• 40477 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

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Research Output

Article

Relationship between body composition and bone mass in women

Khosla, S., Atkinson, E. J., Riggs, B. L. & Melton, L. J., Jun 1 1996, In : Journal of Bone and Mineral Research. 11, 6, p. 857-863 7 p.

Research output: Contribution to journalArticle

257 Scopus citations

Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan

Ng, A. C., Melton, L. J., Atkinson, E. J., Achenbach, S. J., Holets, M. F., Peterson, J. M., Khosla, S. & Drake, M. T., Mar 11 2013, In : Bone. 55, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Relationship of age to bone microstructure independent of areal bone mineral density

Nicks, K. M., Amin, S., Atkinson, E. J., Riggs, B. L., Melton, L. J. & Khosla, S., Mar 1 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 637-644 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Relationship of bone turnover to bone density and fractures

Melton, L. J., Khosla, S., Atkinson, E. J., O'Fallon, W. M. & Riggs, B. L., Jul 1 1997, In : Journal of Bone and Mineral Research. 12, 7, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

311 Scopus citations

Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Mavilia, C., Del Monte, F., Melton, L. J. & Brandi, M. L., Apr 1 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1808-1816 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women

Srinivasan, B., Kopperdahl, D. L., Amin, S., Atkinson, E. J., Camp, J., Robb, R. A., Riggs, B. L., Orwoll, E. S., Melton, L. J., Keaveny, T. M. & Khosla, S., Jan 1 2012, In : Osteoporosis International. 23, 1, p. 155-162 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action

Pattanaungkul, S., Riggs, B. L., Yergey, A. L., Vieira, N. E., O'Fallon, W. M. & Khosla, S., Dec 1 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4023-4027 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Jan 1 2000, In : Metabolism: Clinical and Experimental. 49, 10, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

136 Scopus citations

Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen

Khosla, S., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Klee, G. G. & Riggs, B. L., Nov 16 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 7, p. 2266-2274 9 p.

Research output: Contribution to journalArticle

807 Scopus citations

Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men

Khosla, S., Melton, L. J., Atkinson, E. J. & O'Fallon, W. M., Jan 1 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

Open Access
397 Scopus citations

Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women

Farr, J. N., Charkoudian, N., Barnes, J. N., Monroe, D. G., McCready, L. K., Atkinson, E. J., Amin, S., Melton, L. J., Joyner, M. J. & Khosla, S., Nov 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4219-4227 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Relationship of testosterone and osteocalcin levels during growth

Kirmani, S., Atkinson, E. J., Melton, L. J., Riggs, B. L., Amin, S. & Khosla, S., Sep 1 2011, In : Journal of Bone and Mineral Research. 26, 9, p. 2212-2216 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men

Khosla, S., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A. & Riggs, B. L., May 1 2005, In : Journal of Bone and Mineral Research. 20, 5, p. 730-740 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women

Khosla, S., Riggs, B. L., Robb, R. A., Camp, J. J., Achenbach, S. J., Oberg, A. L., Rouleau, P. A. & Melton, L. J., Sep 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 9, p. 5096-5103 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O'Fallon, W. M., Eastell, R. & Khosla, S., Jan 1 2000, In : Journal of Clinical Investigation. 106, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

Open Access
557 Scopus citations

Relative influence of physical activity, muscle mass and strength on bone density

Proctor, D. N., Melton, L. J., Khosla, S., Crowson, C. S., O'Connor, M. K. & Riggs, B. L., Dec 1 2000, In : Osteoporosis International. 11, 11, p. 944-952 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Response of bipotential human marrow stromal cells to insulin-like growth factors: Effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes

Thomas, T., Gori, F., Spelsberg, T. C., Khosla, S., Riggs, B. L. & Conover, C. A., Jan 1 1999, In : Endocrinology. 140, 11, p. 5036-5044 9 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

Response to Wnt Signaling Pathways

Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Robust QCT/FEA models of proximal femur stiffness and fracture load during a sideways fall on the hip

Dragomir-Daescu, D., Op Den Buijs, J., McEligot, S., Dai, Y., Entwistle, R. C., Salas, C., Melton, L. J., Bennet, K. E., Khosla, S. & Amin, S., Feb 1 2011, In : Annals of Biomedical Engineering. 39, 2, p. 742-755 14 p.

