• 39327 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2020

Article
236 Citations (Scopus)

The rise and fall of primary hyperparathyroidism: A population-based study in Rochester, Minnesota, 1965-1992

Wermers, R. A., Khosla, S., Atkinson, E. J., Hodgson, S. F., O'Fallon, W. M. & Melton, L. J., 1997, In : Annals of Internal Medicine. 126, 6, p. 433-440 8 p.

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Incidence
Population
Hyperparathyroidism
Hypercalcemia
32 Citations (Scopus)

The role of estrogens in men and androgens in women

Khosla, S. & Bilezikian, J. P., Feb 2003, In : Endocrinology and Metabolism Clinics of North America. 32, 1, p. 195-218 24 p.

Research output: Contribution to journalArticle

Androgens
Bone
Estrogens
Steroids
Osteogenesis
231 Citations (Scopus)

The role of the immune system in the pathophysiology of osteoporosis

Clowes, J. A., Riggs, B. L. & Khosla, S., Dec 2005, In : Immunological Reviews. 208, p. 207-227 21 p.

Research output: Contribution to journalArticle

Osteoporosis
Immune System
RANK Ligand
Osteoprotegerin
Bone and Bones
941 Citations (Scopus)

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J. & Riggs, B. L., 2000, In : Journal of Bone and Mineral Research. 15, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Bone Resorption
Osteoclasts
Cytokines
18 Citations (Scopus)

The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice

Mödder, U. I., Sanyal, A., Xu, J., O'Malley, B. W., Spelsberg, T. C. & Khosla, S., Feb 2008, In : Bone. 42, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Knockout Mice
Estrogens
Bone Remodeling
Bone and Bones
1 Citation (Scopus)

The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity

Oppenheimer-Velez, M. L., Giambini, H., Rezaei, A., Camp, J. J., Khosla, S. & Lu, L., Jun 1 2018, In : Clinical Biomechanics. 55, p. 73-78 6 p.

Research output: Contribution to journalArticle

Weight-Bearing
Sex Characteristics
Bone Density
Longitudinal Studies
Population
180 Citations (Scopus)

The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?

Khosla, S., Melton, L. J. & Riggs, B. L., Mar 2011, In : Journal of Bone and Mineral Research. 26, 3, p. 441-451 11 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
Age Factors
27 Citations (Scopus)

Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women

Nicks, K. M., Amin, S., Melton, L. J., Atkinson, E. J., McCready, L. K., Riggs, B. L., Engelke, K. & Khosla, S., 2013, In : Bone. 55, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Bone Density
Femur
Femur Neck
Bone and Bones
Hip Fractures
86 Citations (Scopus)

Towards a diagnostic and therapeutic consensus in male osteoporosis

Kanis, J. A., Bianchi, G., Bilezikian, J. P., Kaufman, J. M., Khosla, S., Orwoll, E. & Seeman, E., Nov 2011, In : Osteoporosis International. 22, 11, p. 2789-2798 10 p.

Research output: Contribution to journalArticle

Osteoporosis
Therapeutics
Education
1 Citation (Scopus)

Trabecular bone deficits among Vietnamese immigrants

Melton, L. J., Marquez, M. A., McCready, L. K., Achenbach, S. J., Riggs, B. L., Amin, S. & Khosla, S., May 2011, In : Osteoporosis International. 22, 5, p. 1627-1631 5 p.

Research output: Contribution to journalArticle

Bone Density
Spine
Estrogens
Bone and Bones
Cancellous Bone
36 Citations (Scopus)

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Osteoclasts
Osteoblasts
Transforming Growth Factor beta
Bone Resorption
25 Citations (Scopus)
Transforming Growth Factors
RNA
Cell Line
Growth
Messenger RNA
16 Citations (Scopus)

Treatment options for osteoporosis.

Khosla, S. & Riggs, B. L., Oct 1995, In : Mayo Clinic Proceedings. 70, 10, p. 978-982 5 p.

