• 5124 Citations
  • 36 Scopus h-Index
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Research Output 2003 2019

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Conference contribution
2019

Automatic strategy for CHO channel reduction in x-ray angiography systems

Gomez-Cardona, D., Leng, S., Favazza, C. P., Schueler, B. A. & Fetterly, K. A., Jan 1 2019, Medical Imaging 2019: Image Perception, Observer Performance, and Technology Assessment. Nishikawa, R. M. & Samuelson, F. W. (eds.). SPIE, 1095205. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10952).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Angiography
angiography
X-Rays
Noise
X rays

Correlation between a deep-learning-based model observer and human observer for a realistic lung nodule localization task in chest CT

Gong, H., Walther, A., Hu, Q., Koo, C. W., Takahashi, E. A., Levin, D. L., Johnson, T., Hora, M. J., Leng, S., Fletcher, J. G., McCollough, C. H. & Yu, L., Jan 1 2019, Medical Imaging 2019: Image Perception, Observer Performance, and Technology Assessment. Nishikawa, R. M. & Samuelson, F. W. (eds.). SPIE, 109520K. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10952).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

chest
nodules
lungs
learning
Thorax

Demonstration of phase-assisted material decomposition with a Talbot-Lau interferometer using a single x-ray tube potential

Shanblatt, E. R., Nelson, B. J., Tao, S., Leng, S. & McCollough, C. H., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109482W. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

x ray tubes
fats
Interferometers
Demonstrations
interferometers

Multi-contrast imaging on dual-source photon-counting-detector (PCD) CT

Tao, S., Rajendran, K., McCollough, C. H. & Leng, S., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109484L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
Light sources
counting
Detectors
Imaging techniques

Optimal acquisition setting for dual-contrast imaging with gadolinium and iodine on a research whole-body photon-counting-detector (PCD) CT

Tao, S., Wu, Y., Rajendran, K., McCollough, C. H. & Leng, S., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109484I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Whole-Body Counting
Gadolinium
gadolinium
Iodine
Photons

Quantitative cartilage imaging using spectral photon-counting detector based computed tomography

Rajendran, K., Tao, S., Benike, A., Leng, S. & McCollough, C. H., Jan 1 2019, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging. Gimi, B. & Krol, A. (eds.). SPIE, 109531A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10953).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

cartilage
Cartilage
Glycosaminoglycans
Photons
Tomography

Simulation of CT images reconstructed with different kernels using a convolutional neural network and its implications for efficient CT workflow

Missert, A. D., Leng, S., McCollough, C. H., Fletcher, J. G. & Yu, L., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109482Y. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Workflow
Tomography
tomography
X-Ray Computed Tomography Scanners
Neural networks

Visibility guided phase contrast denoising

Nelson, B., Koenig, T., Shanblatt, E., Leng, S. & McCollough, C. H., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109484V. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Interferometry
phase contrast
visibility
Visibility
low visibility
2018
1 Citation (Scopus)

Correlation between model observers in uniform background and human observers in patient liver background for a low-contrast detection task in CT

Gong, H., Yu, L., Leng, S., DIlger, S., Zhou, W., Ren, L. & McCollough, C. H., Jan 1 2018, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 10577. 105770M

Research output: Chapter in Book/Report/Conference proceedingConference contribution

liver
Liver
lesions
Computerized tomography
Image quality

Determination of optimal image type and lowest detectable concentration for iodine detection on a photon counting detector-based multi-energy CT system

Zhou, W., Schornak, R., Michalak, G., Weaver, J., Abdurakhimova, D., Ferrero, A., Fetterly, K. A., McCollough, C. H. & Leng, S., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 105734U

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Iodine
Photons
iodine
low concentrations
counting

Impact of photon counting detector technology on kV selection and diagnostic workflow in CT

Zhou, W., Abdurakhimova, D., Bruesewitz, M., Halaweish, A., McCollough, C. H. & Leng, S., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 105731C

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Workflow
Iodine
Photons
Noise
counting

Ultra-high resolution photon-counting detector CT reconstruction using spectral prior image constrained compressed-sensing (UHR-SPICCS)

Rajendran, K., Tao, S., Abdurakhimova, D., Leng, S. & McCollough, C. H., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 1057318

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Compressed sensing
Photons
counting
Noise
Detectors
2017
3 Citations (Scopus)

A virtual clinical trial using projection-based nodule insertion to determine radiologist reader performance in lung cancer screening CT

Yu, L., Hu, Q., Koo, C. W., Takahashi, E. A., Levin, D. L., Johnson, T., Hora, M. J., Dirks, S., Chen, B., McMillan, K., Leng, S., Fletcher, J. G. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101321R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

nodules
readers
Early Detection of Cancer
lungs
insertion
2 Citations (Scopus)

Detection of increased vasa vasorum in artery walls: Improving CT number accuracy using image deconvolution

Rajendran, K., Leng, S., Jorgensen, S. M., Abdurakhimova, D., Ritman, E. L. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101323O

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vasa Vasorum
Deconvolution
arteries
Tomography
Arteries
2 Citations (Scopus)

Dual energy CT kidney stone differentiation in photon counting computed tomography

Gutjahr, R., Polster, C., Henning, A., Kappler, S., Leng, S., McCollough, C. H., Sedlmair, M. U., Schmidt, B., Krauss, B. & Flohr, T. G., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 1013237

Research output: Chapter in Book/Report/Conference proceedingConference contribution

kidney stones
Apatites
Calcium Oxalate
Kidney Calculi
Apatite
3 Citations (Scopus)

Lung nodule volume quantification and shape differentiation with an ultra-high resolution technique on a photon counting detector CT system

Zhou, W., Montoya, J., Gutjahr, R., Ferrero, A., Halaweish, A., Kappler, S., McCollough, C. H. & Leng, S., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101323Q

Research output: Chapter in Book/Report/Conference proceedingConference contribution

nodules
Photons
ROC Curve
lungs
Macros
2 Citations (Scopus)

Practical implementation of channelized hotelling observers: Effect of ROI size

Ferrero, A., Favazza, C. P., Yu, L., Leng, S. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101320G

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gabor filters
Diagnostic Imaging
Anatomy
Research Personnel
Image acquisition
2 Citations (Scopus)

Renal stone characterization using high resolution imaging mode on a photon counting detector CT system

Ferrero, A., Gutjahr, R., Henning, A., Kappler, S., Halaweish, A., Abdurakhimova, D., Peterson, Z., Montoya, J., Leng, S. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101323J

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cystines
Calcium Oxalate
Cystine
Uric Acid
Photons
14 Citations (Scopus)

Ultra-high spatial resolution multi-energy CT using photon counting detector technology

Leng, S., Gutjahr, R., Ferrero, A., Kappler, S., Henning, A., Halaweish, A., Zhou, W., Montoya, J. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101320Y

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
Macros
Noise
counting
spatial resolution
2016
11 Citations (Scopus)

A high-resolution imaging technique using a whole-body, research photon counting detector CT system

Leng, S., Yu, Z., Halaweish, A., Kappler, S., Hahn, K., Henning, A., Li, Z., Lane, J., Levin, D. L., Jorgensen, S., Ritman, E. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97831I

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
imaging techniques
Temporal Bone
counting
Bone
3 Citations (Scopus)

An open library of CT patient projection data

Chen, B., Leng, S., Yu, L., Holmes III, D. R., Fletcher, J. G. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97831B

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Digital Imaging and Communications in Medicine (DICOM)
abdomen
chest
files
Abdomen
8 Citations (Scopus)

Arterial wall perfusion measured with photon counting spectral X-ray CT

Jorgensen, S. M., Korinek, M. J., Vercnocke, A. J., Anderson, J. L., Halaweish, A., Leng, S., McCollough, C. H. & Ritman, E. L., 2016, Developments in X-Ray Tomography X. SPIE, Vol. 9967. 99670B

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photon Counting
Arteries
Contrast Media
counting
Photons
7 Citations (Scopus)

Dual-source multi-energy CT with triple or quadruple x-ray beams

Yu, L., Li, Z., Leng, S. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 978312

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
X-Rays
Decomposition
X rays
Contrast Media
1 Citation (Scopus)

Estimation of signal and noise for a whole-body photon counting research CT system

Li, Z., Leng, S., Yu, Z., Kappler, S. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97831F

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Whole-Body Counting
Photons
Noise
counting
photons
3 Citations (Scopus)

Evaluation of a projection-domain lung nodule insertion technique in thoracic CT

Ma, C., Chen, B., Koo, C. W., Takahashi, E. A., Fletcher, J. G., McCollough, C. H., Levin, D. L., Kuzo, R. S., Viers, L. D., Vincent Sheldon, S. A., Leng, S. & Yu, L., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97835Y

Research output: Chapter in Book/Report/Conference proceedingConference contribution

nodules
lungs
lesions
Tomography
insertion
6 Citations (Scopus)

Low-dose performance of a whole-body research photon-counting CT scanner

Yu, Z., Leng, S., Kappler, S., Hahn, K., Li, Z., Halaweish, A. F., Henning, A., Ritman, E. L. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97835Q

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
scanners
counting
dosage
photons
3 Citations (Scopus)

Predicting detection performance with model observers: Fourier domain or spatial domain?

Chen, B., Yu, L., Leng, S., Kofler, J., Favazza, C., Vrieze, T. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 978326

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Computer-Assisted Image Processing
Image reconstruction
image reconstruction
Noise
inserts
2015
6 Citations (Scopus)

Construction of realistic liver phantoms from patient images using 3D printer and its application in CT image quality assessment

Leng, S., Yu, L., Vrieze, T., Kuhlmann, J., Chen, B. & McCollough, C. H., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9412. 94124E

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3D printers
printers
liver
Liver
Image quality
14 Citations (Scopus)

Image-based material decomposition with a general volume constraint for photon-counting CT

Li, Z., Leng, S., Yu, L., Yu, Z. & McCollough, C. H., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9412. 94120T

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
counting
Decomposition
decomposition
photons

Impact of number of repeated scans on model observer performance for a low-contrast detection task in CT

Ma, C., Yu, L., Chen, B., Vrieze, T., Favazza, C., Leng, S. & McCollough, C. H., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9416. 94160K

Research output: Chapter in Book/Report/Conference proceedingConference contribution

ROC Curve
dosage
Covariance matrix
Image quality
filters
34 Citations (Scopus)

Initial results from a prototype whole-body photon-counting computed tomography system

Yu, Z., Leng, S., Jorgensen, S. M., Li, Z., Gutjahr, R., Chen, B., Duan, X., Halaweish, A. F., Yu, L., Ritman, E. L. & McCollough, C. H., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9412. 94120W

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Whole-Body Counting
Photons
Tomography
counting
tomography
5 Citations (Scopus)

Lesion insertion in projection domain for computed tomography image quality assessment

Chen, B., Ma, C., Yu, Z., Leng, S., Yu, L. & McCollough, C. H., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9412. 94121R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liver
lesions
Image quality
Tomography
insertion
2014

Determination of minor and trace elements in kidney stones by x-ray fluorescence analysis

Srivastava, A., Heisinger, B. J., Sinha, V., Lee, H. K., Liu, X., Qu, M., Duan, X., Leng, S. & McCollough, C. H., 2014, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9033. 90335R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

kidney stones
x ray fluorescence
Kidney Calculi
Trace Elements
Trace elements
2013

3D-3D Registration of partial capitate bones using spin-images

Breighner, R., Holmes III, D. R., Leng, S., An, K. N., McCollough, C. H. & Zhao, K. D., 2013, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 8671. 867113

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bone
bones
Registration
Partial
registers
2012
7 Citations (Scopus)

Correlation between model observer and human observer performance in CT imaging when lesion location is uncertain

Leng, S., Yu, L., Chen, L., Ramirez Giraldo, J. C. & McCollough, C. H., 2012, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8313. 83131M

Research output: Chapter in Book/Report/Conference proceedingConference contribution

lesions
Imaging techniques
ROC Curve
Area Under Curve
curves
2010
2 Citations (Scopus)

Differentiation of uric acid versus non-uric acid kidney stones in the presence of iodine using dual-energy CT

Wang, J., Qu, M., Leng, S. & McCollough, C. H., 2010, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 2 ed. Vol. 7622. 76223O

Research output: Chapter in Book/Report/Conference proceedingConference contribution

kidney stones
uric acid
Kidney Calculi
Uric Acid
Iodine
12 Citations (Scopus)

Non-convex prior image constrained compressed sensing (NC-PICCS)

Ramírez Giraldo, J. C., Trazasko, J. D., Leng, S., McCollough, C. H. & Manduca, A., 2010, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 2 ed. Vol. 7622. 76222C

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Compressed sensing
Computer-Assisted Image Processing
Noise
Perfusion
Tomography
2009
11 Citations (Scopus)

High temporal resolution cardiac cone-beam CT using a slowly rotating C-arm gantry

Chen, G. H., Tang, J., Nett, B., Leng, S., Zambelli, J., Qi, Z., Bevins, N., Reeder, S. & Rowley, H., 2009, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7258. 72580C

Research output: Chapter in Book/Report/Conference proceedingConference contribution

gantry cranes
Compressed sensing
Cone-Beam Computed Tomography
temporal resolution
Cones
2008
4 Citations (Scopus)

Exact and approximate cone-beam reconstruction algorithms for C-arm based cone-beam CT using a two-concentric-arc source trajectory

Zhuang, T., Zambelli, J., Nett, B., Leng, S. & Chen, G. H., 2008, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6913. 691321

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Image reconstruction
Cones
Trajectories
Geometry
Scanning
48 Citations (Scopus)

Prior Image Constrained Compressed Sensing (PICCS)

Chen, G. H., Tang, J. & Leng, S., 2008, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6856. 685618

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Compressed sensing
Medical imaging
Image reconstruction
Tomography
Pixels
33 Citations (Scopus)

Tomosynthesis via total variation minimization reconstruction and Prior Image Constrained Compressed Sensing (PICCS) on a C-arm system

Nett, B., Tang, J., Leng, S. & Chen, G. H., 2008, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6913. 69132D

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Compressed sensing
Image reconstruction
Image quality
Tomography
Radiation
2007
43 Citations (Scopus)

Limited view angle tomographic image reconstruction via total variation minimization

Velikina, J., Leng, S. & Chen, G. H., 2007, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 2 ed. Vol. 6510. 651020

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Image reconstruction
Tomography
Cones
Sampling
X rays
11 Citations (Scopus)

Motion artifact reduction in fan-beam and cone-beam computed tomography via the Fan-beam Data Consistency Condition (FDCC)

Leng, S., Nett, B., Speidel, M. & Chen, G. H., 2007, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 2 ed. Vol. 6510. 65101W

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fans
Tomography
Cones
Contamination
8 Citations (Scopus)

Novel C-arm based cone-beam CT using a source trajectory of two concentric arcs

Zambelli, J., Nett, B. E., Leng, S., Riddell, C., Belanger, B. & Chen, G. H., 2007, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 1 ed. Vol. 6510. 65101Q

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cones
Trajectories
Tomography
Calibration
3 Citations (Scopus)

Planar tomosynthesis reconstruction in a parallel-beam framework via virtual object reconstruction

Nett, B. E., Leng, S. & Chen, G. H., 2007, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 2 ed. Vol. 6510. 651028

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cones
Image reconstruction
Affine transforms
Geometry
Parallel algorithms
2006
2 Citations (Scopus)

Guidance for cone-beam CT design: Tradeoff between view sampling rate and completeness of scanning trajectories

Chen, G. H., Siewerdsen, J. H., Leng, S., Moseley, D., Nett, B. E., Hsieh, J., Jaffray, D. & Mistretta, C. A., 2006, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6142 I. 614212

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cones
Trajectories
Sampling
Scanning
Image reconstruction
2004
1 Citation (Scopus)

A generalized projection-slice theorem for the divergent beam projections

Chen, G. H., Leng, S. & Mistretta, C. A., 2004, Proceedings of SPIE - The International Society for Optical Engineering. Bonse, U. (ed.). Vol. 5535. p. 301-309 9 p. 33

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fourier transforms
theorems
projection
Fans
fans