• 4725 Citations
  • 36 Scopus h-Index
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ (EBioMedicine (2019) 47 (446–456), (S2352396419305912), (10.1016/j.ebiom.2019.08.069))

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 18 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Allison, D. B., Dickinson, S. L., Ejima, K., Atkinson, E. J., Lenburg, M., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Feb 2020, In : EBioMedicine. 52, 102595.

Research output: Contribution to journalComment/debate

Open Access

Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva

Pignolo, R. J. & Kaplan, F. S., Apr 2 2020, In : Expert Opinion on Orphan Drugs. 8, 4, p. 101-109 9 p.

Research output: Contribution to journalReview article

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome

Pignolo, R. J., Wang, H. & Kaplan, F. S., Jan 10 2020, In : Frontiers in Endocrinology. 10, 908.

Research output: Contribution to journalReview article

Open Access

Reducing Senescent Cell Burden in Aging and Disease

Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T. & Kirkland, J. L., Jan 1 2020, (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry

Pignolo, R. J., Cheung, K., Kile, S., Fitzpatrick, M. A., De Cunto, C., Al Mukaddam, M., Hsiao, E. C., Baujat, G., Delai, P., Eekhoff, E. M. W., Di Rocco, M., Grunwald, Z., Haga, N., Keen, R., Levi, B., Morhart, R., Scott, C., Sherman, A., Zhang, K. & Kaplan, F. S., May 2020, In : Bone. 134, 115274.

Research output: Contribution to journalArticle

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F. & Pignolo, R. J., Jan 1 2020, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Assessing and Counseling the Older Driver: A Concise Review for the Generalist Clinician

Hill, L. J. N., Pignolo, R. J. & Tung, E. E., Aug 2019, In : Mayo Clinic proceedings. 94, 8, p. 1582-1588 7 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Correction to: Natural history of fibrodysplasia ossificans progressiva: Cross-sectional analysis of annotated baseline phenotypes (Orphanet J Rare Dis (2019) 14 (98) DOI: 10.1186/s13023-019-1068-7)

Pignolo, R. J., Baujat, G., Brown, M. A., De Cunto, C., Di Rocco, M., Hsiao, E. C., Keen, R., Al Mukaddam, M., Sang, K. H. L. Q., Wilson, A., White, B., Grogan, D. R. & Kaplan, F. S., May 23 2019, In : Orphanet Journal of Rare Diseases. 14, 1, 113.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R. J., Sep 1 2019, In : Journal of the American Geriatrics Society. 67, 9, p. 1934-1939 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Exceptional Human Longevity

Pignolo, R., Jan 1 2019, In : Mayo Clinic Proceedings. 94, 1, p. 110-124 15 p.

Research output: Contribution to journalReview article

10 Scopus citations

Feasibility of medical image-based bio 3D printing of variable tissue compositions

Shinde, R., Nigh, D. J. P., Miguez, S. M., Rhodes, S. S., Udupa, J. K., Shetye, S., Chandra, A., Pignolo, R. & Rajapakse, C. S., Jan 1 2019, Medical Imaging 2019: Imaging Informatics for Healthcare, Research, and Applications. Bak, P. R. & Chen, P-H. (eds.). SPIE, 1095409. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10954).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification

Gupta, A., Zimmermann, M. T., Wang, H., Broski, S. M., Sigafoos, A. N., Macklin, S. K., Urrutia, R. A., Clark, K. J., Atwal, P. S., Pignolo, R. J. & Klee, E. W., Jan 1 2019, In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

2 Scopus citations

Natural history of fibrodysplasia ossificans progressiva: Cross-sectional analysis of annotated baseline phenotypes

Pignolo, R. J., Baujat, G., Brown, M. A., De Cunto, C., Dirocco, M., Hsiao, E. C., Keen, R., Al Mukaddam, M., Sang, K. H. L. Q., Wilson, A., White, B., Grogan, D. R. & Kaplan, F. S., May 3 2019, In : Orphanet Journal of Rare Diseases. 14, 1, 98.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Potential role of senescence in radiation-induced damage of the aged skeleton

Chandra, A., Park, S. S. & Pignolo, R., Mar 1 2019, In : Bone. 120, p. 423-431 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP)

Hsiao, E. C., Di Rocco, M., Cali, A., Zasloff, M., Al Mukaddam, M., Pignolo, R. J., Grunwald, Z., Netelenbos, C., Keen, R., Baujat, G., Brown, M. A., Cho, T. J., De Cunto, C., Delai, P., Haga, N., Morhart, R., Scott, C., Zhang, K., Diecidue, R. J., Friedman, C. S. & 2 others, Kaplan, F. S. & Eekhoff, E. M. W., Jun 2019, In : British Journal of Clinical Pharmacology. 85, 6, p. 1199-1207 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

Targeting Cell Senescence for the Treatment of Age-Related Bone Loss

Pignolo, R., Samsonraj, R. M., Law, S. F., Wang, H. & Chandra, A., Apr 15 2019, In : Current Osteoporosis Reports. 17, 2, p. 70-85 16 p.

