• 11942 Citations
  • 54 Scopus h-Index
1991 …2020

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Article
2020

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access
2019

Case-Based Learning in Translational Biomedical Research Education: Providing Realistic and Adaptive Skills for Early-Career Scientists

Greenberg-Worisek, A. J., Campbell, K. A., Klee, E. W., Staff, N. P., Schimmenti, L. A., Weavers, K. M., Ekker, S. C. & Windebank, A. J., Feb 1 2019, In : Academic Medicine. 94, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Taking a closer look at whole organisms

Ichino, N. & Ekker, S. C., Jun 14 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

The Gene Sculpt Suite: a set of tools for genome editing

Mann, C. M., Martínez-Gálvez, G., Welker, J. M., Wierson, W. A., Ata, H., Almeida, M. P., Clark, K. J., Essner, J. J., Mcgrail, M., Ekker, S. C. & Dobbs, D., Jul 1 2019, In : Nucleic acids research. 47, W1, p. W175-W182

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins

Thierer, J. H., Ekker, S. C. & Farber, S. A., Dec 1 2019, In : Nature communications. 10, 1, 3426.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Adolescent mental health education InSciEd Out: A case study of an alternative middle school population

Yang, J., Lopez Cervera, R., Tye, S. J., Ekker, S. C. & Pierret, C., Apr 3 2018, In : Journal of Translational Medicine. 16, 1, 84.

Research output: Contribution to journalArticle

5 Scopus citations

Fishing for understanding: Unlocking the zebrafish gene editor's toolbox

Simone, B. W., Martínez-Gálvez, G., WareJoncas, Z. & Ekker, S. C., Jan 1 2018, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

7 Scopus citations

Humidity as a non-pharmaceutical intervention for influenza A

Reiman, J. M., Das, B., Sindberg, G. M., Urban, M. D., Hammerlund, M. E. M., Lee, H. B., Spring, K. M., Lyman-Gingerich, J., Generous, A. R., Koep, T. H., Ewing, K., Lilja, P., Enders, F. T., Ekker, S. C., Huskins, W. C., Fadel, H. J. & Pierret, C., Sep 2018, In : PloS one. 13, 9, e0204337.

Research output: Contribution to journalArticle

10 Scopus citations

Precision gene editing technology and applications in nephrology

WareJoncas, Z., Campbell, J. M., Martínez-Gálvez, G., Gendron, W. A. C., Barry, M. A., Harris, P. C., Sussman, C. R. & Ekker, S. C., Jan 1 2018, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalArticle

13 Scopus citations

Robust activation of microhomology-mediated end joining for precision gene editing applications

Ata, H., Ekstrom, T. L., Martínez-Gálvez, G., Mann, C. M., Dvornikov, A. V., Schaefbauer, K. J., Ma, A. C., Dobbs, D., Clark, K. J. & Ekker, S. C., Sep 2018, In : PLoS genetics. 14, 9, e1007652.

Research output: Contribution to journalArticle

8 Scopus citations

Tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

Ignatius, M. S., Hayes, M. N., Moore, F. E., Tang, Q., Garcia, S. P., Blackburn, P. R., Baxi, K., Wang, L., Jin, A., Ramakrishnan, A., Reeder, S., Chen, Y., Nielsen, G. P., Chen, E. Y., Hasserjian, R. P., Tirode, F., Ekker, S. C. & Langenau, D. M., Sep 2018, In : eLife. 7, e37202.

Research output: Contribution to journalArticle

11 Scopus citations

Workshop Report: Zebrafish and Other Fish Models - Description of Extrinsic Environmental Factors for Rigorous Experiments and Reproducible Results

Varga, Z. M., Ekker, S. C. & Lawrence, C., Dec 1 2018, In : Zebrafish. 15, 6, p. 533-535 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

Ding, Y., Long, P. A., Bos, J. M., Shih, Y. H., Ma, X., Sundsbak, R. S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M. J., Lin, X., Ekker, S. C., Redfield, M. M., Olson, T. M. & Xu, X. H., Apr 20 2017, In : JCI insight. 2, 8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly

El-Rass, S., Eisa-Beygi, S., Khong, E., Brand-Arzamendi, K., Mauro, A., Zhang, H., Clark, K. J., Ekker, S. C. & Wen, X. Y., Mar 15 2017, In : Biology Open. 6, 3, p. 348-357 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Guidelines for morpholino use in zebrafish

Stainier, D. Y. R., Raz, E., Lawson, N. D., Ekker, S. C., Burdine, R. D., Eisen, J. S., Ingham, P. W., Schulte-Merker, S., Yelon, D., Weinstein, B. M., Mullins, M. C., Wilson, S. W., Ramakrishnan, L., Amacher, S. L., Neuhauss, S. C. F., Meng, A., Mochizuki, N., Panula, P. & Moens, C. B., Oct 2017, In : PLoS genetics. 13, 10, e1007000.

Research output: Contribution to journalArticle

100 Scopus citations
2016

Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer

Zhao, Y., Wang, L., Ren, S., Wang, L., Blackburn, P. R., McNulty, M. S., Gao, X., Qiao, M., Vessella, R. L., Kohli, M., Zhang, J., Karnes, R. J., Tindall, D. J., Kim, Y., MacLeod, R., Ekker, S. C., Kang, T., Sun, Y. & Huang, H., Apr 19 2016, In : Cell reports. 15, 3, p. 599-610 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Active recombinant Tol2 transposase for gene transfer and gene discovery applications

Ni, J., Wangensteen, K. J., Nelsen, D., Balciunas, D., Skuster, K. J., Urban, M. D. & Ekker, S. C., Jan 1 2016, In : Mobile DNA. 7, 1, 6.

Research output: Contribution to journalArticle

7 Scopus citations

FusX: A rapid one-step transcription activator-like effector assembly system for genome science

Ma, A. C., Mcnulty, M. S., Poshusta, T. L., Campbell, J. M., Martínez-Gálvez, G., Argue, D. P., Lee, H. B., Urban, M. D., Bullard, C. E., Blackburn, P. R., Man, T. K., Clark, K. J. & Ekker, S. C., Jun 1 2016, In : Human gene therapy. 27, 6, p. 451-463 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

GoldyTALEN vectors with improved efficiency for golden gate TALEN assembly

Welker, J. M., Wierson, W. A., Wang, Y., Poshusta, T. L., Mcnulty, M. S., Tisdale, E. E., Solin, S. L., Ekker, S. C., Clark, K. J., Mcgrail, M. & Essner, J. J., Jun 1 2016, In : Human Gene Therapy. 27, 6, p. 423-424 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mayo Clinic Zebrafish Facility Overview

Leveque, R. E., Clark, K. J. & Ekker, S. C., Jul 1 2016, In : Zebrafish. 13, p. S44-S46

Research output: Contribution to journalArticle

3 Scopus citations

Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma

Blackburn, P. R., Hickey, R. D., Nace, R. A., Giama, N. H., Kraft, D. L., Bordner, A. J., Chaiteerakij, R., McCormick, J. B., Radulovic, M., Graham, R. P., Torbenson, M. S., Tortorelli, S., Scott, C. R., Lindor, N. M., Milliner, D. S., Oglesbee, D., Al-Qabandi, W., Grompe, M., Gavrilov, D. K., El-Youssef, M. & 5 others, Clark, K. J., Atwal, P. S., Roberts, L. R., Klee, E. W. & Ekker, S. C., Oct 1 2016, In : Human mutation. 37, 10, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Students being and becoming scientists: Measured success in a novel science education partnership

Yang, J., Labounty, T. J., Ekker, S. C. & Pierret, C., 2016, In : Palgrave Communications. 2, 16005.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Etv2 and Fli1b function together as key regulators of vasculogenesis and angiogenesis

Craig, M. P., Grajevskaja, V., Liao, H. K., Balciuniene, J., Ekker, S. C., Park, J. S., Essner, J. J., Balciunas, D. & Sumanas, S., Apr 27 2015, In : Arteriosclerosis, thrombosis, and vascular biology. 35, 4, p. 865-876 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein-trap insertional mutagenesis uncovers new genes involved in zebrafish skin development, including a Neuregulin 2a-based ErbB signaling pathway required during median fin fold morphogenesis

Westcot, S. E., Hatzold, J., Urban, M. D., Richetti, S. K., Skuster, K. J., Harm, R. M., Cervera, R. L., Umemoto, N., McNulty, M. S., Clark, K. J., Hammerschmidt, M. & Ekker, S. C., Jun 25 2015, In : PloS one. 10, 6, e0130688.

