• 39555 Citations
  • 101 Scopus h-Index
1976 …2021
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Research Output 1980 2020

Article
73 Citations (Scopus)

Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography

Burghardt, A. J., Pialat, J. B., Kazakia, G. J., Boutroy, S., Engelke, K., Patsch, J. M., Valentinitsch, A., Liu, D., Szabo, E., Bogado, C. E., Zanchetta, M. B., McKay, H. A., Shane, E., Boyd, S. K., Bouxsein, M. L., Chapurlat, R., Khosla, S. & Majumdar, S., Mar 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

Porosity
Tomography
Imaging Phantoms
Finite Element Analysis
Bone Density
72 Citations (Scopus)

Muscle strength in Osteoporotic versus normal women

Sinaki, M., Khosla, S., Limburg, P. J., Rogers, J. W. & Murtaugh, P. A., Jan 1993, In : Osteoporosis International. 3, 1, p. 8-12 5 p.

Research output: Contribution to journalArticle

Muscle Strength
Osteoporosis
Exercise
Back Pain
Posture
61 Citations (Scopus)

Mutations in the RET protooncogene in sporadic pheochromocytomas

Lindor, N. M., Honchel, R., Khosla, S. & Thibodeau, S. N., 1995, In : Journal of Clinical Endocrinology and Metabolism. 80, 2, p. 627-629 3 p.

Research output: Contribution to journalArticle

Pheochromocytoma
Exons
Mutation
Tumors
Multiple Endocrine Neoplasia
44 Citations (Scopus)

Mutual antagonism of estrogen receptors α and β and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines

Monroe, D. G., Johnsen, S., Subramaniam, M., Getz, B. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Mar 1 2003, In : Journal of Endocrinology. 176, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

Steroid Receptors
Estrogen Receptors
Protein Isoforms
Estrogens
Cell Line
9 Citations (Scopus)

Mutual enhancement of differentiation of osteoblasts and osteocytes occurs through direct cell-cell contact

Fujita, K., Xing, Q., Khosla, S. & Monroe, D. G., Nov 1 2014, In : Journal of Cellular Biochemistry. 115, 11, p. 2039-2044 6 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Gene expression
Bone
Genes
39 Citations (Scopus)
Myostatin
Sarcopenia
Mass Spectrometry
Muscles
Follistatin-Related Proteins
20 Citations (Scopus)

Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts

Doran, P. M., Turner, R. T., Chen, D., Facteau, S. M., Ludvigson, J. M., Khosla, S., Riggs, B. L. & Russell, S. J., Apr 2004, In : Experimental Hematology. 32, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Bone Diseases
Heterografts
Genes
Neoplasms
5 Citations (Scopus)

Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women

Collins, J. D., Arch, E. S., Crenshaw, J. R., Bernhardt, K. A., Khosla, S., Amin, S. & Kaufman, K. R., May 1 2018, In : Gait and Posture. 62, p. 311-316 6 p.

Research output: Contribution to journalArticle

Ankle
Foot Orthoses
Gait
Independent Living
Walking Speed
4 Citations (Scopus)

New hope for symptom management during natural and iatrogenic menopause transitions

Woodruff, T. K. & Khosla, S., Aug 1 2017, In : Biology of Reproduction. 97, 2, p. 177-178 2 p.

Research output: Contribution to journalArticle

Menopause
Bone and Bones
Gonadal Hormones
Peptide Hormones
Estrogens
23 Citations (Scopus)

New Insights into Androgen and Estrogen Receptor Regulation of the Male Skeleton

Khosla, S., Jul 1 2015, In : Journal of Bone and Mineral Research. 30, 7, p. 1134-1137 4 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Androgen Receptors
Osteoclasts
Osteoblasts
Skeleton
28 Citations (Scopus)

New selective estrogen and androgen receptor modulators

Clarke, B. & Khosla, S., Jul 2009, In : Current Opinion in Rheumatology. 21, 4, p. 374-379 6 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Androgen Receptors
Clinical Trials
Estrogen Receptors
Tamoxifen
30 Citations (Scopus)

Nonoxidative free fatty acid disposal is greater in young women than men

Koutsari, C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Feb 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 2, p. 541-547 7 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Insulin Resistance
Insulin
Fatty Acids
Oxidation
58 Citations (Scopus)

Non-suppressible parathyroid hormone secretion is related to gland size in uremic secondary hyperparathyroidism

Indridason, O. S., Heath, H., Khosla, S., Yohay, D. A. & Quarles, L. D., Nov 1996, In : Kidney International. 50, 5, p. 1663-1671 9 p.

