• 118790 Citations
  • 154 Scopus h-Index
1974 …2020

Research output per year

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Research Output

Article

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

ADGC, Alzheimer’s Disease Neuroimaging Initiative, Jun 1 2017, In : Acta Neuropathologica. 133, 6, p. 955-966 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Ertekin-Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff-Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

11 Scopus citations

Genome-wide analysis of genetic loci associated with Alzheimer disease

Seshadri, S., Fitzpatrick, A. L., Ikram, M. A., DeStefano, A. L., Gudnason, V., Boada, M., Bis, J. C., Smith, A. V., Carassquillo, M. M., Lambert, J. C., Harold, D., Schrijvers, E. M. C., Ramirez-Lorca, R., Debette, S., Longstreth, W. T., Janssens, A. C. J. W., Pankratz, V. S., Dartigues, J. F., Hollingworth, P., Aspelund, T. & 43 others, Hernandez, I., Beiser, A., Kuller, L. H., Koudstaal, P. J., Dickson, D. W., Tzourio, C., Abraham, R., Antunez, C., Du, Y., Rotter, J. I., Aulchenko, Y. S., Harris, T. B., Petersen, R. C., Berr, C., Owen, M. J., Lopez-Arrieta, J., Varadarajan, B. N., Becker, J. T., Rivadeneira, F., Nalls, M. A., Graff Radford, N. R., Campion, D., Auerbach, S., Rice, K., Hofman, A., Jonsson, P. V., Schmidt, H., Lathrop, M., Mosley, T. H., Au, R., Psaty, B. M., Uitterlinden, A. G., Farrer, L. A., Lumley, T., Ruiz, A., Williams, J., Amouyel, P., Younkin, S. G., Wolf, P. A., Launer, L. J., Lopez, O. L., Van Duijn, C. M. & Breteler, M. M. B., May 12 2010, In : JAMA - Journal of the American Medical Association. 303, 18, p. 1832-1840 9 p.

Research output: Contribution to journalArticle

798 Scopus citations

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Scientific reports. 9, 1, 14498.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genome-wide association interaction analysis for Alzheimer's disease

GERAD1 Consortium, Nov 1 2014, In : Neurobiology of Aging. 35, 11, p. 2436-2443 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetic Consortium (ADGC), May 1 2017, In : Acta Neuropathologica. 133, 5, p. 839-856 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Genome-wide association study of CSF biomarkers Aβ1-42, t-tau, and p-tau181p in the ADNI cohort

Kim, S., Swaminathan, S., Shen, L., Risacher, S. L., Nho, K., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Potkin, S. G., Huentelman, M. J., Craig, D. W., Dechairo, B. M., Aisen, P. S., Petersen, R. C., Weiner, M. W. & Saykin, A. J., Jan 4 2011, In : Neurology. 76, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

137 Scopus citations

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

for the Alzheimer's Disease Neuroimaging Initiative, Jun 29 2016, In : BMC Genomics. 17, 436.

Research output: Contribution to journalArticle

2 Scopus citations

Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks

Ramanan, V. K., Kim, S., Holohan, K., Shen, L., Nho, K., Risacher, S. L., Foroud, T. M., Mukherjee, S., Crane, P. K., Aisen, P. S., Petersen, R. C., Weiner, M. W. & Saykin, A. J., 2012, In : Brain Imaging and Behavior. 6, 4, p. 634-648 15 p.

Research output: Contribution to journalArticle

45 Scopus citations

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

Carrasquillo, M. M., Nicholson, A. M., Finch, N., Gibbs, J. R., Baker, M., Rutherford, N. J., Hunter, T. A., Dejesus-Hernandez, M., Bisceglio, G. D., MacKenzie, I. R., Singleton, A., Cookson, M. R., Crook, J., Dillman, A., Hernandez, D., Petersen, R. C., Graff Radford, N. R., Younkin, S. G. & Rademakers, R. V., Dec 10 2010, In : American Journal of Human Genetics. 87, 6, p. 890-897 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Glaucoma and dementia: More than meets the eye?

