• 39327 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2020

Article
423 Citations (Scopus)

DHEA in elderly women and DHEA or testosterone in elderly men

Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Man, C. D., Tindall, D. J., Melton, L. J., Smith, G. E., Khosla, S. & Jensen, M. D., Oct 19 2006, In : New England Journal of Medicine. 355, 16, p. 1647-1659 13 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Testosterone
Placebos
Body Composition
Bone Density
13 Citations (Scopus)

Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood

Farr, J., Khosla, S., Achenbach, S. J., Atkinson, E. J., Kirmani, S., McCready, L. K., Melton, L. J. & Amin, S., Oct 1 2014, In : Journal of Bone and Mineral Research. 29, 10, p. 2193-2202 10 p.

Research output: Contribution to journalArticle

Forearm
Bone and Bones
Wounds and Injuries
Tibia
Bone Density
14 Citations (Scopus)

Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing

Roforth, M. M., Atkinson, E. J., Levin, E. R., Khosla, S. & Monroe, D. G., Apr 28 2014, In : PLoS One. 9, 4, e95987.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Dissection
Estrogen Receptor alpha
osteoblasts
Osteoblasts
19 Citations (Scopus)

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

Syed, F. A., Fraser, D. G., Monroe, D. G. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Bone and Bones
Response Elements
Estrogens
38 Citations (Scopus)

Does reduced skeletal loading account for age-related bone loss?

Melton, L. J., Riggs, B. L., Achenbach, S. J., Amin, S., Camp, J. J., Rouleau, P. A., Robb, R. A., Oberg, A. L. & Khosla, S., Dec 2006, In : Journal of Bone and Mineral Research. 21, 12, p. 1847-1855 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Femur Neck
Skeletal Muscle
Exercise
Teriparatide
Hormone Replacement Therapy
Bone Density
53 Citations (Scopus)

Dose-response of estrogen on bone versus the uterus in ovariectomized mice

Mödder, U. I. L., Riggs, B. L., Spelsberg, T. C., Fraser, D. G., Atkinson, E. J., Arnold, R. & Khosla, S., Oct 2004, In : European Journal of Endocrinology. 151, 4, p. 503-510 8 p.

Research output: Contribution to journalArticle

Uterus
Estrogens
Bone and Bones
Inbred C57BL Mouse
Ovariectomy
34 Citations (Scopus)
Sex Hormone-Binding Globulin
Steroids
53 Citations (Scopus)

Editorial: Leptin - Central or peripheral to the regulation of bone metabolism?

Khosla, S., Nov 1 2002, In : Endocrinology. 143, 11, p. 4161-4164 4 p.

Research output: Contribution to journalArticle

Food Deprivation
Physiologic Calcification
Bone Development
Leptin
Body Composition
28 Citations (Scopus)

Editorial: Idiopathic osteoporosis - Is the osteoblast to blame?

Khosla, S., 1997, In : Journal of Clinical Endocrinology and Metabolism. 82, 9, p. 2792-2794 3 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Somatomedins
Osteoporosis
68 Citations (Scopus)

Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men

Basu, R., Dalla Man, C., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Aug 2007, In : Diabetes Care. 30, 8, p. 1972-1978 7 p.

Research output: Contribution to journalArticle

Testosterone
Insulin
Glucose
Liver
C-Peptide
147 Citations (Scopus)

Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women

Charatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L. K. & Riggs, B. L., May 2007, In : Journal of Bone and Mineral Research. 22, 5, p. 724-729 6 p.