Research output: Contribution to journalArticle

Secondary Hyperparathyroidism
Parathyroid Hormone
Calcium
Parathyroid Glands
Primary Hyperparathyroidism
6 Citations (Scopus)

Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD

Bonaretti, S., Carpenter, R. D., Saeed, I., Burghardt, A. J., Yu, L., Bruesewitz, M., Khosla, S. & Lang, T., Dec 21 2014, In : Physics in Medicine and Biology. 59, 24, p. 7819-7834 16 p.

Research output: Contribution to journalArticle

Thigh
Bone Density
Hip
Body Size
Tomography
39 Citations (Scopus)

Nucleotide sequence of cloned cDNAs encoding chicken preproparathyroid hormone

Khosla, S., Demay, M., Pines, M., Hurwitz, S., Potts, J. T. & Kronenberg, H. M., 1988, In : Journal of Bone and Mineral Research. 3, 6, p. 689-698 10 p.

Research output: Contribution to journalArticle

Chickens
Complementary DNA
Hormones
Nucleotides
Amino Acids
19 Citations (Scopus)

Odanacatib: Location and timing are everything

Khosla, S., Mar 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 506-508 3 p.

Research output: Contribution to journalArticle

Biphenyl Compounds
Bone Density Conservation Agents
Lumbar Vertebrae
Organ Size
Bone Remodeling
17 Citations (Scopus)

Oestrogen, bones and men: When testosterone just isn't enough

Khosla, S., 2002, In : Clinical Endocrinology. 56, 3, p. 291-293 3 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Resorption
Estrogen Receptors
Testosterone
Estrogens
15 Citations (Scopus)

Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training

Bonaretti, S., Vilayphiou, N., Chan, C. M., Yu, A., Nishiyama, K., Liu, D., Boutroy, S., Ghasem-Zadeh, A., Boyd, S. K., Chapurlat, R., McKay, H., Shane, E., Bouxsein, M. L., Black, D. M., Majumdar, S., Orwoll, E. S., Lang, T. F., Khosla, S. & Burghardt, A. J., Jul 30 2016, (Accepted/In press) In : Osteoporosis International. p. 1-13 13 p.

Research output: Contribution to journalArticle

Software
Tomography
Bone Fractures
Tibia
Radiology
45 Citations (Scopus)
Jaw Diseases
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Density Conservation Agents
Osteonecrosis
Diphosphonates
117 Citations (Scopus)

Osteocalcin Expression by Circulating Endothelial Progenitor Cells in Patients With Coronary Atherosclerosis

Gössl, M., Mödder, U. I., Atkinson, E. J., Lerman, A. & Khosla, S., Oct 14 2008, In : Journal of the American College of Cardiology. 52, 16, p. 1314-1325 12 p.

Research output: Contribution to journalArticle

Osteocalcin
Coronary Artery Disease
Vascular Endothelial Growth Factor Receptor-2
Coronary Vessels
Endothelial Progenitor Cells
44 Citations (Scopus)

Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis

Flammer, A. J., Gössl, M., Widmer, R. J., Reriani, M., Lennon, R., Loeffler, D., Shonyo, S., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : European Heart Journal. 33, 23, p. 2963-2969 7 p.

Research output: Contribution to journalArticle

Osteocalcin
Atherosclerosis
Stem Cells
Coronary Artery Disease
Cell Count
26 Citations (Scopus)

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Weivoda, M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Osteogenesis
Osteoblasts
Bone and Bones
19 Citations (Scopus)

Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis

Collin, J., Gössl, M., Matsuo, Y., Cilluffo, R. R., Flammer, A. J., Loeffler, D., Lennon, R. J., Simari, R. D., Spoon, D. B., Erbel, R., Lerman, L. O., Khosla, S. & Lerman, A., Feb 15 2015, In : International Journal of Cardiology. 181, p. 57-64 8 p.

Research output: Contribution to journalArticle

Coronary Circulation
Osteocalcin
Monocytes
Atherosclerosis
Alkaline Phosphatase

Osteology: further debate.

Kleerekoper, M., Deftos, L., Khosla, S., Marcus, R., Matrici, M., McClung, M., Rosen, C. & Shane, E., Jun 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, 6, p. 1017 1 p.

Research output: Contribution to journalArticle

Osteology
Metabolic Bone Diseases
65 Citations (Scopus)

Osteopenia

Khosla, S. & Melton, L. J., May 31 2007, In : New England Journal of Medicine. 356, 22, p. 2293-2300 8 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Weights and Measures
Femur Neck
Hip Fractures
Wine
50 Citations (Scopus)

Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study

French, A. R., Mason, T., Nelson, A. M., Crowson, C., O'Fallon, W. M., Khosla, S. & Gabriel, S. E., 2002, In : Journal of Rheumatology. 29, 5, p. 1065-1070 6 p.

