• 39555 Citations
  • 101 Scopus h-Index
1976 …2021
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Research Output 1980 2020

Article
41 Citations (Scopus)

Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells

Kopher, R. A., Penchev, V. R., Islam, M. S., Hill, K. L., Khosla, S. & Kaufman, D. S., Oct 2010, In : Bone. 47, 4, p. 718-728 11 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stem Cells
Human Embryonic Stem Cells
Pluripotent Stem Cells
Endothelial Cells
6 Citations (Scopus)

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PLoS One. 6, 9, e24876.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus env Gene Products
osteoblasts
Osteoblasts
Human immunodeficiency virus
apoptosis
47 Citations (Scopus)

Identification of multiple endocrine neoplasia, type 2 gene carriers using linkage analysis and analysis of the RET proto-oncogene

Tsai, M. S., Ledger, G. A., Khosla, S., Gharib, H. & Thibodeau, S. N., May 1994, In : Journal of Clinical Endocrinology and Metabolism. 78, 5, p. 1261-1264 4 p.

Research output: Contribution to journalArticle

Multiple Endocrine Neoplasia Type 2a
Proto-Oncogenes
Genes
Exons
DNA sequences

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
osteoblasts
Osteoblasts
metabolism
Osteoclasts
Energy Metabolism
8 Citations (Scopus)

Identification of Rorβ targets in cultured osteoblasts and in human bone

Roforth, M. M., Khosla, S. & Monroe, D. G., Nov 1 2013, In : Biochemical and Biophysical Research Communications. 440, 4, p. 768-773 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone
Genes
Bone and Bones
Extracellular Matrix
79 Citations (Scopus)

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Phenotype
Satellite DNA
Cell Aging
16 Citations (Scopus)

Idiopathic osteoporosis: A heterogeneous entity

Heshmati, H. M. & Khosla, S., Mar 1998, In : Annales de Medecine Interne. 149, 2, p. 77-81 5 p.

Research output: Contribution to journalArticle

Osteoporosis
Colles' Fracture
Hypercalciuria
Compression Fractures
Bone and Bones
1 Citation (Scopus)

Idiopathic osteoporosis: Is the osteoblast to blame? [4] (multiple letters)

Parfitt, A. M., Weinstein, R. S. & Khosla, S., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 2, p. 716 1 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteoporosis
7 Citations (Scopus)

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., 1999, In : Clinical Chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

Immunoradiometric Assay
Osteocalcin
Assays
Plasmas
Edetic Acid
304 Citations (Scopus)

Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA

Dawson-Hughes, B., Tosteson, A. N. A., Melton, L. J., Baim, S., Favus, M. J., Khosla, S. & Lindsay, R. L., Apr 2008, In : Osteoporosis International. 19, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Osteoporosis
Hip Fractures
Health Care Costs
Economics
28 Citations (Scopus)

Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Christen, D., Melton, L. J., Zwahlen, A., Amin, S., Khosla, S. & Müller, R., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

Odds Ratio
Tomography
Confidence Intervals
Bone and Bones
Forearm
304 Citations (Scopus)

Incidence of Childhood Distal Forearm Fractures over 30 Years: A Population-Based Study

Khosla, S., Melton, L. J., Dekutoski, M. B., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Sep 17 2003, In : Journal of the American Medical Association. 290, 11, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

Forearm
Confidence Intervals
Incidence
Population
Exercise
248 Citations (Scopus)

Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: An update on the changing epidemiology of the disease

Wermers, R. A., Khosla, S., Atkinson, E. J., Achenbach, S. J., Oberg, A. L., Grant, C. S. & Melton, L. J., Jan 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Epidemiology
Incidence
Parathyroidectomy
Calcium
57 Citations (Scopus)

Increasing options for the treatment of osteoporosis

Khosla, S., Aug 20 2009, In : New England Journal of Medicine. 361, 8, p. 818-820 3 p.

Research output: Contribution to journalArticle

Osteoporosis
3 Citations (Scopus)

Increasing Rates of Forearm Fractures in Children [4] (multiple letters)

Swiontkowski, M. F., Khosla, S., Melton, L. J. & Dekutoski, M. B., Dec 24 2003, In : Journal of the American Medical Association. 290, 24, p. 3193 1 p.

Research output: Contribution to journalArticle

Ulna Fractures
Radius Fractures
Forearm
Incidence
2 Citations (Scopus)

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Young Adult
Estrogens
Bone and Bones
19 Citations (Scopus)

Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow

Undale, A., Fraser, D., Hefferan, T., Kopher, R. A., Herrick, J., Evans, G. L., Li, X., Kakar, S., Hayes, M., Atkinson, E., Yaszemski, M. J., Kaufman, D. S., Westendorf, J. J. & Khosla, S., Dec 2011, In : Journal of Orthopaedic Research. 29, 12, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone Marrow
Fracture Healing
Control Groups
Human Embryonic Stem Cells
25 Citations (Scopus)
Cell Aging
Osteoporosis
Bone
Aging of materials
Bone and Bones
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor II
1 Citation (Scopus)

Insulin-like growth factor binding protein-2: A novel regulator of skeletal gender differences?

