Robert R Mc Williams, MD

  • 6420 Citations
  • 43 Scopus h-Index
20032019
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Research Output 2003 2019

  • 6420 Citations
  • 43 Scopus h-Index
  • 119 Article
  • 2 Letter
  • 1 Chapter
2019
2 Citations (Scopus)

Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine

Vera, J., Paludo, J., Kottschade, L., Brandt, J., Yan, Y., Block, M. S., Mc Williams, R. R., Dronca, R. S., Loprinzi, C. L., Grothey, A. F. & Markovic, S. N., Jan 1 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Colchicine
Fever
Mitogen-Activated Protein Kinases
Familial Mediterranean Fever
Therapeutics

Clinical impact of celiac ganglia metastasis upon pancreatic ductal adenocarcinoma

Malikowski, T., Lehrke, H. D., Henry, M. R., Gleeson, F. C., Alberts, S. R., Kendrick, M. L., Lennon, R. J., McWilliams, R. R., Takahashi, N., Topazian, M. D., Gara, N., Abu Dayyeh, B. K., Chandrasekhara, V., Chari, S. T., Iyer, P. G., Rajan, E., Storm, A. C., Wang, K. K. & Levy, M. J., Jan 1 2019, (Accepted/In press) In : Pancreatology.

Research output: Contribution to journalArticle

Sympathetic Ganglia
Adenocarcinoma
Neoplasm Metastasis
Survival
Neoplasms

Intratumoral CD3+ and CD8+ T-cell densities in patients with DNA mismatch repair–deficient metastatic colorectal cancer receiving programmed cell death-1 blockade

Chakrabarti, S., Huebner, L. J., Finnes, H. D., Muranyi, A., Clements, J., Singh, S., Hubbard, J. M., McWilliams, R. R., Shanmugam, K. & Sinicrope, F. A., Jan 1 2019, In : JCO Precision Oncology. 3

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Propensity Score
Cholangiocarcinoma
Adjuvant Chemotherapy
Drug Therapy
Survival

Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma

Huffman, B. M., Jin, Z., Yadav, S., Patel, S., Nagorney, D. M., Truty, M., Mc Williams, R. R., Halfdanarson, T. R. & Mahipal, A., Jan 1 2019, In : Clinical colorectal cancer.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Adjuvant Chemotherapy
Monocytes
Neoplasms
19 Citations (Scopus)

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

Meric-Bernstam, F., Hurwitz, H., Raghav, K. P. S., Mc Williams, R. R., Fakih, M., VanderWalde, A., Swanton, C., Kurzrock, R., Burris, H., Sweeney, C., Bose, R., Spigel, D. R., Beattie, M. S., Blotner, S., Stone, A., Schulze, K., Cuchelkar, V. & Hainsworth, J., Apr 1 2019, In : The Lancet Oncology. 20, 4, p. 518-530 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Therapeutics
Trastuzumab
pertuzumab
Chills

Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma

Chakrabarti, S., Zemla, T. J., Ahn, D. H., Ou, F. S., Fruth, B., Borad, M. J., Hartgers, M. L., Wessling, J., Walkes, R. L., Alberts, S. R., McWilliams, R. R., Liu, M. C., Durgin, L. M., Bekaii-Saab, T. S. & Mahipal, A., Jan 1 2019, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Trifluridine
Biliary Tract
Carcinoma
Confidence Intervals
Safety
1 Citation (Scopus)

Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status

Antwi, S., Fagan, S. E., Chaffee, K. G., Bamlet, W. R., Hu, C., Polley, E., Hart, S., Shimelis, H., Lilyquist, J., Gnanaolivu, R. D., Mc Williams, R. R., Oberg, A. L., Couch, F. J. & Petersen, G. M., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 264-271 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genes
Confidence Intervals
Neoplasms

Solid Pseudopapillary Neoplasms of the Pancreas: A Large American Cohort

Sanhueza, C. T., Huffman, B. M., Jin, Z., Hartgers, M. L., Smyrk, T. C., Westin, G., Mc Williams, R. R., Ma, W. W., Alberts, S. R. & Mahipal, A., Apr 1 2019, In : Pancreas. 48, 4, p. E21-E22

Research output: Contribution to journalLetter

Pancreatic Neoplasms

Survival and prognostic factors in patients with pancreatic squamous cell carcinoma

Tella, S. H., Kommalapati, A., Yadav, S., Bergquist, J. R., Truty, M., Durgin, L., Ma, W. W., Cleary, S. P., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Survival
Neoplasms
Drug Therapy
Survival Analysis

The role of serum lactate dehydrogenase level as a prognostic indicator in resected, high risk melanoma

Kumar, A. B., Aguilera, J. V., Velazquez, A., Yan, Y., Jakub, J. W., Brewer, J., Hieken, T. J., Block, M. S., Mc Williams, R. R., Otley, C., Markovic, S. N. & Kottschade, L., Jan 1 2019, In : Dermatologic Therapy. e12813.

Research output: Contribution to journalLetter

L-Lactate Dehydrogenase
Melanoma
Serum
2018
8 Citations (Scopus)

Adjuvant systemic therapy after resection of node positive gallbladder cancer: Time for a well-designed trial? (Results of a US-national retrospective cohort study)

Bergquist, J. R., Shah, H. N., Habermann, E. B., Hernandez, M. C., Ivanics, T., Kendrick, M. L., Smoot, R. L., Nagorney, D. M., Borad, M. J., Mc Williams, R. R. & Truty, M., Apr 1 2018, In : International Journal of Surgery. 52, p. 171-179 9 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Cohort Studies
Retrospective Studies
Adjuvant Chemotherapy
Gallbladder

AlternativeOutpatientChemotherapy scheduling method to improve patient service quality and nurse satisfaction

Huang, Y. L., Bryce, A. H., Culbertson, T., Connor, S. L., Looker, S. A., Altman, K. M., Collins, J. G., Stellner, W., Mc Williams, R. R., Moreno Aspitia, A., Ailawadhi, S. & Mesa, R. A., Feb 1 2018, In : Journal of Oncology Practice. 14, 2, p. e82-e91

Research output: Contribution to journalArticle

Nurses
Workload
Safety
Drug Therapy
Nursing Staff
4 Citations (Scopus)

An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A Trial of the ECOG-ACRIN Cancer Research Group (E2204)

Berlin, J. D., Feng, Y., Catalano, P., Abbruzzese, J. L., Philip, P. A., Mc Williams, R. R., Lowy, A. M., Benson, A. B. & Blackstock, A. W., Jan 1 2018, In : Oncology (Switzerland). 94, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

gemcitabine
Research
Neoplasms
Disease-Free Survival
Therapeutics
62 Citations (Scopus)

Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer

Hu, C., Hart, S., Polley, E., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S., Bamlet, W. R., Chaffee, K. G., DiCarlo, J., Wu, Z., Samara, R., Kasi, P. M., Mc Williams, R. R., Petersen, G. M. & Couch, F. J., Jun 19 2018, In : JAMA - Journal of the American Medical Association. 319, 23, p. 2401-2409 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasm Genes
Pancreatic Neoplasms
Odds Ratio
Exome
1 Citation (Scopus)

CDKN2A germline rare coding variants and risk of pancreatic cancer in minority populations

Mc Williams, R. R., Wieben, E. D., Chaffee, K. G., Antwi, S., Raskin, L., Olopade, O. I., Li, D., Highsmith, W. E. J., Colon-Otero, G., Khanna, L. G., Permuth, J. B., Olson, J. E., Frucht, H., Genkinger, J., Zheng, W., Blot, W. J., Wu, L., Almada, L. L., Fernandez-Zapico, M. E., Sicotte, H. & 2 others, Pedersen, K. S. & Petersen, G. M., Nov 1 2018, In : Cancer Epidemiology Biomarkers and Prevention. 27, 11, p. 1364-1370 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
African Americans
Population
Odds Ratio
Confidence Intervals
70 Citations (Scopus)

Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma who received dabrafenib combined with trametinib

Long, G. V., Eroglu, Z., Infante, J., Patel, S., Daud, A., Johnson, D. B., Gonzalez, R., Kefford, R., Hamid, O., Schuchter, L., Cebon, J., Sharfman, W., Mc Williams, R. R., Sznol, M., Redhu, S., Gasal, E., Mookerjee, B., Weber, J. & Flaherty, K. T., Mar 1 2018, In : Journal of Clinical Oncology. 36, 7, p. 667-673 7 p.

Research output: Contribution to journalArticle

Melanoma
Mitogen-Activated Protein Kinase Kinases
Safety
Disease-Free Survival
trametinib
20 Citations (Scopus)

Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history

Chaffee, K. G., Oberg, A. L., Mc Williams, R. R., Majithia, N., Allen, B. A., Kidd, J., Singh, N., Hartman, A. R., Wenstrup, R. J. & Petersen, G. M., Jan 1 2018, In : Genetics in Medicine. 20, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasm Genes
Pancreatic Neoplasms
Adenocarcinoma
Mutation
19 Citations (Scopus)

Rucaparib monotherapy in patients with pancreatic cancer and a known deleterious BRCA mutation

Shroff, R. T., Hendifar, A., McWilliams, R. R., Geva, R., Epelbaum, R., Rolfe, L., Goble, S., Lin, K. K., Biankin, A. V., Giordano, H., Vonderheide, R. H. & Domchek, S. M., Jan 1 2018, In : JCO Precision Oncology. 2

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Germ-Line Mutation
Drug Therapy
Anemia
3 Citations (Scopus)

The Vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation

Innocenti, F., Owzar, K., Jiang, C., Etheridge, A. S., Gordân, R., Sibley, A. B., Mulkey, F., Niedzwiecki, D., Glubb, D., Neel, N., Talamonti, M. S., Bentrem, D. J., Seiser, E., Yeh, J. J., Van Loon, K., McLeod, H., Ratain, M. J., Kindler, H. L., Venook, A. P., Nakamura, Y. & 4 others, Kubo, M., Petersen, G. M., Bamlet, W. R. & Mc Williams, R. R., Aug 1 2018, In : PLoS One. 13, 8, e0202272.

Research output: Contribution to journalArticle

pancreatic neoplasms
Calcitriol Receptors
gemcitabine
vitamin D
Pancreatic Neoplasms
2017
6 Citations (Scopus)

Association between the use of surveillance PET/CT and the detection of potentially salvageable occult recurrences among patients with resected high-risk melanoma

Leon-Ferre, R. A., Kottschade, L. A., Block, M. S., Mc Williams, R. R., Dronca, R. S., Creagan, E. T., Allred, J. B., Lowe, V. & Markovic, S. N., Mar 14 2017, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

Melanoma
Recurrence
Salvage Therapy
Confidence Intervals
Survival
15 Citations (Scopus)

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

Bryce, A. H., Egan, J. B., Borad, M. J., Stewart, A. K., Nowakowski, G. S., Chanan Khan, A. A., Patnaik, M. M., Ansell, S. M., Banck, M. S., Robinson, S., Mansfield, A., Klee, E. W., Oliver, G. R., McCormick, J. B., Huneke, N. E., Tagtow, C. M., Jenkins, R. B., Rumilla, K. M., Kerr, S. E., Kocher, J-P. & 5 others, Beck, S. A., Fernandez-Zapico, M. E., Farrugia, G., Lazaridis, K. N. & Mc Williams, R. R., 2017, In : Oncotarget. 8, 16, p. 27145-27154 10 p.

Research output: Contribution to journalArticle

Genomics
Neoplasms
Precision Medicine
Standard of Care
Therapeutics
36 Citations (Scopus)

Genomic Profiling of Small-Bowel Adenocarcinoma

Schrock, A. B., Devoe, C. E., Mc Williams, R. R., Sun, J., Aparicio, T., Stephens, P. J., Ross, J. S., Wilson, R., Miller, V. A., Ali, S. M. & Overman, M. J., Nov 1 2017, In : JAMA oncology. 3, 11, p. 1546-1553 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Colorectal Neoplasms
Intestinal Neoplasms
Microsatellite Instability
Tumor Burden
242 Citations (Scopus)

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., Gabriel, S. B., Meyerson, M., Cibulskis, C., Fei, S. S., Hinoue, T., Shen, H., Laird, P. W., Ling, S., Lu, Y., Mills, G. B. & 251 others, Akbani, R., Loher, P., Londin, E. R., Rigoutsos, I., Telonis, A. G., Gibb, E. A., Goldenberg, A., Mezlini, A. M., Hoadley, K. A., Collisson, E., Lander, E., Murray, B. A., Hess, J., Rosenberg, M., Bergelson, L., Zhang, H., Cho, J., Tiao, G., Kim, J., Livitz, D., Leshchiner, I., Reardon, B., Van Allen, E., Kamburov, A., Beroukhim, R., Saksena, G., Schumacher, S. E., Noble, M. S., Heiman, D. I., Gehlenborg, N., Kim, J., Lawrence, M. S., Adsay, V., Petersen, G. M., Klimstra, D., Bardeesy, N., Leiserson, M. D. M., Bowlby, R., Kasaian, K., Birol, I., Mungall, K. L., Sadeghi, S., Weinstein, J. N., Spellman, P. T., Liu, Y., Amundadottir, L. T., Tepper, J., Singhi, A. D., Dhir, R., Paul, D., Smyrk, T. C., Zhang, L., Kim, P., Bowen, J., Frick, J., Gastier-Foster, J. M., Gerken, M., Lau, K., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Renkel, J., Sherman, M., Wise, L., Yena, P., Zmuda, E., Shih, J., Ally, A., Balasundaram, M., Carlsen, R., Chu, A., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Brooks, D., Auman, J. T., Balu, S., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, C. M., Perou, A. H., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Parker, J. S., Wilkerson, M. D., Korkut, A., Senbabaoglu, Y., Burch, P., Mc Williams, R. R., Chaffee, K., Oberg, A. L., Zhang, W., Gingras, M. C., Wheeler, D. A., Xi, L., Albert, M., Bartlett, J., Sekhon, H., Stephen, Y., Howard, Z., Judy, M., Breggia, A., Shroff, R. T., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Jennifer, S., Roggin, K., Becker, K. F., Behera, M., Bennett, J., Boice, L., Burks, E., Carlotti Junior, C. G., Chabot, J., Pretti da Cunha Tirapelli, D., Sebastião dos Santos, J., Dubina, M., Eschbacher, J., Huang, M., Huelsenbeck-Dill, L., Jenkins, R., Karpov, A., Kemp, R., Lyadov, V., Maithel, S., Manikhas, G., Montgomery, E., Noushmehr, H., Osunkoya, A., Owonikoko, T., Paklina, O., Potapova, O., Ramalingam, S., Rathmell, W. K., Rieger-Christ, K., Saller, C., Setdikova, G., Shabunin, A., Sica, G., Su, T., Sullivan, T., Swanson, P., Tarvin, K., Tavobilov, M., Thorne, L. B., Urbanski, S., Voronina, O., Wang, T., Crain, D., Curley, E., Gardner, J., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Janssen, K. P., Bathe, O., Bahary, N., Slotta-Huspenina, J., Johns, A., Hibshoosh, H., Hwang, R. F., Sepulveda, A., Radenbaugh, A., Baylin, S. B., Berrios, M., Bootwalla, M. S., Holbrook, A., Lai, P. H., Maglinte, D. T., Mahurkar, S., Triche, T. J., Van Den Berg, D. J., Weisenberger, D. J., Chin, L., Kucherlapati, R., Kucherlapati, M., Pantazi, A., Park, P., Saksena, G., Voet, D., Lin, P., Frazer, S., Defreitas, T., Meier, S., Chin, L., Kwon, S. Y., Kim, Y. H., Park, S. J., Han, S. S., Kim, S. H., Kim, H., Furth, E., Tempero, M., Sander, C., Biankin, A., Chang, D., Bailey, P., Gill, A., Kench, J., Grimmond, S., Johns, A., Cancer Genome Initiative (APGI, A. P., Postier, R., Zuna, R., Sicotte, H., Demchok, J. A., Ferguson, M. L., Hutter, C. M., Mills Shaw, K. R., Sheth, M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J. J., Felau, I. & Zenklusen, J. C., Aug 14 2017, In : Cancer Cell. 32, 2, p. 185-203.e13

Research output: Contribution to journalArticle

Adenocarcinoma
Mutation
Exome
Neoplasms
Untranslated RNA
4 Citations (Scopus)

NCCTG N0879 (Alliance): A randomized phase 2 cooperative group trial of carboplatin, paclitaxel, and bevacizumab±everolimus for metastatic melanoma

Mc Williams, R. R., Allred, J. B., Slostad, J. A., Katipamula, R., Dronca, R. S., Rumilla, K. M., Erickson, L. A., Bryce, A. H., Joseph, R. W., Kottschade, L. A., King, D. M., Leitch, J. M. & Markovic, S. N., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Melanoma
Disease-Free Survival
Therapeutics
88 Citations (Scopus)

Non-V600BRAF mutations define a clinically distinct molecular subtype of metastatic colorectal cancer

Jones, J. C., Renfro, L. A., Al-Shamsi, H. O., Schrock, A. B., Rankin, A., Zhang, B. Y., Kasi, P. M., Voss, J. S., Leal, A. D., Sun, J., Ross, J., Ali, S. M., Hubbard, J. M., Kipp, B. R., Mc Williams, R. R., Kopetz, S., Wolff, R. A. & Grothey, A. F., Aug 10 2017, In : Journal of Clinical Oncology. 35, 23, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Survival
Neoplasms
Molecular Diagnostic Techniques
13 Citations (Scopus)

North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma

Mc Williams, R. R., Foster, N. R., Mahoney, M. R., Smyrk, T. C., Murray, J. A., Ames, M. M., Horvath, L. E., Schneider, D. J., Hobday, T. J., Jatoi, A., Meyers, J. P. & Goetz, M. P., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

irinotecan
oxaliplatin
Pharmacogenetics
Adenocarcinoma
Genotype
45 Citations (Scopus)

Phase III prospective randomized comparison trial of depot octreotide plus interferon Alfa-2b versus depot octreotide plus bevacizumab in patients with advanced carcinoid tumors: SWOG S0518

Yao, J. C., Moran, C., Guthrie, K. A., McDonough, S., Strosberg, J. R., Kulke, M. H., Chan, J. A., Loconte, N., Mc Williams, R. R., Wolin, E. M., Wolin, E. M., Mattar, B., Chen, H., Blanke, C. D. & Hochster, H. S., May 20 2017, In : Journal of Clinical Oncology. 35, 15, p. 1695-1703 9 p.

Research output: Contribution to journalArticle

interferon alfa-2b
Octreotide
Carcinoid Tumor
Neuroendocrine Tumors
Disease-Free Survival
2 Citations (Scopus)

Undifferentiated Pancreatic Carcinomas Display Enrichment for Frequency and Extent of PD-L1 Expression by Tumor Cells

Lehrke, H. D., Graham, R., Mc Williams, R. R., Lam-Himlin, D. M., Smyrk, T. C., Jenkins, S., Dong, H. M. & Zhang, L., Nov 2 2017, In : American Journal of Clinical Pathology. 148, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

Ligands
Carcinoma
Neoplasms
Adenocarcinoma
Pancreatic Carcinoma
2016
10 Citations (Scopus)

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
DNA Fingerprinting
Patient Preference
Pharmaceutical Preparations

Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib

Bryce, A. H., Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., McCullough, A. E., Hunt, K. S., Ritacca, N. R., Barrett, M., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Stanton, M. L., Cheville, J., Swanson, S., Schneider, D. E., Mc Williams, R. R. & 16 others, Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Von Hoff, D. D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Nov 3 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

MacHiela, M. J., Zhou, W., Karlins, E., Sampson, J. N., Freedman, N. D., Yang, Q., Hicks, B., Dagnall, C., Hautman, C., Jacobs, K. B., Abnet, C. C., Aldrich, M. C., Amos, C., Amundadottir, L. T., Arslan, A. A., Beane-Freeman, L. E., Berndt, S. I., Black, A., Blot, W. J., Bock, C. H. & 156 others, Bracci, P. M., Brinton, L. A., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J. E., Butler, M. A., Canzian, F., Carreón, T., Chaffee, K. G., Chang, I. S., Chatterjee, N., Chen, C., Chen, C., Chen, K., Chung, C. C., Cook, L. S., Crous Bou, M., Cullen, M., Davis, F. G., De Vivo, I., Ding, T., Doherty, J., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Friedenreich, C. M., Fuchs, C. S., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., Gaudet, M. M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Haiman, C. A., Hallmans, G., Hankinson, S. E., Harris, C. C., Henriksson, R., Holly, E. A., Hong, Y. C., Hoover, R. N., Hsiung, C. A., Hu, N., Hu, W., Hunter, D. J., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, A. P., Klein, R., Koh, W. P., Kolonel, L. N., Kooperberg, C., Kraft, P., Krogh, V., Kurtz, R. C., Lacroix, A., Lan, Q., Landi, M. T., Marchand, L. L., Li, D., Liang, X., Liao, L. M., Lin, D., Liu, J., Lissowska, J., Lu, L., Magliocco, A. M., Malats, N., Matsuo, K., McNeill, L. H., Mc Williams, R. R., Melin, B. S., Mirabello, L., Moore, L., Olson, S. H., Orlow, I., Park, J. Y., Patinõ-Garcia, A., Peplonska, B., Peters, U., Petersen, G. M., Pooler, L., Prescott, J., Prokunina-Olsson, L., Purdue, M. P., Qiao, Y. L., Rajaraman, P., Real, F. X., Riboli, E., Risch, H. A., Rodriguez-Santiago, B., Ruder, A. M., Savage, S. A., Schumacher, F., Schwartz, A. G., Schwartz, K. L., Seow, A., Wendy Setiawan, V., Severi, G., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Van Den Berg, D., Visvanathan, K., Wacholder, S., Wang, J. C., Wang, Z., Wentzensen, N., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wong, M. P., Wu, C., Wu, T., Wu, X., Wu, Y. L., Wunder, J. S., Xia, L., Yang, H. P., Yang, P. C., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Ziegler, R. G., Perez-Jurado, L. A., Caporaso, N. E., Rothman, N., Tucker, M., Dean, M. C., Yeager, M. & Chanock, S. J., Jun 13 2016, In : Nature Communications. 7, 11843.

Research output: Contribution to journalArticle

Mosaicism
chromosomes
X Chromosome
Chromosomes
Sex Chromosomes
3 Citations (Scopus)

Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer

Li, L., Zhang, J. W., Jenkins, G., Xie, F., Carlson, E. E., Fridley, B. L., Bamlet, W. R., Petersen, G. M., Mc Williams, R. R. & Wang, L. M., Oct 4 2016, (Accepted/In press) In : Pharmacogenetics and Genomics.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Single Nucleotide Polymorphism
Cell Line
Gene Knockdown Techniques
15 Citations (Scopus)

Integrated genomic analysis of pancreatic ductal adenocarcinomas reveals genomic rearrangement events as significant drivers of disease

Murphy, S. J., Hart, S., Halling, G. C., Johnson, S. H., Smadbeck, J., Drucker, T., Lima, J. F., Rohakhtar, F. R., Harris, F. R., Kosari, F., Subramanian, S., Petersen, G. M., Wiltshire, T. D., Kipp, B. R., Truty, M., Mc Williams, R. R., Couch, F. J. & Vasmatzis, G., Feb 1 2016, In : Cancer Research. 76, 3, p. 749-761 13 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Disease Progression
Genes
Exome
Gene Dosage
17 Citations (Scopus)

Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: Determination of frequency and distribution pattern

Al-Shamsi, H. O., Jones, J., Fahmawi, Y., Dahbour, I., Tabash, A., Abdel-Wahab, R., Abousamra, A. O. S., Shaw, K. R., Xiao, L., Hassan, M. M., Kipp, B. R., Kopetz, S., Soliman, A. S., Mc Williams, R. R. & Wolff, R. A., 2016, In : Journal of Gastrointestinal Oncology. 7, 6, p. 882-902 21 p.

Research output: Contribution to journalArticle

APC Genes
Mutation Rate
Colorectal Neoplasms
Mutation
Population
15 Citations (Scopus)

Phase I Study of CHK1 Inhibitor LY2603618 in Combination with Gemcitabine in Patients with Solid Tumors

Calvo, E., Braiteh, F., Von Hoff, D., Mc Williams, R. R., Becerra, C., Galsky, M. D., Jameson, G., Lin, J., McKane, S., Wickremsinhe, E. R., Hynes, S. M., Bence Lin, A., Hurt, K. & Richards, D., Sep 7 2016, (Accepted/In press) In : Oncology (Switzerland).

Research output: Contribution to journalArticle

gemcitabine
Neoplasms
Non-Small Cell Lung Carcinoma
Pharmacokinetics
Antimetabolites
30 Citations (Scopus)

Phase I study of DMOT4039A, an antibody-drug conjugate targeting mesothelin, in patients with unresectable pancreatic or platinum-resistant ovarian cancer

Weekes, C. D., Lamberts, L. E., Borad, M. J., Voortman, J., Mc Williams, R. R., Diamond, J. R., De Vries, E. G. E., Verheul, H. M., Lieu, C. H., Kim, G. P., Wang, Y., Scales, S. J., Samineni, D., Brunstein, F., Choi, Y., Maslyar, D. J. & Colon-Otero, G., Mar 1 2016, In : Molecular Cancer Therapeutics. 15, 3, p. 439-447 9 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Platinum
Ovarian Neoplasms
Appointments and Schedules
Pancreatic Neoplasms
57 Citations (Scopus)

Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients

Hu, C., Hart, S., Bamlet, W. R., Moore, R. M., Nandakumar, K., Eckloff, B. W., Lee, Y. K., Petersen, G. M., Mc Williams, R. R. & Couch, F. J., Jan 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 1, p. 207-211 5 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Pancreatic Neoplasms
Mutation
Adenocarcinoma
Germ-Line Mutation
20 Citations (Scopus)

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

Mc Williams, R. R., Maisonneuve, P., Bamlet, W. R., Petersen, G. M., Li, D., Risch, H. A., Yu, H., Fontham, E. T. H., Luckett, B., Bosetti, C., Negri, E., La Vecchia, C., Talamini, R., De Mesquita, H. B. B., Bracci, P., Gallinger, S., Neale, R. E. & Lowenfels, A. B., Feb 1 2016, In : Pancreas. 45, 2, p. 311-316 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Alcohols
Obesity
Smoking
43 Citations (Scopus)

The use of pembrolizumab for the treatment of metastatic uveal melanoma

Kottschade, L. A., Mc Williams, R. R., Markovic, S. N., Block, M. S., Villasboas Bisneto, J. J. C. ., Pham, A. Q., Esplin, B. L. & Dronca, R. S., Feb 4 2016, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

Therapeutics
Uveal melanoma
pembrolizumab
Central Nervous System Diseases
Disease-Free Survival
2015
101 Citations (Scopus)

BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study

Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Cote, M. L., Mc Williams, R. R., Roberts, N. J., Cannon-Albright, L. A., Li, D., Moyes, K., Wenstrup, R. J., Hartman, A. R., Seminara, D., Klein, A. P. & Petersen, G. M., Jul 2 2015, In : Genetics in Medicine. 17, 7, p. 569-577 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genetic Testing
Genes
Viverridae
3 Citations (Scopus)

BRCA2-associated pancreatic cancer and current screening guidelines

Kasi, P. M., Pedersen, K. S. & Mc Williams, R. R., Sep 1 2015, In : Cancer. 121, 17, p. 3046 1 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Guidelines
45 Citations (Scopus)

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., Mc Williams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American Journal of Human Genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

Mosaicism
Genome-Wide Association Study
Meta-Analysis
Genome
Population
61 Citations (Scopus)

Clinical trial designs for rare diseases: Studies developed and discussed by the International Rare Cancers Initiative

Bogaerts, J., Sydes, M. R., Keat, N., McConnell, A., Benson, A., Ho, A., Roth, A., Fortpied, C., Eng, C., Peckitt, C., Coens, C., Pettaway, C., Arnold, D., Hall, E., Marshall, E., Sclafani, F., Hatcher, H., Earl, H., Ray-Coquard, I., Paul, J. & 26 others, Blay, J. Y., Whelan, J., Panageas, K., Wheatley, K., Harrington, K., Licitra, L., Billingham, L., Hensley, M., McCabe, M., Patel, P. M., Carvajal, R., Wilson, R., Glynne-Jones, R., Mc Williams, R. R., Leyvraz, S., Rao, S., Nicholson, S., Filiaci, V., Negrouk, A., Lacombe, D., Dupont, E., Pauporté, I., Welch, J. J., Law, K., Trimble, T. & Seymour, M., 2015, In : European Journal of Cancer. 51, 3, p. 271-281 11 p.

Research output: Contribution to journalArticle

Rare Diseases
Clinical Trials
Neoplasms
Research
Randomized Controlled Trials
21 Citations (Scopus)

Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: A Mayo Clinic phase II consortium study

Pedersen, K. S., Kim, G. P., Foster, N. R., Wang-Gillam, A., Erlichman, C. & Mc Williams, R. R., Aug 1 2015, In : Investigational New Drugs. 33, 4, p. 963-968 6 p.

Research output: Contribution to journalArticle

tanespimycin
gemcitabine
Pancreatic Neoplasms
HSP90 Heat-Shock Proteins
Medical Futility

Should vital signs be routinely obtained prior to intravenous chemotherapy? Results from a 2-center study

Menon, S., Foster, N. R., Looker, S., Sorgatz, K., Kasi, P. M., Mc Williams, R. R. & Jatoi, A., Oct 1 2015, In : Cancer Control. 22, 4, p. 515-519 5 p.

Research output: Contribution to journalArticle

Vital Signs
Drug Therapy
Hospital Emergency Service
Hospitalization
gemcitabine
25 Citations (Scopus)
Phosphotransferases
Survival
Therapeutics
Eye Neoplasms
Proxy
2014
25 Citations (Scopus)

Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: A gene- and pathway-based interaction analysis of GWAS data

Tang, H., Wei, P., Duell, E. J., Risch, H. A., Olson, S. H., Bueno-de-Mesquita, H. B., Gallinger, S., Holly, E. A., Petersen, G. M., Bracci, P. M., Mc Williams, R. R., Jenab, M., Riboli, E., Tjønneland, A., Boutron-Ruault, M. C., Kaaks, R., Trichopoulos, D., Panico, S., Sund, M., Peeters, P. H. M. & 3 others, Khaw, K. T., Amos, C. I. & Li, D., 2014, In : Carcinogenesis. 35, 5, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Pancreatic Neoplasms
Smoking
Genes
Single Nucleotide Polymorphism
122 Citations (Scopus)

Combined BRAF (dabrafenib) and MEK inhibition (trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor

Johnson, D. B., Flaherty, K. T., Weber, J. S., Infante, J. R., Kim, K. B., Kefford, R. F., Hamid, O., Schuchter, L., Cebon, J., Sharfman, W. H., Mc Williams, R. R., Sznol, M., Lawrence, D. P., Gibney, G. T., Burris, H. A., Falchook, G. S., Algazi, A., Lewis, K., Long, G. V., Patel, K. & 7 others, Ibrahim, N., Sun, P., Little, S., Cunningham, E., Sosman, J. A., Daud, A. & Gonzalez, R., Nov 20 2014, In : Journal of Clinical Oncology. 32, 33, p. 3697-3704 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Disease-Free Survival
Therapeutics
Safety
88 Citations (Scopus)

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

Graham, R., Barr Fritcher, E. G., Pestova, E., Schulz, J., Sitailo, L. A., Vasmatzis, G., Murphy, S. J., Mc Williams, R. R., Hart, S., Halling, K. C., Roberts, L. R., Gores, G. J., Couch, F. J., Zhang, L., Borad, M. J. & Kipp, B. R., 2014, In : Human Pathology. 45, 8, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Cholangiocarcinoma
Bile Duct Neoplasms
Neoplasms
Fluorescence In Situ Hybridization