• 112201 Citations
  • 148 Scopus h-Index
1974 …2019
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Research Output 1974 2019

2016
10 Citations (Scopus)

Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment

Krell-Roesch, J., Pink, A., Roberts, R. O., Stokin, G. B., Mielke, M. M., Spangehl, K. A., Bartley, M. M., Knopman, D. S., Christianson, T. J. H., Petersen, R. C. & Geda, Y. E., Dec 1 2016, In : Journal of the American Geriatrics Society. 64, 12, p. 2479-2486 8 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Genotype
Exercise
Confidence Intervals
Light
6 Citations (Scopus)

Tracking the development of agrammatic aphasia: A tensor-based morphometry study

Whitwell, J. L., Duffy, J. R., Machulda, M. M., Clark, H., Strand, E. A., Senjem, M. L., Gunter, J. L., Spychalla, A. J., Petersen, R. C., Jack, C. R. J. & Josephs, K. A., Mar 22 2016, (Accepted/In press) In : Cortex.

Research output: Contribution to journalArticle

Aphasia
Broca Aphasia
Apraxias
Thalamus
Putamen
9 Citations (Scopus)

TREM2 p.R47H substitution is not associated with dementia with Lewy bodies

Walton, R. L., Soto-Ortolaza, A. I., Murray, M. E., Lorenzo-Betancor, O., Ogaki, K., Heckman, M. G., Rayaprolu, S., Rademakers, R. V., Taner, N., Uitti, R. J., Van Gerpen, J. A., Wszolek, Z. K., Smith, G. E., Kantarci, K. M., Lowe, V., Parisi, J. E., Jones, D. T., Savica, R., Graff-Radford, J., Knopman, D. S. & 7 others, Petersen, R. C., Graff Radford, N. R., Ferman, T. J., Dickson, D. W., Boeve, B. F., Ross, O. A. & Labbé, C., Aug 1 2016, In : Neurology: Genetics. 2, 4, e85.

Research output: Contribution to journalComment/debate

Lewy Body Disease
28 Citations (Scopus)

TYROBP genetic variants in early-onset Alzheimer's disease

Pottier, C., Ravenscroft, T. A., Brown, P. H., Finch, N. C. A., Baker, M., Parsons, M., Asmann, Y., Ren, Y., Christopher, E., Levitch, D., Van Blitterswijk, M., Cruchaga, C., Campion, D., Nicolas, G., Richard, A. C., Guerreiro, R., Bras, J. T., Zuchner, S., Gonzalez, M. A., Bu, G. D. & 10 others, Younkin, S. G., Knopman, D. S., Josephs, K. A., Parisi, J. E., Petersen, R. C., Taner, N., Graff Radford, N. R., Boeve, B. F., Dickson, D. W. & Rademakers, R. V., Dec 1 2016, In : Neurobiology of Aging. 48, p. 222.e9-222.e15

Research output: Contribution to journalArticle

Alzheimer Disease
Genes
Exome
Age of Onset
Mutation
63 Citations (Scopus)

Updated TDP-43 in Alzheimer’s disease staging scheme

Josephs, K. A., Murray, M. E., Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Petrucelli, L., Liesinger, A. M., Petersen, R. C., Parisi, J. E. & Dickson, D. W., Apr 1 2016, In : Acta Neuropathologica. 131, 4, p. 571-585 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Parahippocampal Gyrus
Medulla Oblongata
Entorhinal Cortex
Globus Pallidus
1 Citation (Scopus)

Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

for the Alzheimer's Disease Neuroimaging Initiative, Jun 29 2016, In : BMC Genomics. 17, 439.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Cerebrospinal Fluid
Brain
Brain Diseases
3' Untranslated Regions

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

for the Alzheimer's Disease Neuroimaging Initiative, Jun 29 2016, In : BMC Genomics. 17, 437.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Proteins
Single Nucleotide Polymorphism
Genome-Wide Association Study
Chemokines
Genes
2015
124 Citations (Scopus)

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Alzheimer's Disease Neuroimaging Initiative, Jun 1 2015, In : Alzheimer's and Dementia. 11, 6, p. e1-e120

Research output: Contribution to journalArticle

Neuroimaging
Alzheimer Disease
Biomarkers
Cerebrospinal Fluid
Amyloid
11 Citations (Scopus)

Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative, Jun 1 2015, In : NeuroImage. 113, p. 61-69 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Clinical Trials
Sample Size
Neuroimaging
Disease Progression
132 Citations (Scopus)

Age, sex, and APOE ϵ4 effects on memory, brain structure, and β-Amyloid across the adult life Span

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Knopman, D. S., Vemuri, P. D., Mielke, M. M., Lowe, V., Senjem, M. L., Gunter, J. L., Machulda, M. M., Gregg, B. E., Pankratz, V. S., Rocca, W. A. & Petersen, R. C., May 1 2015, In : JAMA Neurology. 72, 5, p. 511-519 9 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Brain
Amyloidosis
Amyloid Plaques
9 Citations (Scopus)

Age and Education Corrected Older Adult Normative Data for a Short Form Version of the Financial Capacity Instrument

Gerstenecker, A., Eakin, A., Triebel, K., Martin, R., Swenson-Dravis, D., Petersen, R. C. & Marson, D., Jul 13 2015, (Accepted/In press) In : Psychological Assessment.

Research output: Contribution to journalArticle

Education
Activities of Daily Living
Independent Living
Aptitude
Alzheimer Disease
117 Citations (Scopus)

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

Goetzl, E. J., Boxer, A., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L. & Kapogiannis, D., Jul 7 2015, In : Neurology. 85, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

Exosomes
Alzheimer Disease
Proteins
Lysosome-Associated Membrane Glycoproteins
Frontotemporal Dementia
12 Citations (Scopus)

Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans

Aisen, P. S., Petersen, R. C., Donohue, M. & Weiner, M. W., Jul 1 2015, In : Alzheimer's and Dementia. 11, 7, p. 734-739 6 p.

Research output: Contribution to journalArticle

Neuroimaging
Alzheimer Disease
Clinical Trials
Natural History
Population
61 Citations (Scopus)

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

Risacher, S. L., Kim, S., Nho, K., Foroud, T., Shen, L., Petersen, R. C., Jack, C. R. J., Beckett, L. A., Aisen, P. S., Koeppe, R. A., Jagust, W. J., Shaw, L. M., Trojanowski, J. Q., Weiner, M. W., Saykin, A. J. & Alzheimer's Disease Neuroimaging Initiative (ADNI), D. N. I. ADNI., Dec 1 2015, In : Alzheimer's and Dementia. 11, 12, p. 1417-1429 13 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Alzheimer Disease
Biomarkers
Apolipoprotein E4
Amyloid
16 Citations (Scopus)

Association of long runs of homozygosity with Alzheimer disease among African American individuals

Ghani, M., Reitz, C., Cheng, R., Vardarajan, B. N., Jun, G., Sato, C., Naj, A., Rajbhandary, R., Wang, L. S., Valladares, O., Lin, C. F., Larson, E. B., Graff Radford, N. R., Evans, D., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Murrell, J. R., Raj, T., Taner, N. & 153 others, Logue, M., Baldwin, C. T., Green, R. C., Barnes, L. L., Cantwell, L. B., Fallin, M. D., Go, R. C. P., Griffith, P. A., Obisesan, T. O., Manly, J. J., Lunetta, K. L., Kamboh, M. I., Lopez, O. L., Bennett, D. A., Hendrie, H., Hall, K. S., Goate, A. M., Byrd, G. S., Kukull, W. A., Foroud, T. M., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Lee, J. H., Schellenberg, G. D., St. George-Hyslop, P., Mayeux, R., Rogaeva, E., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barmada, M. M., Beach, T. G., Beecham, G. W., Beekly, D., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cai, G., Cairns, N. J., Cao, C., Carlson, C. S., Carney, R. M., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Cruchaga, C., DeCarli, C., DeKosky, S. T., Demirci, F. Y., Dick, M., Faber, K. M., Fallon, K. B., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Gilman, S., Glass, J. D., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Hamilton-Nelson, K. L., Haroutunian, V., Harrell, L. E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kauwe, J. S. K., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., Kramer, P., LaFerla, F. M., Lah, J. J., Lang-Walker, R., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Olichney, J. M., Parisi, J. E., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Ringman, J. M., Roberson, E. D., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. E. & Yu, L., Nov 1 2015, In : JAMA Neurology. 72, 11, p. 1313-1323 11 p.

Research output: Contribution to journalArticle

African Americans
Alzheimer Disease
Single Nucleotide Polymorphism
Consensus
Dementia
2 Citations (Scopus)

Association of pancreatic polypeptide with mild cognitive impairment varies by APOE ε4 allele

Roberts, R. O., Aakre, J. A., Cha, R. H., Kremers, W. K., Mielke, M. M., Velgos, S. N., Geda, Y. E., Knopman, D. S. & Petersen, R. C., 2015, In : Frontiers in Aging Neuroscience. 7, SEP, 172.

Research output: Contribution to journalArticle

Apolipoprotein E4
Pancreatic Polypeptide
Alleles
Type 2 Diabetes Mellitus
Cognitive Dysfunction
55 Citations (Scopus)

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

Alzheimer’s Disease Genetics Consortium, The GERAD1 Consortium & EPIC-InterAct Consortium, Jun 1 2015, In : PLoS Medicine. 12, 6, e1001841.

Research output: Contribution to journalArticle

Random Allocation
Alzheimer Disease
Smoking
Odds Ratio
Mendelian Randomization Analysis
22 Citations (Scopus)

Atrial fibrillation, cognitive impairment, and neuroimaging

Graff-Radford, J., Madhavan, M., Vemuri, P. D., Rabinstein, A., Cha, R. H., Mielke, M. M., Kantarci, K. M., Lowe, V., Senjem, M. L., Gunter, J. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J. & Roberts, R. O., 2015, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Neuroimaging
Atrial Fibrillation
Infarction
Cerebrovascular Disorders
Cognitive Dysfunction
139 Citations (Scopus)

At the interface of sensory and motor dysfunctions and Alzheimer's disease

Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., Duffy, C. J., Gall, C. M., Gates, G. A., Granholm, A. C., Hensch, T., Holtzer, R., Hyman, B. T., Lin, F. R., McKee, A. C., Morris, J. C. & 8 others, Petersen, R. C., Silbert, L. C., Struble, R. G., Trojanowski, J. Q., Verghese, J., Wilson, D. A., Xu, S. & Zhang, L. I., 2015, In : Alzheimer's and Dementia. 11, 1, p. 70-98 29 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Education
National Institute on Aging (U.S.)
Neurobehavioral Manifestations
Central Nervous System
46 Citations (Scopus)

Brain atrophy over time in genetic and sporadic frontotemporal dementia: A study of 198 serial magnetic resonance images

Whitwell, J. L., Boeve, B. F., Weigand, S. D., Senjem, M. L., Gunter, J. L., Baker, M. C., Dejesus-Hernandez, M., Knopman, D. S., Wszolek, Z. K., Petersen, R. C., Rademakers, R. V., Jack, C. R. J. & Josephs, K. A., May 1 2015, In : European Journal of Neurology. 22, 5, p. 745-752 8 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Atrophy
Microtubule-Associated Proteins
Magnetic Resonance Spectroscopy
Brain
103 Citations (Scopus)

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Morley, J. E., Morris, J. C., Berg-Weger, M., Borson, S., Carpenter, B. D., del Campo, N., Dubois, B., Fargo, K., Fitten, L. J., Flaherty, J. H., Ganguli, M., Grossberg, G. T., Malmstrom, T. K., Petersen, R. C., Rodriguez, C., Saykin, A. J., Scheltens, P., Tangalos, E. G., Verghese, J., Wilcock, G. & 3 others, Winblad, B., Woo, J. & Vellas, B., Sep 1 2015, In : Journal of the American Medical Directors Association. 16, 9, p. 731-739 9 p.

Research output: Contribution to journalArticle

Consensus
Health
Brain
Delivery of Health Care
Centers for Medicare and Medicaid Services (U.S.)
123 Citations (Scopus)

Cascading network failure across the Alzheimer's disease spectrum

Jones, D. T., Knopman, D. S., Gunter, J. L., Graff-Radford, J., Vemuri, P. D., Boeve, B. F., Petersen, R. C., Weiner, M. W. & Jack, C. R. J., Dec 21 2015, In : Brain. 139, 2, p. 547-562 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Neuroimaging
Amyloid Plaques
Brain
Frontal Lobe
39 Citations (Scopus)

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

Gendron, T. D., Van Blitterswijk, M., Bieniek, K. F., Daughrity, L. M., Jiang, J., Rush, B. K., Pedraza, O. D., Lucas, J. A., Murray, M. E., Desaro, P., Robertson, A., Overstreet, K., Thomas, C. S., Crook, J., Castanedes-Casey, M., Rousseau, L., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C. & 9 others, Boeve, B. F., Graff Radford, N. R., Rademakers, R. V., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Dickson, D. W., Petrucelli, L. & Boylan, K. B., Oct 26 2015, In : Acta Neuropathologica. 130, 4, p. 559-573 15 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Chromosomes, Human, Pair 9
Open Reading Frames
Amyotrophic Lateral Sclerosis
Cerebellum
148 Citations (Scopus)

Clinicopathologic and <sup>11</sup>C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum

Murray, M. E., Lowe, V., Graff Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K. M., Ross, O. A., Duara, R., Knopman, D. S., Jack, C. R. J. & Dickson, D. W., May 1 2015, In : Brain. 138, 5, p. 1370-1381 12 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Cerebral Amyloid Angiopathy
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Pittsburgh
10 Citations (Scopus)

Diabetes is Associated with Worse Executive Function in Both Eastern and Western Populations: Shanghai Aging Study and Mayo Clinic Study of Aging

Shanghai Aging Study (SAS), Mayo Clinic Study of Aging (MCSA) & Shane Pankratz, V., 2015, In : Journal of Alzheimer's Disease. 47, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

Executive Function
Diabetes Mellitus
Population
Vascular Diseases
Cognition
62 Citations (Scopus)

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Knopman, D. S., Mielke, M. M., Vemuri, P. D., Lowe, V., Senjem, M. L., Gunter, J. L., Reyes, D., Machulda, M. M., Roberts, R. O. & Petersen, R. C., Dec 1 2015, In : Brain. 138, 12, p. 3747-3759 13 p.

Research output: Contribution to journalArticle

Amyloid
Amyloidosis
Biomarkers
Positron-Emission Tomography
Alzheimer Disease
15 Citations (Scopus)

Direct medical costs and source of cost differences across the spectrum of cognitive decline: A population-based study

Leibson, C. L., Long, K. H., Ransom, J. E., Roberts, R. O., Hass, S. L., Duhig, A. M., Smith, C. Y., Emerson, J. A., Pankratz, V. S. & Petersen, R. C., Aug 1 2015, In : Alzheimer's and Dementia. 11, 8, p. 917-932 16 p., 1965.

Research output: Contribution to journalArticle

Dementia
Costs and Cost Analysis
Population
Cognitive Dysfunction
Inpatients
12 Citations (Scopus)

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Parkinson Disease
Exons
Mutation
Introns
113 Citations (Scopus)

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease

Kapogiannis, D., Boxer, A., Schwartz, J. B., Abner, E. L., Biragyn, A., Masharani, U., Frassetto, L., Petersen, R. C., Miller, B. L. & Goetzl, E. J., Feb 1 2015, In : FASEB Journal. 29, 2, p. 589-596 8 p.

Research output: Contribution to journalArticle

Exosomes
Insulin Receptor Substrate Proteins
Alzheimer Disease
Blood
Frontotemporal Dementia
12 Citations (Scopus)

FASTKD2 is associated with memory and hippocampal structure in older adults

Ramanan, V. K., Nho, K., Shen, L., Risacher, S. L., Kim, S., McDonald, B. C., Farlow, M. R., Foroud, T. M., Gao, S., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Aisen, P. S., Petersen, R. C., Jack, C. R. J., Shaw, L. M., Trojanowski, J. Q. & 7 others, Weiner, M. W., Green, R. C., Toga, A. W., De Jager, P. L., Yu, L., Bennett, D. A. & Saykin, A. J., Oct 29 2015, In : Molecular Psychiatry. 20, 10, p. 1197-1204 8 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Memory Disorders
Neuroprotective Agents
Sirolimus
Genomics
96 Citations (Scopus)

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Alzheimer's Disease Neuroimaging Initiative, May 19 2015, In : Nature Communications. 6, 6760.

Research output: Contribution to journalArticle

cerebrospinal fluid
Cerebrospinal fluid
Ferritins
Cerebrospinal Fluid
Alzheimer Disease
8 Citations (Scopus)

Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease

Gungor, I., Sarro, L., Graff-Radford, J., Zuk, S. M., Tosakulwong, N., Przybelski, S. A., Lesnick, T., Boeve, B. F., Ferman, T. J., Smith, G. E., Knopman, D. S., Filippi, M., Petersen, R. C., Jack, C. R. J. & Kantarci, K. M., Sep 1 2015, In : Parkinsonism and Related Disorders. 21, 9, p. 1101-1104 4 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Alzheimer Disease
Occipital Lobe
Dementia
Parietal Lobe
5 Citations (Scopus)

Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility

Sevlever, D., Zou, F., Ma, L., Carrasquillo, S., Crump, M. G., Culley, O. J., Hunter, T. A., Bisceglio, G. D., Younkin, L., Allen, M., Carrasquillo, M. M., Sando, S. B., Aasly, J. O., Dickson, D. W., Graff Radford, N. R., Petersen, R. C., Morgan, K. & Belbin, O., Apr 9 2015, In : Molecular Neurodegeneration. 10, 1, 18.

Research output: Contribution to journalArticle

Vesicle-Associated Membrane Protein 1
Alzheimer Disease
SNARE Proteins
Memory Disorders
Exocytosis
17 Citations (Scopus)

Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses

Adult Changes in Thought Study Investigators, Religious Orders Study/Memory and Aging Project Investigators & Alzheimer's Disease Genetics Consortium, Dec 1 2015, In : Alzheimer's and Dementia. 11, 12, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Alzheimer Disease
Body Mass Index
Phenotype
Odds Ratio
46 Citations (Scopus)

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP

Ramanan, V. K., Risacher, S. L., Nho, K., Kim, S., Shen, L., McDonald, B. C., Yoder, K. K., Hutchins, G. D., West, J. D., Tallman, E. F., Gao, S., Foroud, T. M., Farlow, M. R., De Jager, P. L., Bennett, D. A., Aisen, P. S., Petersen, R. C., Jack, C. R. J., Toga, A. W., Green, R. C. & 3 others, Jagust, W. J., Weiner, M. W. & Saykin, A. J., Oct 1 2015, In : Brain. 138, 10, p. 3076-3088 13 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Amyloid
Transcriptional Activation
Alzheimer Disease
Interleukin-1 Receptor Accessory Protein
27 Citations (Scopus)

HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study

Leduc, V., De Beaumont, L., Théroux, L., Dea, D., Aisen, P., Petersen, R. C., Dufour, R. & Poirier, J., Jul 24 2015, In : Molecular Psychiatry. 20, 7, p. 867-873 7 p.

Research output: Contribution to journalArticle

Coenzyme A
Age of Onset
Alzheimer Disease
Oxidoreductases
Cohort Studies
209 Citations (Scopus)

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

Fiandaca, M. S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J. B., Abner, E. L., Petersen, R. C., Federoff, H. J., Miller, B. L. & Goetzl, E. J., Jun 1 2015, In : Alzheimer's and Dementia. 11, 6, p. 600-607.e1

Research output: Contribution to journalArticle

Exosomes
Case-Control Studies
Alzheimer Disease
Frontotemporal Dementia
Amyloid
81 Citations (Scopus)

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Cedarbaum, J., Donohue, M. C., Green, R. C., Harvey, D., Jack, C. R. J., Jagust, W., Morris, J. C., Petersen, R. C., Saykin, A. J., Shaw, L., Thompson, P. M., Toga, A. W. & Trojanowski, J. Q., Jul 1 2015, In : Alzheimer's and Dementia. 11, 7, p. 865-884 20 p.

Research output: Contribution to journalArticle

Neuroimaging
Alzheimer Disease
Biomarkers
Clinical Trials
Publications
16 Citations (Scopus)

Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort

Mielke, M. M., Machulda, M. M., Hagen, C. E., Christianson, T. J., Roberts, R. O., Knopman, D. S., Vemuri, P. D., Lowe, V., Kremers, W. K., Jack, C. R. J. & Petersen, R. C., 2015, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Apolipoproteins E
Amyloid
Cognition
Genotype
Episodic Memory
20 Citations (Scopus)

Large-scale genomics unveil polygenic architecture of human cortical surface area

Chen, C. H., Peng, Q., Schork, A. J., Lo, M. T., Fan, C. C., Wang, Y., Desikan, R. S., Bettella, F., Hagler, D. J., Westlye, L. T., Kremen, W. S., Jernigan, T. L., Le Hellard, S., Steen, V. M., Espeseth, T., Huentelman, M., Håberg, A. K., Agartz, I., Djurovic, S., Andreassen, O. A. & 86 others, Schork, N., Dale, A. M., McCabe, C., Chang, L., Akshoomoff, N., Newman, E., Ernst, T., Van Zijl, P., Kuperman, J., Murray, S., Bloss, C., Appelbaum, M., Gamst, A., Thompson, W., Bartsch, H., Weiner, M., Aisen, P., Petersen, R. C., Jack, C. R. J., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Khachaturian, Z., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulman, M. M., Potter, W., Snyder, P. J., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Harvey, D., Bernstein, M. A., Fox, N., Thompson, P., Schuff, N., DeCarli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P. D., Jones, D. T., Kantarci, K. M., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Householder, E., Taylor-Reinwald, L., Lee, V. M. Y., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Faber, K., Kim, S., Nho, K., Thal, L., Frank, R., Buckholtz, N., Albert, M. & Hsiao, J., Jul 20 2015, In : Nature Communications. 6, 7549.

Research output: Contribution to journalArticle

polymorphism
nucleotides
Genomics
Polymorphism
Single Nucleotide Polymorphism
24 Citations (Scopus)

Late-onset Alzheimer disease risk variants mark brain regulatory loci

Allen, M., Kachadoorian, M., Carrasquillo, M. M., Karhade, A., Manly, L., Burgess, J. D., Wang, C., Serie, D., Wang, X., Siuda, J., Zou, F., Chai, H. S., Younkin, C., Crook, J., Medway, C., Nguyen, T., Ma, L., Malphrus, K., Lincoln, S., Petersen, R. C. & 5 others, Graff Radford, N. R., Asmann, Y., Dickson, D. W., Younkin, S. G. & Taner, N., Aug 1 2015, In : Neurology: Genetics. 1, 2, e15.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Single Nucleotide Polymorphism
Genome-Wide Association Study
Temporal Lobe
46 Citations (Scopus)

Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease

Carrasquillo, M. M., Crook, J., Pedraza, O. D., Thomas, C. S., Pankratz, V. S., Allen, M., Nguyen, T., Malphrus, K. G., Ma, L., Bisceglio, G. D., Roberts, R. O., Lucas, J. A., Smith, G. E., Ivnik, R. J., Machulda, M. M., Graff Radford, N. R., Petersen, R. C., Younkin, S. G. & Taner, N., Jan 1 2015, In : Neurobiology of Aging. 36, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Genome-Wide Association Study
Cognitive Dysfunction
7 Citations (Scopus)

Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials

Donohue, M. C., Moghadam, S. H., Roe, A. D., Sun, C. K., Edland, S. D., Thomas, R. G., Petersen, R. C., Sano, M., Galasko, D., Aisen, P. S. & Rissman, R. A., Sep 1 2015, In : Alzheimer's and Dementia. 11, 9, p. 1069-1079 11 p., 1909.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Clinical Trials
Simvastatin
Apolipoprotein E4
60 Citations (Scopus)

Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Goetzl, E. J., Boxer, A., Schwartz, J. B., Abner, E. L., Petersen, R. C., Miller, B. L., Carlson, O. D., Mustapic, M. & Kapogiannis, D., Jul 1 2015, In : Annals of Clinical and Translational Neurology. 2, 7, p. 769-773 5 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Transcription Factors
Transcriptional Silencer Elements
Survival
Frontotemporal Dementia
10 Citations (Scopus)

Microbleeds in atypical presentations of Alzheimer's disease: A comparison to dementia of the Alzheimer's type

Whitwell, J. L., Kantarci, K. M., Weigand, S. D., Lundt, E. S., Gunter, J. L., Duffy, J. R., Strand, E. A., Machulda, M. M., Spychalla, A. J., Drubach, D., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., 2015, In : Journal of Alzheimer's Disease. 45, 4, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Frontal Lobe
Language
Amyloid
Cognition
15 Citations (Scopus)

Mild Neurocognitive disorder: An old wine in a new bottle

Stokin, G. B., Krell-Roesch, J., Petersen, R. C. & Geda, Y. E., Sep 19 2015, In : Harvard Review of Psychiatry. 23, 5, p. 368-376 9 p.

Research output: Contribution to journalArticle

Wine
Diagnostic and Statistical Manual of Mental Disorders
Cognitive Dysfunction
Delirium
Mental Disorders
27 Citations (Scopus)

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, Puschmann, A., Nishioka, K., Funayama, M., Hattori, N., Parisi, J. E., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Springer, W., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Dec 8 2015, In : Neurology. 85, 23, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

Lewy Bodies
Lewy Body Disease
Parkinson Disease
Genes
Exons
16 Citations (Scopus)
Sex Factors
Life Style
Mortality
Heart Diseases
Exercise
8 Citations (Scopus)

MRS in Mild Cognitive Impairment: Early Differentiation of Dementia with Lewy Bodies and Alzheimer's Disease

Zhang, B., Ferman, T. J., Boeve, B. F., Smith, G. E., Maroney-Smith, M., Spychalla, A. J., Knopman, D. S., Jack, C. R. J., Petersen, R. C. & Kantarci, K. M., Mar 1 2015, In : Journal of Neuroimaging. 25, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Dementia
Alzheimer Disease
Magnetic Resonance Spectroscopy
Gyrus Cinguli