Research output: Contribution to journalArticle

Bone Resorption
Interleukin-1
Interleukin 1 Receptor Antagonist Protein
Estrogens
Serum
14 Citations (Scopus)

Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women

Vincent, A., Riggs, B. L., Atkinson, E. J., Oberg, A. L. & Khosla, S., Mar 2003, In : Menopause. 10, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Parathyroid Hormone
Estrogens
Calcium
Kidney
152 Citations (Scopus)

Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men

Khosla, S., Atkinson, E. J., Dunstan, C. R. & O'Fallon, W. M., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 4, p. 1550-1554 5 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Testosterone
Estrogens
Cytokines
Bone Resorption
30 Citations (Scopus)

Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): A companion analysis of a randomised controlled trial

Goss, P. E., Hershman, D. L., Cheung, A. M., Ingle, J. N., Khosla, S., Stearns, V., Chalchal, H., Rowland, K., Muss, H. B., Linden, H. M., Scher, J., Pritchard, K. I., Elliott, C. R., Badovinac-Crnjevic, T., St Louis, J., Chapman, J. A. W. & Shepherd, L. E., 2014, In : The Lancet Oncology. 15, 4, p. 474-482 9 p.

Research output: Contribution to journalArticle

exemestane
Bone Density
Randomized Controlled Trials
Breast Neoplasms
Aromatase Inhibitors
27 Citations (Scopus)

Effects of age and estrogen on skeletal gene expression in humans as assessed by RNA sequencing

Farr, J., Roforth, M. M., Fujita, K., Nicks, K. M., Cunningham, J. M., Atkinson, E. J., Therneau, T. M., McCready, L. K., Peterson, J. M., Drake, M. M., Monroe, D. G. & Khosla, S., Sep 24 2015, In : PLoS One. 10, 9, e0138347.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Gene expression
estrogens
Bone
Estrogens
200 Citations (Scopus)

Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: A population-based study

Khosla, S., Atkinson, E. J., Melton, L. J. & Riggs, B. L., 1997, In : Journal of Clinical Endocrinology and Metabolism. 82, 5, p. 1522-1527 6 p.

Research output: Contribution to journalArticle

Bone Remodeling
Parathyroid Hormone
Bone
Estrogens
Biomarkers
53 Citations (Scopus)

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Roforth, M. M., Fujita, K., McGregor, U. I., Kirmani, S., McCready, L. K., Peterson, J. M., Drake, M. M., Monroe, D. G. & Khosla, S., 2014, In : Bone. 59, p. 1-6 6 p.

Research output: Contribution to journalArticle

Osteogenesis
Bone and Bones
Messenger RNA
Genes
Osteoporosis
70 Citations (Scopus)

Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line

Gori, F., Hofbauer, L. C., Conover, C. A. & Khosla, S., 1999, In : Endocrinology. 140, 12, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

Somatomedins
Androgens
Insulin-Like Growth Factor I
Cell Line
Insulin-Like Growth Factor Binding Proteins
23 Citations (Scopus)

Effects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women

Peris, P., Atkinson, E. J., Gössl, M., Kane, T. L., McCready, L. K., Lerman, A., Khosla, S. & McGregor, U. I., Jan 2013, In : Mayo Clinic Proceedings. 88, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Diphosphonates
Vascular Calcification
Osteocalcin
Osteoblasts
Down-Regulation
85 Citations (Scopus)

Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men

Melton, L. J., Khosla, S., Achenbach, S. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

Body Size
Bone Density
Osteoporosis
Bone and Bones
Spine
33 Citations (Scopus)

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 2010, In : Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Spine
Differentiation Antigens
Gene Expression
9 Citations (Scopus)

Effects of estrogen and testosterone on resting energy expenditure in older men

Santosa, S., Khosla, S., McCready, L. K. & Jensen, M. D., Dec 2010, In : Obesity. 18, 12, p. 2392-2394 3 p.

Research output: Contribution to journalArticle

Energy Metabolism
Testosterone
Estrogens
Steroids
Leuprolide
31 Citations (Scopus)

Effects of estrogen on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in postmenopausal women

Fujita, K., Roforth, M. M., Demaray, S., McGregor, U., Kirmani, S., McCready, L. K., Peterson, J. M., Drake, M. M., Monroe, D. G. & Khosla, S., Jan 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 1

Research output: Contribution to journalArticle

Metabolism
Bone
Estrogens
Genes
Bone and Bones
54 Citations (Scopus)

Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 202-207 6 p.

