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  • 36 Scopus h-Index
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Research Output 2003 2019

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Article
2019

Ability of dual-energy CT to detect silicone gel breast implant rupture and nodal silicone spread

Glazebrook, K. N., Doerge, S., Leng, S., Drees, T. A., Hunt, K. N., Zingula, S. N., Pruthi, S., Geske, J. R., Carter, R. E., McCollough, C. H. & Fletcher, J. G., Apr 1 2019, In : American Journal of Roentgenology. 212, 4, p. 933-942 10 p.

Research output: Contribution to journalArticle

Silicone Gels
Breast Implants
Silicones
Rupture
Breast

A deep learning- and partial least square regression-based model observer for a low-contrast lesion detection task in CT

Gong, H., Yu, L., Leng, S., Dilger, S. K., Ren, L., Zhou, W., Fletcher, J. G. & McCollough, C. H., Jan 1 2019, In : Medical physics.

Research output: Contribution to journalArticle

Least-Squares Analysis
Learning
Noise
Liver
Radiation
1 Citation (Scopus)
Cryosurgery
Ice
Pelvis
Spine
Tomography
1 Citation (Scopus)

Dual-source photon counting detector CT with a tin filter: a phantom study on iodine quantification performance

Tao, A., Huang, R., Tao, S., Michalak, G. J., McCollough, C. H. & Leng, S., May 31 2019, In : Physics in medicine and biology. 64, 11, 1 p.

Research output: Contribution to journalArticle

Tin
Photons
Iodine
Research Design
Least-Squares Analysis
Photons
Gadolinium
Bismuth
Noise
Head

Forward model for propagation-based X-ray phase contrast imaging in parallel- and conebeam geometry

Shanblatt, E. R., Sung, Y., Gupta, R., Nelson, B. J., Leng, S., Graves, W. S. & McCollough, C. H., Jan 1 2019, In : Optics Express. 27, 4, p. 4504-4521 18 p.

Research output: Contribution to journalArticle

phase contrast
propagation
geometry
x rays
cones
1 Citation (Scopus)

High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography

Bartlett, D. J., Koo, C. W., Bartholmai, B. J., Rajendran, K., Weaver, J. M., Halaweish, A. F., Leng, S., McCollough, C. H. & Fletcher, J. G., Mar 1 2019, In : Investigative Radiology. 54, 3, p. 129-137 9 p.

Research output: Contribution to journalArticle

Photons
Bronchi
Thorax
Tomography
Lung
Iodine
Noise
Photons
X-Rays
Whole-Body Counting
Theoretical Models
Liver
Water
Task Performance and Analysis
ROC Curve
1 Citation (Scopus)
Liver
Water
Noise
Computer-Assisted Image Processing
ROC Curve
1 Citation (Scopus)

Photon-counting detector CT: System design and clinical applications of an emerging technology

Leng, S., Bruesewitz, M., Tao, S., Rajendran, K., Halaweish, A. F., Campeau, N. G., Fletcher, J. G. & McCollough, C. H., May 1 2019, In : Radiographics. 39, 3, p. 729-743 15 p.

Research output: Contribution to journalArticle

Photons
Technology
Contrast Media
Artifacts
Noise

Reducing radiation dose for multi-phase contrast-enhanced dual energy renal CT: pilot study evaluating prior iterative reconstruction

Navin, P. J., Kim, B., Wells, M., Khandelwal, A., Halaweish, A. F., Moen, T. R., Johnson, M. P., McCollough, S., Lee, Y. S., Leng, S., McCollough, C. H. & Fletcher, J. G., Jan 1 2019, (Accepted/In press) In : Abdominal Radiology.

Research output: Contribution to journalArticle

Radiation
Kidney
Computer-Assisted Image Processing
Neoplasms
Kidney Neoplasms
3 Citations (Scopus)

Reduction of Metal Artifacts and Improvement in Dose Efficiency Using Photon-Counting Detector Computed Tomography and Tin Filtration

Zhou, W., Bartlett, D. J., Diehn, F. E., Glazebrook, K. N., Kotsenas, A. L., Carter, R. E., Fletcher, J. G., McCollough, C. H. & Leng, S., Apr 1 2019, In : Investigative radiology. 54, 4, p. 204-211 8 p.

