• 36135 Citations
  • 93 Scopus h-Index
1986 …2020
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Research Output 1986 2020

2020

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

Electronic Health Records
Learning systems
Health
Epidemiology
Medical Record Linkage
2019

A Bayesian Approach to Multistate Hidden Markov Models: Application to Dementia Progression

Williams, J. P., Storlie, C., Therneau, T. M., Jr, C. R. J. & Hannig, J., Jan 1 2019, In : Journal of the American Statistical Association.

Research output: Contribution to journalArticle

Dementia
Multi-state
Progression
Bayesian Approach
Markov Model
7 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)
Natural Language Processing
Life Style
Alzheimer Disease
Electronic Health Records
Dementia

Cognitive function and neuropathological outcomes: a forward-looking approach

Munoz, E., Filshtein, T., Bettcher, B. M., McLaren, D., Hedden, T., Tommet, D., Mungas, D. & Therneau, T. M., Jan 1 2019, (Accepted/In press) In : Journal of Neurology.

Research output: Contribution to journalArticle

Cognition
Autopsy
Episodic Memory
Proportional Hazards Models
Health Status
4 Citations (Scopus)

Comparative analysis of staging systems in AL amyloidosis

Muchtar, E., Therneau, T. M., Larson, D. R., Gertz, M., Lacy, M., Buadi, F. K., Dingli, D. M., Hayman, S. R., Kapoor, P., Gonsalves, W., Kourelis, T., Warsame, R., Fonder, A., Hobbs, M., Hwa, Y. L., Leung, N., Russell, S. J., Lust, J. A., Lin, Y., Go, R. S. & 5 others, Zeldenrust, S., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Dispenzieri, A., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Amyloidosis
Systems Analysis
1 Citation (Scopus)

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
11 Citations (Scopus)
Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Software
Research
Facial Recognition
9 Citations (Scopus)

Incidence of AL Amyloidosis in Olmsted County, Minnesota, 1990 through 2015

Kyle, R. A., Larson, D. R., Kurtin, P. J., Kumar, S. K., Cerhan, J. R., Therneau, T. M., Rajkumar, S. V., Vachon, C. M. & Dispenzieri, A., Jan 1 2019, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Amyloidosis
Incidence
Immunoglobulin Light Chains
Congo Red
Medical Records
1 Citation (Scopus)

Large Chromosomal Rearrangements Yield Biomarkers to Distinguish Low-Risk From Intermediate- and High-Risk Prostate Cancer

Vasmatzis, G., Kosari, F., Murphy, S. J., Terra, S., Kovtun, I. V., Harris, F. R., Zarei, S., Smadbeck, J., Johnson, S. H., Gaitatzes, A. G., Therneau, T. M., Rangel, L. J., Knudson, R. A., Greipp, P. T., Sukov, W. R., Knutson, D. L., Kloft-Nelson, S. M., Karnes, R. J. & Cheville, J., Jan 1 2019, In : Mayo Clinic Proceedings. 94, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Biomarkers
Area Under Curve
Neoplasm Grading
Needle Biopsy
1 Citation (Scopus)

Polyclonal serum free light chain elevation is associated with increased risk of monoclonal gammopathies

Kumar, S. K., Larson, D. R., Dispenzieri, A., Therneau, T. M., Murray, D. L., Bergsagel, P. L., Kyle, R. A. & Rajkumar, S. V., Jun 1 2019, In : Blood cancer journal. 9, 6, 49.

Research output: Contribution to journalArticle

Open Access
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
Light
Serum
Plasma Cells
6 Citations (Scopus)

Predicting Progression to Mild Cognitive Impairment

Petersen, R. C., Lundt, E. S., Therneau, T. M., Weigand, S. D., Knopman, D. S., Mielke, M. M., Roberts, R. O., Lowe, V., Machulda, M. M., Kremers, W. K., Geda, Y. E. & Jack, C. R. J., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

Biomarkers
Amyloid
Cognitive Dysfunction
Alzheimer Disease
Population

Prediction and Inference With Missing Data in Patient Alert Systems

Storlie, C., Therneau, T. M., Carter, R. E., Chia, N. D., Bergquist, J. R., Huddleston, J. M. & Romero-Brufau, S., Jan 1 2019, In : Journal of the American Statistical Association.