Khosla, S., May 2008, In : Endocrinology. 149, 5, p. 2048-2050 3 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Biological Models
Organ Size
Bone Development
Knockout Mice
81 Citations (Scopus)

Insulin-like growth factor system abnormalities in hepatitis C- associated osteosclerosis. Potential insights into increasing bone mass in adults

Khosla, S., Hassoun, A. A. K., Baker, B. K., Liu, F., Zein, N. N., Whyte, M. P., Reasner, C. A., Nippoldt, T. B., Tiegs, R. D., Hintz, R. L. & Conover, C. A., May 15 1998, In : Journal of Clinical Investigation. 101, 10, p. 2165-2173 9 p.

Research output: Contribution to journalArticle

Osteosclerosis
Insulin-Like Growth Factor II
Somatomedins
Hepatitis C
Insulin-Like Growth Factor Binding Protein 2
10 Citations (Scopus)

Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity

Bush, N. C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Nov 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

Adiposity
Nonesterified Fatty Acids
Intra-Abdominal Fat
Palmitates
Insulin Resistance
4 Citations (Scopus)

Interaction between estrogen and vitamin D-endocrine system: A potential addition to the unitary model of osteoporosis

Liel, Y., Shany, S., Schwartz, B., Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., 1998, In : Journal of Bone and Mineral Research. 13, 12, p. 1954-1955 2 p.

Research output: Contribution to journalArticle

Biological Models
Calcitriol Receptors
Endocrine System
Intestinal Mucosa
Vitamin D
491 Citations (Scopus)

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

RANK Ligand
Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha
Gene Expression
84 Citations (Scopus)

In vitro and in vivo detection of somatostatin receptors in pheochromocytomas and paragangliomas

Reubi, J. C., Waser, B., Khosla, S., Kvols, L., Goellner, J. R., Krenning, E. & Lamberts, S., May 1992, In : Journal of Clinical Endocrinology and Metabolism. 74, 5, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

Paraganglioma
Somatostatin Receptors
Pheochromocytoma
Tumors
Loss of Heterozygosity
247 Citations (Scopus)

In vivo assessment of bone quality in postmenopausal women with type 2 diabetes

Farr, J., Drake, M. M., Amin, S., Melton, L. J., McCready, L. K. & Khosla, S., 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Bone and Bones
Bone Density
Bone Remodeling
Diabetes Complications
26 Citations (Scopus)

Is familial hyperparathyroidism a unique disease?

Barry, M. K., Van Heerden, J. A., Grant, C. S., Thompson, G. B. & Khosla, S., Dec 1997, In : Surgery. 122, 6, p. 1028-1033 6 p.

Research output: Contribution to journalArticle

Hyperparathyroidism
Nephrolithiasis
Parathyroid Diseases
Multiple Endocrine Neoplasia
Thymectomy
15 Citations (Scopus)

Is nitroglycerin a novel and inexpensive treatment for osteoporosis?

Khosla, S., Feb 23 2011, In : JAMA - Journal of the American Medical Association. 305, 8, p. 826-827 2 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Postmenopause
Nitric Oxide Donors
Bone Fractures
Nitroglycerin
15 Citations (Scopus)

Isolation and characterization of human osteoblasts from needle biopsies without in vitro culture

Fujita, K., Roforth, M. M., Atkinson, E. J., Peterson, J. M., Drake, M. M., McCready, L. K., Farr, J., Monroe, D. G. & Khosla, S., Mar 2014, In : Osteoporosis International. 25, 3, p. 887-895 9 p.

Research output: Contribution to journalArticle

Needle Biopsy
Osteoblasts
Alkaline Phosphatase
Bone and Bones
Genes
69 Citations (Scopus)

Is vitamin D a determinant of muscle mass and strength?

Marantes, I., Achenbach, S. J., Atkinson, E. J., Khosla, S., Melton, L. J. & Amin, S., Dec 2011, In : Journal of Bone and Mineral Research. 26, 12, p. 2860-2871 12 p.

Research output: Contribution to journalArticle

Muscle Strength
Parathyroid Hormone
Vitamin D
Knee
Linear Models
25 Citations (Scopus)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Andersen, T. L., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 373-386 14 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Postmenopausal Osteoporosis
Mesenchymal Stromal Cells
Bone
Osteoblasts
597 Citations (Scopus)

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Stromal Cells
Leptin
Osteoblasts
Adipocytes
Bone Marrow
247 Citations (Scopus)

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

Ovariectomy
Leptin
Bone and Bones
RANK Ligand
Fat Body
1 Citation (Scopus)
Parabiosis
Cell Lineage
Osteoclasts
Collagen Type I
Green Fluorescent Proteins
2 Citations (Scopus)

Letter to the editor [2]

Khosla, S., Moedder, U. I. & Syed, F. A., Feb 2006, In : Bone. 38, 2, p. 289 1 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures

Giambini, H., Khosla, S., Nassr, A., Zhao, C. D. & An, K. N., Jan 2013, In : Clinical Biomechanics. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Bone Density
Spine
Body Regions
Individuality
Osteoporosis
15 Citations (Scopus)

Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 896-907 12 p.

