• 41833 Citations
  • 104 Scopus h-Index
1980 …2020

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2017

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. T., Pignolo, R. J., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

227 Scopus citations

The circumstances, orientations, and impact locations of falls in community-dwelling older women

Crenshaw, J. R., Bernhardt, K. A., Achenbach, S. J., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Nov 2017, In : Archives of Gerontology and Geriatrics. 73, p. 240-247 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions

Bonaretti, S., Majumdar, S., Lang, T. F., Khosla, S. & Burghardt, A. J., Jul 1 2017, In : Osteoporosis International. 28, 7, p. 2115-2128 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

for the Osteoporotic Fractures in Men (MrOS) Study Research Group, Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 633-640 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

ASPREE Investigator Group, Aug 2016, In : Injury Prevention. 22, 4, p. 297-301 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Comprehensive assessment of osteoporosis and bone fragility with ct colonography

Fidler, J. L., Murthy, N. S., Khosla, S., Clarke, B. L., Bruining, D. H., Kopperdahl, D. L., Lee, D. C. & Keaveny, T. M., Jan 2016, In : Radiology. 278, 1, p. 172-180 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice

Nicks, K. M., Fujita, K., Fraser, D., McGregor, U., Drake, M. T., McGee-Lawrence, M. E., Westendorf, J. J., Monroe, D. G. & Khosla, S., Mar 1 2016, In : Journal of Bone and Mineral Research. 31, 3, p. 606-614 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., McNiven, M. A., Farr, J. N., Khosla, S., Oursler, M. J. & Westendorf, J. J., Jan 1 2016, In : Journal of Bone and Mineral Research. 31, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Identification of Senescent Cells in the Bone Microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R. J., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women with Fracture Independently of Total Hip T-Score: An International Multicenter Study

Boutroy, S., Khosla, S., Sornay-Rendu, E., Zanchetta, M. B., McMahon, D. J., Zhang, C. A., Chapurlat, R. D., Zanchetta, J., Stein, E. M., Bogado, C., Majumdar, S., Burghardt, A. J. & Shane, E., Jun 1 2016, In : Journal of Bone and Mineral Research. 31, 6, p. 1158-1166 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Weivoda, M. M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., Jan 1 2016, In : Journal of Bone and Mineral Research. 31, 1, p. 76-85 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., Miller, J. D., Bergen, H. R. & LeBrasseur, N. K., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A., Bouxsein, M. L., Eriksen, E. F., Khosla, S., Nyman, J. S., Papapoulos, S. & Tang, S. Y., Dec 1 2016, In : Bone Reports. 5, p. 181-185 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Dec 13 2016, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm

Christen, P., Schulte, F. A., Zwahlen, A., Van Rietbergen, B., Boutroy, S., Melton, L. J., Amin, S., Khosla, S., Goldhahn, J. & Müller, R., Jan 1 2016, In : Journal of the Royal Society Interface. 13, 114, 20150991.

Research output: Contribution to journalArticle

14 Scopus citations

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Weivoda, M. M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., Jan 1 2016, In : Journal of Bone and Mineral Research. 31, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis

Peris, P., Roforth, M. M., Nicks, K. M., Fraser, D., Fujita, K., Jilka, R. L., Khosla, S. & McGregor, U., Jan 1 2015, In : Journal of cellular biochemistry. 116, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Can vitamin D metabolite measurements facilitate a “treat-to-target” paradigm to guide vitamin D supplementation?

Binkley, N., Lappe, J., Singh, R. J., Khosla, S., Krueger, D., Drezner, M. K. & Blank, R. D., May 1 2015, In : Osteoporosis International. 26, 5, p. 1655-1660 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Clinical Use of Quantitative Computed Tomography (QCT) of the Hip in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part I

Engelke, K., Lang, T., Khosla, S., Qin, L., Zysset, P., Leslie, W. D., Shepherd, J. A. & Schousboe, J. T., Jul 1 2015, In : Journal of Clinical Densitometry. 18, 3, p. 338-358 21 p.

