Steven G Younkin, MD, PhD

  • 42121 Citations
  • 89 Scopus h-Index
1974 …2019
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Research Output 1974 2019

  • 42121 Citations
  • 89 Scopus h-Index
  • 252 Article
  • 1 Conference contribution
  • 1 Comment/debate
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Article
2019

Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures

Sakae, N., Heckman, M. G., Vargas, E. R., Carrasquillo, M. M., Murray, M. E., Kasanuki, K., Ertekin-Taner, N., Younkin, S. G. & Dickson, D. W., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 3, p. 659-666 8 p.

Research output: Contribution to journalArticle

Microglia
Alzheimer Disease
Outcome Assessment (Health Care)
Cerebral Amyloid Angiopathy
Disease Susceptibility
86 Citations (Scopus)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein
5 Citations (Scopus)

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

Ebbert, M. T. W., Jensen, T. D., Jansen-West, K., Sens, J. P., Reddy, J. S., Ridge, P. G., Kauwe, J. S. K., Belzil, V., Pregent, L., Carrasquillo, M. M., Keene, D., Larson, E., Crane, P., Asmann, Y., Taner, N., Younkin, S. G., Ross, O. A., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., May 20 2019, In : Genome biology. 20, 1, 97.

Research output: Contribution to journalArticle

Open Access
gene
Technology
Alzheimer disease
Genes
Alzheimer Disease
2018
2 Citations (Scopus)

Association study between multiple system atrophy and TREM2 p.R47H

Ogaki, K., Heckman, M. G., Koga, S., Martens, Y. A., Labbé, C., Lorenzo-Betancor, O., Walton, R. L., Soto, A. I., Vargas, E. R., Fujioka, S., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Younkin, S. G., Wszolek, Z. K., Low, P. A., Singer, W., Bu, G. D., Dickson, D. W. & Ross, O. A., Aug 1 2018, In : Neurology: Genetics. 4, 4, e257.

Research output: Contribution to journalArticle

Multiple System Atrophy
Myeloid Cells
Alzheimer Disease
Odds Ratio
Sample Size
5 Citations (Scopus)

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

Allen, M., Wang, X., Serie, D. J., Strickland, S. L., Burgess, J. D., Koga, S., Younkin, C. S., Nguyen, T. T., Malphrus, K. G., Lincoln, S. J., Alamprese, M., Zhu, K., Chang, R., Carrasquillo, M. M., Kouri, N., Murray, M. E., Reddy, J. S., Funk, C., Price, N. D., Golde, T. E. & 5 others, Younkin, S. G., Asmann, Y., Crook, J., Dickson, D. W. & Taner, N., Jan 1 2018, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Gene Expression
Brain
Pathology
Coiled Bodies
3 Citations (Scopus)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease

Chung, J., Zhang, X., Allen, M., Wang, X., Ma, Y., Beecham, G., Montine, T. J., Younkin, S. G., Dickson, D. W., Golde, T. E., Price, N. D., Taner, N., Lunetta, K. L., Mez, J., Mayeux, R., Haines, J. L., Pericak-Vance, M. A., Schellenberg, G., Jun, G. R. & Farrer, L. A., Feb 20 2018, In : Alzheimer's Research and Therapy. 10, 1, 22.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Cerebral Amyloid Angiopathy
Alzheimer Disease
Genome
Amyloid Plaques
29 Citations (Scopus)

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Cerebrospinal Fluid
Alzheimer Disease
Neurofibrillary Tangles
7 Citations (Scopus)

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease

Chakrabarty, P., Li, A., Ladd, T. B., Strickland, M. R., Koller, E. J., Burgess, J. D., Funk, C. C., Cruz, P. E., Allen, M., Yaroshenko, M., Wang, X., Younkin, C., Reddy, J., Lohrer, B., Mehrke, L., Moore, B. D., Liu, X., Ceballos‑Diaz, C., Rosario, A. M., Medway, C. & 8 others, Janus, C., Li, H. D., Dickson, D. W., Giasson, B. I., Price, N. D., Younkin, S. G., Taner, N. & Golde, T. E., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2247-2264 18 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 5
Amyloid
Alzheimer Disease
Therapeutics
Flagellin
2017
5 Citations (Scopus)

African American exome sequencing identifies potential risk variants at Alzheimer disease loci

N'songo, A., Carrasquillo, M. M., Wang, X., Burgess, J. D., Nguyen, T., Asmann, Y., Serie, D. J., Younkin, S. G., Allen, M., Pedraza, O. D., Duara, R., Custo, M. T. G., Graff Radford, N. R. & Taner, N., Jan 1 2017, In : Neurology: Genetics. 3, 2, e141.

