Robert R Mc Williams, MD

  • 6746 Citations
  • 43 Scopus h-Index
20032020

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2020

Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

DeLeon, T. T., Almquist, D. R., Kipp, B. R., Langlais, B. T., Mangold, A., Winters, J. L., Kosiorek, H. E., Joseph, R. W., Dronca, R. S., Block, M. S., McWilliams, R. R., Kottschade, L. A., Rumilla, K. M., Voss, J. S., Seetharam, M., Sekulic, A., Markovic, S. N. & Bryce, A. H., Jan 1 2020, In : PloS one. 15, 3, e0230306.

Research output: Contribution to journalArticle

Open Access

Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

McCleary-Wheeler, A. L., Carr, R. M., Palmer, S. R., Smyrk, T. C., Allred, J. B., Almada, L. L., Tolosa, E. J., Lamberti, M. J., Marks, D. L., Borad, M. J., Molina, J. R., Qi, Y., Lingle, W. L., Grothey, A., Pitot, H. C., Jatoi, A., Northfelt, D. W., Bryce, A. H., McWilliams, R. R., Okuno, S. H. & 10 others, Haluska, P., Kim, G. P., Colon-Otero, G., Lowe, V. J., Callstrom, M. R., Ma, W. W., Bekaii-Saab, T., Hung, M. C., Erlichman, C. & Fernandez-Zapico, M. E., Jan 2020, In : Pancreatology. 20, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma

Chakrabarti, S., Zemla, T. J., Ahn, D. H., Ou, F. S., Fruth, B., Borad, M. J., Hartgers, M. L., Wessling, J., Walkes, R. L., Alberts, S. R., McWilliams, R. R., Liu, M. C., Durgin, L. M., Bekaii-Saab, T. S. & Mahipal, A., May 1 2020, In : Oncologist. 25, 5, p. 380-e763

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine

Vera, J., Paludo, J., Kottschade, L., Brandt, J., Yan, Y., Block, M. S., Mc Williams, R. R., Dronca, R. S., Loprinzi, C. L., Grothey, A. F. & Markovic, S. N., Jan 1 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical impact of celiac ganglia metastasis upon pancreatic ductal adenocarcinoma

Malikowski, T., Lehrke, H. D., Henry, M. R., Gleeson, F. C., Alberts, S. R., Kendrick, M. L., Lennon, R. J., McWilliams, R. R., Takahashi, N., Topazian, M. D., Gara, N., Abu Dayyeh, B. K., Chandrasekhara, V., Chari, S. T., Iyer, P. G., Rajan, E., Storm, A. C., Wang, K. K. & Levy, M. J., Jan 1 2019, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Intratumoral CD3+ and CD8+ T-cell densities in patients with DNA mismatch repair–deficient metastatic colorectal cancer receiving programmed cell death-1 blockade

Chakrabarti, S., Huebner, L. J., Finnes, H. D., Muranyi, A., Clements, J., Singh, S., Hubbard, J. M., McWilliams, R. R., Shanmugam, K. & Sinicrope, F. A., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

3 Scopus citations

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

6 Scopus citations

Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma

Huffman, B. M., Jin, Z., Yadav, S., Patel, S., Nagorney, D. M., Truty, M., Mc Williams, R. R., Halfdanarson, T. R. & Mahipal, A., Jan 1 2019, In : Clinical colorectal cancer.

Research output: Contribution to journalArticle

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

Meric-Bernstam, F., Hurwitz, H., Raghav, K. P. S., McWilliams, R. R., Fakih, M., VanderWalde, A., Swanton, C., Kurzrock, R., Burris, H., Sweeney, C., Bose, R., Spigel, D. R., Beattie, M. S., Blotner, S., Stone, A., Schulze, K., Cuchelkar, V. & Hainsworth, J., Apr 2019, In : The Lancet Oncology. 20, 4, p. 518-530 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status

