Research output per year
Research output per year
- 1 - 50 out of 125 results
Search results
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2024
Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo
Cabrera, G. T., Meijboom, K. E., Abdallah, A., Tran, H., Foster, Z., Weiss, A., Wightman, N., Stock, R., Gendron, T., Gruntman, A., Giampetruzzi, A., Petrucelli, L., Brown, R. H. & Mueller, C., Mar 2024, In: Gene Therapy. 31, 3-4, p. 105-118 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains
Chung, M., Carter, E. K., Veire, A. M., Dammer, E. B., Chang, J., Duong, D. M., Raj, N., Bassell, G. J., Glass, J. D., Gendron, T. F., Nelson, P. T., Levey, A. I., Seyfried, N. T. & McEachin, Z. T., Jun 2024, In: Acta neuropathologica. 147, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19 (iScience (2022) 25(11), (S2589004222015449), (10.1016/j.isci.2022.105272))
Erben, Y., Prudencio, M., Marquez, C. P., Jansen-West, K. R., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., Qosja, N., Song, Y., Al Shaikh, R. H., Daughrity, L. M., Bartfield, J. L., Day, G. S., Oskarsson, B., Nicholson, K. A., Wszolek, Z. K., Hoyne, J. B., Gendron, T. F., & 2 others, Apr 19 2024, In: iScience. 27, 4, 109501.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Fluid biomarkers for amyotrophic lateral sclerosis: a review
Irwin, K. E., Sheth, U., Wong, P. C. & Gendron, T. F., Dec 2024, In: Molecular neurodegeneration. 19, 1, 9.Research output: Contribution to journal › Review article › peer-review
Open Access -
2023
Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers
for the ALLFTD Consortium, Jan 1 2023, In: JAMA neurology. 80, 1, p. 82-90 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
Fujino, Y., Ueyama, M., Ishiguro, T., Ozawa, D., Ito, H., Sugiki, T., Murata, A., Ishiguro, A., Gendron, T., Mori, K., Tokuda, E., Taminato, T., Konno, T., Koyama, A., Kawabe, Y., Takeuchi, T., Furukawa, Y., Fujiwara, T., Ikeda, M., Mizuno, T., & 9 others, 2023, In: eLife. 12, 84338.Research output: Contribution to journal › Article › peer-review
Open Access -
Immunological drivers of amyotrophic lateral sclerosis
Gendron, T. F. & Petrucelli, L., 2023, In: Science translational medicine. 15, 721, eadj9332.Research output: Contribution to journal › Review article › peer-review
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Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
Lorenzini, I., Alsop, E., Levy, J., Gittings, L. M., Lall, D., Rabichow, B. E., Moore, S., Pevey, R., Bustos, L. M., Burciu, C., Bhatia, D., Singer, M., Saul, J., McQuade, A., Tzioras, M., Mota, T. A., Logemann, A., Rose, J., Almeida, S., Gao, F. B., & 12 others, 2023, In: Frontiers in Cellular Neuroscience. 17, 1179796.Research output: Contribution to journal › Article › peer-review
Open Access -
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions
Park, J., Wu, Y., Shao, W., Gendron, T. F., van der Spek, S. J. F., Sultanakhmetov, G., Basu, A., Castellanos Otero, P., Jones, C. J., Jansen-West, K., Daughrity, L. M., Phanse, S., del Rosso, G., Tong, J., Castanedes-Casey, M., Jiang, L., Libera, J., Oskarsson, B., Dickson, D. W., Sanders, D. W., & 5 others, Aug 29 2023, In: Cell reports. 42, 8, 112822.Research output: Contribution to journal › Article › peer-review
Open Access -
Race affects adverse outcomes of deep vein thrombosis, pulmonary embolism, and acute kidney injury in coronavirus disease 2019 hospitalized patients
Erben, Y., Marquez, C. P., Prudencio, M., Fortich, S., Gendron, T., Sanghavi, D., Hickson, L. T., Li, Y., Edwards, M. A., Ritchie, C., Franco, P. M., Petrucelli, L. & Meschia, J. F., Jan 2023, In: Journal of Vascular Surgery: Venous and Lymphatic Disorders. 11, 1, p. 19-24.e3Research output: Contribution to journal › Article › peer-review