Research output: Contribution to journalArticle

Exome
African Americans
Alzheimer Disease
Genome-Wide Association Study
Endophenotypes
32 Citations (Scopus)

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Astrocytes
Apolipoproteins E
Genotype
Protein Isoforms
41 Citations (Scopus)

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

Park, L., Uekawa, K., Garcia-Bonilla, L., Koizumi, K., Murphy, M., Pistik, R., Younkin, L., Younkin, S. G., Zhou, P., Carlson, G., Anrather, J. & Iadecola, C., Jul 21 2017, In : Circulation Research. 121, 3, p. 258-269 12 p.

Research output: Contribution to journalArticle

Macrophages
Peptides
Brain
Reactive Oxygen Species
Alzheimer Disease
1 Citation (Scopus)

Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants

N'Songo, A., Carrasquillo, M. M., Wang, X., Nguyen, T., Asmann, Y., Younkin, S. G., Allen, M., Duara, R., Custo, M. T. G., Graff Radford, N. R. & Taner, N., 2017, In : Journal of Alzheimer's Disease. 56, 4, p. 1215-1222 8 p.

Research output: Contribution to journalArticle

African Americans
Alzheimer Disease
Genes
Exome
Population
12 Citations (Scopus)

Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases

Allen, M., Wang, X., Burgess, J. D., Watzlawik, J., Serie, D. J., Younkin, C. S., Nguyen, T., Malphrus, K. G., Lincoln, S., Carrasquillo, M. M., Ho, C., Chakrabarty, P., Strickland, S., Murray, M. E., Swarup, V., Geschwind, D. H., Seyfried, N. T., Dammer, E. B., Lah, J. J., Levey, A. I. & 11 others, Golde, T. E., Funk, C., Li, H., Price, N. D., Petersen, R. C., Graff Radford, N. R., Younkin, S. G., Dickson, D. W., Crook, J., Asmann, Y. & Taner, N., Jan 1 2017, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Alzheimer Disease
Brain
Temporal Lobe
Gene Regulatory Networks
10 Citations (Scopus)

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience

for the Alzheimer's Disease Neuroimaging Initative, Nov 29 2017, In : Genome Medicine. 9, 1, 100.

Research output: Contribution to journalArticle

Alzheimer Disease
Genome
Single Nucleotide Polymorphism
Pedigree
Odds Ratio
208 Citations (Scopus)