Antwi, S., Fagan, S. E., Chaffee, K. G., Bamlet, W. R., Hu, C., Polley, E., Hart, S., Shimelis, H., Lilyquist, J., Gnanaolivu, R. D., Mc Williams, R. R., Oberg, A. L., Couch, F. J. & Petersen, G. M., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 264-271 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Survival and prognostic factors in patients with pancreatic squamous cell carcinoma

Tella, S. H., Kommalapati, A., Yadav, S., Bergquist, J. R., Truty, M., Durgin, L., Ma, W. W., Cleary, S. P., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

ZEBRA: an ACCRU/IRCI multicenter phase 2 study of pembrolizumab in patients with advanced small bowel adenocarcinoma (SBA)

Pedersen, K., Foster, N., Overman, M., Boland, P., Kim, S., Arrambide, K., Jaszewski, B., Welch, J., Wilson, R. & McWilliams, R., Jul 1 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, p. iv128

Research output: Contribution to journalArticle

2018

Adjuvant systemic therapy after resection of node positive gallbladder cancer: Time for a well-designed trial? (Results of a US-national retrospective cohort study)

Bergquist, J. R., Shah, H. N., Habermann, E. B., Hernandez, M. C., Ivanics, T., Kendrick, M. L., Smoot, R. L., Nagorney, D. M., Borad, M. J., McWilliams, R. R. & Truty, M. J., Apr 2018, In : International Journal of Surgery. 52, p. 171-179 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

AlternativeOutpatientChemotherapy scheduling method to improve patient service quality and nurse satisfaction

Huang, Y. L., Bryce, A. H., Culbertson, T., Connor, S. L., Looker, S. A., Altman, K. M., Collins, J. G., Stellner, W., Mc Williams, R. R., Moreno Aspitia, A., Ailawadhi, S. & Mesa, R. A., Feb 1 2018, In : Journal of Oncology Practice. 14, 2, p. e82-e91

Research output: Contribution to journalArticle

1 Scopus citations

An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A Trial of the ECOG-ACRIN Cancer Research Group (E2204)

Berlin, J. D., Feng, Y., Catalano, P., Abbruzzese, J. L., Philip, P. A., Mc Williams, R. R., Lowy, A. M., Benson, A. B. & Blackstock, A. W., Jan 1 2018, In : Oncology (Switzerland). 94, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer

Hu, C., Hart, S., Polley, E., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S., Bamlet, W. R., Chaffee, K. G., DiCarlo, J., Wu, Z., Samara, R., Kasi, P. M., Mc Williams, R. R., Petersen, G. M. & Couch, F. J., Jun 19 2018, In : JAMA - Journal of the American Medical Association. 319, 23, p. 2401-2409 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

CDKN2A germline rare coding variants and risk of pancreatic cancer in minority populations

Mc Williams, R. R., Wieben, E. D., Chaffee, K. G., Antwi, S., Raskin, L., Olopade, O. I., Li, D., Highsmith, W. E. J., Colon-Otero, G., Khanna, L. G., Permuth, J. B., Olson, J. E., Frucht, H., Genkinger, J., Zheng, W., Blot, W. J., Wu, L., Almada, L. L., Fernandez-Zapico, M. E., Sicotte, H. & 2 others, Pedersen, K. S. & Petersen, G. M., Nov 1 2018, In : Cancer Epidemiology Biomarkers and Prevention. 27, 11, p. 1364-1370 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma who received dabrafenib combined with trametinib

Long, G. V., Eroglu, Z., Infante, J., Patel, S., Daud, A., Johnson, D. B., Gonzalez, R., Kefford, R., Hamid, O., Schuchter, L., Cebon, J., Sharfman, W., McWilliams, R., Sznol, M., Redhu, S., Gasal, E., Mookerjee, B., Weber, J. & Flaherty, K. T., Mar 1 2018, In : Journal of Clinical Oncology. 36, 7, p. 667-673 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Riaz, I. B., Sharma, P., Mahipal, A. & McWilliams, R., Oct 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. viii260-viii261