Research output: Contribution to journalArticle

Tin
Photons
Artifacts
Metals
Tomography
2018
9 Citations (Scopus)

150-μm Spatial Resolution Using Photon-Counting Detector Computed Tomography Technology: Technical Performance and First Patient Images

Leng, S., Rajendran, K., Gong, H., Zhou, W., Halaweish, A. F., Henning, A., Kappler, S., Baer, M., Fletcher, J. G. & McCollough, C. H., Nov 1 2018, In : Investigative Radiology. 53, 11, p. 655-662 8 p.

Research output: Contribution to journalArticle

Photons
Tomography
Technology
Noise
Research Ethics Committees
2 Citations (Scopus)

Characterization of Urinary Stone Composition by Use of Whole-body, Photon-counting Detector CT

Ferrero, A., Gutjahr, R., Halaweish, A. F., Leng, S. & McCollough, C. H., Jan 1 2018, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Whole-Body Counting
Urinary Calculi
Photons
Tomography
ROC Curve
1 Citation (Scopus)

Comparison of a photon-counting-detector CT with an energy-integrating-detector CT for temporal bone imaging: A cadaveric study

Zhou, W., Lane, J. I., Carlson, M. L., Bruesewitz, M. R., Witte, R. J., Koeller, K. K., Eckel, L. J., Carter, R. E., McCollough, C. H. & Leng, S., Sep 1 2018, In : American Journal of Neuroradiology. 39, 9, p. 1733-1738 6 p.

Research output: Contribution to journalArticle

Temporal Bone
Photons
Stapes
Comb and Wattles
Anatomy
4 Citations (Scopus)

Detection and characterization of renal stones by using photon-counting-based CT

Marcus, R. P., Fletcher, J. G., Ferrero, A., Leng, S., Halaweish, A. F., Gutjahr, R., Vrtiska, T. J., Wells, M., Enders, F. T. & McCollough, C. H., Nov 1 2018, In : Radiology. 289, 2, p. 436-442 7 p.

Research output: Contribution to journalArticle

Photons
Kidney
Cone-Beam Computed Tomography
Uric Acid
Research
6 Citations (Scopus)

Dual-source multienergy CT with triple or quadruple x-ray beams

Yu, L., Ren, L., Li, Z., Leng, S. & McCollough, C. H., Jul 1 2018, In : Journal of Medical Imaging. 5, 3, 033502.

Research output: Contribution to journalArticle

Photons
X-Rays
Contrast Media
Computer Simulation
Noise

Evaluation of a photon counting Medipix3RX cadmium zinc telluride spectral x-ray detector

Marsh, J. F., Jorgensen, S. M., Rundle, D. S., Vercnocke, A. J., Leng, S., Butler, P. H., McCollough, C. H. & Ritman, E. L., Oct 1 2018, In : Journal of Medical Imaging. 5, 4, 043503.

Research output: Contribution to journalArticle

X-Ray Microtomography
Photons
X-Rays
Brachytherapy
Linear Models
2 Citations (Scopus)

Evaluation of projection- and dual-energy-based methods for metal artifact reduction in CT using a phantom study

Long, Z., Bruesewitz, M. R., Delone, D. R., Morris, J. M., Amrami, K. K., Adkins, M. C., Glazebrook, K. N., Kofler, J. M., Leng, S., McCollough, C. H., Fletcher, J. G., Halaweish, A. F. & Yu, L., Jan 1 2018, (Accepted/In press) In : Journal of Applied Clinical Medical Physics.

Research output: Contribution to journalArticle

Artifacts
artifacts
projection
Metals
evaluation

Impact of Effective Detector Pixel and CT Voxel Size on Accurate Estimation of Blood Volume in Opacified Microvasculature

Sheikhzadeh, M., Vercnocke, A. J., Tao, S., Rajendran, K., Leng, S., Ritman, E. L. & McCollough, C. H., Jan 1 2018, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Microvessels
Blood Volume
Photons
Swine
X-Ray Microtomography
4 Citations (Scopus)

Material decomposition with prior knowledge aware iterative denoising (MD-PKAID)

Tao, S., Rajendran, K., McCollough, C. H. & Leng, S., Sep 21 2018, In : Physics in Medicine and Biology. 63, 19, 195003.