Research output: Contribution to journalArticle

Juvenile Arthritis
Metabolic Bone Diseases
Bone Density
Population
Spine
1063 Citations (Scopus)

Osteoporosis: Now and the future

Rachner, T. D., Khosla, S. & Hofbauer, L. C., Apr 9 2011, In : The Lancet. 377, 9773, p. 1276-1287 12 p.

Research output: Contribution to journalArticle

Osteoporosis
Osteoclasts
Bone and Bones
Osteogenesis
Cathepsin K
32 Citations (Scopus)

Osteoporosis: Gender differences and similarities

Khosla, S., Melton, L. J. & Riggs, B. L., 1999, In : Lupus. 8, 5, p. 393-396 4 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
Bone Resorption
15 Citations (Scopus)

Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)

Adams, A. L., Fischer, H., Kopperdahl, D. L., Lee, D. C., Black, D. M., Bouxsein, M. L., Fatemi, S., Khosla, S., Orwoll, E. S., Siris, E. S. & Keaveny, T. M., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Photon Absorptiometry
Hip Fractures
Osteoporosis
Pelvic Bones
Tomography
36 Citations (Scopus)

Osteoporosis assessment by whole body region vs. site-specific DXA

Melton, L. J., Looker, A. C., Shepherd, J. A., O'Connor, M. K., Achenbach, S. J., Riggs, B. L. & Khosla, S., Dec 2005, In : Osteoporosis International. 16, 12, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

Body Regions
Osteoporosis
Spine
Whole Body Imaging
Femur Neck
15 Citations (Scopus)

Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings

Egorov, V., Tatarinov, A., Sarvazyan, N., Wood, R., Magidenko, L., Amin, S., Khosla, S., Ruh, R. J., Ruh, J. M. & Sarvazyan, A., 2014, In : Ultrasonics. 54, 5, p. 1170-1177 8 p.

Research output: Contribution to journalArticle

ultrasonic scanners
osteoporosis
bones
curves
tibia
236 Citations (Scopus)

Osteoporosis in men

Khosla, S., Amin, S. & Orwoll, E., Jun 2008, In : Endocrine Reviews. 29, 4, p. 441-464 24 p.

Research output: Contribution to journalArticle

Osteoporosis
Reference Values
Hip Fractures
Diphosphonates
Osteoblasts
30 Citations (Scopus)

Osteoporosis in men - Consensus is premature

Seeman, E., Bianchi, G., Adami, S., Kanis, J., Khosla, S. & Orwoll, E., Aug 2004, In : Calcified Tissue International. 75, 2, p. 120-122 3 p.

Research output: Contribution to journalArticle

Bone Development
Bone Fractures
Puberty
Sex Characteristics
Italy
101 Citations (Scopus)

Osteoporosis treatment: Recent developments and ongoing challenges

Khosla, S. & Hofbauer, L. C., 2017, (Accepted/In press) In : The Lancet Diabetes and Endocrinology.

Research output: Contribution to journalArticle

Osteoporosis
Diphosphonates
Pharmaceutical Preparations
Estrogens
Teriparatide
19 Citations (Scopus)

Osteoporosis Update From the 2010 Santa Fe Bone Symposium

Lewiecki, E. M., Bilezikian, J. P., Khosla, S., Marcus, R., McClung, M. R., Miller, P. D., Watts, N. B. & Maricic, M., Jan 2011, In : Journal of Clinical Densitometry. 14, 1, p. 1-21 21 p.

Research output: Contribution to journalArticle

Osteoporosis
Metabolic Bone Diseases
Bone and Bones
Biomedical Technology Assessment
Fracture Healing
4 Citations (Scopus)

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

Farr, J., Weivoda, M., Nicks, K. M., Fraser, D. G., Negley, B. A., Onken, J. L., Thicke, B. S., Ruan, M., Liu, H., Forrest, D., Hawse, J. R., Khosla, S. & Monroe, D. G., Apr 1 2018, In : Journal of Bone and Mineral Research. 33, 4, p. 720-731 12 p.

