• 41743 Citations
  • 104 Scopus h-Index
1980 …2020

Research output per year

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Article
2003

Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β

Rickard, D. J., Monroe, D. G., Ruesink, T. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Jun 1 2003, In : Journal of cellular biochemistry. 89, 3, p. 633-646 14 p.

Research output: Contribution to journalArticle

99 Scopus citations
40 Scopus citations

Role of parathyroid hormone in mediating age-related changes in bone resorption in men

Kennel, K. A., Riggs, B. L., Achenbach, S. J., Oberg, A. L. & Khosla, S., Aug 2003, In : Osteoporosis International. 14, 8, p. 631-636 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

Eghbali-Fatourechi, G., Khosla, S., Sanyal, A., Boyle, W. J., Lacey, D. L. & Riggs, B. L., Apr 2003, In : Journal of Clinical Investigation. 111, 8, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

558 Scopus citations

Surrogates for Fracture Endpoints in Clinical Trials

Khosla, S., Jun 1 2003, In : Journal of Bone and Mineral Research. 18, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

29 Scopus citations
2002

Correlates of osteoprotegerin levels in women and men

Khosla, S., Arrighi, H. M., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Dunstan, C. & Riggs, B. L., Jun 24 2002, In : Osteoporosis International. 13, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men

Khosla, S., Atkinson, E. J., Dunstan, C. R. & O'Fallon, W. M., Jan 1 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 4, p. 1550-1554 5 p.

Research output: Contribution to journalArticle

Open Access
153 Scopus citations

Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts

Rickard, D. J., Waters, K. M., Ruesink, T. J., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Riggs, B. L. & Spelsberg, T. C., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 4, p. 580-592 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Fracture risk in primary hyperparathyroidism

Khosla, S. & Melton, L. J., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2, p. N103-N107

Research output: Contribution to journalArticle

70 Scopus citations

Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study

French, A. R., Mason, T., Nelson, A. M., Crowson, C. S., O'Fallon, W. M., Khosla, S. & Gabriel, S. E., May 20 2002, In : Journal of Rheumatology. 29, 5, p. 1065-1070 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells

Hofbauer, L. C., Hicok, K. C., Chen, D. & Khosla, S., Aug 2002, In : European journal of endocrinology. 147, 2, p. 269-273 5 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women

Heshmati, H. M., Khosla, S., Robins, S. P., O'Fallon, W. M., Melton, L. J. & Riggs, B. L., 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

163 Scopus citations

Secondary osteoporosis and the risk of distal forearm fractures in men and women

Melton, L. J., Achenbach, S. J., O'fallon, W. M. & Khosla, S., Jan 1 2002, In : Bone. 31, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalArticle

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

60 Scopus citations
50 Scopus citations
Open Access
27 Scopus citations
2001

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

72 Scopus citations

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells

Hofbauer, L. C., Shui, C., Riggs, B. L., Dunstan, C. R., Spelsberg, T. C., O'Brien, T. & Khosla, S., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 280, 1, p. 334-339 6 p.

Research output: Contribution to journalArticle

184 Scopus citations

Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men

Doran, P. M., Riggs, B. L., Atkinson, E. J. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 2118-2125 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., 2001, In : Journal of cellular biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle

72 Scopus citations

Estrogens and bone health in men

Khosla, S., Melton, L. J. & Riggs, B. L., Nov 17 2001, In : Calcified Tissue International. 69, 4, p. 189-192 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., Jan 1 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

Open Access
250 Scopus citations
Open Access
66 Scopus citations

Regulation of osteoclastogenesis and RANK expression by TGF-β1

Yan, T., Riggs, B. L., Boyle, W. J. & Khosla, S., Oct 6 2001, In : Journal of cellular biochemistry. 83, 2, p. 320-325 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men

Khosla, S., Melton, L. J., Atkinson, E. J. & O'Fallon, W. M., Jan 1 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

Open Access
400 Scopus citations

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Aug 21 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