Research output: Contribution to journalArticle

Noise
Whole-Body Counting
Least-Squares Analysis
Photons
Iodine
1 Citation (Scopus)

Observer performance with varying radiation dose and reconstruction methods for detection of hepatic metastases

Fletcher, J. G., Fidler, J. L., Venkatesh, S. K., Hough, D. M., Takahashi, N. M., Yu, L., Johnson, M., Leng, S., Holmes III, D. R., Carter, R. E. & McCollough, C. H., Nov 1 2018, In : Radiology. 289, 2, p. 455-464 10 p.

Research output: Contribution to journalArticle

Radiation
Neoplasm Metastasis
Liver
ROC Curve
Cone-Beam Computed Tomography
2017
1 Citation (Scopus)
Calculi
Swine
Radiation
Kidney
X-Ray Computed Tomography Scanners
9 Citations (Scopus)

An effective noise reduction method for multi-energy CT images that exploit spatio-spectral features

Li, Z., Leng, S., Yu, L., Manduca, A. & McCollough, C. H., May 1 2017, In : Medical Physics. 44, 5, p. 1610-1623 14 p.

Research output: Contribution to journalArticle

Noise
Cadaver
Radiology
Swine
Head
2 Citations (Scopus)

Cochlear Implant Electrode Localization Using an Ultra-High Resolution Scan Mode on Conventional 64-Slice and New Generation 192-Slice Multi-Detector Computed Tomography

Carlson, M. L., Leng, S., Diehn, F. E., Witte, R. J., Krecke, K. N., Grimes, J., Koeller, K. K., Bruesewitz, M. R., McCollough, C. H. & Lane, J. I., May 31 2017, (Accepted/In press) In : Otology and Neurotology.

Research output: Contribution to journalArticle

Cochlear Implants
X-Ray Computed Tomography Scanners
Electrodes
Tomography
Artifacts
1 Citation (Scopus)

Consistency of renal stone volume measurements across CT scanner model and reconstruction algorithm configurations

Huang, A. E., Montoya, J. C., Shiung, M., Leng, S. & McCollough, C. H., Jul 1 2017, In : American Journal of Roentgenology. 209, 1, p. 116-121 6 p.

Research output: Contribution to journalArticle

Kidney Calculi
Kidney
Prospective Studies
11 Citations (Scopus)

Correlation between a 2D channelized Hotelling observer and human observers in a low-contrast detection task with multislice reading in CT

Yu, L., Chen, B., Kofler, J. M., Favazza, C. P., Leng, S., Kupinski, M. A. & McCollough, C. H., Aug 1 2017, In : Medical Physics. 44, 8, p. 3990-3999 10 p.

Research output: Contribution to journalArticle

Reading
Confidence Intervals
Radiation
10 Citations (Scopus)

Estimating patient dose from CT exams that use automatic exposure control: Development and validation of methods to accurately estimate tube current values

Mcmillan, K., Bostani, M., Cagnon, C. H., Yu, L., Leng, S., McCollough, C. H. & Mcnitt-Gray, M. F., 2017, (Accepted/In press) In : Medical Physics.

Research output: Contribution to journalArticle

Pelvis
Abdomen
Thorax
Breast
Spleen
3 Citations (Scopus)

Estimation of signal and noise for a whole-body research photon-counting CT system

Li, Z., Leng, S., Yu, Z., Kappler, S. & McCollough, C. H., Apr 1 2017, In : Journal of Medical Imaging. 4, 2, 023505.

Research output: Contribution to journalArticle

Photons
Noise
Research
Table lookup
Detectors

Evaluation of a projection-domain lung nodule insertion technique in thoracic computed tomography

Ma, C., Yu, L., Chen, B., Koo, C. W., Takahashi, E. A., Fletcher, J. G., Levin, D. L., Kuzo, R. S., Viers, L. D., Vincent-Sheldon, S. A., Leng, S. & McCollough, C. H., Jan 1 2017, In : Journal of Medical Imaging. 4, 1, 013510.

Research output: Contribution to journalArticle

Tomography
Thorax
Confidence Intervals
Lung
Image quality
14 Citations (Scopus)

Low-dose CT for the detection and classification of metastatic liver lesions: Results of the 2016 Low Dose CT Grand Challenge

McCollough, C. H., Bartley, A. C., Carter, R. E., Chen, B., Drees, T. A., Edwards, P., Holmes III, D. R., Huang, A. E., Khan, F., Leng, S., McMillan, K. L., Michalak, G. J., Nunez, K. M., Yu, L. & Fletcher, J. G., Oct 1 2017, In : Medical Physics. 44, 10, p. e339-e352

Research output: Contribution to journalArticle

Liver
Neoplasm Metastasis
Noise
ROC Curve
Information Dissemination
4 Citations (Scopus)

Low kV versus dual-energy virtual monoenergetic CT imaging for proven liver lesions: what are the advantages and trade-offs in conspicuity and image quality? A pilot study

Hanson, G. J., Michalak, G. J., Childs, R., McCollough, B., Kurup, A. N., Hough, D. M., Frye, J. M., Fidler, J. L., Venkatesh, S. K., Leng, S., Yu, L., Halaweish, A. F., Harmsen, W. S., McCollough, C. H. & Fletcher, J. G., Oct 5 2017, (Accepted/In press) In : Abdominal Radiology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Noise
Artifacts
Liver
Iodine
Radiologists
3 Citations (Scopus)

Lung nodule volume quantification and shape differentiation with an ultra-high resolution technique on a photon-counting detector computed tomography system

Zhou, W., Montoya, J., Gutjahr, R., Ferrero, A., Halaweish, A., Kappler, S., McCollough, C. H. & Leng, S., Oct 1 2017, In : Journal of Medical Imaging. 4, 4, 043502.

Research output: Contribution to journalArticle

Photons
Tomography
X-Ray Computed Tomography Scanners
Lung
Cone-Beam Computed Tomography
2 Citations (Scopus)

Measuring arterial wall perfusion using photon-counting computed tomography (CT): Improving CT number accuracy of artery wall using image deconvolution

Rajendran, K., Leng, S., Jorgensen, S. M., Anderson, J. L., Halaweish, A. F., Abdurakhimova, D., Ritman, E. L. & McCollough, C. H., Oct 1 2017, In : Journal of Medical Imaging. 4, 4, 044006.

Research output: Contribution to journalArticle

Vasa Vasorum
Photons
Arteries
Perfusion
Tomography
1 Citation (Scopus)

Phase-contrast imaging with a compact x-ray light source: System design

Sung, Y., Gupta, R., Nelson, B., Leng, S., McCollough, C. H. & Graves, W. S., Oct 1 2017, In : Journal of Medical Imaging. 4, 4, 043503.

Research output: Contribution to journalArticle

X-Rays
Light
Noise
Cysts
Coronary Vessels
3 Citations (Scopus)

Selection of optimal tube potential settings for dual-energy CT virtual mono-energetic imaging of iodine in the abdomen

Michalak, G., Grimes, J., Fletcher, J. G., Halaweish, A., Yu, L., Leng, S. & McCollough, C. H., Apr 1 2017, (Accepted/In press) In : Abdominal Radiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Photons
Iodine
Abdomen
Water
Information Systems
19 Citations (Scopus)

Spectral performance of a whole-body research photon counting detector CT: Quantitative accuracy in derived image sets

Leng, S., Zhou, W., Yu, Z., Halaweish, A., Krauss, B., Schmidt, B., Yu, L., Kappler, S. & McCollough, C. H., Aug 21 2017, In : Physics in Medicine and Biology. 62, 17, p. 7216-7232 17 p.

Research output: Contribution to journalArticle

Photons
Iodine
X-Ray Computed Tomography Scanners
Research
Tomography
1 Citation (Scopus)
Pelvis
Abdomen
CT protocol
3 Citations (Scopus)

Utility of single-energy and dual-energy computed tomography in clot characterization: An in-vitro study

Brinjikji, W., Michalak, G., Kadirvel, R. D., Dai, D., Gilvarry, M., Duffy, S., Kallmes, D. F., McCollough, C. H. & Leng, S., Jun 1 2017, In : Interventional Neuroradiology. 23, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

Erythrocytes
Tomography
Fibrin
In Vitro Techniques
ROC Curve
2016
5 Citations (Scopus)

A robust noise reduction technique for time resolved CT

Li, Z., Yu, L., Leng, S., Williamson, E. E., Kotsenas, A. L., DeLone, D. R., Manduca, A. & McCollough, C. H., Jan 1 2016, In : Medical Physics. 43, 1, p. 347-359 13 p.

Research output: Contribution to journalArticle

Noise
Perfusion
Brain
Four-Dimensional Computed Tomography
13 Citations (Scopus)

Construction of realistic phantoms from patient images and a commercial three-dimensional printer

Leng, S., Chen, B., Vrieze, T., Kuhlmann, J., Yu, L., Alexander, A., Matsumoto, J., Morris, J. & McCollough, C. H., Jul 1 2016, In : Journal of Medical Imaging. 3, 3, 033501.

Research output: Contribution to journalArticle

Tomography
Liver
Printing
Cerebrospinal fluid
Cerebrospinal Fluid
5 Citations (Scopus)

CT negative attenuation pixel distribution and texture analysis for detection of fat in small angiomyolipoma on unenhanced CT

Takahashi, N., Takeuchi, M., Sasaguri, K., Leng, S., Froemming, A. & Kawashima, A., Jun 1 2016, In : Abdominal Radiology. 41, 6, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

Angiomyolipoma
Fats
Renal Cell Carcinoma
Kidney
Software
8 Citations (Scopus)

Dealing with uncertainty in CT images

Fletcher, J. G., Leng, S., Yu, L. & McCollough, C. H., Apr 1 2016, In : Radiology. 279, 1, p. 5-10 6 p.

Research output: Contribution to journalArticle

X Ray Computed Tomography
Uncertainty
24 Citations (Scopus)

Dose-efficient ultrahigh-resolution scan mode using a photon counting detector computed tomography system

Leng, S., Yu, Z., Halaweish, A., Kappler, S., Hahn, K., Henning, A., Li, Z., Lane, J., Levin, D. L., Jorgensen, S., Ritman, E. & McCollough, C. H., Oct 1 2016, In : Journal of Medical Imaging. 3, 4, 043504.

Research output: Contribution to journalArticle

Photons
Tomography
Detectors
Swine
Image resolution
13 Citations (Scopus)

Dual-energy CT for quantification of urinary stone composition in mixed stones: A phantom study

Leng, S., Huang, A., Cardona, J. M., Duan, X., Williams, J. C. & McCollough, C. H., Aug 1 2016, In : American Journal of Roentgenology. 207, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Urinary Calculi
Uric Acid
Acids
Water
6 Citations (Scopus)

Estimation of Observer Performance for Reduced Radiation Dose Levels in CT. Eliminating Reduced Dose Levels That Are Too Low Is the First Step

Fletcher, J. G., Yu, L., Fidler, J. L., Levin, D. L., DeLone, D. R., Hough, D. M., Takahashi, N., Venkatesh, S. K., Sykes, A-M. G., White, D., Lindell, R. M., Kotsenas, A. L., Campeau, N. G., Lehman, V. T., Bartley, A. C., Leng, S., Holmes III, D. R., Toledano, A. Y., Carter, R. E. & McCollough, C. H., Aug 30 2016, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Tomography
Radiation
Head
ROC Curve
Thorax
85 Citations (Scopus)

Evaluation of conventional imaging performance in a research whole-body CT system with a photon-counting detector array

Yu, Z., Leng, S., Jorgensen, S. M., Li, Z., Gutjahr, R., Chen, B., Halaweish, A. F., Kappler, S., Yu, L., Ritman, E. L. & McCollough, C. H., Feb 2 2016, In : Physics in Medicine and Biology. 61, 4, p. 1572-1595 24 p., 1572.

Research output: Contribution to journalArticle

Photons
Research
Noise
Whole-Body Counting
X-Rays
20 Citations (Scopus)

How Low Can We Go in Radiation Dose for the Data-Completion Scan on a Research Whole-Body Photon-Counting Computed Tomography System

Yu, Z., Leng, S., Li, Z., Halaweish, A. F., Kappler, S., Ritman, E. L. & McCollough, C. H., Apr 20 2016, (Accepted/In press) In : Journal of Computer Assisted Tomography.

Research output: Contribution to journalArticle

Whole-Body Counting
Photons
Tomography
Radiation
Research
64 Citations (Scopus)

Human Imaging With Photon Counting–Based Computed Tomography at Clinical Dose Levels: Contrast-to-Noise Ratio and Cadaver Studies

Gutjahr, R., Halaweish, A. F., Yu, Z., Leng, S., Yu, L., Li, Z., Jorgensen, S. M., Ritman, E. L., Kappler, S. & McCollough, C. H., Jan 25 2016, (Accepted/In press) In : Investigative Radiology.

Research output: Contribution to journalArticle

Photons
Cadaver
Noise
Tomography
X-Ray Computed Tomography Scanners