Ward, M. E. & Petersen, R. C., Aug 2013, In : Annals of Neurology. 74, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: An association study with mechanistic implications

Allen, M., Zou, F., Chai, H. S., Younkin, C. S., Miles, R., Nair, A. A., Crook, J., Pankratz, V. S., Carrasquillo, M. M., Rowley, C. N., Nguyen, T., Ma, L., Malphrus, K. G., Bisceglio, G., Ortolaza, A. I., Palusak, R., Middha, S., Maharjan, S., Georgescu, C., Schultz, D. & 14 others, Rakhshan, F., Kolbert, C. P., Jen, J., Sando, S. B., Aasly, J. O., Barcikowska, M., Uitti, R. J., Wszolek, Z. K., Ross, O. A., Petersen, R. C., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Taner, N., 2012, In : Molecular Neurodegeneration. 7, 1, 13.

Research output: Contribution to journalArticle

44 Scopus citations

Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia

Whitwell, J. L., Avula, R., Senjem, M. L., Kantarci, K. M., Weigand, S. D., Samikoglu, A., Edmonson, H. A., Vemuri, P. D., Knopman, D. S., Boeve, B. F., Petersen, R. C., Josephs, K. A. & Jack, C. R. J., Apr 2010, In : Neurology. 74, 16, p. 1279-1287 9 p.

Research output: Contribution to journalArticle

165 Scopus citations

Guamanian neurodegenerative disease: Investigation of the calcium metabolism/heavy metal hypothesis

Ahlskog, J. E., Waring, S. C., Kurland, L. T., Petersen, R. C., Moyer, T. P., Harmsen, W. S., Maraganore, D. M., O'Brien, P. C., Esteban-Santillan, C. & Bush, V., 1995, In : Neurology. 45, 7, p. 1340-1344 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Guamanian neurodegenerative disease: Electrophysiologic findings

Ahlskog, J. E., Litchya, W. J., Petersen, R. C., Waring, S. C., Esteban-Santillan, C., Chen, K. M., Harper, C. M., Craig, U. K. & Kurland, L. T., Jun 15 1999, In : Journal of the Neurological Sciences. 166, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Guamanian neurodegenerative disease: Are diabetes mellitus and altered humoral immunity clues to pathogenesis?

Ahlskog, J. E., Petersen, R. C., Waring, S. C., Esteban-Santillan, C., Craig, U. K., Maraganore, D. M., Lennon, V. A. & Kurland, L. T., May 1997, In : Neurology. 48, 5, p. 1356-1362 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Guamanian neurodegenerative disease: Ultrastructural studies of skin

Ono, S., Waring, S. C., Kurland, L. L., Katrina-Craig, U. & Petersen, R. C., Feb 27 1997, In : Journal of the Neurological Sciences. 146, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP

Ramanan, V. K., Risacher, S. L., Nho, K., Kim, S., Shen, L., McDonald, B. C., Yoder, K. K., Hutchins, G. D., West, J. D., Tallman, E. F., Gao, S., Foroud, T. M., Farlow, M. R., De Jager, P. L., Bennett, D. A., Aisen, P. S., Petersen, R. C., Jack, C. R. J., Toga, A. W., Green, R. C. & 3 others, Jagust, W. J., Weiner, M. W. & Saykin, A. J., Oct 1 2015, In : Brain. 138, 10, p. 3076-3088 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study

Mielke, M. M., Savica, R., Wiste, H. J., Weigand, S. D., Vemuri, P. D., Knopman, D. S., Lowe, V., Roberts, R. O., Machulda, M. M., Geda, Y. E., Petersen, R. C. & Jack, C. R. J., Jan 7 2014, In : Neurology. 82, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Heritability and genetic variance of dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Jul 1 2019, In : Neurobiology of Disease. 127, p. 492-501 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal

Roberts, R. O., Knopman, D. S., Mielke, M. M., Cha, R. H., Pankratz, V. S., Christianson, T. J. H., Geda, Y. E., Boeve, B. F., Ivnik, R. J., Tangalos, E. G., Rocca, W. A. & Petersen, R. C., Jan 28 2014, In : Neurology. 82, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