Research output: Contribution to journalReview article

4 Scopus citations
2018

A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings

Amalfitano, M., Fyfe, B., Thomas, S. V., Egan, K. P., Xu, M., Smith, A. G., Kaplan, F. S., Shore, E. M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 56-60 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
13 Scopus citations

Acute and chronic rapamycin use in patients with Fibrodysplasia Ossificans Progressiva: A report of two cases

Kaplan, F. S., Zeitlin, L., Dunn, S. P., Benor, S., Hagin, D., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 281-284 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Acute unilateral hip pain in fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 115-119 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP)

Lindborg, C. M., Brennan, T. A., Wang, H., Kaplan, F. S. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 153-157 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Circulating osteogentic precursor cells in non-hereditary heterotopic ossification

Egan, K. P., Duque, G., Keenan, M. A. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 61-64 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva

Wentworth, K. L., Bigay, K., Chan, T. V., Ho, J. P., Morales, B. M., Connor, J., Brooks, E., Shahriar Salamat, M., Sanchez, H. C., Wool, G., Pignolo, R., Kaplan, F. S. & Hsiao, E. C., Apr 1 2018, In : Bone. 109, p. 104-110 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Clinical staging of Fibrodysplasia Ossificans Progressiva (FOP)

Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 111-114 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Diagnosis and management of pseudohypoparathyroidism and related disorders: First international Consensus Statement

Mantovani, G., Bastepe, M., Monk, D., De Sanctis, L., Thiele, S., Usardi, A., Ahmed, S. F., Bufo, R., Choplin, T., De Filippo, G., Devernois, G., Eggermann, T., Elli, F. M., Freson, K., García Ramirez, A., Germain-Lee, E. L., Groussin, L., Hamdy, N., Hanna, P., Hiort, O. & 26 others, Jüppner, H., Kamenický, P., Knight, N., Kottler, M. L., Le Norcy, E., Lecumberri, B., Levine, M. A., Mäkitie, O., Martin, R., Martos-Moreno, G. Á., Minagawa, M., Murray, P., Pereda, A., Pignolo, R., Rejnmark, L., Rodado, R., Rothenbuhler, A., Saraff, V., Shoemaker, A. H., Shore, E. M., Silve, C., Turan, S., Woods, P., Carola Zillikens, M., De Nanclares, G. P. & Linglart, A., Aug 1 2018, In : Nature Reviews Endocrinology. 14, 8, p. 476-500 25 p.

Research output: Contribution to journalArticle

32 Scopus citations

Early clinical observations on the use of imatinib mesylate in FOP: A report of seven cases

Kaplan, F. S., Andolina, J. R., Adamson, P. C., Teachey, D. T., Finklestein, J. Z., Ebb, D. H., Whitehead, B., Jacobs, B., Siegel, D. M., Keen, R., Hsiao, E. & Pignolo, R. J., Apr 2018, In : Bone. 109, p. 276-280 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

ECSIT links TLR and BMP signaling in FOP connective tissue progenitor cells

Wang, H., Behrens, E. M., Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 201-209 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Genetic disorders of heterotopic ossification: Fibrodysplasia ossificans progressiva and progressive osseous heteroplasia

Kaplan, F. S., Pignolo, R., Mukaddam, M. A. & Shore, E. M., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 865-870 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Heterotopic Ossification: The Keys to the Kingdom

Kaplan, F. S., Pignolo, R. & Shore, E. M., Apr 1 2018, In : Bone. 109, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Histopathology of periarticular non-hereditary heterotopic ossification

Foley, K. L., Hebela, N., Keenan, M. A. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 65-70 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Imaging assessment of fibrodysplasia ossificans progressiva: Qualitative, quantitative and questionable

Al Mukaddam, M., Rajapakse, C. S., Pignolo, R. J., Kaplan, F. S. & Smith, S. E., Apr 2018, In : Bone. 109, p. 147-152 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Joint-specific risk of impaired function in fibrodysplasia ossificans progressiva (FOP)