Research output: Contribution to journalArticle

Osteoporosis
Estradiol Congeners
Postmenopausal Osteoporosis
Estrogen Replacement Therapy
Diphosphonates
11 Citations (Scopus)

Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression

Bauer, D. C., Black, D. M., Bouxsein, M. L., Lui, L. Y., Cauley, J. A., de Papp, A. E., Grauer, A., Khosla, S., Mcculloch, C. E. & Eastell, R., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Fracture Fixation
Bone Remodeling
Bone Fractures
Risk Reduction Behavior
Clinical Trials
96 Citations (Scopus)

Trends in fracture incidence: A population-based study over 20 years

Amin, S., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Melton, L. J., Mar 2014, In : Journal of Bone and Mineral Research. 29, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

Incidence
Population
Hip Fractures
Forearm
Confidence Intervals
45 Citations (Scopus)

Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Mar 2007, In : Diabetes. 56, 3, p. 753-766 14 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Insulin
Glucose
Placebos
Glucose Tolerance Test

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

Electronic Health Records
Learning systems
Health
Epidemiology
Medical Record Linkage
119 Citations (Scopus)

Update in male osteoporosis

Khosla, S., Jan 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone
Tomography
Estradiol
Teriparatide
112 Citations (Scopus)

Update on estrogens and the skeleton

Khosla, S., Aug 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 3569-3577 9 p.

Research output: Contribution to journalArticle

Skeleton
Estrogens
Bone
Bone and Bones
Tissue
14 Citations (Scopus)

Update on primary osteoporosis

Hurley, D. L. & Khosla, S., 1997, In : Mayo Clinic Proceedings. 72, 10, p. 943-949 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Life Expectancy
Population
Delivery of Health Care
Bone and Bones
9 Citations (Scopus)

Use of renal function measurements for assessing fracture risk in postmenopausal women

McCarthy, J. T., Rule, A. D., Achenbach, S. J., Bergstralh, E. J., Khosla, S. & Melton, L. J., 2008, In : Mayo Clinic Proceedings. 83, 11, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Creatinine
Kidney
Bone Density
Body Weight
Glomerular Filtration Rate
26 Citations (Scopus)
Osteosclerosis
Hepatitis C
Hypoglycemia
Tumors
Insulin-Like Growth Factor Binding Protein 2
29 Citations (Scopus)

Validation of a CT-derived method for osteoporosis screening in IBD patients undergoing contrast-enhanced CT enterography

Weber, N. K., Fidler, J. L., Keaveny, T. M., Clarke, B., Khosla, S., Fletcher, J. G., Lee, D. C., Pardi, D. S., Loftus, Jr, E. V., Kane, S. V., Barlow, J. M., Murthy, N. S., Becker, B. D. & Bruining, D. H., 2014, In : American Journal of Gastroenterology. 109, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Osteoporosis
Photon Absorptiometry
Bone Density
Tomography
2 Citations (Scopus)

Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments

Drake, M. M., Fenske, J. S., Blocki, F. A., Zierold, C., Appelman-Dijkstra, N., Papapoulos, S. & Khosla, S., Jun 1 2018, In : Bone. 111, p. 36-43 8 p.

Research output: Contribution to journalArticle

Serum
Teriparatide
Luminescent Measurements
Bone and Bones
Osteocytes

Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans

Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J. & Müller, R., Feb 1 2019, In : PloS one. 14, 2, e0212280.

Research output: Contribution to journalArticle

Open Access
morphometry
computed tomography
Tomography
preserves
Bone
13 Citations (Scopus)

Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm

Christen, P., Schulte, F. A., Zwahlen, A., Van Rietbergen, B., Boutroy, S., Melton, L. J., Amin, S., Khosla, S., Goldhahn, J. & Müller, R., Jan 1 2016, In : Journal of the Royal Society Interface. 13, 114, 20150991.

Research output: Contribution to journalArticle

Bone
Bone and Bones
Tomography
Volume fraction
Bone Remodeling
7 Citations (Scopus)

What do we tell our patients about calcium and vitamin D supplementation?

Khosla, S., Jan 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 1, p. 69-71 3 p.

Research output: Contribution to journalArticle

Vitamin D
Calcium
39 Citations (Scopus)

Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells

Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 2011, In : Journal of Cellular Biochemistry. 112, 5, p. 1392-1402 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Genes
Wnt Signaling Pathway
Chemical activation
Microarrays
48 Citations (Scopus)

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Weivoda, M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoclasts
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Catenins
Osteoblasts
176 Citations (Scopus)

β-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin

Fisher, J., Belasco, J. G., Khosla, S. & Knowles, J. R., 1980, In : Biochemistry. 19, 13, p. 2895-2901 7 p.