Research output: Contribution to journalArticle

45 Scopus citations

Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III

Engelke, K., Lang, T., Khosla, S., Qin, L., Zysset, P., Leslie, W. D., Shepherd, J. A. & Shousboe, J. T., Jul 1 2015, In : Journal of Clinical Densitometry. 18, 3, p. 393-407 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Clinical Use of Quantitative Computed Tomography-Based Finite Element Analysis of the Hip and Spine in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part II

Zysset, P., Qin, L., Lang, T., Khosla, S., Leslie, W. D., Shepherd, J. A., Schousboe, J. T. & Engelke, K., Jul 1 2015, In : Journal of Clinical Densitometry. 18, 3, p. 359-392 34 p.

Research output: Contribution to journalArticle

63 Scopus citations

Effects of age and estrogen on skeletal gene expression in humans as assessed by RNA sequencing

Farr, J. N., Roforth, M. M., Fujita, K., Nicks, K. M., Cunningham, J. M., Atkinson, E. J., Therneau, T. M., McCready, L. K., Peterson, J. M., Drake, M. T., Monroe, D. G. & Khosla, S., Sep 24 2015, In : PloS one. 10, 9, e0138347.

Research output: Contribution to journalArticle

33 Scopus citations

Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women

Roforth, M. M., Farr, J. N., Fujita, K., McCready, L. K., Atkinson, E. J., Therneau, T. M., Cunningham, J. M., Drake, M. T., Monroe, D. G. & Khosla, S., Jul 1 2015, In : Bone. 76, p. 49-57 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
41 Scopus citations

Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis

Collin, J., Gössl, M., Matsuo, Y., Cilluffo, R. R., Flammer, A. J., Loeffler, D., Lennon, R. J., Simari, R. D., Spoon, D. B., Erbel, R., Lerman, L. O., Khosla, S. & Lerman, A., Feb 15 2015, In : International Journal of Cardiology. 181, p. 57-64 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Response to Wnt Signaling Pathways

Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The achilles’ heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, In : Aging Cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journalArticle

547 Scopus citations
2014

Aromatase inhibitor-associated bone fractures: A case-cohort GWAS and functional genomics

Liu, M., Goss, P. E., Ingle, J. N., Kubo, M., Furukawa, Y., Batzler, A., Jenkins, G. D., Carlson, E. E., Nakamura, Y., Schaid, D. J., Chapman, J. A. W., Shepherd, L. E., Ellis, M. J., Khosla, S., Wang, L. & Weinshilboum, R. M., Oct 1 2014, In : Molecular Endocrinology. 28, 10, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Body composition during childhood and adolescence: Relations to bone strength and microstructure

Farr, J. N., Amin, S., LeBrasseur, N. K., Atkinson, E. J., Achenbach, S. J., McCready, L. K., Melton, L. J. & Khosla, S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. 4641-4648 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Bone strength and structural deficits in children and adolescents with a distal forearm fracture resulting from mild trauma

Farr, J. N., Amin, S., Melton, L. J., Kirmani, S., McCready, L. K., Atkinson, E. J., Müller, R. & Khosla, S., Mar 2014, In : Journal of Bone and Mineral Research. 29, 3, p. 590-599 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women

Prasad, M., Reriani, M., Khosla, S., Gössl, M., Lennon, R., Gulati, R., Prasad, A., Lerman, L. O. & Lerman, A., 2014, In : Vascular health and risk management. 10, p. 533-538 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cortical porosity identifies women with osteopenia at increased risk for forearm fractures

Bala, Y., Zebaze, R., Ghasem-Zadeh, A., Atkinson, E. J., Iuliano, S., Peterson, J. M., Amin, S., Bjørnerem, Å., Melton, L. J., Johansson, H., Kanis, J. A., Khosla, S. & Seeman, E., Jun 2014, In : Journal of Bone and Mineral Research. 29, 6, p. 1356-1362 7 p.

Research output: Contribution to journalArticle

101 Scopus citations

Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood

Farr, J. N., Khosla, S., Achenbach, S. J., Atkinson, E. J., Kirmani, S., McCready, L. K., Melton, L. J. & Amin, S., Oct 1 2014, In : Journal of Bone and Mineral Research. 29, 10, p. 2193-2202 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing

Roforth, M. M., Atkinson, E. J., Levin, E. R., Khosla, S. & Monroe, D. G., Apr 28 2014, In : PloS one. 9, 4, e95987.

Research output: Contribution to journalArticle

15 Scopus citations

Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): A companion analysis of a randomised controlled trial

Goss, P. E., Hershman, D. L., Cheung, A. M., Ingle, J. N., Khosla, S., Stearns, V., Chalchal, H., Rowland, K., Muss, H. B., Linden, H. M., Scher, J., Pritchard, K. I., Elliott, C. R., Badovinac-Crnjevic, T., St Louis, J., Chapman, J. A. W. & Shepherd, L. E., Apr 2014, In : The Lancet Oncology. 15, 4, p. 474-482 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Roforth, M. M., Fujita, K., McGregor, U. I., Kirmani, S., McCready, L. K., Peterson, J. M., Drake, M. T., Monroe, D. G. & Khosla, S., Feb 2014, In : Bone. 59, p. 1-6 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Effects of estrogen on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in postmenopausal women

Fujita, K., Roforth, M. M., Demaray, S., McGregor, U., Kirmani, S., McCready, L. K., Peterson, J. M., Drake, M. T., Monroe, D. G. & Khosla, S., Jan 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 1, p. E81-E88

Research output: Contribution to journalArticle

36 Scopus citations

In vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Farr, J. N., Drake, M. T., Amin, S., Melton, L. J., McCready, L. K. & Khosla, S., Apr 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

266 Scopus citations

Isolation and characterization of human osteoblasts from needle biopsies without in vitro culture

Fujita, K., Roforth, M. M., Atkinson, E. J., Peterson, J. M., Drake, M. T., McCready, L. K., Farr, J. N., Monroe, D. G. & Khosla, S., Mar 2014, In : Osteoporosis International. 25, 3, p. 887-895 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutual Enhancement of Differentiation of Osteoblasts and Osteocytes Occurs Through Direct Cell-Cell Contact

Fujita, K., Xing, Q., Khosla, S. & Monroe, D. G., Nov 1 2014, In : Journal of cellular biochemistry. 115, 11, p. 2039-2044 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD

Bonaretti, S., Carpenter, R. D., Saeed, I., Burghardt, A. J., Yu, L., Bruesewitz, M., Khosla, S. & Lang, T., Dec 21 2014, In : Physics in medicine and biology. 59, 24, p. 7819-7834 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings

Egorov, V., Tatarinov, A., Sarvazyan, N., Wood, R., Magidenko, L., Amin, S., Khosla, S., Ruh, R. J., Ruh, J. M. & Sarvazyan, A., Jul 2014, In : Ultrasonics. 54, 5, p. 1170-1177 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group

Siris, E. S., Adler, R., Bilezikian, J., Bolognese, M., Dawson-Hughes, B., Favus, M. J., Harris, S. T., Jan De Beur, S. M., Khosla, S., Lane, N. E., Lindsay, R., Nana, A. D., Orwoll, E. S., Saag, K., Silverman, S. & Watts, N. B., 2014, In : Osteoporosis International. 25, 5, p. 1439-1443 5 p.

Research output: Contribution to journalArticle

231 Scopus citations

Trends in fracture incidence: A population-based study over 20 years

Amin, S., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Melton, L. J., Mar 2014, In : Journal of Bone and Mineral Research. 29, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Validation of a CT-derived method for osteoporosis screening in IBD patients undergoing contrast-enhanced CT enterography

Weber, N. K., Fidler, J. L., Keaveny, T. M., Clarke, B. L., Khosla, S., Fletcher, J. G., Lee, D. C., Pardi, D. S., Loftus, E. V., Kane, S. V., Barlow, J. M., Murthy, N. S., Becker, B. D. & Bruining, D. H., Mar 2014, In : American Journal of Gastroenterology. 109, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J. N., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

40 Scopus citations

Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

Klingberg, E., Lorentzon, M., Göthlin, J., Mellström, D., Geijer, M., Ohlsson, C., Atkinson, E. J., Khosla, S., Carlsten, H. & Forsblad-d'Elia, H., Nov 5 2013, In : Arthritis Research and Therapy. 15, 6, R179.

Research output: Contribution to journalArticle

50 Scopus citations

Effects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women

Peris, P., Atkinson, E. J., Gössl, M., Kane, T. L., McCready, L. K., Lerman, A., Khosla, S. & McGregor, U. I., Jan 2013, In : Mayo Clinic proceedings. 88, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

23 Scopus citations