Research output: Contribution to journalArticle

Open Access

Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history

Chaffee, K. G., Oberg, A. L., Mc Williams, R. R., Majithia, N., Allen, B. A., Kidd, J., Singh, N., Hartman, A. R., Wenstrup, R. J. & Petersen, G. M., Jan 1 2018, In : Genetics in Medicine. 20, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rucaparib monotherapy in patients with pancreatic cancer and a known deleterious BRCA mutation

Shroff, R. T., Hendifar, A., McWilliams, R. R., Geva, R., Epelbaum, R., Rolfe, L., Goble, S., Lin, K. K., Biankin, A. V., Giordano, H., Vonderheide, R. H. & Domchek, S. M., Jan 1 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

28 Scopus citations

The Vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation

Innocenti, F., Owzar, K., Jiang, C., Etheridge, A. S., Gordân, R., Sibley, A. B., Mulkey, F., Niedzwiecki, D., Glubb, D., Neel, N., Talamonti, M. S., Bentrem, D. J., Seiser, E., Yeh, J. J., Van Loon, K., McLeod, H., Ratain, M. J., Kindler, H. L., Venook, A. P., Nakamura, Y. & 4 others, Kubo, M., Petersen, G. M., Bamlet, W. R. & McWilliams, R. R., Aug 2018, In : PloS one. 13, 8, e0202272.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Association between the use of surveillance PET/CT and the detection of potentially salvageable occult recurrences among patients with resected high-risk melanoma

Leon-Ferre, R. A., Kottschade, L. A., Block, M. S., Mc Williams, R. R., Dronca, R. S., Creagan, E. T., Allred, J. B., Lowe, V. & Markovic, S. N., Mar 14 2017, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

7 Scopus citations

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

Bryce, A. H., Egan, J. B., Borad, M. J., Keith Stewart, A., Nowakowski, G. S., Chanan-Khan, A., Patnaik, M. M., Ansell, S. M., Banck, M. S., Robinson, S. I., Mansfield, A. S., Klee, E. W., Oliver, G. R., McCormick, J. B., Huneke, N. E., Tagtow, C. M., Jenkins, R. B., Rumilla, K. M., Kerr, S. E., Kocher, J. P. A. & 5 others, Beck, S. A., Fernandez-Zapico, M. E., Farrugia, G., Lazaridis, K. N. & McWilliams, R. R., Jan 1 2017, In : Oncotarget. 8, 16, p. 27145-27154 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Genomic Profiling of Small-Bowel Adenocarcinoma