Open Access -
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Attendees of the inaugural C9ORF72 FTD/ALS Summit, Dec 2023, In: Neurology and Therapy. 12, 6, p. 1821-1843 23 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo
Riemenschneider, H., Simonetti, F., Sheth, U., Katona, E., Roth, S., Hutten, S., Farny, D., Michaelsen, M., Nuscher, B., Schmidt, M. K., Flatley, A., Schepers, A., Gruijs da Silva, L. A., Zhou, Q., Klopstock, T., Liesz, A., Arzberger, T., Herms, J., Feederle, R., Gendron, T. F., & 2 others, Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 112.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome
Bush, J. A., Meyer, S. M., Fuerst, R., Tong, Y., Li, Y., Benhamou, R. I., Aikawa, H., Zanon, P. R. A., Gibaut, Q. M. R., Angelbello, A. J., Gendron, T. F., Zhang, Y. J., Petrucelli, L., Jensen, T. H., Childs-Disney, J. L. & Disney, M. D., Nov 29 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, e2210532119.Research output: Contribution to journal › Article › peer-review
Open Access -
ASLPrep: a platform for processing of arterial spin labeled MRI and quantification of regional brain perfusion
the ALLFTD Consortium, Jun 2022, In: Nature Methods. 19, 6, p. 683-686 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
ALLFTD consortium, Apr 19 2022, In: Cell Reports Medicine. 3, 4, 100607.Research output: Contribution to journal › Article › peer-review
Open Access -
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease
Jambeau, M., Meyer, K. D., Hruska-Plochan, M., Tabet, R., Lee, C. Z., Ray-Soni, A., Aguilar, C., Savage, K., Mishra, N., Cavegn, N., Borter, P., Lin, C. C., Jansen-West, K. R., Jiang, J., Freyermuth, F., Li, N., De Rossi, P., Pérez-Berlanga, M., Jiang, X., Daughrity, L. M., & 24 others, Dec 6 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 49, e2123487119.Research output: Contribution to journal › Article › peer-review
Open Access -
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
Meijboom, K. E., Abdallah, A., Fordham, N. P., Nagase, H., Rodriguez, T., Kraus, C., Gendron, T. F., Krishnan, G., Esanov, R., Andrade, N. S., Rybin, M. J., Ramic, M., Stephens, Z. D., Edraki, A., Blackwood, M. T., Kahriman, A., Henninger, N., Kocher, J. P. A., Benatar, M., Brodsky, M. H., & 6 others, Dec 2022, In: Nature communications. 13, 1, 6286.Research output: Contribution to journal › Article › peer-review
Open Access -
Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
Pickles, S., Gendron, T. F., Koike, Y., Yue, M., Song, Y., Kachergus, J. M., Shi, J., DeTure, M., Thompson, E. A., Oskarsson, B., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Wszolek, Z. K., Josephs, K. A., Dickson, D. W., Petrucelli, L., Cook, C. N. & Prudencio, M., Dec 2022, In: Acta Neuropathologica Communications. 10, 1, 107.Research output: Contribution to journal › Article › peer-review
Open Access -
Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Erben, Y., Prudencio, M., Marquez, C. P., Jansen-West, K. R., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., Qosja, N., Song, Y., Hanna Al Shaikh, R., Daughrity, L. M., Bartfield, J. L., Day, G. S., Oskarsson, B., Nicholson, K. A., Wszolek, Z. K., Hoyne, J. B., Gendron, T. F., & 2 others, Nov 18 2022, In: iScience. 25, 11, 105272.Research output: Contribution to journal › Article › peer-review
Open Access -
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
