• 39968 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

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Research Output

Article

Skeletal changes through the lifespan - From growth to senescence

Farr, J. & Khosla, S., Sep 20 2015, In : Nature Reviews Endocrinology. 11, 9, p. 513-521 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2

Mödder, U. I., Monroe, D. G., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Géhin, M., Chambon, P., O'Malley, B. W. & Khosla, S., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 18767-18777 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 1 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
67 Scopus citations
50 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features

Carballido-Gamio, J., Bonaretti, S., Kazakia, G. J., Khosla, S., Majumdar, S., Lang, T. F. & Burghardt, A. J., Nov 9 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-14 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., Jan 1 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

Open Access
578 Scopus citations

Structural determinants of vertebral fracture risk

Mellon, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Hoffmann, P. F., Camp, J. J., Rouleau, P. A., Bouxsein, M. L., Amin, S., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 1 2007, In : Journal of Bone and Mineral Research. 22, 12, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 1 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Surrogates for Fracture Endpoints in Clinical Trials

Khosla, S., Jun 1 2003, In : Journal of Bone and Mineral Research. 18, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Survival after the diagnosis of hyperparathyroidism: A population-based study

Wermers, R. A., Khosla, S., Atkinson, E. J., Grant, C. S., Hodgson, S. F., O'Fallon, W. M. & Melton, L. J., Feb 1 1998, In : American Journal of Medicine. 104, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

214 Scopus citations

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Khosla, S., Drake, M. M., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G. & Farr, J., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4832-4842 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F. & Pignolo, R. J., Jan 1 2020, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

171 Scopus citations

Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A., Bouxsein, M. L., Eriksen, E. F., Khosla, S., Nyman, J. S., Papapoulos, S. & Tang, S. Y., Dec 1 2016, In : Bone Reports. 5, p. 181-185 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 1 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The Achilles' heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., La Russo, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J., Khosla, S., Stout, M. B. & 13 others, Mcgowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

449 Scopus citations

The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line

Hofbauer, L. C., Ten, R. M. & Khosla, S., Jan 1 1999, In : Journal of Bone and Mineral Research. 14, 8, p. 1330-1337 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

The bone and beyond: A shift in calcium

Khosla, S., Apr 1 2011, In : Nature Medicine. 17, 4, p. 430-431 2 p.

Research output: Contribution to journalArticle

19 Scopus citations

The circumstances, orientations, and impact locations of falls in community-dwelling older women

Crenshaw, J. R., Bernhardt, K. A., Achenbach, S. J., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Nov 1 2017, In : Archives of Gerontology and Geriatrics. 73, p. 240-247 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group

Siris, E. S., Adler, R., Bilezikian, J., Bolognese, M., Dawson-Hughes, B., Favus, M. J., Harris, S. T., Jan De Beur, S. M., Khosla, S., Lane, N. E., Lindsay, R., Nana, A. D., Orwoll, E. S., Saag, K., Silverman, S. & Watts, N. B., Jan 1 2014, In : Osteoporosis International. 25, 5, p. 1439-1443 5 p.

Research output: Contribution to journalArticle

193 Scopus citations

The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions

Bonaretti, S., Majumdar, S., Lang, T. F., Khosla, S. & Burghardt, A. J., Apr 8 2017, (Accepted/In press) In : Osteoporosis International. p. 1-14 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The effects of androgens on osteoblast function in vitro

Khosla, S., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S51-S54

Research output: Contribution to journalArticle

4 Scopus citations

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis

DuSell, C. D., Nelson, E. R., Wang, X., Abdo, J., Mödder, U. I., Umetani, M., Gesty-Palmer, D., Javitt, N. B., Khosla, S. & McDonnell, D. P., Aug 1 2010, In : Endocrinology. 151, 8, p. 3675-3685 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., Jan 1 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

Open Access
241 Scopus citations
50 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Dec 13 2016, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

Orwoll, E. S., Lapidus, J., Wang, P. Y., Vandenput, L., Hoffman, A., Fink, H. A., Laughlin, G. A., Nethander, M., Ljunggren, Ö., Kindmark, A., Lorentzon, M., Karlsson, M. K., Mellström, D., Kwok, A., Khosla, S., Kwok, T. & Ohlsson, C., 2016, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

17 Scopus citations

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors

Nelson, E. R., DuSell, C. D., Wang, X., Howe, M. K., Evans, G., Michalek, R. D., Umetani, M., Rathmell, J. C., Khosla, S., Gesty-Palmer, D. & McDonnell, D. P., Dec 1 2011, In : Endocrinology. 152, 12, p. 4691-4705 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The rise and fall of primary hyperparathyroidism: A population-based study in Rochester, Minnesota, 1965-1992

Wermers, R. A., Khosla, S., Atkinson, E. J., Hodgson, S. F., O'Fallon, W. M. & Melton, L. J., Jan 1 1997, In : Annals of internal medicine. 126, 6, p. 433-440 8 p.

Research output: Contribution to journalArticle

238 Scopus citations

The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice

Mödder, U. I., Sanyal, A., Xu, J., O'Malley, B. W., Spelsberg, T. C. & Khosla, S., Feb 2008, In : Bone. 42, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity

Oppenheimer-Velez, M. L., Giambini, H., Rezaei, A., Camp, J. J., Khosla, S. & Lu, L., Jun 1 2018, In : Clinical Biomechanics. 55, p. 73-78 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women

Nicks, K. M., Amin, S., Melton, L. J., Atkinson, E. J., McCready, L. K., Riggs, B. L., Engelke, K. & Khosla, S., Mar 14 2013, In : Bone. 55, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Towards a diagnostic and therapeutic consensus in male osteoporosis

Kanis, J. A., Bianchi, G., Bilezikian, J. P., Kaufman, J. M., Khosla, S., Orwoll, E. & Seeman, E., Nov 1 2011, In : Osteoporosis International. 22, 11, p. 2789-2798 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Trabecular bone deficits among Vietnamese immigrants

Melton, L. J., Marquez, M. A., McCready, L. K., Achenbach, S. J., Riggs, B. L., Amin, S. & Khosla, S., May 1 2011, In : Osteoporosis International. 22, 5, p. 1627-1631 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M. M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 1 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
25 Scopus citations

Treatment Options for Osteoporosis

Khosla, S. & Riggs, B. L., Jan 1 1995, In : Mayo Clinic proceedings. 70, 10, p. 978-982 5 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression

Bauer, D. C., Black, D. M., Bouxsein, M. L., Lui, L. Y., Cauley, J. A., de Papp, A. E., Grauer, A., Khosla, S., Mcculloch, C. E. & Eastell, R., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

12 Scopus citations

Trends in fracture incidence: A population-based study over 20 years

Amin, S., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Melton, L. J., Mar 1 2014, In : Journal of Bone and Mineral Research. 29, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Mar 1 2007, In : Diabetes. 56, 3, p. 753-766 14 p.

Research output: Contribution to journalArticle

45 Scopus citations

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

Update in male osteoporosis

Khosla, S., Jan 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

Use of renal function measurements for assessing fracture risk in postmenopausal women

McCarthy, J. T., Rule, A. D., Achenbach, S. J., Bergstralh, E. J., Khosla, S. & Melton, L. J., Nov 2008, In : Mayo Clinic proceedings. 83, 11, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
27 Scopus citations