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, R., Van Der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., Raybould, R., Bis, J. C., Martin, E. R., Grenier-Boley, B., Heilmann-Heimbach, S., Chouraki, V., Kuzma, A. B., Sleegers, K., Vronskaya, M., Ruiz, A., Graham, R. R., Olaso, R. & 429 others, Hoffmann, P., Grove, M. L., Vardarajan, B. N., Hiltunen, M., Nöthen, M. M., White, C. C., Hamilton-Nelson, K. L., Epelbaum, J., Maier, W., Choi, S. H., Beecham, G. W., Dulary, C., Herms, S., Smith, A. V., Funk, C. C., Derbois, C., Forstner, A. J., Ahmad, S., Li, H., Bacq, D., Harold, D., Satizabal, C. L., Valladares, O., Squassina, A., Thomas, R., Brody, J. A., Qu, L., Sánchez-Juan, P., Morgan, T., Wolters, F. J., Zhao, Y., Garcia, F. S., Denning, N., Fornage, M., Malamon, J., Naranjo, M. C. D., Majounie, E., Mosley, T. H., Dombroski, B., Wallon, D., Lupton, M. K., Dupuis, J., Whitehead, P., Fratiglioni, L., Medway, C., Jian, X., Mukherjee, S., Keller, L., Brown, K., Lin, H., Cantwell, L. B., Panza, F., McGuinness, B., Moreno-Grau, S., Burgess, J. D., Solfrizzi, V., Proitsi, P., Adams, H. H., Allen, M., Seripa, D., Pastor, P., Cupples, L. A., Price, N. D., Hannequin, D., Frank-García, A., Levy, D., Chakrabarty, P., Caffarra, P., Giegling, I., Beiser, A. S., Giedraitis, V., Hampel, H., Garcia, M. E., Wang, X., Lannfelt, L., Mecocci, P., Eiriksdottir, G., Crane, P. K., Pasquier, F., Boccardi, V., Henández, I., Barber, R. C., Scherer, M., Tarraga, L., Adams, P. M., Leber, M., Chen, Y., Albert, M. S., Riedel-Heller, S., Emilsson, V., Beekly, D., Braae, A., Schmidt, R., Blacker, D., Masullo, C., Schmidt, H., Doody, R. S., Spalletta, G., Jr, W. T. L., Fairchild, T. J., Bossù, P., Lopez, O. L., Frosch, M. P., Sacchinelli, E., Ghetti, B., Yang, Q., Huebinger, R. M., Jessen, F., Li, S., Kamboh, M. I., Morris, J., Sotolongo-Grau, O., Katz, M. J., Corcoran, C., Dunstan, M., Braddel, A., Thomas, C., Meggy, A., Marshall, R., Gerrish, A., Chapman, J., Aguilar, M., Taylor, S., Hill, M., Fairén, M. D., Hodges, A., Vellas, B., Soininen, H., Kloszewska, I., Daniilidou, M., Uphill, J., Patel, Y., Hughes, J. T., Lord, J., Turton, J., Hartmann, A. M., Cecchetti, R., Fenoglio, C., Serpente, M., Arcaro, M., Caltagirone, C., Orfei, M. D., Ciaramella, A., Pichler, S., Mayhaus, M., Gu, W., Lleó, A., Fortea, J., Blesa, R., Barber, I. S., Brookes, K., Cupidi, C., Maletta, R. G., Carrell, D., Sorbi, S., Moebus, S., Urbano, M., Pilotto, A., Kornhuber, J., Bosco, P., Todd, S., Craig, D., Johnston, J., Gill, M., Lawlor, B., Lynch, A., Fox, N. C., Hardy, J., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barnes, L. L., Barral, S., Beach, T. G., Becker, J. T., Bigio, E. H., Bird, T. D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Diaz, C. C., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Decarli, C., Dick, M., Duara, R., Evans, D. A., Faber, K. M., Fallon, K. B., Fardo, D. W., Farlow, M. R., Ferris, S., Foroud, T. M., Galasko, D. R., Gearing, M., Geschwind, D. H., Gilbert, J. R., Graff Radford, N. R., Green, R. C., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Honig, L. S., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Abner, E., Jin, L. W., Jun, G., Karydas, A., Kaye, J. A., Kim, R., Kowall, N. W., Kramer, J. H., Laferla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lunetta, K. L., Lyketsos, C. G., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Morris, J. C., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Parisi, J. E., Parisi, J. E., Paulson, H. L., Perry, W., Peskind, E., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Sager, M. A., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Swerdlow, R. H., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Wilhelmsen, K. C., Williamson, J., Wingo, T. S., Woltjer, R. L., Wright, C. B., Yu, C. E., Yu, L., Garzia, F., Golamaully, F., Septier, G., Engelborghs, S., Vandenberghe, R., De Deyn, P. P., Fernadez, C. M., Benito, Y. A., Thonberg, H., Forsell, C., Lilius, L., Kinhult-Stählbom, A., Kilander, L., Brundin, R., Concari, L., Helisalmi, S., Koivisto, A. M., Haapasalo, A., Dermecourt, V., Fievet, N., Hanon, O., Dufouil, C., Brice, A., Ritchie, K., Dubois, B., Himali, J. J., Keene, C. D., Tschanz, J., Fitzpatrick, A. L., Kukull, W. A., Norton, M., Aspelund, T., Larson, E. B., Munger, R., Rotter, J. I., Lipton, R. B., Bullido, M. J., Hofman, A., Montine, T. J., Coto, E., Petersen, R. C., Petersen, R. C., Alvarez, V., Rivadeneira, F., Reiman, E. M., Gallo, M., O'Donnell, C. J., Reisch, J. S., Bruni, A. C., Royall, D. R., Dichgans, M., Sano, M., Galimberti, D., St George-Hyslop, P., Scarpini, E., Tsuang, D. W., Mancuso, M., Bonuccelli, U., Winslow, A. R., Daniele, A., Wu, C. K., Peters, O., Nacmias, B., Riemenschneider, M., Heun, R., Brayne, C., Rubinsztein, D. C., Bras, J., Guerreiro, R., Al-Chalabi, A., Shaw, C. E., Collinge, J., Mann, D., Tsolaki, M., Clarimón, J., Sussams, R., Lovestone, S., O'Donovan, M. C., Owen, M. J., Behrens, T. W., Mead, S., Goate, A. M., Uitterlinden, A. G., Holmes, C., Cruchaga, C., Ingelsson, M., Bennett, D. A., Powell, J., Golde, T. E., Taner, N., De Jager, P. L., Morgan, K., Ertekin-Taner, N., Younkin, S. G., Psaty, B. M., Passmore, P., Younkin, S. G., Dickson, D. W., Gudnason, V., Rujescu, D., Dickson, D. W., Dartigues, J. F., Destefano, A. L., Ortega-Cubero, S., Hakonarson, H., Campion, D., Boada, M., Kauwe, J. K., Farrer, L. A., Van Broeckhoven, C., Ikram, M. A., Jones, L., Haines, J. L., Tzourio, C., Launer, L. J., Escott-Price, V., Mayeux, R., Deleuze, J. F., Amin, N., Holmans, P. A., Pericak-Vance, M. A., Amouyel, P., Van Duijn, C. M., Ramirez, A., Wang, L. S., Lambert, J. C., Seshadri, S., Williams, J. & Schellenberg, G. D., Sep 1 2017, In : Nature Genetics. 49, 9, p. 1373-1384 12 p.

