• 41833 Citations
  • 104 Scopus h-Index
1980 …2020

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Article
2013
28 Scopus citations

Identification of Rorβ targets in cultured osteoblasts and in human bone

Roforth, M. M., Khosla, S. & Monroe, D. G., Nov 1 2013, In : Biochemical and Biophysical Research Communications. 440, 4, p. 768-773 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Christen, D., Melton, L. J., Zwahlen, A., Amin, S., Khosla, S. & Müller, R., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures

Giambini, H., Khosla, S., Nassr, A., Zhao, C. & An, K. N., Jan 2013, In : Clinical Biomechanics. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography

Burghardt, A. J., Pialat, J. B., Kazakia, G. J., Boutroy, S., Engelke, K., Patsch, J. M., Valentinitsch, A., Liu, D., Szabo, E., Bogado, C. E., Zanchetta, M. B., McKay, H. A., Shane, E., Boyd, S. K., Bouxsein, M. L., Chapurlat, R., Khosla, S. & Majumdar, S., Mar 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

79 Scopus citations

Pathogenesis of age-related bone loss in humans

Khosla, S., Oct 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 10, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells

Flammer, A. J., Martin, E. A., Gössl, M., Widmer, R. J., Lennon, R. J., Sexton, J. A., Loeffler, D., Khosla, S., Lerman, L. O. & Lerman, A., Feb 2013, In : European Journal of Nutrition. 52, 1, p. 289-296 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Proximal femoral density distribution and structure in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Mar 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan

Ng, A. C., Melton, L. J., Atkinson, E. J., Achenbach, S. J., Holets, M. F., Peterson, J. M., Khosla, S. & Drake, M. T., 2013, In : Bone. 55, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 2013, In : Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women

Nicks, K. M., Amin, S., Melton, L. J., Atkinson, E. J., McCready, L. K., Riggs, B. L., Engelke, K. & Khosla, S., 2013, In : Bone. 55, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
44 Scopus citations
2012

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 2012, In : Journal of cellular biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8, p. E979-E986

Research output: Contribution to journalArticle

20 Scopus citations

Assessing fracture risk using gradient boosting machine (GBM) models

Atkinson, E. J., Therneau, T. M., Melton, L. J., Camp, J. J., Achenbach, S. J., Amin, S. & Khosla, S., Jun 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: A nested substudy of the MAP.3 randomised controlled trial

Cheung, A. M., Tile, L., Cardew, S., Pruthi, S., Robbins, J., Tomlinson, G., Kapral, M. K., Khosla, S., Majumdar, S., Erlandson, M., Scher, J., Hu, H., Demaras, A., Lickley, L., Bordeleau, L., Elser, C., Ingle, J., Richardson, H. & Goss, P. E., Mar 1 2012, In : The Lancet Oncology. 13, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection

Mödder, U. I., Roforth, M. M., Nicks, K. M., Peterson, J. M., McCready, L. K., Monroe, D. G. & Khosla, S., Mar 2012, In : Bone. 50, 3, p. 804-810 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Emerging role of circulating calcifying cells in the bone-vascular axis

Fadini, G. P., Rattazzi, M., Matsumoto, T., Asahara, T. & Khosla, S., Jun 5 2012, In : Circulation. 125, 22, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Examination of ERα signaling pathways in bone of mutant mouse models reveals the importance of ERE-dependent signaling

Chokalingam, K., Roforth, M. M., Nicks, K. M., McGregor, U., Fraser, D., Khosla, S. & Monroe, D. G., Nov 1 2012, In : Endocrinology. 153, 11, p. 5325-5333 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Examination of nuclear receptor expression in osteoblasts reveals rorβ as an important regulator of osteogenesis

Roforth, M. M., Liu, G., Khosla, S. & Monroe, D. G., Apr 2012, In : Journal of Bone and Mineral Research. 27, 4, p. 891-901 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Fracture risk in women with breast cancer: A population-based study

Melton, L. J., Hartmann, L. C., Achenbach, S. J., Atkinson, E. J., Therneau, T. M. & Khosla, S., May 2012, In : Journal of Bone and Mineral Research. 27, 5, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity

Bush, N. C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Nov 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis

Flammer, A. J., Gössl, M., Widmer, R. J., Reriani, M., Lennon, R., Loeffler, D., Shonyo, S., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : European heart journal. 33, 23, p. 2963-2969 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers

Flammer, A. J., Gössl, M., Li, J., Matsuo, Y., Reriani, M., Loeffler, D., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4761-4768 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Potential extensions of the US FRAX algorithm

Melton, L. J., Atkinson, E. J., Achenbach, S. J., Kanis, J. A., Therneau, T. M., Johansson, H., Khosla, S. & Amin, S., 2012, In : Journal of Osteoporosis. 2012, 528790.