Research output: Contribution to journalArticle

Response Elements
Gene expression
Estrogen Receptors
Bone
Estrogens
108 Citations (Scopus)

Loss of heterozygosity suggests multiple Genetic alterations in pheochromocytomas and medullary thyroid carcinomas

Khosla, S., Patel, V. M., Hay, I. D., Schaid, D. J., Grant, C. S., Van Heerden, J. A. & Thibodeau, S. N., May 1991, In : Journal of Clinical Investigation. 87, 5, p. 1691-1699 9 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Pheochromocytoma
Multiple Endocrine Neoplasia Type 2a
Genetic Loci
Chromosomes

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Aquino-Martinez, R., Rowsey, J. L., Fraser, D. G., Eckhardt, B. A., Khosla, S., Farr, J. N. & Monroe, D. G., Mar 2020, In : Bone. 132, 115220.

Research output: Contribution to journalArticle

Alveolar Bone Loss
Osteocytes
Bone Diseases
Periodontal Diseases
Lipopolysaccharides
4 Citations (Scopus)

Magic bullets to kill nasty osteoclasts

Khosla, S., Aug 2005, In : Endocrinology. 146, 8, p. 3233-3234 2 p.

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Osteoprotegerin
Biological Models
Magic
44 Citations (Scopus)

Male Osteoporosis

Drake, M. M. & Khosla, S., Sep 2012, In : Endocrinology and Metabolism Clinics of North America. 41, 3, p. 629-641 13 p.

Research output: Contribution to journalArticle

Osteoporosis
Hip Fractures
Estradiol
Morbidity
Bone and Bones
12 Citations (Scopus)

Measurement of gene expression following cryogenic μ-CT scanning of human iliac crest biopsies

Maran, A., Khosla, S., Riggs, B. L., Zhang, M., Ritman, E. L. & Turner, R. T., Mar 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Biopsy
Gene Expression
Bone and Bones
Transforming Growth Factors
Bone Matrix
103 Citations (Scopus)

Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause - A clinical research center study

McKane, W. R., Khosla, S., Burritt, M. F., Kao, P. C., Wilson, D. M., Ory, S. J. & Riggs, B. L., 1995, In : Journal of Clinical Endocrinology and Metabolism. 80, 12, p. 3458-3464 7 p.

Research output: Contribution to journalArticle

Postmenopause
Estrogen Replacement Therapy
Conservation
Estrogens
Calcium
274 Citations (Scopus)

Mechanisms of sex steroid effects on bone

Syed, F. & Khosla, S., Mar 18 2005, In : Biochemical and Biophysical Research Communications. 328, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

Bone
Bone Remodeling
Steroids
Bone and Bones
Osteoblasts
162 Citations (Scopus)

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone

Locklin, R. M., Khosla, S., Turner, R. T. & Riggs, B. L., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 180-190 11 p.

Research output: Contribution to journalArticle

RANK Ligand
Parathyroid Hormone
Osteoprotegerin
Bone
Insulin-Like Growth Factor I
130 Citations (Scopus)

Mesenchymal stem cells for bone repair and metabolic bone diseases

Undale, A. H., Westendorf, J. J., Yaszemski, M. J. & Khosla, S., 2009, In : Mayo Clinic Proceedings. 84, 10, p. 893-902 10 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
Bone and Bones
Hypophosphatasia
38 Citations (Scopus)

Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women with Fracture Independently of Total Hip T-Score: An International Multicenter Study

Boutroy, S., Khosla, S., Sornay-Rendu, E., Zanchetta, M. B., McMahon, D. J., Zhang, C. A., Chapurlat, R. D., Zanchetta, J., Stein, E. M., Bogado, C., Majumdar, S., Burghardt, A. J. & Shane, E., Jun 1 2016, In : Journal of Bone and Mineral Research. 31, 6, p. 1158-1166 9 p.

Research output: Contribution to journalArticle

Multicenter Studies
Hip
Tibia
Radius Fractures
Hip Fractures
1027 Citations (Scopus)

Minireview: The OPG/RANKL/RANK system

Khosla, S., 2001, In : Endocrinology. 142, 12, p. 5050-5055 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Stromal Cells
Osteogenesis
Bone and Bones
Osteopetrosis
8 Citations (Scopus)

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

Aquino-Martinez, R., Farr, J., Weivoda, M., Negley, B. A., Onken, J. L., Thicke, B. S., Fulcer, M. M., Fraser, D. G., van Wijnen, A. J., Khosla, S. & Monroe, D. G., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoblasts
Osteoporosis
Bone and Bones
MicroRNAs
Retinoic Acid Receptors
6 Citations (Scopus)

Modulators of androgen and estrogen receptor activity

Clarke, B. & Khosla, S., 2010, In : Critical Reviews in Eukaryotic Gene Expression. 20, 4, p. 275-294 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Selective Estrogen Receptor Modulators
Estrogens
Estrogen Receptors
Clinical Trials