• 39968 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

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Research Output

Article
71 Scopus citations

Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study

Farr, J., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Amin, S., Dec 1 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2347-2354 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fracture Risk After Bilateral Oophorectomy in Elderly Women

Melton, L. J., Khosla, S., Malkasian, G. D., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., May 1 2003, In : Journal of Bone and Mineral Research. 18, 5, p. 900-905 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Fracture risk after surgery for peptic ulcer disease: A population-based cohort study

Melton, L. J., Crowson, C. S., Khosla, S. & O'Fallon, W. M., Jul 1 1999, In : Bone. 25, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Fracture risk among patients with urolithiasis: A population-based cohort study

Melton, L. J., Crowson, C. S., Khosla, S., Wilson, D. M. & O'Fallon, W. M., Jan 1 1998, In : Kidney international. 53, 2, p. 459-464 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Fracture risk following bilateral orchiectomy

Melton, L. J., Alothman, K. I., Khosla, S., Achenbach, S. J., Oberg, A. L. & Zincke, H., May 1 2003, In : Journal of Urology. 169, 5, p. 1747-1750 4 p.

Research output: Contribution to journalArticle

130 Scopus citations

Fracture risk in men with prostate cancer: A population-based study

Melton, L. J., Lieber, M. M., Atkinson, E. J., Achenbach, S. J., Zincke, H., Therneau, T. M. & Khosla, S., Aug 1 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1808-1815 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Fracture risk in monoclonal gammopathy of undetermined significance

Melton, L. J., Rajkumar, S. V., Khosla, S., Achenbach, S. J., Oberg, A. L. & Kyle, R. A., Jan 1 2004, In : Journal of Bone and Mineral Research. 19, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Fracture risk in primary hyperparathyroidism

Khosla, S. & Melton, L. J., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2, p. N103-N107

Research output: Contribution to journalArticle

69 Scopus citations

Fracture risk in type 2 diabetes: Update of a population-based study

Melton, L. J., Leibson, C. L., Achenbach, S. J., Therneau, T. M. & Khosla, S., Aug 1 2008, In : Journal of Bone and Mineral Research. 23, 8, p. 1334-1342 9 p.

Research output: Contribution to journalArticle

226 Scopus citations

Fracture risk in women with breast cancer: A population-based study

Melton, L. J., Hartmann, L. C., Achenbach, S. J., Atkinson, E. J., Therneau, T. M. & Khosla, S., May 1 2012, In : Journal of Bone and Mineral Research. 27, 5, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Fractures following thyroidectomy in women: A population-based cohort study

Melton, L. J., Ardila, E., Crowson, C. S., O'Fallon, W. M. & Khosla, S., Nov 13 2000, In : Bone. 27, 5, p. 695-700 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetic testing in medullary thyroid carcinoma syndromes: Mutation types and clinical significance

Heshmati, H. M., Gharib, H., Khosla, S., Abu-Lebdeh, H. S., Lindor, N. M. & Thibodeau, S. N., Jan 1 1997, In : Mayo Clinic proceedings. 72, 5, p. 430-436 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Genetic testing in the diagnosis and management of multiple endocrine neoplasia type II

Ledger, G. A., Khosla, S., Lindor, N. M., Thibodeau, S. N. & Gharib, H., Jan 1 1995, In : Annals of internal medicine. 122, 2, p. 118-124 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Getting to the bare bones of fertility

Khosla, S. & Rosen, C., 2011, In : Nature Medicine. 17, 5, p. 550-551 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women

Roforth, M. M., Farr, J., Fujita, K., McCready, L. K., Atkinson, E. J., Therneau, T. M., Cunningham, J. M., Drake, M. M., Monroe, D. G. & Khosla, S., Jul 1 2015, In : Bone. 76, p. 49-57 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

Rianon, N. J., Smith, S. M., Lee, M. J., Pervin, H., Musgrave, P., Watt, G. P., Nader, S., Khosla, S., Ambrose, C. G., McCormick, J. B. & Fisher-Hoch, S. P., Jan 1 2018, In : Journal of Osteoporosis. 2018, 7153021.

Research output: Contribution to journalArticle

1 Scopus citations

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

27 Scopus citations

Hepatitis C-associated osteosclerosis: An unusual syndrome of acquired osteosclerosis in adults

Hassoun, A. A. K., Nippoldt, T. B., Tiegs, R. D. & Khosla, S., Jul 1997, In : American Journal of Medicine. 103, 1, p. 70-73 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements

Henderson, G. C., Dhatariya, K., Ford, G. C., Klaus, K. A., Basu, R., Rizza, R. A., Jensen, M. D., Khosla, S., O'Brien, P. & Nair, K. S., Feb 1 2009, In : FASEB Journal. 23, 2, p. 631-641 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women

Amin, S., Riggs, B. L., Melton, L. J., Achenbach, S. J., Atkinson, E. J. & Khosla, S., Jun 1 2007, In : Journal of Bone and Mineral Research. 22, 6, p. 799-807 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men

Khosla, S., Melton, L. J., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Mar 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 885-891 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Hormonal and systemic regulation of sclerostin

Drake, M. M. & Khosla, S., Jul 28 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

24 Scopus citations

Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells

Kopher, R. A., Penchev, V. R., Islam, M. S., Hill, K. L., Khosla, S. & Kaufman, D. S., Oct 1 2010, In : Bone. 47, 4, p. 718-728 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PloS one. 6, 9, e24876.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of multiple endocrine neoplasia, type 2 gene carriers using linkage analysis and analysis of the RET proto-oncogene

Tsai, M. S., Ledger, G. A., Rhosla, S., Gharib, H. & Thibodeau, S. N., May 1994, In : Journal of Clinical Endocrinology and Metabolism. 78, 5, p. 1261-1264 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identification of Rorβ targets in cultured osteoblasts and in human bone

Roforth, M. M., Khosla, S. & Monroe, D. G., Nov 1 2013, In : Biochemical and Biophysical Research Communications. 440, 4, p. 768-773 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., Jan 1 1999, In : Clinical chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA

Dawson-Hughes, B., Tosteson, A. N. A., Melton, L. J., Baim, S., Favus, M. J., Khosla, S. & Lindsay, R. L., Apr 1 2008, In : Osteoporosis International. 19, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

304 Scopus citations

Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Christen, D., Melton, L. J., Zwahlen, A., Amin, S., Khosla, S. & Müller, R., Dec 1 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Incidence of Childhood Distal Forearm Fractures over 30 Years: A Population-Based Study

Khosla, S., Melton, L. J., Dekutoski, M. B., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Sep 17 2003, In : Journal of the American Medical Association. 290, 11, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

307 Scopus citations

Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: An update on the changing epidemiology of the disease

Wermers, R. A., Khosla, S., Atkinson, E. J., Achenbach, S. J., Oberg, A. L., Grant, C. S. & Melton, L. J., Jan 1 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow

Undale, A., Fraser, D., Hefferan, T., Kopher, R. A., Herrick, J., Evans, G. L., Li, X., Kakar, S., Hayes, M., Atkinson, E., Yaszemski, M. J., Kaufman, D. S., Westendorf, J. J. & Khosla, S., Dec 1 2011, In : Journal of Orthopaedic Research. 29, 12, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
26 Scopus citations

Insulin-like growth factor system abnormalities in hepatitis C- associated osteosclerosis. Potential insights into increasing bone mass in adults

Khosla, S., Hassoun, A. A. K., Baker, B. K., Liu, F., Zein, N. N., Whyte, M. P., Reasner, C. A., Nippoldt, T. B., Tiegs, R. D., Hintz, R. L. & Conover, C. A., May 15 1998, In : Journal of Clinical Investigation. 101, 10, p. 2165-2173 9 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations

Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity

Bush, N. C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Nov 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

493 Scopus citations

In vitro and in vivo detection of somatostatin receptors in pheochromocytomas and paragangliomas

Reubi, J. C., Waser, B., Khosla, S., Kvols, L., Goellner, J. R., Krenning, E. & Lamberts, S., May 1992, In : Journal of Clinical Endocrinology and Metabolism. 74, 5, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

In vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Farr, J. N., Drake, M. T., Amin, S., Melton, L. J., McCready, L. K. & Khosla, S., Apr 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

251 Scopus citations

Is familial hyperparathyroidism a unique disease?

Barry, M. K., Van Heerden, J. A., Grant, C. S., Thompson, G. B. & Khosla, S., Dec 1997, In : Surgery. 122, 6, p. 1028-1033 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Isolation and characterization of human osteoblasts from needle biopsies without in vitro culture

Fujita, K., Roforth, M. M., Atkinson, E. J., Peterson, J. M., Drake, M. T., McCready, L. K., Farr, J. N., Monroe, D. G. & Khosla, S., Mar 1 2014, In : Osteoporosis International. 25, 3, p. 887-895 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Is vitamin D a determinant of muscle mass and strength?

Marantes, I., Achenbach, S. J., Atkinson, E. J., Khosla, S., Melton, L. J. & Amin, S., Dec 1 2011, In : Journal of Bone and Mineral Research. 26, 12, p. 2860-2871 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Andersen, T. L., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 373-386 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., Jan 1 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Open Access
597 Scopus citations

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., Jan 1 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

Open Access
248 Scopus citations

Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures

Giambini, H., Khosla, S., Nassr, A., Zhao, C. & An, K. N., Jan 1 2013, In : Clinical Biomechanics. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of cellular biochemistry. 103, 3, p. 896-907 12 p.

Research output: Contribution to journalArticle

15 Scopus citations