Gao, J., Mewborne, Q. T., Girdhar, A., Sheth, U., Coyne, A. N., Punathil, R., Kang, B. G., Dasovich, M., Veire, A., DeJesus Hernandez, M., Liu, S., Shi, Z., Dafinca, R., Fouquerel, E., Talbot, K., Kam, T. I., Zhang, Y. J., Dickson, D., Petrucelli, L., van Blitterswijk, M., & 8 others, Sep 14 2022, In: Science translational medicine. 14, 662, abq3215.Research output: Contribution to journal › Article › peer-review
Open Access -
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
Benatar, M., Wuu, J., McHutchison, C., Postuma, R. B., Boeve, B. F., Petersen, R., Ross, C. A., Rosen, H., Arias, J. J., Fradette, S., McDermott, M. P., Shefner, J., Stanislaw, C., Abrahams, S., Cosentino, S., Andersen, P. M., Finkel, R. S., Granit, V., Grignon, A. L., Rohrer, J. D., & 37 others, Jan 1 2022, In: Brain. 145, 1, p. 27-44 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Temporal order of clinical and biomarker changes in familial frontotemporal dementia
Frontotemporal Dementia Prevention Initiative (FPI) Investigators, ALLFTD Investigators & GENFI Investigators, Oct 2022, In: Nature Medicine. 28, 10, p. 2194-2206 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
Shao, W., Todd, T. W., Wu, Y., Jones, C. Y., Tong, J., Jansen-West, K., Daughrity, L. M., Park, J., Koike, Y., Kurti, A., Yue, M., Castanedes-Casey, M., del Rosso, G., Dunmore, J. A., Alepuz, D. Z., Oskarsson, B., Dickson, D. W., Cook, C. N., Prudencio, M., Gendron, T. F., & 3 others, Oct 7 2022, In: Science. 378, 6615, p. 94-99 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
Sonobe, Y., Aburas, J., Krishnan, G., Fleming, A. C., Ghadge, G., Islam, P., Warren, E. C., Gu, Y., Kankel, M. W., Brown, A. E. X., Kiskinis, E., Gendron, T. F., Gao, F. B., Roos, R. P. & Kratsios, P., Dec 1 2021, In: Nature communications. 12, 1, 6025.Research output: Contribution to journal › Article › peer-review
Open Access -
Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial
Krull, A. A., Setter, D. O., Gendron, T. F., Hrstka, S. C. L., Polzin, M. J., Hart, J., Dudakovic, A., Madigan, N. N., Dietz, A. B., Windebank, A. J., van Wijnen, A. J. & Staff, N. P., Dec 2021, In: Stem Cell Research and Therapy. 12, 1, 187.Research output: Contribution to journal › Article › peer-review
Open Access -
A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks
Ursu, A., Baisden, J. T., Bush, J. A., Taghavi, A., Choudhary, S., Zhang, Y. J., Gendron, T. F., Petrucelli, L., Yildirim, I. & Disney, M. D., Nov 3 2021, In: ACS Chemical Neuroscience. 12, 21, p. 4076-4089 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019–positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system
Erben, Y., Franco-Mesa, C., Gloviczki, P., Stone, W., Quinones-Hinojoas, A., Meltzer, A. J., Lin, M., Greenway, M. R. F., Hamid, O., Devcic, Z., Toskich, B., Ritchie, C., Lamb, C. J., De Martino, R. R., Siegel, J., Farres, H., Hakaim, A. G., Sanghavi, D. K., Li, Y., Rivera, C., & 15 others, Nov 2021, In: Journal of Vascular Surgery: Venous and Lymphatic Disorders. 9, 6, p. 1361-1370.e1Research output: Contribution to journal › Article › peer-review
Open Access -
Long-read targeted sequencing uncovers clinicopathological associations for C9orf72-linked diseases
Dejesus-Hernandez, M., Aleff, R. A., Jackson, J. L., Finch, N. A., Baker, M. C., Gendron, T. F., Murray, M. E., McLaughlin, I. J., Harting, J. R., Graff-Radford, N. R., Oskarsson, B., Knopman, D. S., Josephs, K. A., Boeve, B. F., Petersen, R. C., Fryer, J. D., Petrucelli, L., DIckson, D. W., Rademakers, R., Ebbert, M. T. W., & 2 others, Apr 1 2021, In: Brain. 144, 4, p. 1082-1088 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