244 Scopus citations
2000

Cross-sectional versus longitudinal evaluation of bone loss in men and women

Melton, L. J., Khosla, S., Atkinson, E. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 7, p. 592-599 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Cytokine-specific induction of the TGF-β inducible early gene (TIEG): Regulation by specific members of the TGF-β family

Hefferan, T. E., Subramaniam, M., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Aug 9 2000, In : Journal of cellular biochemistry. 78, 3, p. 380-390 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men

Melton, L. J., Khosla, S., Achenbach, S. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Dec 1 2000, In : Osteoporosis International. 11, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Epidemiology of sarcopenia

Melton, J. L., Khosla, S. & Lawrence Riggs, B., 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S10-S13

Research output: Contribution to journalArticle

69 Scopus citations

Epidemiology of sarcopenia

Melton, L. J., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Jun 2000, In : Journal of the American Geriatrics Society. 48, 6, p. 625-630 6 p.

Research output: Contribution to journalArticle

375 Scopus citations

Etidronate for osteoporosis in primary biliary cirrhosis: A randomized trial

Lindor, K. D., Jorgensen, R. A., Tiegs, R. D., Khosla, S. & Dickson, E. R., Jan 1 2000, In : Journal of hepatology. 33, 6, p. 878-882 5 p.

Research output: Contribution to journalArticle

63 Scopus citations

Fractures following thyroidectomy in women: A population-based cohort study

Melton, L. J., Ardila, E., Crowson, C. S., O'Fallon, W. M. & Khosla, S., Nov 13 2000, In : Bone. 27, 5, p. 695-700 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Primary osteoporosis in men: role of sex steroid deficiency

Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S46-S50

Research output: Contribution to journalArticle

19 Scopus citations

Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action

Pattanaungkul, S., Riggs, B. L., Yergey, A. L., Vieira, N. E., O'Fallon, W. M. & Khosla, S., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4023-4027 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Jan 1 2000, In : Metabolism: Clinical and Experimental. 49, 10, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O'Fallon, W. M., Eastell, R. & Khosla, S., 2000, In : Journal of Clinical Investigation. 106, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

Open Access
565 Scopus citations

Relative influence of physical activity, muscle mass and strength on bone density

Proctor, D. N., Melton, L. J., Khosla, S., Crowson, C. S., O'Connor, M. K. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 944-952 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

The effects of androgens on osteoblast function in vitro

Khosla, S., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S51-S54

Research output: Contribution to journalArticle

4 Scopus citations

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., Jan 1 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

Open Access
246 Scopus citations
1999

Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line

Gori, F., Hofbauer, L. C., Conover, C. A. & Khosla, S., Jan 1 1999, In : Endocrinology. 140, 12, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Spelsberg, T. C. & Riggs, B. L., Jan 1 1999, In : Endocrinology. 140, 9, p. 4367-4370 4 p.

Research output: Contribution to journalArticle

Open Access
542 Scopus citations

Fracture risk after surgery for peptic ulcer disease: A population-based cohort study

Melton, L. J., Crowson, C. S., Khosla, S. & O'Fallon, W. M., Jul 1 1999, In : Bone. 25, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., 1999, In : Clinical chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

501 Scopus citations

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., Jan 1 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Open Access
601 Scopus citations

Osteoporosis: Gender differences and similarities

Khosla, S., Melton, L. J. & Riggs, B. L., Jan 1 1999, In : Lupus. 8, 5, p. 393-396 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Primary hyperparathyroidism and the risk of fracture: A population-based study

Khosla, S., Melton, L. J., Wermers, R. A., Crowson, C. S., O'Fallon, W. M. & Riggs, B. L., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, 10, p. 1700-1707 8 p.

Research output: Contribution to journalArticle

278 Scopus citations

Response of bipotential human marrow stromal cells to insulin-like growth factors: Effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes

Thomas, T., Gori, F., Spelsberg, T. C., Khosla, S., Riggs, B. L. & Conover, C. A., Jan 1 1999, In : Endocrinology. 140, 11, p. 5036-5044 9 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations