• 39555 Citations
  • 101 Scopus h-Index
1976 …2021
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Research Output 1980 2020

Short survey
10 Citations (Scopus)

Bone diseases: Romosozumab-on track or derailed?

Khosla, S., Dec 1 2017, In : Nature Reviews Endocrinology. 13, 12, p. 697-698 2 p.

Research output: Contribution to journalShort survey

Bone Diseases
AMG 785
Review article
44 Citations (Scopus)

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

Drake, M. M., Clarke, B., Oursler, M. J. & Khosla, S., Aug 1 2017, In : Endocrine Reviews. 38, 4, p. 325-350 26 p.

Research output: Contribution to journalReview article

Cathepsin K
Osteoporosis
Osteoclasts
Cathepsins
Bone Density
23 Citations (Scopus)

Regulation of bone metabolism by sex steroids

Khosla, S. & Monroe, D. G., Jan 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 1, a031211.

Research output: Contribution to journalReview article

Metabolism
Bone
Estrogens
Steroids
Bone and Bones
1239 Citations (Scopus)

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 1 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalReview article

Skeleton
Steroids
Bone and Bones
Osteoporosis
Osteoblasts
51 Citations (Scopus)

Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes

Sellmeyer, D. E., Civitelli, R., Hofbauer, L. C., Khosla, S., Lecka-Czernik, B. & Schwartz, A. V., Jul 1 2016, In : Diabetes. 65, 7, p. 1757-1766 10 p.

Research output: Contribution to journalReview article

Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Bone Density
Comorbidity
Epidemiology
1 Citation (Scopus)

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

Biological Factors
Practice Guidelines
Physicians
Equipment and Supplies
Pharmaceutical Preparations
Letter

Response to Stoecker et al

Khosla, S. & Shane, E., Jun 1 2017, In : Journal of Bone and Mineral Research. 32, 6, p. 1388 1 p.

Research output: Contribution to journalLetter

Editorial
121 Citations (Scopus)

A Crisis in the Treatment of Osteoporosis

Khosla, S. & Shane, E., Aug 1 2016, In : Journal of Bone and Mineral Research. 31, 8, p. 1485-1487 3 p.

Research output: Contribution to journalEditorial

Osteoporosis
2 Citations (Scopus)

Is It Time to Stop (or Pause) Vertebral Augmentation?

Clarke, B. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Conference contribution
27 Citations (Scopus)

A system for the analysis of whole-bone strength from helical CT images

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., Riggs, B. L. & Robb, R. A., 2004, Proceedings of SPIE - The International Society for Optical Engineering. Amini, A. A. & Mandura, A. (eds.). Vol. 5369. p. 74-88 15 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

bones
Bone
osteoporosis
Minerals
minerals
Comment/debate
1 Citation (Scopus)
Open Access
Wnt Signaling Pathway
Osteoclasts
Minerals
Bone and Bones
Research

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

Osteoporosis
Therapeutics

Skeletal considerations in the medical treatment of transgender people

Khosla, S. & Davidge-Pitts, C., Dec 2019, In : The Lancet Diabetes and Endocrinology. 7, 12, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

Transgender Persons
Therapeutics
Chapter

Bone quality in type 2 diabetes mellitus

Farr, J. & Khosla, S., Jan 1 2016, Diabetic Bone Disease: Basic and Translational Research and Clinical Applications. Springer International Publishing, p. 211-224 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Type 2 Diabetes Mellitus
Bone and Bones
Osteogenesis
Advanced Glycosylation End Products
Premature Mortality
8 Citations (Scopus)

Estrogen, Bone Homeostasis, and Osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 1011-1039 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone
Estrogens
10 Citations (Scopus)

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S. & Pacifici, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1113-1136 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postmenopausal Osteoporosis
Osteoporosis
Estrogens
T-Lymphocytes
RANK Ligand
3 Citations (Scopus)

Estrogen Effects on Bone in the Male Skeleton

Gennari, L., Khosla, S. & Bilezikian, J. P., 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1801-1818 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Bone
Estrogens
Bone and Bones
Androgens
1 Citation (Scopus)

Osteonecrosis of the Jaw and Atypical Femoral Fractures

Shane, E., Khosla, S. & Burr, D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1873-1908 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Femoral Fractures
Osteonecrosis
Diphosphonates
Jaw
Osteoporosis

Parathyroid Hormone in the Pathophysiology of Osteoporosis

Khosla, S., Sep 5 2014, The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., p. 827-835 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parathyroid Hormone
Osteoporosis
Porosity
Bone Remodeling
Bone and Bones
4 Citations (Scopus)

Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 208-213 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Menopause
Osteoporosis
Testosterone
Estrogens
Steroids
1 Citation (Scopus)

Seeding Open Innovation Drug Discovery and Translational Collaborations to Leverage Government Funding: A Case Study of Strategic Partnership between Sanford-Burnham and Mayo Clinic

Chung, T. D. Y., Khosla, S., Badley, A. D. & Jackson, M. R., Apr 14 2014, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley Blackwell, p. 451-486 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Innovation
Translational Medical Research
Drug products
Pharmaceutical Preparations
2 Citations (Scopus)

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C. & Khosla, S., 2006, Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., p. 327-343 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Steroids
Bone and Bones
Estrogens
Androgens
Skeleton
2 Citations (Scopus)

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoblasts
Osteoporosis
Steroids
Bone
Estrogens

The Role of Androgens and Estrogens in the Male Skeleton

Khosla, S. & Bilezikian, J. P., 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 1021-1032 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Androgens
Estrogens
Steroids
Bone
5 Citations (Scopus)

The Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoporosis
Bone
Aging of materials
Steroids
Bone and Bones
Article
2 Citations (Scopus)

{A figure is presented} Long-term fracture risk among women with proven endometriosis

Melton, L. J., Leibson, C. L., Good, A. E., Achenbach, S. J., Oberg, A. L. & Khosla, S., Dec 2006, In : Fertility and Sterility. 86, 6, p. 1576-1583 8 p.

Research output: Contribution to journalArticle

Endometriosis
Confidence Intervals
Selective Estrogen Receptor Modulators
Tamoxifen
Forearm
33 Citations (Scopus)

Abdominal aortic calcification, BMD, and bone microstructure: A population-based study

Chow, J. T., Khosla, S., Melton, L. J., Atkinson, E. J., Camp, J. J. & Kearns, A. E., Oct 2008, In : Journal of Bone and Mineral Research. 23, 10, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

Social Adjustment
Bone and Bones
Population
Vascular Calcification
Femur Neck
2 Citations (Scopus)

Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis

Peris, P., Roforth, M. M., Nicks, K. M., Fraser, D., Fujita, K., Jilka, R. L., Khosla, S. & McGregor, U., Jan 1 2015, In : Journal of Cellular Biochemistry. 116, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Hematopoiesis
Ganciclovir
Osteoblasts
Bone
71 Citations (Scopus)

Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3

Ledger, G. A., Burritt, M. F., Kao, P. C., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Jul 1994, In : Journal of Clinical Endocrinology and Metabolism. 79, 1, p. 211-216 6 p.

Research output: Contribution to journalArticle

Calcitriol
Parathyroid Hormone
Aging of materials
Edetic Acid
Bone
107 Citations (Scopus)

A bone structural basis for fracture risk in diabetes

Melton, L. J., Riggs, B. L., Leibson, C. L., Achenbach, S. J., Camp, J. J., Bouxsein, M. L., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 12, p. 4804-4809 6 p.

Research output: Contribution to journalArticle

Medical problems
Bone
Bone and Bones
Bone Density
Pelvic Bones

ACTH and indomethacin-induced antidiuresis in low salt Brattleboro strain rats: Induction and escape

Khosla, S., Kinter, L. B., Zusman, R. & Beeuwkes, R., 1982, In : Annals of the New York Academy of Sciences. Vol. 394, p. 265-269 5 p.

Research output: Contribution to journalArticle

Brattleboro Rats
Vasopressins
Indomethacin
Adrenocorticotropic Hormone
Rats
58 Citations (Scopus)

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J., Kiel, D. P., Rosen, C., Saag, K. G. & Shane, E., Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Femur
Photon Absorptiometry
Therapeutics
Bone Density Conservation Agents
29 Citations (Scopus)

A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis

Heshmati, H. M., Khosla, S., Burritt, M. F., O'fallon, W. M. & Riggs, B. L., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 6, p. 1916-1920 5 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Conservation
Calcium
Kidney
Defects
24 Citations (Scopus)

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

Forearm
Incidence
Medical Record Linkage
Bone and Bones
Wrist
11 Citations (Scopus)

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 2012, In : Journal of Cellular Biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

Catenins
Osteoblasts
Estrogen Receptors
Mutation
DNA
17 Citations (Scopus)

Adrenal crisis in the setting of high-dose ketoconazole therapy

Khosla, S., Wolfson, J. S., Demerjian, Z. & Godine, J. E., 1989, In : Archives of Internal Medicine. 149, 4, p. 802-804 3 p.

Research output: Contribution to journalArticle

Ketoconazole
Adrenal Insufficiency
Hypothyroidism
Acanthamoeba Keratitis
Therapeutics

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Delivery of Health Care
Health Services
Public-Private Sector Partnerships
Government Agencies
15 Citations (Scopus)

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., 2004, In : Journal of Cellular Biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Anabolic Agents
Osteocalcin
Osteoblasts
Cyclooxygenase 2
Gene expression
113 Citations (Scopus)

Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT

Bouxsein, M. L., Melton, L. J., Riggs, B. L., Muller, J., Atkinson, E. J., Oberg, A. L., Robb, R. A., Camp, J. J., Rouleau, P. A., McCollough, C. H. & Khosla, S., Sep 2006, In : Journal of Bone and Mineral Research. 21, 9, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

Sex Characteristics
Population
Compressive Strength
Body Height
Body Weight
109 Citations (Scopus)

Age-dependence of femoral strength in white women and men

Keaveny, T. M., Kopperdahl, D. L., Melton, L. J., Hoffmann, P. F., Amin, S., Riggs, B. L. & Khosla, S., May 2010, In : Journal of Bone and Mineral Research. 25, 5, p. 994-1001 8 p.

Research output: Contribution to journalArticle

Thigh
Bone Density
Femur Neck
Osteoporosis
Bone and Bones
20 Citations (Scopus)

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8

Research output: Contribution to journalArticle

Kidney
Estrogens
Microvessels
Oxidative Stress
Angiogenesis Inducing Agents
4 Citations (Scopus)

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

Diverticulitis
Obesity
Incidence
Body Mass Index
Population
Osteoporotic Fractures
National Institutes of Health (U.S.)
Osteoporosis
Drug Therapy
Research
115 Citations (Scopus)

Androgen effects on bone metabolism: Recent progress and controversies

Hofbauer, L. C. & Khosla, S., Apr 1999, In : European Journal of Endocrinology. 140, 4, p. 271-286 16 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Androgen Receptor Antagonists
Insulin-Like Growth Factor Binding Proteins
11 Citations (Scopus)

Androgens, estrogens, and bone turnover in men (multiple letters)

Khosla, S., Riggs, B. L., Leder, B. Z. & Finkelstein, J. S., May 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2352-2353 2 p.

Research output: Contribution to journalArticle

Bone Remodeling
Androgens
Bone
Estrogens
114 Citations (Scopus)

Androgens and bone

Clarke, B. & Khosla, S., Mar 2009, In : Steroids. 74, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

Androgens
Testosterone
Bone
Bone and Bones
Estradiol
326 Citations (Scopus)

A population-based assessment of rates of bone loss at multiple skeletal sites: Evidence for substantial trabecular bone loss in young adult women and men

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., McDaniel, L., Amin, S., Rouleau, P. A. & Khosla, S., Feb 2008, In : Journal of Bone and Mineral Research. 23, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Young Adult
Bone and Bones
Population
Tibia
Perimenopause
60 Citations (Scopus)

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Bone Density
Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
37 Citations (Scopus)

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

Indentation
Bone
Bone and Bones
Horses
Clinical Trials
4 Citations (Scopus)

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

ASPREE Investigator Group, May 21 2015, (Accepted/In press) In : Injury Prevention.

Research output: Contribution to journalArticle

Aspirin
Randomized Controlled Trials
Placebos
Hip Fractures
Primary Prevention