Research output: Contribution to journalArticle

Innate Immunity
Gene Frequency
Alzheimer Disease
Odds Ratio
Microglia
35 Citations (Scopus)

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Jun, G. R., Chung, J., Mez, J., Barber, R., Beecham, G. W., Bennett, D. A., Buxbaum, J. D., Byrd, G. S., Carrasquillo, M. M., Crane, P. K., Cruchaga, C., De Jager, P., Ertekin-Taner, N., Evans, D., Fallin, M. D., Foroud, T. M., Friedland, R. P., Goate, A. M., Carrasquillo, M. M., Taner, N. & 31 others, Graff Radford, N. R., Younkin, S. G., Inzelberg, R., Kamboh, M. I., Kauwe, J. S. K., Kukull, W. A., Kunkle, B. W., Kuwano, R., Larson, E. B., Logue, M. W., Manly, J. J., Martin, E. R., Montine, T. J., Mukherjee, S., Naj, A., Reiman, E. M., Reitz, C., Sherva, R., St. George-Hyslop, P. H., Thornton, T., Younkin, S. G., Vardarajan, B. N., Wang, L. S., Wendlund, J. R., Winslow, A. R., Haines, J., Mayeux, R., Pericak-Vance, M. A., Schellenberg, G., Lunetta, K. L. & Petersen, R. C., 2017, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Alzheimer Disease
Genome
Single Nucleotide Polymorphism
Genome-Wide Association Study
Genetic Loci
1 Citation (Scopus)

Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; The Atherosclerosis Risk in Communities-Neurocognitive Study

Simino, J., Wang, Z., Bressler, J., Chouraki, V., Yang, Q., Younkin, S. G., Seshadri, S., Fornage, M., Boerwinkle, E. & Mosley, T. H., Jul 1 2017, In : PLoS One. 12, 7, e0180046.

Research output: Contribution to journalArticle

Exome
African Americans
amyloid
atherosclerosis
Amyloid
2016
43 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
19 Citations (Scopus)

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Carrasquillo, M. M., Allen, M., Burgess, J. D., Wang, X., Strickland, S. L., Aryal, S., Siuda, J., Kachadoorian, M. L., Medway, C., Younkin, C. S., Nair, A., Wang, C., Chanana, P., Serie, D., Nguyen, T., Lincoln, S., Malphrus, K. G., Morgan, K., Golde, T. E., Price, N. D. & 10 others, White, C. C., De Jager, P. L., Bennett, D. A., Asmann, Y., Crook, J., Petersen, R. C., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Taner, N., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Multigene Family
Alzheimer Disease
Quantitative Trait Loci
Gene Expression
Meta-Analysis
33 Citations (Scopus)

Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

Alzheimer's Disease Genetics Consortium (ADGC), Feb 1 2016, In : PLoS One. 11, 2, e0148717.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Alzheimer disease
Polymorphism
Gene expression
Alzheimer Disease
80 Citations (Scopus)

A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J. C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L. S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L., Ikram, M. A. & 97 others, Fievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S. H., Boland, A., Becker, T., Kukull, W. A., Van Der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Berr, C., Tsolaki, M., Buxbaum, J. D., Lopez, O. L., Deramecourt, V., Fox, N. C., Cantwell, L. B., Tárraga, L., Dufouil, C., Hardy, J., Crane, P. K., Eiriksdottir, G., Hannequin, D., Clarke, R., Evans, D., Mosley, T. H., Letenneur, L., Brayne, C., Maier, W., De Jager, P., Emilsson, V., Dartigues, J. F., Hampel, H., Kamboh, M. I., De Bruijn, R. F. A. G., Tzourio, C., Pastor, P., Larson, E. B., Rotter, J. I., O'Donovan, M. C., Montine, T. J., Nalls, M. A., Mead, S., Reiman, E. M., Jonsson, P. V., Holmes, C., St George-Hyslop, P. H., Boada, M., Passmore, P., Wendland, J. R., Schmidt, R., Morgan, K., Winslow, A. R., Powell, J. F., Carrasquillo, M. M., Younkin, S. G., Jakobsdóttir, J., Kauwe, J. S. K., Wilhelmsen, K. C., Rujescu, D., Nöthen, M. M., Hofman, A., Jones, L., Haines, J. L., Psaty, B. M., Van Broeckhoven, C., Holmans, P., Launer, L. J., Mayeux, R., Lathrop, M., Goate, A. M., Escott-Price, V., Seshadri, S., Pericak-Vance, M. A., Amouyel, P., Williams, J., Van Duijn, C. M., Schellenberg, G. D. & Petersen, R. C., Jan 1 2016, In : Molecular Psychiatry. 21, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

tau Proteins
Single Nucleotide Polymorphism
Alzheimer Disease
Genes
Exons
20 Citations (Scopus)

Assessment of the genetic variance of late-onset Alzheimer's disease

Alzheimer's Disease Genetics Consortium (ADGC), May 1 2016, In : Neurobiology of Aging. 41, p. 200.e13-200.e20

Research output: Contribution to journalArticle

Alzheimer Disease
Single Nucleotide Polymorphism
Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Myeloid Cells
10 Citations (Scopus)

Evaluating pathogenic dementia variants in posterior cortical atrophy

Carrasquillo, M. M., Barber, I., Lincoln, S. J., Murray, M. E., Camsari, G. B., Khan, Q. U. A., Nguyen, T., Ma, L., Bisceglio, G. D., Crook, J., Younkin, S. G., Dickson, D. W., Boeve, B. F., Graff Radford, N. R., Morgan, K. & Taner, N., 2016, In : Neurobiology of Aging. 37, p. 38-44 7 p.

Research output: Contribution to journalArticle

Atrophy
Dementia
Exome
Alzheimer Disease
Genes
21 Citations (Scopus)

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains

Ma, L., Allen, M., Sakae, N., Taner, N., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Sevlever, D., Nov 25 2016, In : Molecular Neurodegeneration. 11, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Myeloid Cells
Alzheimer Disease
Brain
Proteins
RNA Isoforms
20 Citations (Scopus)

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci

Allen, M., Burgess, J. D., Ballard, T., Serie, D., Wang, X., Younkin, C. S., Sun, Z. D., Kouri, N., Baheti, S., Wang, C., Carrasquillo, M. M., Nguyen, T., Lincoln, S., Malphrus, K., Murray, M. E., Golde, T. E., Price, N. D., Younkin, S. G., Schellenberg, G. D., Asmann, Y. & 4 others, Ordog, T., Crook, J., Dickson, D. W. & Taner, N., Apr 26 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-15 15 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Methylation
Gene Expression
Coiled Bodies
Single Nucleotide Polymorphism
36 Citations (Scopus)

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

Allen, M., Carrasquillo, M. M., Funk, C., Heavner, B. D., Zou, F., Younkin, C. S., Burgess, J. D., Chai, H. S., Crook, J., Eddy, J. A., Li, H., Logsdon, B., Peters, M. A., Dang, K. K., Wang, X., Serie, D., Wang, C., Nguyen, T., Lincoln, S., Malphrus, K. & 11 others, Bisceglio, G., Li, M., Golde, T. E., Mangravite, L. M., Asmann, Y., Price, N. D., Petersen, R. C., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Taner, N., Oct 11 2016, In : Scientific data. 3, 160089.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Genotype
Brain
Genome
Genes
10 Citations (Scopus)

MAPT haplotype diversity in multiple system atrophy

Labbé, C., Heckman, M. G., Lorenzo-Betancor, O., Murray, M. E., Ogaki, K., Soto-Ortolaza, A. I., Walton, R. L., Fujioka, S., Koga, S., Uitti, R. J., Van Gerpen, J. A., Petersen, R. C., Graff Radford, N. R., Younkin, S. G., Boeve, B. F., Cheshire, W. P., Low, P. A., Sandroni, P., Coon, E., Singer, W. & 3 others, Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Apr 14 2016, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Multiple System Atrophy
Haplotypes
Neurodegenerative Diseases
14 Citations (Scopus)

Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain

Jaeger, P. A., Lucin, K. M., Britschgi, M., Vardarajan, B., Huang, R. P., Kirby, E. D., Abbey, R., Boeve, B. F., Boxer, A. L., Farrer, L. A., Finch, N., Graff Radford, N. R., Head, E., Hofree, M., Huang, R., Johns, H., Karydas, A., Knopman, D. S., Loboda, A., Masliah, E. & 10 others, Narasimhan, R., Petersen, R. C., Podtelezhnikov, A., Pradhan, S., Rademakers, R. V., Sun, C. H., Younkin, S. G., Miller, B. L., Ideker, T. & Wyss-Coray, T., Apr 26 2016, In : Molecular Neurodegeneration. 11, 1, 31.

Research output: Contribution to journalArticle

Proteomics
Alzheimer Disease
Brain
Growth Differentiation Factors
Access to Information
23 Citations (Scopus)

Shared genetic contribution to ischemic stroke and Alzheimer's disease

Traylor, M., Adib-Samii, P., Harold, D., Dichgans, M., Williams, J., Lewis, C. M., Markus, H. S., Fornage, M., Holliday, E. G., Sharma, P., Bis, J. C., Psaty, B. M., Seshadri, S., Nalls, M. A., Devan, W. J., Boncoraglio, G., Malik, R., Mitchell, B. D., Kittner, S. J., Ikram, M. A. & 188 others, Clarke, R., Rosand, J., Meschia, J. F., Sudlow, C., Rothwell, P. M., Levi, C., Bevan, S., Kilarski, L. L., Walters, M., Thijs, V., Slowik, A., Lindgren, A., De Bakker, P. I. W., Lambert, J. C., Ibrahim-Verbaas, C. A., Naj, A. C., Sims, R., Bellenguez, C., Jun, G., Destefano, A. L., Beecham, G. W., Grenier-Boley, B., Russo, G., Thornton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M. T., Choi, S. H., Reitz, C., Pasquier, F., Hollingworth, P., Ramirez, A., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Baldwin, C., Becker, T., Gudnason, V., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiçvet, N., Huentelman, M. J., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuinness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Deniz Naranjo, M. C., Bosco, P., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannfelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., De Bruijn, R. F. A. G., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S. K., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltunen, M., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., Van Duijn, C. M., Van Broeckhoven, C., Moskvina, V., Schellenberg, G. D. & Amouyel, P., May 1 2016, In : Annals of Neurology. 79, 5, p. 739-747 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Stroke
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
29 Citations (Scopus)

TYROBP genetic variants in early-onset Alzheimer's disease

Pottier, C., Ravenscroft, T. A., Brown, P. H., Finch, N. C. A., Baker, M., Parsons, M., Asmann, Y., Ren, Y., Christopher, E., Levitch, D., Van Blitterswijk, M., Cruchaga, C., Campion, D., Nicolas, G., Richard, A. C., Guerreiro, R., Bras, J. T., Zuchner, S., Gonzalez, M. A., Bu, G. D. & 10 others, Younkin, S. G., Knopman, D. S., Josephs, K. A., Parisi, J. E., Petersen, R. C., Taner, N., Graff Radford, N. R., Boeve, B. F., Dickson, D. W. & Rademakers, R. V., Dec 1 2016, In : Neurobiology of Aging. 48, p. 222.e9-222.e15

Research output: Contribution to journalArticle

Alzheimer Disease
Genes
Exome
Age of Onset
Mutation
2015
143 Citations (Scopus)

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Myeloid Cells
Ligands
Microglia
Phagocytosis
18 Citations (Scopus)

Association of long runs of homozygosity with Alzheimer disease among African American individuals

Ghani, M., Reitz, C., Cheng, R., Vardarajan, B. N., Jun, G., Sato, C., Naj, A., Rajbhandary, R., Wang, L. S., Valladares, O., Lin, C. F., Larson, E. B., Graff Radford, N. R., Evans, D., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Murrell, J. R., Raj, T., Taner, N. & 153 others, Logue, M., Baldwin, C. T., Green, R. C., Barnes, L. L., Cantwell, L. B., Fallin, M. D., Go, R. C. P., Griffith, P. A., Obisesan, T. O., Manly, J. J., Lunetta, K. L., Kamboh, M. I., Lopez, O. L., Bennett, D. A., Hendrie, H., Hall, K. S., Goate, A. M., Byrd, G. S., Kukull, W. A., Foroud, T. M., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Lee, J. H., Schellenberg, G. D., St. George-Hyslop, P., Mayeux, R., Rogaeva, E., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barmada, M. M., Beach, T. G., Beecham, G. W., Beekly, D., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cai, G., Cairns, N. J., Cao, C., Carlson, C. S., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Cruchaga, C., DeCarli, C., DeKosky, S. T., Demirci, F. Y., Dick, M., Faber, K. M., Fallon, K. B., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Gilman, S., Glass, J. D., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Hamilton-Nelson, K. L., Haroutunian, V., Harrell, L. E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kauwe, J. S. K., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., Kramer, P., LaFerla, F. M., Lah, J. J., Lang-Walker, R., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Olichney, J. M., Parisi, J. E., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Ringman, J. M., Roberson, E. D., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. E. & Yu, L., Nov 1 2015, In : JAMA Neurology. 72, 11, p. 1313-1323 11 p.

Research output: Contribution to journalArticle

African Americans
Alzheimer Disease
Single Nucleotide Polymorphism
Consensus
Dementia
64 Citations (Scopus)

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

Alzheimer’s Disease Genetics Consortium, The GERAD1 Consortium & EPIC-InterAct Consortium, Jun 1 2015, In : PLoS Medicine. 12, 6, e1001841.

