbaugh, A., Van Den Berg, D., Weinstein, J. N., Zhu, J., Albert, M., Alexopoulou, I., Andersen, J. J., Auman, J. T., Bartlett, J., Bastacky, S., Bergsten, J., Blute, M. L., Boice, L., Bollag, R. J., Boyd, J., Castle, E. P., Chen, Y. B., Cheville, J., Curley, E., Davies, B., DeVolk, A., Dhir, R., Dike, L., Eckman, J., Engel, J., Harr, J., Hrebinko, R., Huang, M., Huelsenbeck-Dill, L., Iacocca, M., Jacobs, B., Lobis, M., Maranchie, J. K., McMeekin, S., Myers, J., Nelson, J., Parfitt, J., Parwani, A., Petrelli, N., Rabeno, B., Roy, S., Salner, A. L., Slaton, J., Stanton, M., Thompson, R. H., Thorne, L., Tucker, K., Weinberger, P. M., Winemiller, C., Zach, L. A. & Zuna, R., Jan 14 2016, In : New England Journal of Medicine. 374, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Antioxidant Response Elements
CpG Islands
Kidney Neoplasms
Phenotype
16 Citations (Scopus)

Correlation Between Molecular Subclassifications of Clear Cell Renal Cell Carcinoma and Targeted Therapy Response

Ho, T. H., Choueiri, T. K., Wang, K., Karam, J. A., Chalmers, Z., Frampton, G., Elvin, J. A., Johnson, A., Liu, X., Lin, Y., Joseph, R. W., Stanton, M. L., Miller, V. A., Stephens, P. J., Ross, J. S., Ali, S. M. & Pal, S. K., Jun 1 2016, In : European Urology Focus. 2, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Sirolimus
Vascular Endothelial Growth Factor Receptor
Therapeutics
7 Citations (Scopus)

Detection of tumor-associated cells in cryopreserved peripheral blood mononuclear cell samples for retrospective analysis

Zhu, P., Stanton, M. L., Castle, E. P., Joseph, R. W., Adams, D. L., Li, S., Amstutz, P., Tang, C. M. & Ho, T. H., Jul 2 2016, In : Journal of Translational Medicine. 14, 1, 198.

Research output: Contribution to journalArticle

Microfiltration
Macrophages
Cryopreservation
Tumors
Blood Cells
21 Citations (Scopus)

DNA methylation signature reveals cell ontogeny of renal cell carcinomas

Malouf, G. G., Su, X., Zhang, J., Creighton, C. J., Ho, T. H., Lu, Y., Raynal, N. J. M., Karam, J. A., Tamboli, P., Allanick, F., Mouawad, R., Spano, J. P., Khayat, D., Wood, C. G., Jelinek, J. & Tannir, N. M., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6236-6246 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Renal Cell Carcinoma
Gene Expression Profiling
Epigenomics
Distal Kidney Tubule
56 Citations (Scopus)

Dual Chromatin and Cytoskeletal Remodeling by SETD2

Park, I. Y., Powell, R. T., Tripathi, D. N., Dere, R., Ho, T. H., Blasius, T. L., Chiang, Y. C., Davis, I. J., Fahey, C. C., Hacker, K. E., Verhey, K. J., Bedford, M. T., Jonasch, E., Rathmell, W. K. & Walker, C. L., Aug 11 2016, In : Cell. 166, 4, p. 950-962 13 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Tubulin
Microtubules
Histones
Chromatin
23 Citations (Scopus)

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

DNA Methylation
Renal Cell Carcinoma
Developmental Genes
Phenotype
Cell Line
18 Citations (Scopus)

Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death

Ho, T. H., Kapur, P., Joseph, R. W., Serie, D. J., Eckel-Passow, J. E., Tong, P., Wang, J., Castle, E. P., Stanton, M. L., Cheville, J. C., Jonasch, E., Brugarolas, J. & Parker, A., Jan 1 2016, In : Modern Pathology. 29, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Histones
Lysine
Survival
Atlases
116 Citations (Scopus)

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

Chen, F., Zhang, Y., Şenbabaoğlu, Y., Ciriello, G., Yang, L., Reznik, E., Shuch, B., Micevic, G., De Velasco, G., Shinbrot, E., Noble, M. S., Lu, Y., Covington, K. R., Xi, L., Drummond, J. A., Muzny, D., Kang, H., Lee, J., Tamboli, P., Reuter, V. & 20 others, Shelley, C. S., Kaipparettu, B. A., Bottaro, D. P., Godwin, A. K., Gibbs, R. A., Getz, G., Kucherlapati, R., Park, P. J., Sander, C., Henske, E. P., Zhou, J. H., Kwiatkowski, D. J., Ho, T. H., Choueiri, T. K., Hsieh, J. J., Akbani, R., Mills, G. B., Hakimi, A. A., Wheeler, D. A. & Creighton, C. J., Mar 15 2016, In : Cell Reports. 14, 10, p. 2476-2489 14 p.

