Takahisa Kanekiyo, MD, PhD

  • 3813 Citations
  • 31 Scopus h-Index
20052019

Research output per year

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Research Output

  • 3813 Citations
  • 31 Scopus h-Index
  • 52 Article
  • 8 Review article
  • 2 Comment/debate
  • 1 Chapter
2019

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Aikawa, T., Ren, Y., Yamazaki, Y., Tachibana, M., Johnson, M. R., Anderson, C. T., Martens, Y. A., Holm, M. L., Asmann, Y. W., Saito, T., Saido, T. C., Fitzgerald, M. L., Bu, G. & Kanekiyo, T., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23790-23796 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles

dos Santos Rodrigues, B., Kanekiyo, T. & Singh, J., Nov 1 2019, In : Pharmaceutical research. 36, 11, 161.

Research output: Contribution to journalArticle

1 Scopus citations

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties

Santos Rodrigues, B. D., Lakkadwala, S., Kanekiyo, T. & Singh, J., Jan 1 2019, In : International journal of nanomedicine. 14, p. 6497-6517 21 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Functionalized liposomal nanoparticles for efficient gene delivery system to neuronal cell transfection

dos Santos Rodrigues, B., Banerjee, A., Kanekiyo, T. & Singh, J., Jul 20 2019, In : International Journal of Pharmaceutics. 566, p. 717-730 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T. & Bu, G., Jan 1 2019, In : Brain. 142, 4, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

ABCA7 and pathogenic pathways of Alzheimer’s disease

Aikawa, T., Holm, M. L. & Kanekiyo, T., Feb 1 2018, In : Brain Sciences. 8, 2, 27.

Research output: Contribution to journalReview article

20 Scopus citations

Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection

dos Santos Rodrigues, B., Oue, H., Banerjee, A., Kanekiyo, T. & Singh, J., Sep 28 2018, In : Journal of Controlled Release. 286, p. 264-278 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G. D., Zhou, Y. & Li, Y., Jul 1 2018, In : Tissue Engineering - Part A. 24, 13-14, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. & Ross, O. A., Apr 2018, In : Movement Disorders. 33, 4, p. 647-650 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Tachibana, M., Yamazaki, Y., Liu, C-C., Bu, G. D. & Kanekiyo, T., Feb 1 2018, In : Experimental Neurology. 300, p. 13-21 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Blood-brain barrier dysfunction and the pathogenesis of alzheimer’s disease

Yamazaki, Y. & Kanekiyo, T., Sep 13 2017, In : International Journal of Molecular Sciences. 18, 9, 1965.

Research output: Contribution to journalReview article

56 Scopus citations

Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies

Shinohara, M., Tachibana, M., Kanekiyo, T. & Bu, G. D., 2017, In : Journal of Lipid Research. 58, 7, p. 1267-1281 15 p.

Research output: Contribution to journalReview article

36 Scopus citations

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

35 Scopus citations

Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease

Kanekiyo, T. & Bu, G. D., 2016, Genes, Environment and Alzheimer's Disease. Elsevier Inc., p. 171-196 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C. C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G., May 5 2016, In : Molecular neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

22 Scopus citations

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., DeTure, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C. C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J. E., Dickson, D. W., Bu, G. & Kanekiyo, T., Aug 1 2016, In : Acta neuropathologica. 132, 2, p. 225-234 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways

Yang, L., Liu, C. C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F. & Bu, G., Dec 8 2016, In : Journal of Neuroinflammation. 13, 1, 304.

Research output: Contribution to journalArticle

31 Scopus citations

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

Liu, C-C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Mar 30 2016, In : Science Translational Medicine. 8, 332, 332ra44.

Research output: Contribution to journalArticle

43 Scopus citations

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

Tachibana, M., Shinohara, M., Yamazaki, Y., Liu, C-C., Rogers, J., Bu, G. D. & Kanekiyo, T., Mar 1 2016, In : Experimental Neurology. 277, p. 1-9 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

The role of APOE in cerebrovascular dysfunction

Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J. & Bu, G., May 1 2016, In : Acta neuropathologica. 131, 5, p. 709-723 15 p.

Research output: Contribution to journalReview article

58 Scopus citations

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C-C., Van Deursen, J., Brott, T. G., Bu, G. D. & Kanekiyo, T., Feb 16 2016, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

40 Scopus citations
2015

Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway

Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G. D. & Kanekiyo, T., May 29 2015, In : Journal of Biological Chemistry. 290, 22, p. 14208-14217 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., Miller, C. A., Schneider, J. A., Maeda, M., Maeda, T., Sugawara, T. & 2 others, Ichida, J. K. & Zlokovic, B. V., Jun 25 2015, In : Nature Neuroscience. 18, 7, p. 978-987 10 p.

Research output: Contribution to journalArticle

163 Scopus citations

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T. & Bu, G., Sep 15 2015, In : Molecular neurodegeneration. 10, 1, 42.

Research output: Contribution to journalArticle

28 Scopus citations

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

Harriott, A. M., Heckman, M. G., Rayaprolu, S., Soto-Ortolaza, A. I., Diehl, N. N., Kanekiyo, T., Liu, C-C., Bu, G. D., Malik, R., Cole, J. W., Meschia, J. F., Ross, O. A. & for the METASTROKE Consortium, T. METASTROKE. C., Aug 1 2015, In : European Journal of Neurology. 22, 8, p. 1235-1241 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

Liu, C-C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T. & Bu, G. D., Apr 8 2015, In : Journal of Neuroscience. 35, 14, p. 5851-5859 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2014

ApoE and Aβ in Alzheimer's disease: Accidental encounters or partners?

Kanekiyo, T., Xu, H. & Bu, G., Feb 19 2014, In : Neuron. 81, 4, p. 740-754 15 p.

Research output: Contribution to journalReview article

247 Scopus citations

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C. C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

85 Scopus citations
15 Scopus citations

Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Zhao, J., Fu, Y., Liu, C. C., Shinohara, M., Nielsen, H. M., Dong, Q., Kanekiyo, T. & Bu, G., Apr 18 2014, In : Journal of Biological Chemistry. 289, 16, p. 11282-11292 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
99 Scopus citations

Tyrosine-based signal mediates lrp6 receptor endocytosis and desensitization of wnt/β-catenin pathway signaling

Liu, C. C., Kanekiyo, T., Roth, B. & Bu, G., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 27562-27570 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy

Liu, C. C., Kanekiyo, T., Xu, H. & Bu, G., Feb 1 2013, In : Nature Reviews Neurology. 9, 2, p. 106-118 13 p.

Research output: Contribution to journalReview article

1106 Scopus citations
8 Scopus citations

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Kanekiyo, T., Cirrito, J. R., Liu, C. C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M. & Bu, G., Dec 9 2013, In : Journal of Neuroscience. 33, 49, p. 19276-19283 8 p.

Research output: Contribution to journalArticle

118 Scopus citations
2012

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of alzheimer disease

Youmans, K. L., Tai, L. M., Nwabuisi-Heath, E., Jungbauer, L., Kanekiyo, T., Gan, M., Kim, J., Eimer, W. A., Estus, S., Rebeck, G. W., Weeber, E. J., Bu, G., Yu, C. & LaDu, M. J., Dec 7 2012, In : Journal of Biological Chemistry. 287, 50, p. 41774-41786 13 p.

Research output: Contribution to journalArticle

117 Scopus citations

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M. J., Xu, H. & Bu, G., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44593-44601 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Familial frontotemporal dementia-associated Presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice

Watanabe, H., Xia, D., Kanekiyo, T., Kelleher, R. J. & Shen, J., Apr 11 2012, In : Journal of Neuroscience. 32, 15, p. 5085-5096 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Youmans, K. L., Tai, L. M., Kanekiyo, T., Stine, W. B., Michon, S. C., Nwabuisi-Heath, E., Manelli, A. M., Fu, Y., Riordan, S., Eimer, W. A., Binder, L., Bu, G., Yu, C., Hartley, D. M. & Ladu, M. J., Mar 19 2012, In : Molecular neurodegeneration. 7, 1, 8.

Research output: Contribution to journalArticle

85 Scopus citations

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

Kanekiyo, T., Liu, C. C., Shinohara, M., Li, J. & Bu, G., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16458-16465 8 p.

Research output: Contribution to journalArticle

111 Scopus citations