Takahisa Kanekiyo, MD, PhD

  • 3561 Citations
  • 30 Scopus h-Index
20052019
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Research Output 2005 2019

  • 3561 Citations
  • 30 Scopus h-Index
  • 58 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
Serotonin 5-HT3 Receptor Antagonists
Ondansetron
secretions
Apolipoproteins E
liver

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Aikawa, T., Ren, Y., Yamazaki, Y., Tachibana, M., Johnson, M. R., Anderson, C. T., Martens, Y. A., Holm, M. L., Asmann, Y. W., Saito, T., Saido, T. C., Fitzgerald, M. L., Bu, G. & Kanekiyo, T., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23790-23796 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid
Brain
Nonsense Codon
Microglia

ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles

Dos Santos Rodrigues, B., Kanekiyo, T. & Singh, J., Sep 16 2019, In : Pharmaceutical research. 36, 11, 1 p.

Research output: Contribution to journalArticle

Gene therapy
Apolipoproteins E
Transferrin
Liposomes
Genetic Therapy
5 Citations (Scopus)

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid
Apolipoprotein E4
Pathology
Alzheimer Disease

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties

Santos Rodrigues, B. D., Lakkadwala, S., Kanekiyo, T. & Singh, J., Jan 1 2019, In : International journal of nanomedicine. 14, p. 6497-6517 21 p.

Research output: Contribution to journalArticle

Open Access
Liposomes
Nanoparticles
Lipids
Brain
Screening
1 Citation (Scopus)

Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection

dos Santos Rodrigues, B., Banerjee, A., Kanekiyo, T. & Singh, J., Jul 20 2019, In : International Journal of Pharmaceutics. 566, p. 717-730 14 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Liposomes
Nanoparticles
Transfection
Endocytosis
6 Citations (Scopus)

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T. & Bu, G. D., Apr 1 2019, In : Brain : a journal of neurology. 142, 4, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Disease Progression
Alzheimer Disease
Amyloid
Brain
2018
9 Citations (Scopus)

Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection

dos Santos Rodrigues, B., Oue, H., Banerjee, A., Kanekiyo, T. & Singh, J., Sep 28 2018, In : Journal of Controlled Release. 286, p. 264-278 15 p.

Research output: Contribution to journalArticle

Coculture Techniques
Blood-Brain Barrier
Liposomes
Transfection
Genes
9 Citations (Scopus)

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G. D., Zhou, Y. & Li, Y., Jul 1 2018, In : Tissue Engineering - Part A. 24, 13-14, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

Organoids
Stem cells
Induced Pluripotent Stem Cells
Alzheimer Disease
Stem Cells
4 Citations (Scopus)

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. D. & Ross, O. A., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Multiple System Atrophy
Synucleins
Apolipoproteins E
Oligodendroglia
Protein Isoforms
9 Citations (Scopus)

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Tachibana, M., Yamazaki, Y., Liu, C-C., Bu, G. D. & Kanekiyo, T., Feb 1 2018, In : Experimental Neurology. 300, p. 13-21 9 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Pericytes
Amyloid
Pathology
Brain
2017
31 Citations (Scopus)

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Astrocytes
Apolipoproteins E
Genotype
Protein Isoforms
42 Citations (Scopus)

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Liu, C-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Amyloid
Astrocytes
Alzheimer Disease
Brain
9 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
2016
43 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
30 Citations (Scopus)

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Apolipoproteins E
Apolipoprotein E2
Cholesterol
Amyloid
Alleles
32 Citations (Scopus)

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Alzheimer Disease
Research
Therapeutics
Biological Phenomena
19 Citations (Scopus)

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C-C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G. D., May 5 2016, In : Molecular Neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Apolipoproteins
Apolipoproteins E
Amyloid
Lipoproteins
24 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
28 Citations (Scopus)

LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways

Yang, L., Liu, C-C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F. & Bu, G. D., Dec 8 2016, In : Journal of Neuroinflammation. 13, 1, 304.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Phosphotransferases
Microglia
Proteins
Alzheimer Disease
36 Citations (Scopus)

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

Liu, C-C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Mar 30 2016, In : Science Translational Medicine. 8, 332, 332ra44.