Research output: Contribution to journalArticle

Missing Data
Predictors
Prediction
Imputation
Uncertainty
4 Citations (Scopus)
Elasticity Imaging Techniques
Magnetic Resonance Imaging
Liver
Fats
Linear Models
11 Citations (Scopus)
National Institute on Aging (U.S.)
Alzheimer Disease
Amyloid
Research
Positron-Emission Tomography
2 Citations (Scopus)
Open Access
Amyloid
Alzheimer Disease
Tauopathies
Lewy Body Disease
Amyloidosis
1 Citation (Scopus)

The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity – A longitudinal cohort study

Allen, A. M., Hicks, S. B., Mara, K. C., Larson, J. J. & Therneau, T. M., Jan 1 2019, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalArticle

Longitudinal Studies
Cohort Studies
Obesity
Neoplasms
Incidence
1 Citation (Scopus)

The Role of Three-Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Allen, A., Shah, V., Therneau, T. M., Venkatesh, S. K., Mounajjed, T., Larson, J. J., Mara, K. C., Schulte, P., Kellogg, T. A., Kendrick, M. L., McKenzie, T. J., Greiner, S. M., Li, J., Glaser, K. J., Wells, M., Chen, J., Ehman, R. L. & Yin, M., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Bariatric Surgery
Fats
Protons
Magnetic Resonance Imaging

Women With Nonalcoholic Fatty Liver Disease Lose Protection Against Cardiovascular Disease: A Longitudinal Cohort Study

Allen, A. M., Therneau, T. M., Mara, K. C., Larson, J. J., Watt, K. D., Hayes, S. N. & Kamath, P. S., Nov 1 2019, In : The American Journal of Gastroenterology. 114, 11, p. 1764-1771 8 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Cohort Studies
Cardiovascular Diseases
Confidence Intervals
Mortality
2018
2 Citations (Scopus)

Application of multi-state models in cancer clinical trials

Le-Rademacher, J., Peterson, R. A., Therneau, T. M., Sanford, B. L., Stone, R. M. & Mandrekar, S. J., Jan 1 2018, (Accepted/In press) In : Clinical Trials.

Research output: Contribution to journalArticle

4'-N-benzoylstaurosporine
Clinical Trials
Proportional Hazards Models
Neoplasms
Software
1 Citation (Scopus)

Considerations for performing level-2 centiloid transformations for amyloid PET SUVR values

Schwarz, C., Tosakulwong, N., Senjem, M. L., Gunter, J. L., Therneau, T. M., Vemuri, P. D., Lowe, V. & Jack, C. R. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7421.

Research output: Contribution to journalArticle

Linear regression
Amyloid
Manuscripts
Pharmacokinetics
Genes
Neoplasms
9 Citations (Scopus)
Paraproteinemias
Multiple Myeloma
Precision Medicine
Genetic Predisposition to Disease
Cytogenetics
6 Citations (Scopus)
Waldenstrom Macroglobulinemia
Incidence
Population
Immunoglobulin M
Mortality
2 Citations (Scopus)

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation

Zhang, N., Jin, W., Zhou, S., Yang, J. D., Harmsen, W. S., Giama, N. H., Wongjarupong, N., Heimbach, J. K., Watt, K. D., Malhi, H. M., Therneau, T. M. & Roberts, L. R., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Hypothyroidism
Liver Transplantation
Hepatocellular Carcinoma
Survival
Recurrence
8 Citations (Scopus)

Joint associations of β-amyloidosis and cortical thickness with cognition

Knopman, D. S., Lundt, E. S., Therneau, T. M., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T., Petersen, R. C. & Jack, C. R. J., May 1 2018, In : Neurobiology of Aging. 65, p. 121-131 11 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Cognition
Positron-Emission Tomography
Alzheimer Disease
48 Citations (Scopus)

Longitudinal tau PET in ageing and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Schwarz, C., Lowe, V., Senjem, M. L., Vemuri, P. D., Weigand, S. D., Therneau, T. M., Knopman, D. S., Gunter, J. L., Jones, D. T., Graff-Radford, J., Kantarci, K. M., Roberts, R. O., Mielke, M. M., Machulda, M. M. & Petersen, R. C., May 1 2018, In : Brain. 141, 5, p. 1517-1528 12 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Sample Size
Brain
Outcome Assessment (Health Care)
65 Citations (Scopus)

Long-term follow-up of monoclonal gammopathy of undetermined significance

Kyle, R. A., Larson, D. R., Therneau, T. M., Dispenzieri, A., Kumar, S. K., Cerhan, J. R. & Rajkumar, S. V., Jan 18 2018, In : New England Journal of Medicine. 378, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Immunoglobulin M
Population
Light
Survival
2 Citations (Scopus)

Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models

Wongjarupong, N., Negron-Ocasio, G. M., Chaiteerakij, R., Addissie, B. D., Mohamed, E. A., Mara, K. C., Harmsen, W. S., Theobald, J. P., Peters, B. E., Balsanek, J. G., Ward, M. M., Giama, N. H., Venkatesh, S. K., Harnois, D., Charlton, M. R., Yamada, H., Algeciras-Schimnich, A., Snyder, M. R., Therneau, T. M. & Roberts, L. R., Mar 28 2018, In : World Journal of Gastroenterology. 24, 12, p. 1321-1331 11 p.

Research output: Contribution to journalReview article

alpha-Fetoproteins
Tumor Biomarkers
Hepatocellular Carcinoma
Transplants
Biomarkers
47 Citations (Scopus)

Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study

Allen, A., Therneau, T. M., Larson, J. J., Coward, A., Somers, V. & Kamath, P. S., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Incidence
Comorbidity
Mortality
Non-alcoholic Fatty Liver Disease
Young Adult
6 Citations (Scopus)

Predictors of Durability of Radiological Response in Patients with Small Bowel Crohn's Disease

Deepak, P., Fletcher, J. G., Fidler, J. L., Barlow, J. M., Sheedy, S. P., Kolbe, A. B., Harmsen, W. S., Therneau, T. M., Hansel, S. L., Becker, B. D., Loftus, Jr, E. V. & Bruining, D. H., Aug 16 2018, In : Inflammatory Bowel Diseases. 24, 9, p. 1815-1825 11 p.

Research output: Contribution to journalArticle

Crohn Disease
Magnetic Resonance Spectroscopy
Tomography
Maintenance
Confidence Intervals
6 Citations (Scopus)

Reduced Access to Liver Transplantation in Women: Role of Height, MELD Exception Scores, and Renal Function Underestimation

Allen, A., Heimbach, J. K., Larson, J. J., Mara, K. C., Kim, W. R., Kamath, P. S. & Therneau, T. M., Oct 1 2018, In : Transplantation. 102, 10, p. 1710-1716 7 p.

Research output: Contribution to journalArticle

End Stage Liver Disease
Liver Transplantation
Kidney
Tissue and Organ Procurement
Organ Transplantation
1 Citation (Scopus)

The impact of pharmacokinetic gene profiles across human cancers

Zimmermann, M. T., Therneau, T. M. & Kocher, J-P., May 21 2018, In : BMC Cancer. 18, 1, 577.

Research output: Contribution to journalArticle

Pharmacokinetics
Genes
Neoplasms
Survival
Therapeutics
52 Citations (Scopus)
Alzheimer Disease
Amyloid
Brain
Tauopathies
Neurofibrillary Tangles
2017
88 Citations (Scopus)
Tauopathies
Amyloid
Cross-Sectional Studies
Biomarkers
Medical Record Linkage
13 Citations (Scopus)

Beneficial and harmful effects of nonselective beta blockade on acute kidney injury in liver transplant candidates

Kim, S. G., Larson, J. J., Lee, J. S., Therneau, T. M. & Kim, W. R., Jun 1 2017, In : Liver Transplantation. 23, 6, p. 733-740 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Ascites
Transplants
Liver
Fibrosis
15 Citations (Scopus)
Rheumatoid Arthritis
Cardiovascular Diseases
Mortality
Arthritis
Coronary Disease
8 Citations (Scopus)

Factors Influencing Surveillance for Hepatocellular Carcinoma in Patients with Liver Cirrhosis

Ahmed Mohammed, H. A., Yang, J. D., Giama, N. H., Choi, J., Ali, H. M., Mara, K. C., Harmsen, W. S., Wiesner, R. H., Leise, M. D., Therneau, T. M. & Roberts, L. R., Feb 1 2017, In : Liver Cancer. 6, 2, p. 126-136 11 p.

Research output: Contribution to journalArticle

Open Access
Liver Cirrhosis
Hepatocellular Carcinoma
Fibrosis
Primary Health Care
Gastroenterology
11 Citations (Scopus)

Factors predictive of survival and estimated years of life lost in the decade following nontraumatic and traumatic spinal cord injury

Hatch, B. B., Wood-Wentz, C. M., Therneau, T. M., Walker, M. G., Payne, J. M. & Reeves, R. K., Feb 7 2017, (Accepted/In press) In : Spinal Cord.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Survival
Wounds and Injuries
Blood Vessels
Length of Stay
11 Citations (Scopus)
Rheumatoid Arthritis
Arthritis
Population
Linear Models
Heart Failure
19 Citations (Scopus)

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10-49 years old: a population-based study from the National Health and Nutrition Examination Survey

Landgren, O., Graubard, B. I., Kumar, S. K., Kyle, R. A., Katzmann, J. A., Murata, K., Costello, R., Dispenzieri, A., Caporaso, N., Mailankody, S., Korde, N., Hultcrantz, M., Therneau, T. M., Larson, D. R., Cerhan, J. R. & Rajkumar, S. V., Oct 20 2017, In : Blood Cancer Journal. 7, 10, p. e618

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Nutrition Surveys
Population
Age Groups
Age of Onset
3 Citations (Scopus)

The rationale, design, and methods of a randomized, controlled trial to evaluate the effectiveness of collaborative telecare in preserving function among patients with late stage cancer and hematologic conditions

Cheville, A. L., Moynihan, T., Basford, J. R., Nyman, J. A., Tuma, M. L., Macken, D. A., Therneau, T. M., Satelel, D. & Kroenke, K., 2017, (Accepted/In press) In : Contemporary Clinical Trials.

Research output: Contribution to journalArticle

Rehabilitation
Randomized Controlled Trials
Pain
Neoplasms
Quality of Life
2016
32 Citations (Scopus)

Aspirin use and the risk of cholangiocarcinoma

Choi, J., Ghoz, H. M., Peeraphatdit, T., Baichoo, E., Addissie, B. D., Harmsen, W. S., Therneau, T. M., Olson, J. E., Chaiteerakij, R. & Roberts, L. R., 2016, In : Hepatology. 64, 3, p. 785-796 12 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Aspirin
Confidence Intervals
Odds Ratio
Sclerosing Cholangitis
54 Citations (Scopus)

Assessing calibration of prognostic risk scores

Crowson, C., Atkinson, E. J., Therneau, T. M., Lawson, A. B., Lee, D. & MacNab, Y., Aug 1 2016, In : Statistical Methods in Medical Research. 25, 4, p. 1692-1706 15 p.

Research output: Contribution to journalArticle

Calibration
Survival Data
Binary Regression
Poisson Regression
Cox Model
6 Citations (Scopus)

A Topic-modeling Based Framework for Drug-drug Interaction Classification from Biomedical Text

Li, D., Liu, S., Rastegar-Mojarad, M., Wang, Y., Chaudhary, V., Therneau, T. M. & Liu, H. D., 2016, In : AMIA ... Annual Symposium proceedings. AMIA Symposium. 2016, p. 789-798 10 p.

Research output: Contribution to journalArticle

Drug Interactions
Pharmaceutical Preparations
Medication Errors
Learning
115 Citations (Scopus)

Defining imaging biomarker cut points for brain aging and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Therneau, T. M., Lowe, V., Knopman, D. S., Gunter, J. L., Senjem, M. L., Jones, D. T., Kantarci, K. M., Machulda, M. M., Mielke, M. M., Roberts, R. O., Vemuri, P. D., Reyes, D. A. & Petersen, R. C., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Brain Diseases
Positron-Emission Tomography
Alzheimer Disease
Biomarkers
Deoxyglucose
8 Citations (Scopus)

Peripheral Neutrophil to Lymphocyte Ratio Improves Prognostication in Colon Cancer

Rashtak, S., Ruan, X., Druliner, B. R., Liu, H. D., Therneau, T. M., Mouchli, M. & Boardman, L. A., Aug 18 2016, (Accepted/In press) In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Colonic Neoplasms
Neutrophils
Lymphocytes
Rectal Neoplasms
Survival
2015
4 Citations (Scopus)

Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma

Chaiteerakij, R., Juran, B. D., Aboelsoud, M. M., Harmsen, W. S., Moser, C. D., Giama, N. H., Allotey, L. K., Mettler, T. A., Baichoo, E., Zhang, X., Therneau, T. M., Lazaridis, K. N. & Roberts, L. R., Oct 1 2015, In : Cancer Medicine. 4, 10, p. 1599-1602 4 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Neoplasm Genes
Inflammation
Survival
Single Nucleotide Polymorphism
34 Citations (Scopus)

Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation

Chaiteerakij, R., Zhang, X., Addissie, B. D., Mohamed, E. A., Harmsen, W. S., Theobald, P. J., Peters, B. E., Balsanek, J. G., Ward, M. M., Giama, N. H., Moser, C. D., Oseini, A. M., Umeda, N., Venkatesh, S. K., Harnois, D., Charlton, M. R., Yamada, H., Satomura, S., Algeciras-Schimnich, A., Snyder, M. R. & 2 others, Therneau, T. M. & Roberts, L. R., May 1 2015, In : Liver Transplantation. 21, 5, p. 599-606 8 p.

Research output: Contribution to journalArticle

alpha-Fetoproteins
Liver Transplantation
Hepatocellular Carcinoma
Biomarkers
Recurrence