Research output: Contribution to journalArticle

Transcription Factors
Osteogenesis
TCF Transcription Factors
Osteoprotegerin
Bone and Bones
259 Citations (Scopus)

Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines

Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 29 1998, In : Biochemical and Biophysical Research Communications. 250, 3, p. 776-781 6 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Bone Morphogenetic Protein 2
Osteoblasts
Vitamin D
Cytokines
59 Citations (Scopus)

Parathyroid hormone plus alendronate - A combination that does not add up

Khosla, S., Sep 25 2003, In : New England Journal of Medicine. 349, 13, p. 1277-1279 3 p.

Research output: Contribution to journalArticle

Alendronate
Lumbar Vertebrae
Bone Remodeling
Femur Neck
Combination Drug Therapy
53 Citations (Scopus)

Parathyroid hormone-related peptide in lactation and in umbilical cord blood

Khosla, S., Johansen, K. L., Ory, S. J., O'Brien, P. C. & Kao, P. C., 1990, In : Mayo Clinic Proceedings. 65, 11, p. 1408-1414 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Fetal Blood
Lactation
Human Milk
Hyperprolactinemia
94 Citations (Scopus)

Parathyroid hormone-related protein and hypercalcemia secondary to massive mammary hyperplasia

Khosla, S., Van Heerden, J. A., Gharib, H., Jackson, I. T., Danks, J., Hayman, J. A. & Martin, T. J., 1990, In : New England Journal of Medicine. 322, 16, p. 1157 1 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Pregnancy Complications
Hypercalcemia
Hyperplasia
Breast
99 Citations (Scopus)

Pathogenesis of age-related bone loss in humans

Khosla, S., Oct 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 10, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Estrogens
Rodentia
Interleukin-1
180 Citations (Scopus)

Pathophysiology of age-related bone loss and osteoporosis

Khosla, S. & Riggs, B. L., Dec 2005, In : Endocrinology and Metabolism Clinics of North America. 34, 4, p. 1015-1030 16 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone
Bone and Bones
Sarcopenia
Secondary Hyperparathyroidism
23 Citations (Scopus)

Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers

Flammer, A. J., Gössl, M., Li, J., Matsuo, Y., Reriani, M., Loeffler, D., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4761-4768 8 p.

Research output: Contribution to journalArticle

Osteocalcin
Endothelial cells
Cell Count
Vascular Calcification
Glycosylated Hemoglobin A
126 Citations (Scopus)

Physiology of Bone Loss

Clarke, B. & Khosla, S., May 2010, In : Radiologic Clinics of North America. 48, 3, p. 483-495 13 p.

Research output: Contribution to journalArticle

Bone and Bones
Osteoporosis
Estrogens
Sarcopenia
Postmenopausal Osteoporosis
95 Citations (Scopus)

Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β

Rickard, D. J., Monroe, D. G., Ruesink, T. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Jun 1 2003, In : Journal of Cellular Biochemistry. 89, 3, p. 633-646 14 p.

Research output: Contribution to journalArticle

Phytoestrogens
Genistein
Estrogen Receptors
Estrogens
Gene expression
1 Citation (Scopus)

Placebo-controlled fracture trials in osteoporosis - Comment on the article by Stein and Ray

Rosen, C. J. & Khosla, S., Sep 30 2010, In : New England Journal of Medicine. 363, 14

Research output: Contribution to journalArticle

Osteoporosis
Placebos
16 Citations (Scopus)

Placebo-controlled trials in osteoporosis - Proceeding with caution

Rosen, C. J. & Khosla, S., Sep 30 2010, In : New England Journal of Medicine. 363, 14, p. 1365-1367 3 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Postmenopausal Osteoporosis
Bone Fractures
Osteoporosis
Placebos
35 Citations (Scopus)

Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells

Flammer, A. J., Martin, E. A., Gössl, M., Widmer, R. J., Lennon, R. J., Sexton, J. A., Loeffler, D., Khosla, S., Lerman, L. O. & Lerman, A., Feb 2013, In : European Journal of Nutrition. 52, 1, p. 289-296 8 p.

Research output: Contribution to journalArticle

Vaccinium macrocarpon
Osteocalcin
Polyphenols
Blood Vessels
Placebos
79 Citations (Scopus)

Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., McCollough, C. H., Khosla, S. & Bouxsein, M. L., Feb 2006, In : Journal of Bone and Mineral Research. 21, 2, p. 315-323 9 p.

Research output: Contribution to journalArticle

Hip Fractures
Wrist
Bone and Bones
Femur Neck
Population
566 Citations (Scopus)

Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Peterson, J. M., Rouleau, P. A., McCollough, C. H., Bouxsein, M. L. & Khosla, S., Dec 2004, In : Journal of Bone and Mineral Research. 19, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

Sex Characteristics
Bone Density
Bone and Bones
Population
Bone Remodeling