Research output: Contribution to journalArticle

Heparitin Sulfate
Amyloid
Alzheimer Disease
Pathology
Brain
28 Citations (Scopus)

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

Tachibana, M., Shinohara, M., Yamazaki, Y., Liu, C-C., Rogers, J., Bu, G. D. & Kanekiyo, T., Mar 1 2016, In : Experimental Neurology. 277, p. 1-9 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Retinoid X Receptors
Synapses
Apolipoproteins E
Proteins
54 Citations (Scopus)

The role of APOE in cerebrovascular dysfunction

Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J. & Bu, G. D., Feb 16 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-15 15 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Cerebrovascular Circulation
Pericytes
Apolipoproteins E
Astrocytes
33 Citations (Scopus)

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C-C., Van Deursen, J., Brott, T. G., Bu, G. D. & Kanekiyo, T., Feb 16 2016, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

Cell Aging
Pericytes
Blood Vessels
Tight Junctions
Microvessels
2015
22 Citations (Scopus)

Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway

Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G. D. & Kanekiyo, T., May 29 2015, In : Journal of Biological Chemistry. 290, 22, p. 14208-14217 10 p.

Research output: Contribution to journalArticle

rhoA GTP-Binding Protein
Pericytes
Apolipoproteins E
Low Density Lipoprotein Receptor-Related Protein-1
Alzheimer Disease
154 Citations (Scopus)

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G. D., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., Miller, C. A., Schneider, J. A., Maeda, M., Maeda, T., Sugawara, T. & 2 others, Ichida, J. K. & Zlokovic, B. V., Jun 25 2015, In : Nature Neuroscience. 18, 7, p. 978-987 10 p.

Research output: Contribution to journalArticle

Transcytosis
Blood-Brain Barrier
Amyloid
Alzheimer Disease
Brain
27 Citations (Scopus)

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Wren, M. C., Zhao, J., Liu, C-C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R. V., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Sep 15 2015, In : Molecular Neurodegeneration. 10, 1, 42.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Frontotemporal Dementia
Neural Stem Cells
Mutation
Substantia Nigra
5 Citations (Scopus)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

Clusterin
Alzheimer Disease
Genes
Brain
Cerebrospinal Fluid
5 Citations (Scopus)

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

Harriott, A. M., Heckman, M. G., Rayaprolu, S., Soto-Ortolaza, A. I., Diehl, N. N., Kanekiyo, T., Liu, C-C., Bu, G. D., Malik, R., Cole, J. W., Meschia, J. F., Ross, O. A. & for the METASTROKE Consortium, T. METASTROKE. C., Aug 1 2015, In : European Journal of Neurology. 22, 8, p. 1235-1241 7 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-1
Stroke
Genes
Odds Ratio
23 Citations (Scopus)

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Animals
Animal Models
Modulation
Glycogen Synthase Kinase 3
49 Citations (Scopus)

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

Liu, C-C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T. & Bu, G. D., Apr 8 2015, In : Journal of Neuroscience. 35, 14, p. 5851-5859 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Alzheimer Disease
Insulin
Glucose
Brain
2014
231 Citations (Scopus)

ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?

Kanekiyo, T., Xu, H. & Bu, G. D., Feb 19 2014, In : Neuron. 81, 4, p. 740-754 15 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Alzheimer Disease
Apolipoprotein E4
Protein Isoforms
Low Density Lipoprotein Receptor-Related Protein-1
80 Citations (Scopus)

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C-C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G. D., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Amyloid
Alzheimer Disease
Pathology
Protein Deficiency
15 Citations (Scopus)
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Isoxazoles
AMPA Receptors
low density lipoprotein
24 Citations (Scopus)

Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Zhao, J., Fu, Y., Liu, C-C., Shinohara, M., Nielsen, H. M., Dong, Q., Kanekiyo, T. & Bu, G. D., Apr 18 2014, In : Journal of Biological Chemistry. 289, 16, p. 11282-11292 11 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Retinoic Acid Receptors
Apolipoproteins
Apolipoproteins E
Tretinoin
97 Citations (Scopus)
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Amyloid
Alzheimer Disease
Proteins
17 Citations (Scopus)

Tyrosine-based signal mediates lrp6 receptor endocytosis and desensitization of wnt/β-catenin pathway signaling

Liu, C-C., Kanekiyo, T., Roth, B. & Bu, G. D., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 7562-27570 20009 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Catenins
Wnt Signaling Pathway
Endocytosis
Tyrosine
2013
1042 Citations (Scopus)

Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy

Liu, C-C., Kanekiyo, T., Xu, H. & Bu, G. D., Feb 2013, In : Nature Reviews Neurology. 9, 2, p. 106-118 13 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Alzheimer Disease
Alleles
Lipids
8 Citations (Scopus)
Apolipoproteins
Neurology
Alzheimer Disease
Therapeutics
111 Citations (Scopus)

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Kanekiyo, T., Cirrito, J. R., Liu, C-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M. & Bu, G. D., 2013, In : Journal of Neuroscience. 33, 49, p. 19276-19283 8 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Amyloid
Alzheimer Disease
Neurons
Amyloid beta-Protein Precursor
2012
110 Citations (Scopus)

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., Weeber, E. J., Bu, G. D., Yu, C. & LaDu, M. J., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41774-41786 13 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Apolipoprotein E4
Transgenic Mice
Alzheimer Disease
Amyloid
97 Citations (Scopus)

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M. J., Xu, H. & Bu, G. D., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44593-44601 9 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lysosomes
Amyloid
Alzheimer Disease
Protein Isoforms
10 Citations (Scopus)

Familial frontotemporal dementia-associated Presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice

Watanabe, H., Xia, D., Kanekiyo, T., Kelleher, R. J. & Shen, J., Apr 11 2012, In : Journal of Neuroscience. 32, 15, p. 5085-5096 12 p.

Research output: Contribution to journalArticle

Presenilins
Presenilin-1
Frontotemporal Dementia
Dementia
Amyloid Precursor Protein Secretases
82 Citations (Scopus)

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Youmans, K. L., Tai, L. M., Kanekiyo, T., Stine, W. B., Michon, S. C., Nwabuisi-Heath, E., Manelli, A. M., Fu, Y., Riordan, S., Eimer, W. A., Binder, L., Bu, G. D., Yu, C., Hartley, D. M. & Ladu, M. J., 2012, In : Molecular Neurodegeneration. 7, 1, 8.

Research output: Contribution to journalArticle

Antibodies
Brain
Transgenic Mice
Alzheimer Disease
Cathepsin D
107 Citations (Scopus)

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

Kanekiyo, T., Liu, C-C., Shinohara, M., Li, J. & Bu, G. D., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16458-16465 8 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Amyloid
Smooth Muscle Myocytes
Cerebral Amyloid Angiopathy
Lipoproteins
2011
94 Citations (Scopus)
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Heparan Sulfate Proteoglycans
Amyloid
Proteins
2010
73 Citations (Scopus)

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal trafficking

Fuentealba, R. A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J. M., Ladu, M. J. & Bu, G. D., 2010, In : PLoS One. 5, 7, e11884.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
amyloid
low density lipoprotein
Amyloid
2009
65 Citations (Scopus)

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway

Fuentealba, R. A., Liu, Q., Kanekiyo, T., Zhang, J. & Bu, G. D., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 34045-34053 9 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Neurons
Proteins
Insulin Receptor
2 Citations (Scopus)

LRP1 and cerebral amyloid angiopathy

Kanekiyo, T. & Bu, G. D., 2009, In : Future Neurology. 4, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Extracellular Fluid
Drainage
Low Density Lipoprotein Receptor-Related Protein-1
Cerebral Hemorrhage
36 Citations (Scopus)

Receptor-associated protein interacts with amyloid-β peptide and promotes its cellular uptake

Kanekiyo, T. & Bu, G. D., Nov 27 2009, In : Journal of Biological Chemistry. 284, 48, p. 33352-33359 8 p.

Research output: Contribution to journalArticle

Amyloid
Peptides
Proteins
Apolipoproteins E
Cricetulus