Bush, J. A., Aikawa, H., Fuerst, R., Li, Y., Ursu, A., Meyer, S. M., Benhamou, R. I., Chen, J. L., Khan, T., Wagner-Griffin, S., van Meter, M. J., Tong, Y., Olafson, H., McKee, K. K., Childs-Disney, J. L., Gendron, T. F., Zhang, Y., Coyne, A. N., Wang, E. T., Yildirim, I., & 4 others, Oct 27 2021, In: Science translational medicine. 13, 617, eabd5991.Research output: Contribution to journal › Article › peer-review
Open Access -
Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples
Watzlawik, J. O., Hou, X., Fricova, D., Ramnarine, C., Barodia, S. K., Gendron, T. F., Heckman, M. G., DeTure, M., Siuda, J., Wszolek, Z. K., Scherzer, C. R., Ross, O. A., Bu, G., Dickson, D. W., Goldberg, M. S., Fiesel, F. C. & Springer, W., 2021, In: Autophagy. 17, 9, p. 2613-2628 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19
Prudencio, M., Erben, Y., Marquez, C. P., Jansen-West, K. R., Franco-Mesa, C., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., Song, Y., Harlow, C. F., Oskarsson, B., Nicholson, K. A., Wszolek, Z. K., Hickson, L. T. J., O’Horo, J. C., Hoyne, J. B., Gendron, T. F., Meschia, J. F., & 1 others, 2021, In: Science translational medicine. 13, 602, eabi7643.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy
Cook, C. N., Wu, Y., Odeh, H. M., Gendron, T. F., Jansen-West, K., del Rosso, G., Yue, M., Jiang, P., Gomes, E., Tong, J., Daughrity, L. M., Avendano, N. M., Castanedes-Casey, M., Shao, W., Oskarsson, B., Tomassy, G. S., McCampbell, A., Rigo, F., Dickson, D. W., Shorter, J., & 2 others, 2020, In: Science translational medicine. 12, 559, , eabb3774.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
Neuro–CEB Neuropathology Network, Jul 22 2020, In: Neuron. 107, 2, p. 292-305.e6Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes
Vu, L., An, J., Kovalik, T., Gendron, T., Petrucelli, L. & Bowser, R., Apr 1 2020, In: Journal of Neurology, Neurosurgery and Psychiatry. 91, 4, p. 350-358 9 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD
Andrade, N. S., Ramic, M., Esanov, R., Liu, W., Rybin, M. J., Gaidosh, G., Abdallah, A., Del'olio, S., Huff, T. C., Chee, N. T., Anatha, S., Gendron, T. F., Wahlestedt, C., Zhang, Y., Benatar, M., Mueller, C. & Zeier, Z., Feb 24 2020, In: Molecular neurodegeneration. 15, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo
Todd, T. W., McEachin, Z. T., Chew, J., Burch, A. R., Jansen-West, K., Tong, J., Yue, M., Song, Y., Castanedes-Casey, M., Kurti, A., Dunmore, J. H., Fryer, J. D., Zhang, Y. J., San Millan, B., Teijeira Bautista, S., Arias, M., Dickson, D., Gendron, T. F., Sobrido, M. J., Disney, M. D., & 3 others, May 5 2020, In: Cell reports. 31, 5, 107616.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
Ortega, J. A., Daley, E. L., Kour, S., Samani, M., Tellez, L., Smith, H. S., Hall, E. A., Esengul, Y. T., Tsai, Y. H., Gendron, T. F., Donnelly, C. J., Siddique, T., Savas, J. N., Pandey, U. B. & Kiskinis, E., Apr 8 2020, In: Neuron. 106, 1, p. 90-107.e13Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Plasma neurofilament light predicts mortality in patients with stroke
Gendron, T. F., Badi, M. K., Heckman, M. G., Jansen-West, K. R., Vilanilam, G. K., Johnson, P. W., Burch, A. R., Walton, R. L., Ross, O. A., Brott, T. G., Miller, T. M., Berry, J. D., Nicholson, K. A., Wszolek, Z. K., Oskarsson, B. E., Sheth, K. N., Sansing, L. H., Falcone, G. J., Cucchiara, B. L., Meschia, J. F., & 1 others, Nov 11 2020, In: Science translational medicine. 12, 569, eaay1913.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72