Research output: Contribution to journalArticle

10 Scopus citations

RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells

Hoeppner, L. H., Sinha, S., Wang, Y., Bhattacharya, R. D., Dutta, S., Gong, X., Bedell, V. M., Suresh, S., Chun, C., Ramchandran, R., Ekker, S. C. & Mukhopadhyay, D., Jan 1 2015, In : Journal of cell science. 128, 19, p. 3556-3568 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Using engineered endonucleases to create knockout and knockin zebrafish models

Bedell, V. M. & Ekker, S. C., Jan 1 2015, In : Methods in Molecular Biology. 1239, p. 291-306 16 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Detection of 1α,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing

Craig, T. A., Zhang, Y., Magis, A. T., Funk, C. C., Price, N. D., Ekker, S. C. & Kumar, R., Jun 1 2014, In : Zebrafish. 11, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

He, B. L., Shi, X., Man, C. H., Ma, A. C. H., Ekker, S. C., Chow, H. C. H., So, C. W. E., Choi, W. W. L., Zhang, W., Zhang, Y. & Leung, A. Y. H., Apr 17 2014, In : Blood. 123, 16, p. 2518-2529 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Influenza Knowledge, Attitude, and Behavior Survey for Grade School Students: Design and Novel Assessment Methodology

Koep, T. H., Huskins, W. C., Clemens, C., Jenkins, S., Pierret, C., Ekker, S. C. & Enders, F. T., Oct 31 2014, In : Journal of Community Health. 39, 6, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

In vivo orientation of single myosin lever arms in zebrafish skeletal muscle

Sun, X., Ekker, S. C., Shelden, E. A., Takubo, N., Wang, Y. & Burghardt, T. P., Sep 16 2014, In : Biophysical Journal. 107, 6, p. 1403-1414 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Larval zebrafish model for FDA-approved drug repositioning for tobacco dependence treatment

Cousin, M. A., Ebbert, J. O., Wiinamaki, A. R., Urban, M. D., Argue, D. P., Ekker, S. C. & Klee, E. W., Mar 21 2014, In : PloS one. 9, 3, e90467.

Research output: Contribution to journalArticle

22 Scopus citations

TALEN knockout of the PSIP1 gene in human cells: Analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

Fadel, H. J., Morrison, J. H., Saenz, D. T., Fuchs, J. R., Kvaratskhelia, M., Ekker, S. C. & Poeschla, E. M., Jan 1 2014, In : Journal of virology. 88, 17, p. 9704-9717 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

TALEN-mediated genetic tailoring as a tool to analyze the function of acquired mutations in multiple myeloma cells

Wu, X., Blackburn, P. R., Tschumper, R. C., Ekker, S. C. & Jelinek, D. F., May 2014, In : Blood cancer journal. 4, 5, 210.

Research output: Contribution to journalArticle

9 Scopus citations

The Zebrafish GenomeWiki: A crowdsourcing approach to connect the long tail for zebrafish gene annotation

Singh, M., Bhartiya, D., Maini, J., Sharma, M., Singh, A. R., Kadarkaraisamy, S., Rana, R., Sabharwal, A., Nanda, S., Ramachandran, A., Mittal, A., Kapoor, S., Sehgal, P., Asad, Z., Kaushik, K., Vellarikkal, S. K., Jagga, D., Muthuswami, M., Chauhan, R. K., Leonard, E. & 27 others, Priyadarshini, R., Halimani, M., Malhotra, S., Patowary, A., Vishwakarma, H., Joshi, P., Bhardwaj, V., Bhaumik, A., Bhatt, B., Jha, A., Kumar, A., Budakoti, P., Lalwani, M. K., Meli, R., Jalali, S., Joshi, K., Pal, K., Dhiman, H., Laddha, S. V., Jadhav, V., Singh, N., Pandey, V., Sachidanandan, C., Ekker, S. C., Klee, E. W., Scaria, V. & Sivasubbu, S., 2014, In : Database. 2014, bau011.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Anovel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression

Khurana, S., Buckley, S., Schouteden, S., Ekker, S., Petryk, A., Delforge, M., Zwijsen, A. & Verfaillie, C. M., Jan 31 2013, In : Blood. 121, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

A sequence-based variation map of zebrafish

Patowary, A., Purkanti, R., Singh, M., Chauhan, R., Singh, A. R., Swarnkar, M., Singh, N., Pandey, V., Torroja, C., Clark, M. D., Kocher, J. P., Clark, K. J., Stemple, D. L., Klee, E. W., Ekker, S. C., Scaria, V. & Sivasubbu, S., Mar 1 2013, In : Zebrafish. 10, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

High Efficiency In Vivo Genome Engineering with a Simplified 15-RVD GoldyTALEN Design

Ma, A. C., Lee, H. B., Clark, K. J. & Ekker, S. C., May 29 2013, In : PloS one. 8, 5, e65259.

Research output: Contribution to journalArticle

38 Scopus citations

Mojo Hand, a TALEN design tool for genome editing applications

Neff, K. L., Argue, D. P., Ma, A. C., Lee, H. B., Clark, K. J. & Ekker, S. C., Jan 16 2013, In : BMC bioinformatics. 14, 1, 1.