Schrock, A. B., Devoe, C. E., Mc Williams, R. R., Sun, J., Aparicio, T., Stephens, P. J., Ross, J. S., Wilson, R., Miller, V. A., Ali, S. M. & Overman, M. J., Nov 1 2017, In : JAMA oncology. 3, 11, p. 1546-1553 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., Gabriel, S. B., Meyerson, M., Cibulskis, C., Fei, S. S., Hinoue, T., Shen, H., Laird, P. W., Ling, S., Lu, Y., Mills, G. B. & 251 others, Akbani, R., Loher, P., Londin, E. R., Rigoutsos, I., Telonis, A. G., Gibb, E. A., Goldenberg, A., Mezlini, A. M., Hoadley, K. A., Collisson, E., Lander, E., Murray, B. A., Hess, J., Rosenberg, M., Bergelson, L., Zhang, H., Cho, J., Tiao, G., Kim, J., Livitz, D., Leshchiner, I., Reardon, B., Van Allen, E., Kamburov, A., Beroukhim, R., Saksena, G., Schumacher, S. E., Noble, M. S., Heiman, D. I., Gehlenborg, N., Kim, J., Lawrence, M. S., Adsay, V., Petersen, G., Klimstra, D., Bardeesy, N., Leiserson, M. D. M., Bowlby, R., Kasaian, K., Birol, I., Mungall, K. L., Sadeghi, S., Weinstein, J. N., Spellman, P. T., Liu, Y., Amundadottir, L. T., Tepper, J., Singhi, A. D., Dhir, R., Paul, D., Smyrk, T., Zhang, L., Kim, P., Bowen, J., Frick, J., Gastier-Foster, J. M., Gerken, M., Lau, K., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Renkel, J., Sherman, M., Wise, L., Yena, P., Zmuda, E., Shih, J., Ally, A., Balasundaram, M., Carlsen, R., Chu, A., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Brooks, D., Auman, J. T., Balu, S., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, C. M., Perou, A. H., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Parker, J. S., Wilkerson, M. D., Korkut, A., Senbabaoglu, Y., Burch, P., McWilliams, R., Chaffee, K., Oberg, A., Zhang, W., Gingras, M. C., Wheeler, D. A., Xi, L., Albert, M., Bartlett, J., Sekhon, H., Stephen, Y., Howard, Z., Judy, M., Breggia, A., Shroff, R. T., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Jennifer, S., Roggin, K., Becker, K. F., Behera, M., Bennett, J., Boice, L., Burks, E., Carlotti Junior, C. G., Chabot, J., Pretti da Cunha Tirapelli, D., Sebastião dos Santos, J., Dubina, M., Eschbacher, J., Huang, M., Huelsenbeck-Dill, L., Jenkins, R., Karpov, A., Kemp, R., Lyadov, V., Maithel, S., Manikhas, G., Montgomery, E., Noushmehr, H., Osunkoya, A., Owonikoko, T., Paklina, O., Potapova, O., Ramalingam, S., Rathmell, W. K., Rieger-Christ, K., Saller, C., Setdikova, G., Shabunin, A., Sica, G., Su, T., Sullivan, T., Swanson, P., Tarvin, K., Tavobilov, M., Thorne, L. B., Urbanski, S., Voronina, O., Wang, T., Crain, D., Curley, E., Gardner, J., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Janssen, K. P., Bathe, O., Bahary, N., Slotta-Huspenina, J., Johns, A., Hibshoosh, H., Hwang, R. F., Sepulveda, A., Radenbaugh, A., Baylin, S. B., Berrios, M., Bootwalla, M. S., Holbrook, A., Lai, P. H., Maglinte, D. T., Mahurkar, S., Triche, T. J., Van Den Berg, D. J., Weisenberger, D. J., Chin, L., Kucherlapati, R., Kucherlapati, M., Pantazi, A., Park, P., Saksena, G., Voet, D., Lin, P., Frazer, S., Defreitas, T., Meier, S., Chin, L., Kwon, S. Y., Kim, Y. H., Park, S. J., Han, S. S., Kim, S. H., Kim, H., Furth, E., Tempero, M., Sander, C., Biankin, A., Chang, D., Bailey, P., Gill, A., Kench, J., Grimmond, S., Johns, A., Cancer Genome Initiative (APGI, A. P., Postier, R., Zuna, R., Sicotte, H., Demchok, J. A., Ferguson, M. L., Hutter, C. M., Mills Shaw, K. R., Sheth, M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J. J., Felau, I. & Zenklusen, J. C., Aug 14 2017, In : Cancer cell. 32, 2, p. 185-203.e13

Research output: Contribution to journalArticle

298 Scopus citations

Molecular modeling and functional analysis of exome sequencing-derived variants of unknown significance identify a novel, constitutively active FGFR2 mutant in cholangiocarcinoma