Research output: Contribution to journalArticle

Random Allocation
Alzheimer Disease
Smoking
Odds Ratio
Mendelian Randomization Analysis
1 Citation (Scopus)

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Alzheimer's Research UK (ARUK) Consortium, Apr 1 2015, In : Neurobiology of Aging. 36, 4, p. 1767.e1-1767.e2

Research output: Contribution to journalArticle

Alzheimer Disease
Genes
Peptidyl-Dipeptidase A
Genetic Predisposition to Disease
Blood Group Antigens
101 Citations (Scopus)

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP), Jun 1 2015, In : Alzheimer's and Dementia. 11, 6, p. 658-671 14 p.

Research output: Contribution to journalArticle

Genomics
Endocytosis
Immunity
Alzheimer Disease
Cholesterol
19 Citations (Scopus)

Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses

Adult Changes in Thought Study Investigators, Religious Orders Study/Memory and Aging Project Investigators & Alzheimer's Disease Genetics Consortium, Dec 1 2015, In : Alzheimer's and Dementia. 11, 12, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Alzheimer Disease
Body Mass Index
Phenotype
Odds Ratio
23 Citations (Scopus)

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia

Malik, M., Chiles, J., Xi, H. S., Medway, C., Simpson, J., Potluri, S., Howard, D., Liang, Y., Paumi, C. M., Mukherjee, S., Crane, P., Younkin, S. G., Fardo, D. W. & Estus, S., Jan 18 2015, In : Human Molecular Genetics. 24, 12, p. 3557-3570 14 p., ddv092.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Alzheimer Disease
Single Nucleotide Polymorphism
Exons
RNA Splicing
77 Citations (Scopus)

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

Kouri, N., Ross, O. A., Dombroski, B., Younkin, C. S., Serie, D. J., Soto-Ortolaza, A., Baker, M., Finch, N. C. A., Yoon, H., Kim, J., Fujioka, S., Mclean, C. A., Ghetti, B., Spina, S., Cantwell, L. B., Farlow, M. R., Grafman, J., Huey, E. D., Ryung Han, M., Beecher, S. & 34 others, Geller, E. T., Kretzschmar, H. A., Roeber, S., Gearing, M., Juncos, J. L., Vonsattel, J. P. G., Van Deerlin, V. M., Grossman, M., Hurtig, H. I., Gross, R. G., Arnold, S. E., Trojanowski, J. Q., Lee, V. M., Wenning, G. K., White, C. L., Höglinger, G. U., Müller, U., Devlin, B., Golbe, L. I., Crook, J., Parisi, J. E., Boeve, B. F., Josephs, K. A., Wszolek, Z. K., Uitti, R. J., Graff Radford, N. R., Litvan, I., Younkin, S. G., Wang, L. S., Taner, N., Rademakers, R. V., Hakonarsen, H., Schellenberg, G. D. & Dickson, D. W., Jun 16 2015, In : Nature Communications. 6, 7247.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
degeneration
genome
Genome-Wide Association Study
Oligodendroglia
25 Citations (Scopus)

Late-onset Alzheimer disease risk variants mark brain regulatory loci

Allen, M., Kachadoorian, M., Carrasquillo, M. M., Karhade, A., Manly, L., Burgess, J. D., Wang, C., Serie, D., Wang, X., Siuda, J., Zou, F., Chai, H. S., Younkin, C., Crook, J., Medway, C., Nguyen, T., Ma, L., Malphrus, K., Lincoln, S., Petersen, R. C. & 5 others, Graff Radford, N. R., Asmann, Y., Dickson, D. W., Younkin, S. G. & Taner, N., Aug 1 2015, In : Neurology: Genetics. 1, 2, e15.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Single Nucleotide Polymorphism
Genome-Wide Association Study
Temporal Lobe
50 Citations (Scopus)

Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease

Carrasquillo, M. M., Crook, J., Pedraza, O. D., Thomas, C. S., Pankratz, V. S., Allen, M., Nguyen, T., Malphrus, K. G., Ma, L., Bisceglio, G. D., Roberts, R. O., Lucas, J. A., Smith, G. E., Ivnik, R. J., Machulda, M. M., Graff Radford, N. R., Petersen, R. C., Younkin, S. G. & Taner, N., Jan 1 2015, In : Neurobiology of Aging. 36, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Genome-Wide Association Study
Cognitive Dysfunction
39 Citations (Scopus)

Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study

Chouraki, V., Beiser, A., Younkin, L., Preis, S. R., Weinstein, G., Hansson, O., Skoog, I., Lambert, J. C., Au, R., Launer, L., Wolf, P. A., Younkin, S. G. & Seshadri, S., Mar 1 2015, In : Alzheimer's and Dementia. 11, 3, p. 249-257.e1