Research output: Contribution to journalArticle

Estrogens
Cytokines
Bone Marrow
Bone and Bones
Adiponectin
116 Citations (Scopus)

Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women

Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 2008, In : Osteoporosis International. 19, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Adipocytes
Estrogens
Bone Marrow
Therapeutics
Placebos
24 Citations (Scopus)
Progesterone
Bone
Estrogens
Hormones
Microstructure
35 Citations (Scopus)

Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line

Hofbauer, L. C., Hicok, K. C. & Khosla, S., Oct 1 1998, In : Journal of Cellular Biochemistry. 71, 1, p. 96-108 13 p.

Research output: Contribution to journalArticle

Androgen Receptors
Androgens
Cells
Cell Line
Dihydrotestosterone
177 Citations (Scopus)

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells

Hofbauer, L. C., Shui, C., Riggs, B. L., Dunstan, C. R., Spelsberg, T. C., O'Brien, T. & Khosla, S., 2001, In : Biochemical and Biophysical Research Communications. 280, 1, p. 334-339 6 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Immunosuppressive Agents
Smooth Muscle Myocytes
Muscle
30 Citations (Scopus)

Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women

Drake, M. M., Srinivasan, B., Mödder, U. I., Ng, A. C., Undale, A. H., Roforth, M. M., Peterson, J. M., McCready, L. K., Riggs, B. L. & Khosla, S., Sep 2011, In : Bone. 49, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Therapeutics
Vascular Endothelial Growth Factor C
Osteoblasts
Bone Marrow Cells
22 Citations (Scopus)

Effects of loss of classical estrogen response element signaling on bone in male mice

Syed, F. A., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Apr 2007, In : Endocrinology. 148, 4, p. 1902-1910 9 p.

Research output: Contribution to journalArticle

Response Elements
Estrogen Receptors
Estrogens
Bone and Bones
Bone Density
57 Citations (Scopus)

Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice

Mödder, U. I. L., Sanyal, A., Kearns, A. E., Sibonga, J. D., Nishihara, E., Xu, J., O'Malley, B. W., Ritman, E. L., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Feb 2004, In : Endocrinology. 145, 2, p. 913-921 9 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Estrogens
Knockout Mice
Bone and Bones
Nuclear Receptor Coactivators
190 Citations (Scopus)

Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

Drake, M. M., Srinivasan, B., Mödder, U. I., Peterson, J. M., McCready, L. K., Riggs, B. L., Dwyer, D., Stolina, M., Kostenuik, P. & Khosla, S., Nov 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. 5056-5062 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Plasmas
Bone
Bone Marrow
Therapeutics
40 Citations (Scopus)

Effects of physiological variations in circulating insulin levels on bone turnover in humans

Basu, R., Peterson, J., Rizza, R. & Khosla, S., May 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 5, p. 1450-1455 6 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone
Insulin
Osteocalcin
Osteoprotegerin
92 Citations (Scopus)

Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men

Doran, P. M., Riggs, B. L., Atkinson, E. J. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 2118-2125 8 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Bone Remodeling
Biomarkers
Steroids
Lipids
381 Citations (Scopus)

Effects of sex and age on bone microstructure at the ultradistal radius: A population-based noninvasive in vivo assessment

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., McDaniel, L. J., Holets, M., Peterson, J. M. & Melton, L. J., Jan 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

Bone and Bones
Population
Wrist
Immunity
Three-Dimensional Imaging
63 Citations (Scopus)

Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women

Drake, M. M., McCready, L. K., Hoey, K. A., Atkinson, E. J. & Khosla, S., Nov 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. 5063-5068 6 p.

Research output: Contribution to journalArticle

Follicle Stimulating Hormone
Bone Resorption
Bone
Acid Phosphatase
Gonadotropin-Releasing Hormone

Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women

Drake, M. M., McCready, L. K., Hoey, K. A., Atkinson, E. J. & Khosla, S., May 2011, In : Obstetrical and Gynecological Survey. 66, 5, p. 289-290 2 p.