Egan, J. B., Marks, D. L., Hogenson, T. L., Vrabel, A. M., Sigafoos, A. N., Tolosa, E. J., Carr, R. M., Safgren, S. L., Hesles, E. E., Almada, L. L., Romecin-Duran, P. A., Iguchi, E., Ala'Aldeen, A., Kocher, J. P. A., Oliver, G. R., Prodduturi, N., Mead, D. W., Hossain, A., Huneke, N. E., Tagtow, C. M. & 43 others, Ailawadhi, S., Ansell, S. M., Banck, M. S., Bryce, A. H., Carballido, E. M., Chanan-Khan, A. A., Curtis, K. K., Resnik, E., Gawryletz, C. D., Go, R. S., Halfdanarson, T. R., Ho, T. H., Joseph, R. W., Kapoor, P., Mansfield, A. S., Meurice, N., Rao, A. A. N., Nowakowski, G. S., Pardanani, A., Parikh, S. A., Cheville, J. C., Feldman, A. L., Ramanathan, R. K., Robinson, S. I., Tibes, R., Finnes, H. D., McCormick, J. B., McWilliams, R. R., Jatoi, A., Patnaik, M. M., Silva, A. C., Wieben, E. D., McAllister, T. M., Rumilla, K. M., Kerr, S. E., Lazaridis, K. N., Farrugia, G., Keith Stewart, A., Clark, K. J., Kennedy, E. J., Klee, E. W., Borad, M. J. & Fernandez-Zapico, M. E., Jan 1 2017, In : JCO Precision Oncology. 2017, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access

NCCTG N0879 (Alliance): A randomized phase 2 cooperative group trial of carboplatin, paclitaxel, and bevacizumab±everolimus for metastatic melanoma

Mc Williams, R. R., Allred, J. B., Slostad, J. A., Katipamula, R., Dronca, R. S., Rumilla, K. M., Erickson, L. A., Bryce, A. H., Joseph, R. W., Kottschade, L. A., King, D. M., Leitch, J. M. & Markovic, S. N., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

4 Scopus citations

Non-V600BRAF mutations define a clinically distinct molecular subtype of metastatic colorectal cancer

Jones, J. C., Renfro, L. A., Al-Shamsi, H. O., Schrock, A. B., Rankin, A., Zhang, B. Y., Kasi, P. M., Voss, J. S., Leal, A. D., Sun, J., Ross, J., Ali, S. M., Hubbard, J. M., Kipp, B. R., Mc Williams, R. R., Kopetz, S., Wolff, R. A. & Grothey, A. F., Aug 10 2017, In : Journal of Clinical Oncology. 35, 23, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

94 Scopus citations

North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma

Mc Williams, R. R., Foster, N. R., Mahoney, M. R., Smyrk, T. C., Murray, J. A., Ames, M. M., Horvath, L. E., Schneider, D. J., Hobday, T. J., Jatoi, A., Meyers, J. P. & Goetz, M. P., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

15 Scopus citations

Phase III prospective randomized comparison trial of depot octreotide plus interferon Alfa-2b versus depot octreotide plus bevacizumab in patients with advanced carcinoid tumors: SWOG S0518

Yao, J. C., Moran, C., Guthrie, K. A., McDonough, S., Strosberg, J. R., Kulke, M. H., Chan, J. A., Loconte, N., McWilliams, R. R., Wolin, E. M., Wolin, E. M., Mattar, B., Chen, H., Blanke, C. D. & Hochster, H. S., May 20 2017, In : Journal of Clinical Oncology. 35, 15, p. 1695-1703 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells

Lehrke, H. D., Graham, R., Mc Williams, R. R., Lam-Himlin, D. M., Smyrk, T. C., Jenkins, S., Dong, H. M. & Zhang, L., Nov 2 2017, In : American Journal of Clinical Pathology. 148, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

11 Scopus citations

Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib

Bryce, A. H., Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., McCullough, A. E., Hunt, K. S., Ritacca, N. R., Barrett, M., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Stanton, M. L., Cheville, J., Swanson, S., Schneider, D. E., Mc Williams, R. R. & 16 others, Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Von Hoff, D. D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Nov 3 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

