• 39889 Citations
  • 101 Scopus h-Index
1976 …2021

Research output per year

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Research Output

Article

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

239 Scopus citations

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Secondary osteoporosis and the risk of vertebral deformities in women

Melton, L. J., Atkinson, E. J., Khosla, S., O'Fallon, W. M. & Riggs, B. L., Jan 1999, In : Bone. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

220 Scopus citations

Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women

Bhattacharyya, S., Siegel, E. R., Achenbach, S. J., Khosla, S. & Suva, L. J., Jul 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1106-1117 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
20 Scopus citations

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M. D., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Jan 1 2018, (Accepted/In press) In : Clinical Endocrinology.

Research output: Contribution to journalArticle

1 Scopus citations

Skeletal changes through the lifespan - From growth to senescence

Farr, J. & Khosla, S., Sep 20 2015, In : Nature Reviews Endocrinology. 11, 9, p. 513-521 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2

Mödder, U. I., Monroe, D. G., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Géhin, M., Chambon, P., O'Malley, B. W. & Khosla, S., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 18767-18777 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
67 Scopus citations
50 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features

Carballido-Gamio, J., Bonaretti, S., Kazakia, G. J., Khosla, S., Majumdar, S., Lang, T. F. & Burghardt, A. J., Nov 9 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-14 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

578 Scopus citations

Structural determinants of vertebral fracture risk

Mellon, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Hoffmann, P. F., Camp, J. J., Rouleau, P. A., Bouxsein, M. L., Amin, S., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2007, In : Journal of Bone and Mineral Research. 22, 12, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Survival after the diagnosis of hyperparathyroidism: A population-based study

Wermers, R. A., Khosla, S., Atkinson, E. J., Grant, C. S., Hodgson, S. F., O'Fallon, W. M. & Melton, L. J., Feb 1998, In : American Journal of Medicine. 104, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

214 Scopus citations
8 Scopus citations

Systemic assessments utilizing saliva: Part 2 - Osteoporosis and use of saliva to measure bone turnover

Koka, S., Forde, M. D. & Khosla, S., Jan 2006, In : International Journal of Prosthodontics. 19, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop

Bilezikian, J. P., Matsumoto, T., Bellido, T., Khosla, S., Martin, J., Recker, R. R., Heaney, R., Seeman, E., Papapoulos, S. & Goldring, S. R., Mar 2009, In : Journal of Bone and Mineral Research. 24, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

169 Scopus citations

Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A., Bouxsein, M. L., Eriksen, E. F., Khosla, S., Nyman, J. S., Papapoulos, S. & Tang, S. Y., Dec 1 2016, In : Bone Reports. 5, p. 181-185 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Testosterone: More is not always better

Khosla, S., Dec 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4665-4667 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The Achilles' heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., La Russo, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J., Khosla, S., Stout, M. B. & 13 others, Mcgowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

449 Scopus citations

The actions and interactions of sex steroids and growth factors/cytokines on the skeleton

Spelsberg, T. C., Subramaniam, M., Riggs, B. L. & Khosla, S., 1999, In : Molecular Endocrinology. 13, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

201 Scopus citations
60 Scopus citations

The assembly of the adult skeleton during growth and maturation: Implications for senile osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 1999, In : Journal of Clinical Investigation. 104, 6, p. 671-672 2 p.

Research output: Contribution to journalArticle

39 Scopus citations

The bone and beyond: A shift in calcium

Khosla, S., Apr 2011, In : Nature Medicine. 17, 4, p. 430-431 2 p.

Research output: Contribution to journalArticle

19 Scopus citations

The circumstances, orientations, and impact locations of falls in community-dwelling older women

Crenshaw, J. R., Bernhardt, K. A., Achenbach, S. J., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Nov 1 2017, In : Archives of Gerontology and Geriatrics. 73, p. 240-247 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The classical estrogen receptor transcriptional pathway: Implications in human osteoblasts

Monroe, D. G., Secreto, F. J., Khosla, S. & Spelsberg, T. C., 2006, In : Clinical Reviews in Bone and Mineral Metabolism. 4, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
192 Scopus citations
12 Scopus citations

The effects of androgens on osteoblast function in vitro

Khosla, S., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

4 Scopus citations

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis

DuSell, C. D., Nelson, E. R., Wang, X., Abdo, J., Mödder, U. I., Umetani, M., Gesty-Palmer, D., Javitt, N. B., Khosla, S. & McDonnell, D. P., Aug 2010, In : Endocrinology. 151, 8, p. 3675-3685 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

241 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Dec 13 2016, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

Orwoll, E. S., Lapidus, J., Wang, P. Y., Vandenput, L., Hoffman, A., Fink, H. A., Laughlin, G. A., Nethander, M., Ljunggren, Ö., Kindmark, A., Lorentzon, M., Karlsson, M. K., Mellström, D., Kwok, A., Khosla, S., Kwok, T. & Ohlsson, C., 2016, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

17 Scopus citations

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors

Nelson, E. R., DuSell, C. D., Wang, X., Howe, M. K., Evans, G., Michalek, R. D., Umetani, M., Rathmell, J. C., Khosla, S., Gesty-Palmer, D. & McDonnell, D. P., Dec 2011, In : Endocrinology. 152, 12, p. 4691-4705 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

6 Scopus citations