Research output: Contribution to journalArticle

59 Scopus citations

Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools

Koep, T. H., Enders, F. T., Pierret, C., Ekker, S. C., Krageschmidt, D., Neff, K. L., Lipsitch, M., Shaman, J. & Huskins, W. C., Feb 5 2013, In : BMC Infectious Diseases. 13, 1, 71.

Research output: Contribution to journalArticle

18 Scopus citations

Primary Neuron Culture for Nerve Growth and Axon Guidance Studies in Zebrafish (Danio rerio)

Chen, Z., Lee, H., Henle, S. J., Cheever, T. R., Ekker, S. C. & Henley, J. R., Mar 4 2013, In : PloS one. 8, 3, e57539.

Research output: Contribution to journalArticle

31 Scopus citations

The zebrafish as a model to study polycystic liver disease

Tietz Bogert, P. S., Huang, B. Q., Gradilone, S. A., Masyuk, T. V., Moulder, G. L., Ekker, S. C. & Larusso, N. F., Jun 1 2013, In : Zebrafish. 10, 2, p. 211-217 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening

Ding, Y., Liu, W., Deng, Y., Jomok, B., Yang, J., Huang, W., Clark, K. J., Zhong, T. P., Lin, X., Ekker, S. C. & Xu, X., Feb 15 2013, In : Circulation research. 112, 4, p. 606-617 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

An In Vivo Method to Quantify Lymphangiogenesis in Zebrafish

Hoffman, S. J., Psaltis, P. J., Clark, K. J., Spoon, D. B., Chue, C. D., Ekker, S. C. & Simari, R. D., Sep 13 2012, In : PloS one. 7, 9, e45240.

Research output: Contribution to journalArticle

4 Scopus citations

Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton

McNulty, M. S., Bedell, V. M., Greenwood, T. M., Craig, T. A., Ekker, S. C. & Kumar, R., Aug 1 2012, In : Gene Expression Patterns. 12, 7-8, p. 228-235 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional Analysis of Slow Myosin Heavy Chain 1 and Myomesin-3 in Sarcomere Organization in Zebrafish Embryonic Slow Muscles

Xu, J., Gao, J., Li, J., Xue, L., Clark, K. J., Ekker, S. C. & Du, S. J., Feb 1 2012, In : Journal of Genetics and Genomics. 39, 2, p. 69-80 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Improvement in student science proficiency through InSciEd out

Pierret, C., Sonju, J. D., Leicester, J. E., Hoody, M., Labounty, T. J., Frimannsdottir, K. R. & Ekker, S. C., Dec 1 2012, In : Zebrafish. 9, 4, p. 155-168 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

In vivo genome editing using a high-efficiency TALEN system

Bedell, V. M., Wang, Y., Campbell, J. M., Poshusta, T. L., Starker, C. G., Krug, R. G., Tan, W., Penheiter, S. G., Ma, A. C., Leung, A. Y. H., Fahrenkrug, S. C., Carlson, D. F., Voytas, D. F., Clark, K. J., Essner, J. J. & Ekker, S. C., Nov 1 2012, In : Nature. 491, 7422, p. 114-118 5 p.

Research output: Contribution to journalArticle

657 Scopus citations

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability

Hoeppner, L. H., Phoenix, K. N., Clark, K. J., Bhattacharya, R., Gong, X., Sciuto, T. E., Vohra, P., Suresh, S., Bhattacharya, S., Dvorak, A. M., Ekker, S. C., Dvorak, H. F., Claffey, K. P. & Mukhopadhyay, D., Sep 13 2012, In : Blood. 120, 11, p. 2167-2173 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

TGFβ1-Induced Baf60c Regulates both Smooth Muscle Cell Commitment and Quiescence

Sohni, A., Mulas, F., Ferrazzi, F., Luttun, A., Bellazzi, R., Huylebroeck, D., Ekker, S. C. & Verfaillie, C. M., Oct 26 2012, In : PloS one. 7, 10, e47629.

Research output: Contribution to journalArticle

5 Scopus citations

The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development

Bedell, V. M., Person, A. D., Larson, J. D., McLoon, A., Balciunas, D., Clark, K. J., Neff, K. I., Nelson, K. E., Bill, B. R., Schimmenti, L. A., Beiraghi, S. & Ekker, S. C., Feb 15 2012, In : Development. 139, 4, p. 793-804 12 p.

Research output: Contribution to journalArticle

17 Scopus citations