• 39889 Citations
  • 101 Scopus h-Index
1976 …2021

Research output per year

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Research Output

1998

Interaction between estrogen and vitamin D-endocrine system: A potential addition to the unitary model of osteoporosis

Liel, Y., Shany, S., Schwartz, B., Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., 1998, In : Journal of Bone and Mineral Research. 13, 12, p. 1954-1955 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines

Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 29 1998, In : Biochemical and Biophysical Research Communications. 250, 3, p. 776-781 6 p.

Research output: Contribution to journalArticle

260 Scopus citations

Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen

Khosla, S., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Klee, G. G. & Riggs, B. L., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 7, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

801 Scopus citations

Survival after the diagnosis of hyperparathyroidism: A population-based study

Wermers, R. A., Khosla, S., Atkinson, E. J., Grant, C. S., Hodgson, S. F., O'Fallon, W. M. & Melton, L. J., Feb 1998, In : American Journal of Medicine. 104, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

214 Scopus citations
1999

Androgen effects on bone metabolism: Recent progress and controversies

Hofbauer, L. C. & Khosla, S., Apr 1999, In : European Journal of Endocrinology. 140, 4, p. 271-286 16 p.

Research output: Contribution to journalArticle

115 Scopus citations

Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line

Gori, F., Hofbauer, L. C., Conover, C. A. & Khosla, S., 1999, In : Endocrinology. 140, 12, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Spelsberg, T. C. & Riggs, B. L., 1999, In : Endocrinology. 140, 9, p. 4367-4370 4 p.

Research output: Contribution to journalArticle

535 Scopus citations

Fracture risk after surgery for peptic ulcer disease: A population-based cohort study

Melton, L. J., Crowson, C., Khosla, S. & O'Fallon, W. M., Jul 1999, In : Bone. 25, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., 1999, In : Clinical Chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

493 Scopus citations

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

597 Scopus citations

Osteology: further debate.

Kleerekoper, M., Deftos, L., Khosla, S., Marcus, R., Matrici, M., McClung, M., Rosen, C. & Shane, E., Jun 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, 6, p. 1017 1 p.

Research output: Contribution to journalArticle

Osteoporosis: Gender differences and similarities

Khosla, S., Melton, L. J. & Riggs, B. L., 1999, In : Lupus. 8, 5, p. 393-396 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Primary hyperparathyroidism and the risk of fracture: A population-based study

Khosla, S., Melton, L. J., Wermers, R. A., Crowson, C., O'Fallon, W. M. & Riggs, B. L., 1999, In : Journal of Bone and Mineral Research. 14, 10, p. 1700-1707 8 p.

Research output: Contribution to journalArticle

274 Scopus citations

Response of bipotential human marrow stromal cells to insulin-like growth factors: Effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes

Thomas, T., Gori, F., Spelsberg, T. C., Khosla, S., Riggs, B. L. & Conover, C. A., 1999, In : Endocrinology. 140, 11, p. 5036-5044 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Secondary osteoporosis and the risk of vertebral deformities in women

Melton, L. J., Atkinson, E. J., Khosla, S., O'Fallon, W. M. & Riggs, B. L., Jan 1999, In : Bone. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

578 Scopus citations

The actions and interactions of sex steroids and growth factors/cytokines on the skeleton

Spelsberg, T. C., Subramaniam, M., Riggs, B. L. & Khosla, S., 1999, In : Molecular Endocrinology. 13, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

201 Scopus citations
60 Scopus citations

The assembly of the adult skeleton during growth and maturation: Implications for senile osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 1999, In : Journal of Clinical Investigation. 104, 6, p. 671-672 2 p.