Zhu, Q., Jiang, J., Gendron, T. F., McAlonis-Downes, M., Jiang, L., Taylor, A., Diaz Garcia, S., Ghosh Dastidar, S., Rodriguez, M. J., King, P., Zhang, Y., La Spada, A. R., Xu, H., Petrucelli, L., Ravits, J., Da Cruz, S., Lagier-Tourenne, C. & Cleveland, D. W., May 1 2020, In: Nature Neuroscience. 23, 5, p. 615-624 10 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD
Ursu, A., Wang, K. W., Bush, J. A., Choudhary, S., Chen, J. L., Baisden, J. T., Zhang, Y. J., Gendron, T. F., Petrucelli, L., Yildirim, I. & Disney, M. D., Dec 18 2020, In: ACS Chemical Biology. 15, 12, p. 3112-3123 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3
Prudencio, M., Garcia-Moreno, H., Jansen-West, K. R., AL-Shaikh, R. H., Gendron, T. F., Heckman, M. G., Spiegel, M. R., Carlomagno, Y., Daughrity, L. M., Song, Y., Dunmore, J. A., Byron, N., Oskarsson, B., Nicholson, K. A., Staff, N. P., Gorcenco, S., Puschmann, A., Lemos, J., Januário, C., LeDoux, M. S., & 32 others, Oct 21 2020, In: Science translational medicine. 12, 566, eabb7086.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
NYGC ALS Consortium, Nov 2 2020, In: Journal of Clinical Investigation. 130, 11, p. 6080-6092 13 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2019
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
Chew, J., Cook, C., Gendron, T. F., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. J. & Petrucelli, L., Feb 15 2019, In: Molecular neurodegeneration. 14, 1, 9.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers
Dickson, D. W., Baker, M. C., Jackson, J. L., Dejesus-Hernandez, M., Finch, N. C. A., Tian, S., Heckman, M. G., Pottier, C., Gendron, T. F., Murray, M. E., Ren, Y., Reddy, J. S., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Knopman, D. S., Josephs, K. A., Petrucelli, L., Oskarsson, B., Sheppard, J. W., & 3 others, Oct 8 2019, In: Acta Neuropathologica Communications. 7, 1, 150.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y., & 15 others, Feb 15 2019, In: Science. 363, 6428, eaav2606.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
Yamada, S. B., Gendron, T. F., Niccoli, T., Genuth, N. R., Grosely, R., Shi, Y., Glaria, I., Kramer, N. J., Nakayama, L., Fang, S., Dinger, T. J. I., Thoeng, A., Rocha, G., Barna, M., Puglisi, J. D., Partridge, L., Ichida, J. K., Isaacs, A. M., Petrucelli, L. & Gitler, A. D., Sep 1 2019, In: Nature Neuroscience. 22, 9, p. 1383-1388 6 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
The Hairpin Form of r(G 4 C 2 ) exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules
Wang, Z. F., Ursu, A., Childs-Disney, J. L., Guertler, R., Yang, W. Y., Bernat, V., Rzuczek, S. G., Fuerst, R., Zhang, Y. J., Gendron, T. F., Yildirim, I., Dwyer, B. G., Rice, J. E., Petrucelli, L. & Disney, M. D., Feb 21 2019, In: Cell Chemical Biology. 26, 2, p. 179-190.e12Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD
Yuva-Aydemir, Y., Almeida, S., Krishnan, G., Gendron, T. F. & Gao, F. B., Dec 1 2019, In: Nature communications. 10, 1, 5466.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2018
Amyotrophic Lateral Sclerosis: An Update for 2018
Oskarsson, B., Gendron, T. F. & Staff, N. P., Nov 2018, In: Mayo Clinic proceedings. 93, 11, p. 1617-1628 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access78 Scopus citations -
A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism
Swinnen, B., Bento-Abreu, A., Gendron, T. F., Boeynaems, S., Bogaert, E., Nuyts, R., Timmers, M., Scheveneels, W., Hersmus, N., Wang, J., Mizielinska, S., Isaacs, A. M., Petrucelli, L., Lemmens, R., Van Damme, P., Van Den Bosch, L. & Robberecht, W., Mar 1 2018, In: Acta neuropathologica. 135, 3, p. 427-443 17 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations