• 4799 Citations
  • 37 Scopus h-Index
1987 …2020

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Article
2020

Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry

Pignolo, R. J., Cheung, K., Kile, S., Fitzpatrick, M. A., De Cunto, C., Al Mukaddam, M., Hsiao, E. C., Baujat, G., Delai, P., Eekhoff, E. M. W., Di Rocco, M., Grunwald, Z., Haga, N., Keen, R., Levi, B., Morhart, R., Scott, C., Sherman, A., Zhang, K. & Kaplan, F. S., May 2020, In : Bone. 134, 115274.

Research output: Contribution to journalArticle

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F. & Pignolo, R. J., Jun 1 2020, In : Journal of Bone and Mineral Research. 35, 6, p. 1119-1131 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R. J., Sep 1 2019, In : Journal of the American Geriatrics Society. 67, 9, p. 1934-1939 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification

Gupta, A., Zimmermann, M. T., Wang, H., Broski, S. M., Sigafoos, A. N., Macklin, S. K., Urrutia, R. A., Clark, K. J., Atwal, P. S., Pignolo, R. J. & Klee, E. W., Jan 1 2019, In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

3 Scopus citations

Natural history of fibrodysplasia ossificans progressiva: Cross-sectional analysis of annotated baseline phenotypes

Pignolo, R. J., Baujat, G., Brown, M. A., De Cunto, C., Dirocco, M., Hsiao, E. C., Keen, R., Al Mukaddam, M., Sang, K. H. L. Q., Wilson, A., White, B., Grogan, D. R. & Kaplan, F. S., May 3 2019, In : Orphanet Journal of Rare Diseases. 14, 1, 98.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Potential role of senescence in radiation-induced damage of the aged skeleton

Chandra, A., Park, S. S. & Pignolo, R., Mar 1 2019, In : Bone. 120, p. 423-431 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations
2018

A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings

Amalfitano, M., Fyfe, B., Thomas, S. V., Egan, K. P., Xu, M., Smith, A. G., Kaplan, F. S., Shore, E. M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 56-60 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
13 Scopus citations

Acute and chronic rapamycin use in patients with Fibrodysplasia Ossificans Progressiva: A report of two cases

Kaplan, F. S., Zeitlin, L., Dunn, S. P., Benor, S., Hagin, D., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 281-284 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Acute unilateral hip pain in fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 115-119 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP)

Lindborg, C. M., Brennan, T. A., Wang, H., Kaplan, F. S. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 153-157 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Circulating osteogentic precursor cells in non-hereditary heterotopic ossification

Egan, K. P., Duque, G., Keenan, M. A. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 61-64 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva

Wentworth, K. L., Bigay, K., Chan, T. V., Ho, J. P., Morales, B. M., Connor, J., Brooks, E., Shahriar Salamat, M., Sanchez, H. C., Wool, G., Pignolo, R., Kaplan, F. S. & Hsiao, E. C., Apr 1 2018, In : Bone. 109, p. 104-110 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical staging of Fibrodysplasia Ossificans Progressiva (FOP)

Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 111-114 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Diagnosis and management of pseudohypoparathyroidism and related disorders: First international Consensus Statement

Mantovani, G., Bastepe, M., Monk, D., De Sanctis, L., Thiele, S., Usardi, A., Ahmed, S. F., Bufo, R., Choplin, T., De Filippo, G., Devernois, G., Eggermann, T., Elli, F. M., Freson, K., García Ramirez, A., Germain-Lee, E. L., Groussin, L., Hamdy, N., Hanna, P., Hiort, O. & 26 others, Jüppner, H., Kamenický, P., Knight, N., Kottler, M. L., Le Norcy, E., Lecumberri, B., Levine, M. A., Mäkitie, O., Martin, R., Martos-Moreno, G. Á., Minagawa, M., Murray, P., Pereda, A., Pignolo, R., Rejnmark, L., Rodado, R., Rothenbuhler, A., Saraff, V., Shoemaker, A. H., Shore, E. M., Silve, C., Turan, S., Woods, P., Carola Zillikens, M., De Nanclares, G. P. & Linglart, A., Aug 1 2018, In : Nature Reviews Endocrinology. 14, 8, p. 476-500 25 p.

Research output: Contribution to journalArticle

33 Scopus citations

Early clinical observations on the use of imatinib mesylate in FOP: A report of seven cases

Kaplan, F. S., Andolina, J. R., Adamson, P. C., Teachey, D. T., Finklestein, J. Z., Ebb, D. H., Whitehead, B., Jacobs, B., Siegel, D. M., Keen, R., Hsiao, E. & Pignolo, R. J., Apr 2018, In : Bone. 109, p. 276-280 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

ECSIT links TLR and BMP signaling in FOP connective tissue progenitor cells

Wang, H., Behrens, E. M., Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 201-209 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Histopathology of periarticular non-hereditary heterotopic ossification

Foley, K. L., Hebela, N., Keenan, M. A. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 65-70 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Imaging assessment of fibrodysplasia ossificans progressiva: Qualitative, quantitative and questionable

Al Mukaddam, M., Rajapakse, C. S., Pignolo, R. J., Kaplan, F. S. & Smith, S. E., Apr 2018, In : Bone. 109, p. 147-152 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Joint-specific risk of impaired function in fibrodysplasia ossificans progressiva (FOP)

Pignolo, R., Durbin-Johnson, B. P., Rocke, D. M. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 124-133 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Longitudinal patient-reported mobility assessment in fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 158-161 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)

Brennan, T. A., Lindborg, C. M., Bergbauer, C. R., Wang, H., Kaplan, F. S. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 259-266 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Prevalence and risk factors for kidney stones in fibrodysplasia ossificans progressiva

Gupta, R. R., Delai, P. L. R., Glaser, D. L., Rocke, D. M., Al Mukaddam, M., Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 120-123 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis

Chandra, A., Wang, L., Young, T., Zhong, L., Tseng, W. J., Levine, M. A., Cengel, K., Sherry Liu, X., Zhang, Y., Pignolo, R. J. & Qin, L., Jan 2018, In : FASEB Journal. 32, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Serum Vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein

Aumailley, L., Dubois, M. J., Brennan, T. A., Garand, C., Paquet, E. R., Pignolo, R., Marette, A. & Lebel, M., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3623-3640 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

The FOP Connection Registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva

Mantick, N., Bachman, E., Baujat, G., Brown, M., Collins, O., De Cunto, C., Delai, P., Eekhoff, M., zum Felde, R., Grogan, D. R., Haga, N., Hsiao, E., Kantanie, S., Kaplan, F., Keen, R., Milosevic, J., Morhart, R., Pignolo, R., Qian, X., di Rocco, M. & 6 others, Scott, C., Sherman, A., Wallace, M., Williams, N., Zhang, K. & Bogard, B., Apr 1 2018, In : Bone. 109, p. 285-290 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A cumulative analogue joint involvement scale (CAJIS) for fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R. J., Aug 1 2017, In : Bone. 101, p. 123-128 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study

Gunawardene, P., Al Saedi, A., Singh, L., Bermeo, S., Vogrin, S., Phu, S., Suriyaarachchi, P., Pignolo, R. & Duque, G., Oct 1 2017, In : Experimental Gerontology. 96, p. 68-72 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Analog Method for Radiographic Assessment of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva

Rajapakse, C. S., Lindborg, C., Wang, H., Newman, B. T., Kobe, E. A., Chang, G., Shore, E. M., Kaplan, F. S. & Pignolo, R., Mar 1 2017, In : Academic Radiology. 24, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways

Ramaswamy, G., Kim, H., Zhang, D., Lounev, V., Wu, J. Y., Choi, Y., Kaplan, F. S., Pignolo, R. & Shore, E. M., Mar 24 2017, In : Scientific Reports. 7, 45140.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

202 Scopus citations

The congenital great toe malformation of fibrodysplasia ossificans progressiva? - A close call

Towler, O. W., Shore, E. M., Xu, M., Bamford, A., Anderson, I., Pignolo, R. J. & Kaplan, F. S., Jul 2017, In : European Journal of Medical Genetics. 60, 7, p. 399-402 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage

Singh, L., Brennan, T. A., Russell, E., Kim, J. H., Chen, Q., Brad Johnson, F. & Pignolo, R., Apr 1 2016, In : Bone. 85, p. 29-36 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

Wang, H., Lindborg, C., Lounev, V., Kim, J. H., McCarrick-Walmsley, R., Xu, M., Mangiavini, L., Groppe, J. C., Shore, E. M., Schipani, E., Kaplan, F. S. & Pignolo, R. J., Sep 1 2016, In : Journal of Bone and Mineral Research. 31, 9, p. 1652-1665 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

96 Scopus citations

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Adler, R. A., El-Hajj Fuleihan, G., Bauer, D. C., Camacho, P. M., Clarke, B., Clines, G. A., Compston, J. E., Drake, M. M., Edwards, B. J., Favus, M. J., Greenspan, S. L., McKinney, R., Pignolo, R. & Sellmeyer, D. E., Jan 1 2016, In : Journal of Bone and Mineral Research. 31, 1, p. 16-35 20 p.