Research output: Contribution to journalArticle

12 Scopus citations

Relationship of age to bone microstructure independent of areal bone mineral density

Nicks, K. M., Amin, S., Atkinson, E. J., Riggs, B. L., Melton, L. J. & Khosla, S., Mar 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 637-644 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women

Srinivasan, B., Kopperdahl, D. L., Amin, S., Atkinson, E. J., Camp, J., Robb, R. A., Riggs, B. L., Orwoll, E. S., Melton, L. J., Keaveny, T. M. & Khosla, S., Jan 2012, In : Osteoporosis International. 23, 1, p. 155-162 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women

Farr, J. N., Charkoudian, N., Barnes, J. N., Monroe, D. G., McCready, L. K., Atkinson, E. J., Amin, S., Melton, L. J., Joyner, M. J. & Khosla, S., Nov 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4219-4227 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Role of circulating osteogenic progenitor cells in calcific aortic stenosis

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Enriquez-Sarano, M., Lennon, R. J., Lerman, L. O. & Lerman, A., Nov 6 2012, In : Journal of the American College of Cardiology. 60, 19, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Sclerostin levels during growth in children

Kirmani, S., Amin, S., McCready, L. K., Atkinson, E. J., Melton, L. J., Müller, R. & Khosla, S., Mar 2012, In : Osteoporosis International. 23, 3, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
70 Scopus citations

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

Association of hip strength estimates by finite-element analysis with fractures in women and men

Amin, S., Kopperdhal, D. L., Melton, L. J., Achenbach, S. J., Therneau, T. M., Riggs, B. L., Keaveny, T. M. & Khosla, S., Jul 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1α levels in patients with MGUS

Ng, A. C., Khosla, S., Charatcharoenwitthaya, N., Kumar, S. K., Achenbach, S. J., Holets, M. F., McCready, L. K., Melton, L. J., Kyle, R. A., Rajkumar, S. V. & Drake, M. T., Dec 15 2011, In : Blood. 118, 25, p. 6529-6534 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Determinants of forearm strength in postmenopausal women

Melton, L. J., Riggs, B. L., Müller, R., Achenbach, S. J., Christen, D., Atkinson, E. J., Amin, S. & Khosla, S., Dec 2011, In : Osteoporosis International. 22, 12, p. 3047-3054 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

Syed, F. A., Fraser, D. G., Monroe, D. G. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 202-207 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women

Drake, M. T., Srinivasan, B., Mödder, U. I., Ng, A. C., Undale, A. H., Roforth, M. M., Peterson, J. M., McCready, L. K., Riggs, B. L. & Khosla, S., Sep 2011, In : Bone. 49, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Effects of physiological variations in circulating insulin levels on bone turnover in humans

Basu, R., Peterson, J., Rizza, R. & Khosla, S., May 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 5, p. 1450-1455 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Abdallah, B. M., Bay-Jensen, A. C., Srinivasan, B., Tabassi, N. C., Garnero, P., Delaissé, J. M., Khosla, S. & Kassem, M., Oct 1 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2548-2551 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Fracture risk in men with prostate cancer: A population-based study

Melton, L. J., Lieber, M. M., Atkinson, E. J., Achenbach, S. J., Zincke, H., Therneau, T. M. & Khosla, S., Aug 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1808-1815 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Getting to the bare bones of fertility

Khosla, S. & Rosen, C., 2011, In : Nature Medicine. 17, 5, p. 550-551 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PloS one. 6, 9, e24876.

Research output: Contribution to journalArticle

6 Scopus citations

Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow

Undale, A., Fraser, D., Hefferan, T., Kopher, R. A., Herrick, J., Evans, G. L., Li, X., Kakar, S., Hayes, M., Atkinson, E., Yaszemski, M. J., Kaufman, D. S., Westendorf, J. J. & Khosla, S., Dec 2011, In : Journal of Orthopaedic Research. 29, 12, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Is vitamin D a determinant of muscle mass and strength?

Marantes, I., Achenbach, S. J., Atkinson, E. J., Khosla, S., Melton, L. J. & Amin, S., Dec 2011, In : Journal of Bone and Mineral Research. 26, 12, p. 2860-2871 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Nonoxidative free fatty acid disposal is greater in young women than men

Koutsari, C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Feb 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 2, p. 541-547 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Regulation of circulating sclerostin levels by sex steroids in women and in men

Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

158 Scopus citations