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Dementia
Biomarkers
Costs and Cost Analysis
37 Citations (Scopus)

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

the Genetic and Environmental Risk for Alzheimer’s Disease (GERAD1) Consortium, May 19 2015, In : Cell Reports. 11, 7, p. 1134-1146 13 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Neurodegenerative Diseases
Proteomics
Alzheimer Disease
Amyloid beta-Protein Precursor
20 Citations (Scopus)

Rarity of the alzheimer disease-protective APP A673T variant in the United States

National Institute on Aging-Late-Onset Alzheimer's Disease (NIA-LOAD) Family Study & Alzheimer's Disease Genetics Consortium, Feb 1 2015, In : JAMA Neurology. 72, 2, p. 209-216 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Genes
Sweden
Alanine
12 Citations (Scopus)

Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice

Santhanam, A. V. R., D'Uscio, L. V., He, T., Das, P., Younkin, S. G. & Katusic, Z. S., Sep 1 2015, In : Journal of Neurochemistry. 134, 6, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Biological Availability
Superoxides
Microvessels
PPAR delta
2014
352 Citations (Scopus)

Alzheimer's disease: Early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., Tang, A., Raj, T., Replogle, J., Brodeur, W., Gabriel, S., Chai, H. S., Younkin, C., Younkin, S. G., Zou, F., Szyf, M. & 9 others, Epstein, C. B., Schneider, J. A., Bernstein, B. E., Meissner, A., Taner, N., Chibnik, L. B., Kellis, M., Mill, J. & Bennett, D. A., Sep 1 2014, In : Nature Neuroscience. 17, 9, p. 1156-1163 8 p.

Research output: Contribution to journalArticle

DNA Methylation
Alzheimer Disease
Brain
Disease Susceptibility
Methylation
10 Citations (Scopus)

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform

Parikh, I., Medway, C., Younkin, S. G., Fardo, D. W. & Estus, S., Aug 29 2014, In : Molecular Neurodegeneration. 9, 1, 32.

Research output: Contribution to journalArticle

Alzheimer Disease
Protein Isoforms
Alleles
Single Nucleotide Polymorphism
Logistic Models
19 Citations (Scopus)

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease

Medway, C. W., Abdul-Hay, S., Mims, T., Ma, L., Bisceglio, G., Zou, F., Pankratz, S., Sando, S. B., Aasly, J. O., Barcikowska, M., Siuda, J., Wszolek, Z. K., Ross, O. A., Carrasquillo, M. M., Dickson, D. W., Graff Radford, N. R., Petersen, R. C., Taner, N., Morgan, K., Bu, G. D. & 1 others, Younkin, S. G., Mar 10 2014, In : Molecular Neurodegeneration. 9, 1, 11.

Research output: Contribution to journalArticle

Apolipoproteins E
Alzheimer Disease
Exome
Alleles
Linkage Disequilibrium
51 Citations (Scopus)

Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels

Allen, M., Kachadoorian, M., Quicksall, Z., Zou, F., Chai, H. S., Younkin, C., Crook, J., Pankratz, V. S., Carrasquillo, M. M., Krishnan, S., Nguyen, T., Ma, L., Malphrus, K., Lincoln, S., Bisceglio, G., Kolbert, C. P., Jen, J., Mukherjee, S., Kauwe, J. K., Crane, P. K. & 11 others, Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Farrer, L. A., Schellenberg, G. D., Parisi, J. E., Petersen, R. C., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Taner, N., Jul 1 2014, In : Alzheimer's Research and Therapy. 6, 4, 39.

Research output: Contribution to journalArticle

Haplotypes
Alzheimer Disease
Gene Expression
Brain
Temporal Lobe
87 Citations (Scopus)

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study

Alzheimer Disease Genetics Consortium, Nov 1 2014, In : JAMA Neurology. 71, 11, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

Genetic Loci
Genome-Wide Association Study
Age of Onset
Alzheimer Disease
Genetic Databases
29 Citations (Scopus)

Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects

Pedraza, O. D., Allen, M., Jennette, K., Carrasquillo, M. M., Crook, J., Serie, D., Pankratz, V. S., Palusak, R., Nguyen, T., Malphrus, K., Ma, L., Bisceglio, G., Roberts, R. O., Lucas, J. A., Ivnik, R. J., Smith, G. E., Graff Radford, N. R., Petersen, R. C., Younkin, S. G. & Taner, N., 2014, In : Alzheimer's and Dementia. 10, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

Endophenotypes
Alzheimer Disease
Short-Term Memory
Reproduction
Single Nucleotide Polymorphism