Research output: Contribution to journalArticle

Cefoxitin
Escherichia coli
Enzymes
Acylation
Substrates
Chapter

Bone quality in type 2 diabetes mellitus

Farr, J. & Khosla, S., Jan 1 2016, Diabetic Bone Disease: Basic and Translational Research and Clinical Applications. Springer International Publishing, p. 211-224 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Type 2 Diabetes Mellitus
Bone and Bones
Osteogenesis
Advanced Glycosylation End Products
Premature Mortality
8 Citations (Scopus)

Estrogen, Bone Homeostasis, and Osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 1011-1039 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone
Estrogens
10 Citations (Scopus)

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S. & Pacifici, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1113-1136 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postmenopausal Osteoporosis
Osteoporosis
Estrogens
T-Lymphocytes
RANK Ligand
3 Citations (Scopus)

Estrogen Effects on Bone in the Male Skeleton

Gennari, L., Khosla, S. & Bilezikian, J. P., 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1801-1818 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Bone
Estrogens
Bone and Bones
Androgens
1 Citation (Scopus)

Osteonecrosis of the Jaw and Atypical Femoral Fractures

Shane, E., Khosla, S. & Burr, D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1873-1908 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Femoral Fractures
Osteonecrosis
Diphosphonates
Jaw
Osteoporosis

Parathyroid Hormone in the Pathophysiology of Osteoporosis

Khosla, S., Sep 5 2014, The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., p. 827-835 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parathyroid Hormone
Osteoporosis
Porosity
Bone Remodeling
Bone and Bones
4 Citations (Scopus)

Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 208-213 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Menopause
Osteoporosis
Testosterone
Estrogens
Steroids
1 Citation (Scopus)

Seeding Open Innovation Drug Discovery and Translational Collaborations to Leverage Government Funding: A Case Study of Strategic Partnership between Sanford-Burnham and Mayo Clinic

Chung, T. D. Y., Khosla, S., Badley, A. D. & Jackson, M. R., Apr 14 2014, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley Blackwell, p. 451-486 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug Discovery
Innovation
Translational Medical Research
Drug products
Pharmaceutical Preparations
2 Citations (Scopus)

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C. & Khosla, S., 2006, Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., p. 327-343 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Steroids
Bone and Bones
Estrogens
Androgens
Skeleton
1 Citation (Scopus)

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoblasts
Osteoporosis
Steroids
Bone
Estrogens

The Role of Androgens and Estrogens in the Male Skeleton

Khosla, S. & Bilezikian, J. P., 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 1021-1032 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Androgens
Estrogens
Steroids
Bone
4 Citations (Scopus)

The Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoporosis
Bone
Aging of materials
Steroids
Bone and Bones
Comment/debate
Open Access
Wnt Signaling Pathway
Osteoclasts
Minerals
Bone and Bones
Research

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

Osteoporosis
Therapeutics

Skeletal considerations in the medical treatment of transgender people

Khosla, S. & Davidge-Pitts, C., Dec 2019, In : The Lancet Diabetes and Endocrinology. 7, 12, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

Transgender Persons
Therapeutics
Conference contribution
27 Citations (Scopus)

A system for the analysis of whole-bone strength from helical CT images

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., Riggs, B. L. & Robb, R. A., 2004, Proceedings of SPIE - The International Society for Optical Engineering. Amini, A. A. & Mandura, A. (eds.). Vol. 5369. p. 74-88 15 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

bones
Bone
osteoporosis
Minerals
minerals
Editorial
119 Citations (Scopus)

A Crisis in the Treatment of Osteoporosis

Khosla, S. & Shane, E., Aug 1 2016, In : Journal of Bone and Mineral Research. 31, 8, p. 1485-1487 3 p.

Research output: Contribution to journalEditorial

Osteoporosis
2 Citations (Scopus)

Is It Time to Stop (or Pause) Vertebral Augmentation?

Clarke, B. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Letter

Response to Stoecker et al

Khosla, S. & Shane, E., Jun 1 2017, In : Journal of Bone and Mineral Research. 32, 6, p. 1388 1 p.

Research output: Contribution to journalLetter

Review article
41 Citations (Scopus)

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

Drake, M. M., Clarke, B., Oursler, M. J. & Khosla, S., Aug 1 2017, In : Endocrine Reviews. 38, 4, p. 325-350 26 p.

Research output: Contribution to journalReview article

Cathepsin K
Osteoporosis
Osteoclasts
Cathepsins
Bone Density