Research output: Contribution to journalArticle

252 Scopus citations

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Adler, R. A., El-Hajj Fuleihan, G., Bauer, D. C., Camacho, P. M., Clarke, B., Clines, G. A., Compston, J. E., Drake, M. M., Edwards, B. J., Favus, M. J., Greenspan, S. L., Mckinney, R., Pignolo, R. & Sellmeyer, D. E., 2016, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

27 Scopus citations

The Natural History of Flare-Ups in Fibrodysplasia Ossificans Progressiva (FOP): A Comprehensive Global Assessment

Pignolo, R., Bedford-Gay, C., Liljesthröm, M., Durbin-Johnson, B. P., Shore, E. M., Rocke, D. M. & Kaplan, F. S., Mar 1 2016, In : Journal of Bone and Mineral Research. 31, 3, p. 650-656 7 p.

Research output: Contribution to journalArticle

65 Scopus citations
2015

Clopidogrel enhances mesenchymal stem cell proliferation following periodontitis

Coimbra, L. S., Steffens, J. P., Alsadun, S., Albiero, M. L., Rossa, C., Pignolo, R., Spolidorio, L. C. & Graves, D. T., Jan 1 2015, In : Journal of Dental Research. 94, 12, p. 1691-1697 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Conservation of pro-longevity genes among mammals

Lindborg, C. M., Propert, K. J. & Pignolo, R. J., Mar 1 2015, In : Mechanisms of Ageing and Development. 146-148, p. 23-27 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism

Ko, K. I., Coimbra, L. S., Tian, C., Alblowi, J., Kayal, R. A., Einhorn, T. A., Gerstenfeld, L. C., Pignolo, R. J. & Graves, D. T., Feb 6 2015, In : Diabetologia. 58, 3, p. 633-642 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients

Kaplan, F. S., Kobori, J. A., Orellana, C., Calvo, I., Rosello, M., Martinez, F., Lopez, B., Xu, M., Pignolo, R. J., Shore, E. M. & Groppe, J. C., Oct 1 2015, In : American Journal of Medical Genetics, Part A. 167, 10, p. 2265-2271 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Teriparatide as a systemic treatment for lower extremity nonunion fractures: A case series

Mancilla, E. E., Brodsky, J. L., Mehta, S., Pignolo, R. J. & Levine, M. A., Feb 1 2015, In : Endocrine Practice. 21, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

Brennan, T. A., Egan, K. P., Lindborg, C. M., Chen, Q., Sweetwyne, M. T., Hankenson, K. D., Xie, S. X., Johnson, F. B. & Pignolo, R. J., May 2014, In : DMM Disease Models and Mechanisms. 7, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Brief report: Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging

Singh, L., Brennan, T. A., Kim, J. H., Egan, K. P., McMillan, E. A., Chen, Q., Hankenson, K. D., Zhang, Y., Emerson, S. G., Johnson, F. B. & Pignolo, R. J., Mar 1 2013, In : Stem Cells. 31, 3, p. 607-611 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

R-spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis

Wang, H., Brennan, T. A., Russell, E., Kim, J. H., Egan, K. P., Chen, Q., Israelite, C., Schultz, D. C., Johnson, F. B. & Pignolo, R. J., Dec 1 2013, In : Journal of Molecular Medicine. 91, 12, p. 1421-1429 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia

Cairns, D. M., Pignolo, R. J., Uchimura, T., Brennan, T. A., Lindborg, C. M., Xu, M., Kaplan, F. S., Shore, E. M. & Zeng, L., Aug 1 2013, In : Journal of Clinical Investigation. 123, 8, p. 3624-3633 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Bone histomorphometry using free and commonly available software

Egan, K. P., Brennan, T. A. & Pignolo, R. J., Dec 1 2012, In : Histopathology. 61, 6, p. 1168-1173 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

CNS demyelination in fibrodysplasia ossificans progressiva

Kan, L., Kitterman, J. A., Procissi, D., Chakkalakal, S., Peng, C. Y., McGuire, T. L., Goldsby, R. E., Pignolo, R. J., Shore, E. M., Kaplan, F. S. & Kessler, J. A., Dec 1 2012, In : Journal of Neurology. 259, 12, p. 2644-2655 12 p.

Research output: Contribution to journalArticle

22 Scopus citations