Research output: Contribution to journalArticle

Follicle Stimulating Hormone
Bone Resorption
10 Citations (Scopus)

Effects of testosterone and estradiol on cutaneous vasodilation during local warming in older men

Sokolnicki, L. A., Khosla, S. & Charkoudian, N., Nov 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 5

Research output: Contribution to journalArticle

Vasodilation
Testosterone
Estradiol
Skin
Vasodilator Agents
67 Citations (Scopus)

Effects of the circadian variation in serum cortisol on markers of bone turnover and calcium homeostasis in normal postmenopausal women

Heshmati, H. M., Riggs, B. L., Burritt, M. F., Mcalister, C. A., Wollan, P. C. & Khosla, S., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 3, p. 751-756 6 p.

Research output: Contribution to journalArticle

Bone Remodeling
Hydrocortisone
Bone
Homeostasis
Calcium
57 Citations (Scopus)

Emerging role of circulating calcifying cells in the bone-vascular axis

Fadini, G. P., Rattazzi, M., Matsumoto, T., Asahara, T. & Khosla, S., Jun 5 2012, In : Circulation. 125, 22, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

Vascular Calcification
Calcinosis
Myeloid Cells
Osteoporosis
Blood Vessels
86 Citations (Scopus)

Emerging therapeutic opportunities for skeletal restoration

Kawai, M., Mödder, U. I., Khosla, S. & Rosen, C. J., Feb 2011, In : Nature Reviews Drug Discovery. 10, 2, p. 141-156 16 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone Density
Pharmaceutical Preparations
Teriparatide
Selective Estrogen Receptor Modulators
131 Citations (Scopus)

Epidemiology and clinical features of osteoporosis in young individuals

Khosla, S., Lufkin, E. G., Hodgson, S. F., Fitzpatrick, L. A. & Melton, L. J., 1994, In : Bone. 15, 5, p. 551-555 5 p.

Research output: Contribution to journalArticle

Osteoporosis
Epidemiology
Osteoblasts
Incidence
Delayed Puberty
357 Citations (Scopus)

Epidemiology of sarcopenia

Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Jun 2000, In : Journal of the American Geriatrics Society. 48, 6, p. 625-630 6 p.

Research output: Contribution to journalArticle

Sarcopenia
Epidemiology
Muscles
Paraphilic Disorders
Photon Absorptiometry
65 Citations (Scopus)

Epidemiology of sarcopenia

Melton, J. L., Khosla, S. & Lawrence Riggs, B., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

Sarcopenia
Epidemiology
Morbidity
1 Citation (Scopus)

Erratum: Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women (Diabetes (2007) 56, (753-766))

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., May 2007, In : Diabetes. 56, 5, p. 1486 1 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Insulin
Glucose
Therapeutics

Erratum: Role of circulating osteogenic progenitor cells in calcific aortic stenosis (Journal of the American College of Cardiology (2012) 60 (194553))

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Sarano, M. E., Lennon, R. J., McGregor, U., Lerman, L. O. & Lerman, A., Dec 18 2012, In : Journal of the American College of Cardiology. 60, 24, p. 2606 1 p.

Research output: Contribution to journalArticle

Stem Cells
Calcification of Aortic Valve
10 Citations (Scopus)
Selective Estrogen Receptor Modulators
Androgen Receptors
Estrogen Receptors
Estrogens
Ligands
15 Citations (Scopus)

Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 2009, In : Osteoporosis International. 20, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptors, Tumor Necrosis Factor, Type II
Estrogens
Bone Marrow Cells
Bone Marrow
36 Citations (Scopus)

Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men

Khosla, S., Sep 2008, In : Bone. 43, 3, p. 414-417 4 p.

Research output: Contribution to journalArticle

Aromatase
Estrogens
Bone and Bones
Bone Remodeling
Skeleton