157 Scopus citations

High normal fasting blood glucose is associated with dementia in Chinese elderly

Mortimer, J. A., Borenstein, A. R., Ding, D., Decarli, C., Zhao, Q., Copenhaver, C., Guo, Q., Chu, S., Galasko, D., Salmon, D. P., Dai, Q., Wu, Y., Petersen, R. C. & Hong, Z., Nov 2010, In : Alzheimer's and Dementia. 6, 6, p. 440-447 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease

Jack, C. R. J., Petersen, R. C., Xu, Y. C., O'Brien, P. C., Waring, S. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., Thibodeau, S. N. & Kokmen, E., Mar 1998, In : Annals of Neurology. 43, 3, p. 303-310 8 p.

Research output: Contribution to journalArticle

147 Scopus citations

Hippocampal atrophy correlates with clinical features of Alzheimer disease in African Americans

Sencakova, D., Graff Radford, N. R., Willis, F. B., Lucas, J. A., Parfitt, F., Cha, R. H., O'Brien, P. C., Petersen, R. C. & Jack, C. R. J., 2001, In : Archives of Neurology. 58, 10, p. 1593-1597 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects

Chiang, G. C., Insel, P. S., Tosun, D., Schuff, N., Truran-Sacrey, D., Raptentsetsang, S. T., Jack, C. R. J., Aisen, P. S., Petersen, R. C. & Weiner, M. W., Nov 30 2010, In : Neurology. 75, 22, p. 1976-1981 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Hippocampal transverse relaxation times in patients with Alzheimer disease

Campeau, N. G., Petersen, R. C., Felmlee, J. P., O'Brien, P. C. & Jack, C. R. J., Oct 1997, In : Radiology. 205, 1, p. 197-201 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Hippocampal Volume Is Associated with Memory but not Nonmemory Cognitive Performance in Patients with Mild Cognitive Impairment

Grundman, M., Jack, C. R. J., Petersen, R. C., Kim, H. T., Taylor, C., Datvian, M., Weiner, M. F., DeCarli, C., DeKosky, S. J., Van Dyck, C., Darvesh, S., Yaffe, K., Kaye, J., Ferris, S. H., Thomas, R. G. & Thal, L. J., 2003, In : Journal of Molecular Neuroscience. 20, 3, p. 241-248 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes

Kantarci, K. M., Petersen, R. C., Przybelski, S. A., Weigand, S. D., Shiung, M. M., Whitwell, J. L., Negash, S., Ivnik, R. J., Boeve, B. F., Knopman, D. S., Smith, G. E. & Jack, C. R. J., Dec 2008, In : Archives of Neurology. 65, 12, p. 1621-1628 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment

Kantarci, K. M., Lesnick, T., Ferman, T. J., Przybelski, S. A., Boeve, B. F., Smith, G. E., Kremers, W. K., Knopman, D. S., Jack, C. R. J. & Petersen, R. C., Nov 29 2016, In : Neurology. 87, 22, p. 2317-2323 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study

Leduc, V., De Beaumont, L., Théroux, L., Dea, D., Aisen, P., Petersen, R. C., Dufour, R. & Poirier, J., Jul 24 2015, In : Molecular Psychiatry. 20, 7, p. 867-873 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

How can we best categorize cognitive impairment in nondemented older adults?

Sachdev, P. S., Ganguli, M. & Petersen, R. C., Aug 2010, In : American Journal of Geriatric Psychiatry. 18, 8, p. 657-661 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

How early can we diagnose Alzheimer disease (and is it sufficient)?

Petersen, R. C., Aug 28 2018, In : Neurology. 91, 9, p. 395-402 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Human state-dependent learning processes involving scopolamine

Petersen, R. C., 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

Allen, M., Carrasquillo, M. M., Funk, C., Heavner, B. D., Zou, F., Younkin, C. S., Burgess, J. D., Chai, H. S., Crook, J., Eddy, J. A., Li, H., Logsdon, B., Peters, M. A., Dang, K. K., Wang, X., Serie, D., Wang, C., Nguyen, T., Lincoln, S., Malphrus, K. & 11 others, Bisceglio, G., Li, M., Golde, T. E., Mangravite, L. M., Asmann, Y., Price, N. D., Petersen, R. C., Graff Radford, N. R., Dickson, D. W., Younkin, S. G. & Taner, N., Oct 11 2016, In : Scientific data. 3, 160089.