Research output: Contribution to journalArticle

144 Scopus citations

Role of biochemical markers in assessment of osteoporosis

Riggs, B. L. & Khosla, S., Jan 1 1995, In : Acta Orthopaedica. 66, S266, p. 14-18 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption

Mckane, W. R., Khosla, S., Egan, K. S., Robins, S. P., Burritt, M. F. & Riggs, B. L., May 21 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 5, p. 1699-1703 5 p.

Research output: Contribution to journalArticle

176 Scopus citations

Role of circulating osteogenic progenitor cells in calcific aortic stenosis

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Enriquez-Sarano, M., Lennon, R. J., Lerman, L. O. & Lerman, A., Nov 6 2012, In : Journal of the American College of Cardiology. 60, 19, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women

McKane, W. R., Khosla, S., Risteli, J., Robins, S. P., Muhs, J. M. & Riggs, B. L., Apr 26 1997, In : Proceedings of the Association of American Physicians. 109, 2, p. 174-180 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
40 Scopus citations

Role of hormonal changes in the pathogenesis of osteoporosis in men

Khosla, S., Aug 1 2004, In : Calcified Tissue International. 75, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women

Heshmati, H. M., Khosla, S., Robins, S. P., O'Fallon, W. M., Melton, L. J. & Riggs, B. L., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

162 Scopus citations

Role of parathyroid hormone in mediating age-related changes in bone resorption in men

Kennel, K. A., Riggs, B. L., Achenbach, S. J., Oberg, A. L. & Khosla, S., Aug 1 2003, In : Osteoporosis International. 14, 8, p. 631-636 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption

Ledger, G. A., Burritt, M. F., Kao, P. C., O’Fallon, W. M., Riggs, B. L. & Khosla, S., Nov 1995, In : Journal of Clinical Endocrinology and Metabolism. 80, 11, p. 3304-3310 7 p.

Research output: Contribution to journalArticle

123 Scopus citations

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

Eghbali-Fatourechi, G., Khosla, S., Sanyal, A., Boyle, W. J., Lacey, D. L. & Riggs, B. L., Apr 1 2003, In : Journal of Clinical Investigation. 111, 8, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

548 Scopus citations

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Aug 21 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

242 Scopus citations

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 1 2013, In : Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sclerostin levels during growth in children

Kirmani, S., Amin, S., McCready, L. K., Atkinson, E. J., Melton, L. J., Müller, R. & Khosla, S., Mar 1 2012, In : Osteoporosis International. 23, 3, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Secondary osteoporosis and the risk of distal forearm fractures in men and women

Melton, L. J., Achenbach, S. J., O'fallon, W. M. & Khosla, S., Jan 1 2002, In : Bone. 31, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Secondary osteoporosis and the risk of vertebral deformities in women

Melton, L. J., Atkinson, E. J., Khosla, S., O'Fallon, W. M. & Riggs, B. L., Jan 1 1999, In : Bone. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

243 Scopus citations

Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women

Bhattacharyya, S., Siegel, E. R., Achenbach, S. J., Khosla, S. & Suva, L. J., Jul 1 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1106-1117 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Feb 1 2019, In : Clinical Endocrinology. 90, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalArticle

Skeletal changes through the lifespan - From growth to senescence

Farr, J. & Khosla, S., Sep 20 2015, In : Nature Reviews Endocrinology. 11, 9, p. 513-521 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2

Mödder, U. I., Monroe, D. G., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Géhin, M., Chambon, P., O'Malley, B. W. & Khosla, S., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 18767-18777 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 1 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
67 Scopus citations
52 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features

Carballido-Gamio, J., Bonaretti, S., Kazakia, G. J., Khosla, S., Majumdar, S., Lang, T. F. & Burghardt, A. J., Nov 9 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-14 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., Jan 1 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

Open Access
581 Scopus citations

Structural determinants of vertebral fracture risk

Mellon, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Hoffmann, P. F., Camp, J. J., Rouleau, P. A., Bouxsein, M. L., Amin, S., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 1 2007, In : Journal of Bone and Mineral Research. 22, 12, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 1 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

60 Scopus citations