Research output: Contribution to journalArticle

39 Scopus citations
2000

Cross-sectional versus longitudinal evaluation of bone loss in men and women

Melton, L. J., Khosla, S., Atkinson, E. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 7, p. 592-599 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Cytokine-specific induction of the TGF-β inducible early gene (TIEG): Regulation by specific members of the TGF-β family

Hefferan, T. E., Subramaniam, M., Khosla, S., Riggs, B. L. & Spelsberg, T. C., 2000, In : Journal of Cellular Biochemistry. 78, 3, p. 380-390 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men

Melton, L. J., Khosla, S., Achenbach, S. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Epidemiology of sarcopenia

Melton, J. L., Khosla, S. & Lawrence Riggs, B., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

66 Scopus citations

Epidemiology of sarcopenia

Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Jun 2000, In : Journal of the American Geriatrics Society. 48, 6, p. 625-630 6 p.

Research output: Contribution to journalArticle

361 Scopus citations

Etidronate for osteoporosis in primary biliary cirrhosis: A randomized trial

Lindor, K. D., Jorgensen, R. A., Tiegs, R. D., Khosla, S. & Dickson, E. R., 2000, In : Journal of Hepatology. 33, 6, p. 878-882 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Fractures following thyroidectomy in women: A population-based cohort study

Melton, L. J., Ardila, E., Crowson, C., O'Fallon, W. M. & Khosla, S., 2000, In : Bone. 27, 5, p. 695-700 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Primary osteoporosis in men: role of sex steroid deficiency

Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

19 Scopus citations

Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action

Pattanaungkul, S., Riggs, B. L., Yergey, A. L., Vieira, N. E., O'Fallon, W. M. & Khosla, S., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4023-4027 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., 2000, In : Metabolism: Clinical and Experimental. 49, 10, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O'Fallon, W. M., Eastell, R. & Khosla, S., 2000, In : Journal of Clinical Investigation. 106, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

553 Scopus citations

Relative influence of physical activity, muscle mass and strength on bone density

Proctor, D. N., Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 944-952 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

The effects of androgens on osteoblast function in vitro

Khosla, S., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

4 Scopus citations

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

241 Scopus citations

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J. & Riggs, B. L., 2000, In : Journal of Bone and Mineral Research. 15, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

945 Scopus citations
2001

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells

Hofbauer, L. C., Shui, C., Riggs, B. L., Dunstan, C. R., Spelsberg, T. C., O'Brien, T. & Khosla, S., 2001, In : Biochemical and Biophysical Research Communications. 280, 1, p. 334-339 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men

Doran, P. M., Riggs, B. L., Atkinson, E. J. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 2118-2125 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., 2001, In : Journal of Cellular Biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle

71 Scopus citations

Estrogens and bone health in men

Khosla, S., Melton, L. J. & Riggs, B. L., 2001, In : Calcified Tissue International. 69, 4, p. 189-192 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

247 Scopus citations

Minireview: The OPG/RANKL/RANK system

Khosla, S., 2001, In : Endocrinology. 142, 12, p. 5050-5055 6 p.

Research output: Contribution to journalArticle

1034 Scopus citations
66 Scopus citations

Regulation of osteoclastogenesis and RANK expression by TGF-β1

Yan, T., Riggs, B. L., Boyle, W. J. & Khosla, S., 2001, In : Journal of Cellular Biochemistry. 83, 2, p. 320-325 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men

Khosla, S., Melton, L. J., Atkinson, E. J. & O'Fallon, W. M., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

396 Scopus citations

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

239 Scopus citations
2002

Bisphosphonates and the upper gastrointestinal tract: Skeletal gain without visceral pain?

Tremaine, W. J. & Khosla, S., Oct 1 2002, In : Mayo Clinic Proceedings. 77, 10, p. 1029-1030 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical review 144: Estrogen and the male skeleton

Khosla, S., Joseph Melton, L. & Lawrence Riggs, B., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 4, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

247 Scopus citations

Correlates of osteoprotegerin levels in women and men

Khosla, S., Arrighi, H. M., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Dunstan, C. & Riggs, B. L., 2002, In : Osteoporosis International. 13, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Editorial: Leptin - Central or peripheral to the regulation of bone metabolism?

Khosla, S., Nov 1 2002, In : Endocrinology. 143, 11, p. 4161-4164 4 p.

Research output: Contribution to journalArticle

53 Scopus citations