Research output: Contribution to journalArticle

38 Scopus citations

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R. J., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C. & Trojanowski, J. Q., Jan 2010, In : The Lancet Neurology. 9, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

2438 Scopus citations

Hypothyroidism and risk of mild cognitive impairment in elderly persons a population-based study

Parsaik, A. K., Singh, B., Roberts, R. O., Pankratz, S., Edwards, K. K., Geda, Y. E., Gharib, H., Boeve, B. F., Knopman, D. S. & Petersen, R. C., Feb 2014, In : JAMA Neurology. 71, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
194 Scopus citations

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

International Frontotemporal Dementia Genomics Consortium, Jan 1 2019, In : Nature Medicine. 25, 1, p. 152-164 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics

Nho, K., Corneveaux, J. J., Kim, S., Lin, H., Risacher, S. L., Shen, L., Swaminathan, S., Ramanan, V. K., Liu, Y., Foroud, T., Inlow, M. H., Siniard, A. L., Reiman, R. A., Aisen, P. S., Petersen, R. C., Green, R. C., Jack, C. R. J., Weiner, M. W., Baldwin, C. T., Lunetta, K. & 14 others, Farrer, L. A., Furney, S. J., Lovestone, S., Simmons, A., Mecocci, P., Vellas, B., Tsolaki, M., Kloszewska, I., Soininen, H., McDonald, B. C., Farlow, M. R., Ghetti, B., Huentelman, M. J. & Saykin, A. J., Jul 2013, In : Molecular Psychiatry. 18, 7, p. 739 1 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

Fiandaca, M. S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J. B., Abner, E. L., Petersen, R. C., Federoff, H. J., Miller, B. L. & Goetzl, E. J., Jun 1 2015, In : Alzheimer's and Dementia. 11, 6, p. 600-607.e1

Research output: Contribution to journalArticle

242 Scopus citations

Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies

Graff-Radford, J., Boeve, B. F., Pedraza, O. D., Ferman, T. J., Przybelski, S., Lesnick, T. G., Vemuri, P. D., Senjem, M. L., Smith, G. E., Knopman, D. S., Lowe, V., Jack, C. R. J., Petersen, R. C. & Kantarci, K. M., Aug 2012, In : Brain. 135, 8, p. 2470-2477 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
36 Scopus citations

Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis

Zeydan, B., Lowe, V. J., Reichard, R. R., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Parisi, J. E., Machulda, M. M., Vemuri, P., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Jan 1 2020, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access

Imaging correlates of pathology in corticobasal syndrome

Whitwell, J. L., Jack, C. R. J., Boeve, B. F., Parisi, J. E., Ahlskog, J. E., Drubach, D., Senjem, M. L., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Nov 23 2010, In : Neurology. 75, 21, p. 1879-1887 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Imaging correlates of posterior cortical atrophy

Whitwell, J. L., Jack, C. R. J., Kantarci, K. M., Weigand, S. D., Boeve, B. F., Knopman, D. S., Drubach, D., Tang-Wai, D. F., Petersen, R. C. & Josephs, K. A., Jul 2007, In : Neurobiology of Aging. 28, 7, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

125 Scopus citations
16 Scopus citations
36 Scopus citations

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

International FTD-Genomics Consortium, Jan 1 2018, In : PLoS Medicine. 15, 1, e1002487.

Research output: Contribution to journalArticle

32 Scopus citations

Impact of apolipoprotein ε4-cerebrospinal fluid beta-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment

Chiang, G. C., Insel, P. S., Tosun, D., Schuff, N., Truran-Sacrey, D., Raptentsetsang, S. T., Thompson, P. M., Reiman, E. M., Jack, C. R. J., Fox, N. C., Jagust, W. J., Harvey, D. J., Beckett, L. A., Gamst, A., Aisen, P. S., Petersen, R. C. & Weiner, M. W., Sep 2011, In : Alzheimer's and Dementia. 7, 5, p. 514-520 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

26 Scopus citations