Research output: Contribution to journalArticle

T-cells
Taxonomies
Genomics
Phosphatidylinositol 3-Kinases
Renal Cell Carcinoma
83 Citations (Scopus)

Mutations in TSC1, TSC2, and MTOR are associated with response to rapalogs in patients with metastatic renal cell carcinoma

Kwiatkowski, D. J., Choueiri, T. K., Fay, A. P., Rini, B. I., Thorner, A. R., De Velasco, G., Tyburczy, M. E., Hamieh, L., Albiges, L., Agarwal, N., Ho, T. H., Song, J., Pignon, J. C., Barrios, P. M., Michaelson, M. D., Van Allen, E. M., Krajewski, K. M., Porta, C., Pal, S. K., Bellmunt, J. & 4 others, McDermott, D. F., Heng, D. Y. C., Gray, K. P. & Signoretti, S., May 15 2016, In : Clinical Cancer Research. 22, 10, p. 2445-2452 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Mutation
Genes
Neoplasms
Neoplasm Genes
3 Citations (Scopus)

Predictors of incipient dysfunction of all cardiac chambers after treatment of metastatic renal cell carcinoma by tyrosine kinase inhibitors

Moustafa, S., Ho, T. H., Shah, P., Murphy, K., Nelluri, B. K., Lee, H., Wilansky, S. & Mookadam, F., 2016, (Accepted/In press) In : Journal of Clinical Ultrasound.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Protein-Tyrosine Kinases
Left Atrial Function
Therapeutics
Heart Atria
70 Citations (Scopus)

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

Fang, D., Gan, H., Lee, J. H., Han, J., Wang, Z., Riester, S. M., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, E., Ho, T. H., Rubin, B. P., Bridge, J. A., Thibodeau, S. N., Ordog, T., Chen, Y., van Wijnen, A. J. & 4 others, Oliveira, A. M., Xu, R. M., Westendorf, J. J. & Zhang, Z., Jun 10 2016, In : Science. 352, 6291, p. 1344-1348 5 p.

Research output: Contribution to journalArticle

Chondroblastoma
Chondrocytes
Histones
Methylation
Mutation
2 Citations (Scopus)

Validation of Gene Expression Signatures to Identify Low-risk Clear-cell Renal Cell Carcinoma Patients at Higher Risk for Disease-related Death

Parasramka, M., Serie, D. J., Asmann, Y., Eckel-Passow, J. E., Castle, E. P., Stanton, M. L., Leibovich, B. C., Thompson, R. H., Thompson, E. A., Parker, A., Ho, T. H. & Joseph, R. W., Dec 15 2016, In : European Urology Focus. 2, 6, p. 608-615 8 p.

Research output: Contribution to journalArticle

Transcriptome
Renal Cell Carcinoma
Genes
Paraffin
Formaldehyde
12 Citations (Scopus)

Whole-exome sequencing in two extreme phenotypes of response to VEGF-targeted therapies in patients with metastatic clear cell renal cell carcinoma

Fay, A. P., De Velasco, G., Ho, T. H., Van Allen, E. M., Murray, B., Albiges, L., Signoretti, S., Hakimi, A. A., Stanton, M. L., Bellmunt, J., McDermott, D. F., Atkins, M. B., Garraway, L. A., Kwiatkowski, D. J. & Choueiri, T. K., Jul 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 7, p. 820-824 5 p.

Research output: Contribution to journalArticle

Exome
Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Phenotype
Mutation
2015
6 Citations (Scopus)

A multidisciplinary biospecimen bank of renal cell carcinomas compatible with discovery platforms at Mayo Clinic, Scottsdale, Arizona

Ho, T. H., Nateras, R. N., Yan, H. D., Park, J. G., Jensen, S., Borges, C., Lee, J. H., Champion, M. D., Tibes, R., Bryce, A. H., Carballido, E. M., Todd, M. A., Joseph, R. W., Wong, W. W., Parker, A., Stanton, M. L. & Castle, E. P., Jul 16 2015, In : PLoS One. 10, 7, e0132831.

Research output: Contribution to journalArticle

kidney cells
Renal Cell Carcinoma
carcinoma
Cells
RNA

Assessing the clinical use of clear cell renal cell carcinoma molecular subtypes identified by RNA expression analysis

Eckel-Passow, J. E., Igel, D. A., Serie, D. J., Joseph, R. W., Ho, T. H., Cheville, J. C. & Parker, A. S., Feb 1 2015, In : Urologic Oncology. 33, 2

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Atlases
Genome
RNA
Necrosis
4 Citations (Scopus)

Assessing the clinical use of clear cell renal cell carcinoma molecular subtypes identified by RNA expression analysis

Eckel-Passow, J. E., Igel, D. A., Serie, D. J., Joseph, R. W., Ho, T. H., Cheville, J. C. & Parker, A., Feb 1 2015, In : Urologic Oncology. 33, 2

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Atlases
Genome
RNA
Necrosis
2 Citations (Scopus)
Renal Cell Carcinoma
Atlases
Genome
RNA
Necrosis