MacHiela, M. J., Zhou, W., Karlins, E., Sampson, J. N., Freedman, N. D., Yang, Q., Hicks, B., Dagnall, C., Hautman, C., Jacobs, K. B., Abnet, C. C., Aldrich, M. C., Amos, C., Amundadottir, L. T., Arslan, A. A., Beane-Freeman, L. E., Berndt, S. I., Black, A., Blot, W. J., Bock, C. H. & 156 others, Bracci, P. M., Brinton, L. A., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J. E., Butler, M. A., Canzian, F., Carreón, T., Chaffee, K. G., Chang, I. S., Chatterjee, N., Chen, C., Chen, C., Chen, K., Chung, C. C., Cook, L. S., Crous Bou, M., Cullen, M., Davis, F. G., De Vivo, I., Ding, T., Doherty, J., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Friedenreich, C. M., Fuchs, C. S., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., Gaudet, M. M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Haiman, C. A., Hallmans, G., Hankinson, S. E., Harris, C. C., Henriksson, R., Holly, E. A., Hong, Y. C., Hoover, R. N., Hsiung, C. A., Hu, N., Hu, W., Hunter, D. J., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, A. P., Klein, R., Koh, W. P., Kolonel, L. N., Kooperberg, C., Kraft, P., Krogh, V., Kurtz, R. C., Lacroix, A., Lan, Q., Landi, M. T., Marchand, L. L., Li, D., Liang, X., Liao, L. M., Lin, D., Liu, J., Lissowska, J., Lu, L., Magliocco, A. M., Malats, N., Matsuo, K., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Moore, L., Olson, S. H., Orlow, I., Park, J. Y., Patinõ-Garcia, A., Peplonska, B., Peters, U., Petersen, G. M., Pooler, L., Prescott, J., Prokunina-Olsson, L., Purdue, M. P., Qiao, Y. L., Rajaraman, P., Real, F. X., Riboli, E., Risch, H. A., Rodriguez-Santiago, B., Ruder, A. M., Savage, S. A., Schumacher, F., Schwartz, A. G., Schwartz, K. L., Seow, A., Wendy Setiawan, V., Severi, G., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Van Den Berg, D., Visvanathan, K., Wacholder, S., Wang, J. C., Wang, Z., Wentzensen, N., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wong, M. P., Wu, C., Wu, T., Wu, X., Wu, Y. L., Wunder, J. S., Xia, L., Yang, H. P., Yang, P. C., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Ziegler, R. G., Perez-Jurado, L. A., Caporaso, N. E., Rothman, N., Tucker, M., Dean, M. C., Yeager, M. & Chanock, S. J., Jun 13 2016, In : Nature communications. 7, 11843.

Research output: Contribution to journalArticle

28 Scopus citations

Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer

Li, L., Zhang, J. W., Jenkins, G., Xie, F., Carlson, E. E., Fridley, B. L., Bamlet, W. R., Petersen, G. M., McWilliams, R. R. & Wang, L., Jan 1 2016, In : Pharmacogenetics and genomics. 26, 12, p. 527-537 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Integrated genomic analysis of pancreatic ductal adenocarcinomas reveals genomic rearrangement events as significant drivers of disease

Murphy, S. J., Hart, S., Halling, G. C., Johnson, S. H., Smadbeck, J., Drucker, T., Lima, J. F., Rohakhtar, F. R., Harris, F. R., Kosari, F., Subramanian, S., Petersen, G. M., Wiltshire, T. D., Kipp, B. R., Truty, M., Mc Williams, R. R., Couch, F. J. & Vasmatzis, G., Feb 1 2016, In : Cancer Research. 76, 3, p. 749-761 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: Determination of frequency and distribution pattern

Al-Shamsi, H. O., Jones, J., Fahmawi, Y., Dahbour, I., Tabash, A., Abdel-Wahab, R., Abousamra, A. O. S., Shaw, K. R., Xiao, L., Hassan, M. M., Kipp, B. R., Kopetz, S., Soliman, A. S., Mc Williams, R. R. & Wolff, R. A., 2016, In : Journal of Gastrointestinal Oncology. 7, 6, p. 882-902 21 p.

Research output: Contribution to journalArticle

18 Scopus citations

Phase I Study of CHK1 Inhibitor LY2603618 in Combination with Gemcitabine in Patients with Solid Tumors

Calvo, E., Braiteh, F., Von Hoff, D., Mc Williams, R. R., Becerra, C., Galsky, M. D., Jameson, G., Lin, J., McKane, S., Wickremsinhe, E. R., Hynes, S. M., Bence Lin, A., Hurt, K. & Richards, D., Sep 7 2016, (Accepted/In press) In : Oncology (Switzerland).

Research output: Contribution to journalArticle

15 Scopus citations

Phase I study of DMOT4039A, an antibody-drug conjugate targeting mesothelin, in patients with unresectable pancreatic or platinum-resistant ovarian cancer

Weekes, C. D., Lamberts, L. E., Borad, M. J., Voortman, J., Mc Williams, R. R., Diamond, J. R., De Vries, E. G. E., Verheul, H. M., Lieu, C. H., Kim, G. P., Wang, Y., Scales, S. J., Samineni, D., Brunstein, F., Choi, Y., Maslyar, D. J. & Colon-Otero, G., Mar 1 2016, In : Molecular Cancer Therapeutics. 15, 3, p. 439-447 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients

Hu, C., Hart, S., Bamlet, W. R., Moore, R. M., Nandakumar, K., Eckloff, B. W., Lee, Y. K., Petersen, G. M., Mc Williams, R. R. & Couch, F. J., Jan 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 1, p. 207-211 5 p.

Research output: Contribution to journalArticle

60 Scopus citations

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

McWilliams, R. R., Maisonneuve, P., Bamlet, W. R., Petersen, G. M., Li, D., Risch, H. A., Yu, H., Fontham, E. T. H., Luckett, B., Bosetti, C., Negri, E., La Vecchia, C., Talamini, R., De Mesquita, H. B. B., Bracci, P., Gallinger, S., Neale, R. E. & Lowenfels, A. B., Feb 1 2016, In : Pancreas. 45, 2, p. 311-316 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

The use of pembrolizumab for the treatment of metastatic uveal melanoma

Kottschade, L. A., Mc Williams, R. R., Markovic, S. N., Block, M. S., Villasboas Bisneto, J. J. C. ., Pham, A. Q., Esplin, B. L. & Dronca, R. S., Feb 4 2016, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

50 Scopus citations
2015

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study

Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Cote, M. L., Mc Williams, R. R., Roberts, N. J., Cannon-Albright, L. A., Li, D., Moyes, K., Wenstrup, R. J., Hartman, A. R., Seminara, D., Klein, A. P. & Petersen, G. M., Jul 2 2015, In : Genetics in Medicine. 17, 7, p. 569-577 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

BRCA2-associated pancreatic cancer and current screening guidelines

Kasi, P. M., Pedersen, K. S. & Mc Williams, R. R., Sep 1 2015, In : Cancer. 121, 17, p. 3046 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American journal of human genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: A Mayo Clinic phase II consortium study

Pedersen, K. S., Kim, G. P., Foster, N. R., Wang-Gillam, A., Erlichman, C. & McWilliams, R. R., Aug 2015, In : Investigational New Drugs. 33, 4, p. 963-968 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Should vital signs be routinely obtained prior to intravenous chemotherapy? Results from a 2-center study

Menon, S., Foster, N. R., Looker, S., Sorgatz, K., Kasi, P. M., Mc Williams, R. R. & Jatoi, A., Oct 1 2015, In : Cancer Control. 22, 4, p. 515-519 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: A gene- and pathway-based interaction analysis of GWAS data

Tang, H., Wei, P., Duell, E. J., Risch, H. A., Olson, S. H., Bueno-de-Mesquita, H. B., Gallinger, S., Holly, E. A., Petersen, G., Bracci, P. M., Mcwilliams, R. R., Jenab, M., Riboli, E., Tjønneland, A., Boutron-Ruault, M. C., Kaaks, R., Trichopoulos, D., Panico, S., Sund, M., Peeters, P. H. M. & 3 others, Khaw, K. T., Amos, C. I. & Li, D., Apr 2014, In : Carcinogenesis. 35, 5, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

26 Scopus citations