Pignolo, R., Durbin-Johnson, B. P., Rocke, D. M. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 124-133 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Longitudinal patient-reported mobility assessment in fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 158-161 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)

Brennan, T. A., Lindborg, C. M., Bergbauer, C. R., Wang, H., Kaplan, F. S. & Pignolo, R., Apr 1 2018, In : Bone. 109, p. 259-266 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Prevalence and risk factors for kidney stones in fibrodysplasia ossificans progressiva

Gupta, R. R., Delai, P. L. R., Glaser, D. L., Rocke, D. M., Al Mukaddam, M., Pignolo, R. & Kaplan, F. S., Apr 1 2018, In : Bone. 109, p. 120-123 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis

Chandra, A., Wang, L., Young, T., Zhong, L., Tseng, W. J., Levine, M. A., Cengel, K., Sherry Liu, X., Zhang, Y., Pignolo, R. J. & Qin, L., Jan 2018, In : FASEB Journal. 32, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Serum Vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein

Aumailley, L., Dubois, M. J., Brennan, T. A., Garand, C., Paquet, E. R., Pignolo, R., Marette, A. & Lebel, M., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3623-3640 18 p.

Research output: Contribution to journalArticle

1 Scopus citations

The FOP Connection Registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva

Mantick, N., Bachman, E., Baujat, G., Brown, M., Collins, O., De Cunto, C., Delai, P., Eekhoff, M., zum Felde, R., Grogan, D. R., Haga, N., Hsiao, E., Kantanie, S., Kaplan, F., Keen, R., Milosevic, J., Morhart, R., Pignolo, R., Qian, X., di Rocco, M. & 6 others, Scott, C., Sherman, A., Wallace, M., Williams, N., Zhang, K. & Bogard, B., Apr 1 2018, In : Bone. 109, p. 285-290 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A cumulative analogue joint involvement scale (CAJIS) for fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Al Mukaddam, M. & Pignolo, R. J., Aug 1 2017, In : Bone. 101, p. 123-128 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study

Gunawardene, P., Al Saedi, A., Singh, L., Bermeo, S., Vogrin, S., Phu, S., Suriyaarachchi, P., Pignolo, R. & Duque, G., Oct 1 2017, In : Experimental Gerontology. 96, p. 68-72 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Analog Method for Radiographic Assessment of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva

Rajapakse, C. S., Lindborg, C., Wang, H., Newman, B. T., Kobe, E. A., Chang, G., Shore, E. M., Kaplan, F. S. & Pignolo, R., Mar 1 2017, In : Academic Radiology. 24, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Feasibility of fabricating personalized 3D-printed bone grafts guided by high-resolution imaging

Hong, A. L., Newman, B. T., Khalid, A., Teter, O. M., Kobe, E. A., Shukurova, M., Shinde, R., Sipzner, D., Pignolo, R., Udupa, J. K. & Rajapakse, C. S., Jan 1 2017, Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications. Cook, T. S. & Zhang, J. (eds.). SPIE, Vol. 10138. 101380O

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways

Ramaswamy, G., Kim, H., Zhang, D., Lounev, V., Wu, J. Y., Choi, Y., Kaplan, F. S., Pignolo, R. & Shore, E. M., Mar 24 2017, In : Scientific Reports. 7, 45140.

Research output: Contribution to journalArticle

6 Scopus citations

Hard targets for a second skeleton: therapeutic horizons for fibrodysplasia ossificans progressiva (FOP)

Kaplan, F. S., Pignolo, R., Al Mukaddam, M. M. & Shore, E. M., Apr 3 2017, In : Expert Opinion on Orphan Drugs. 5, 4, p. 291-294 4 p.

Research output: Contribution to journalEditorial

16 Scopus citations

International physician survey on management of FOP: A modified Delphi study

Di Rocco, M., Baujat, G., Bertamino, M., Brown, M., De Cunto, C. L., Delai, P. L. R., Eekhoff, E. M. W., Haga, N., Hsiao, E., Keen, R., Morhart, R., Pignolo, R. & Kaplan, F. S., Jun 12 2017, In : Orphanet Journal of Rare Diseases. 12, 1, 110.

Research output: Contribution to journalReview article

4 Scopus citations

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

190 Scopus citations

The congenital great toe malformation of fibrodysplasia ossificans progressiva? - A close call

Towler, O. W., Shore, E. M., Xu, M., Bamford, A., Anderson, I., Pignolo, R. J. & Kaplan, F. S., Jul 2017, In : European Journal of Medical Genetics. 60, 7, p. 399-402 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage

Singh, L., Brennan, T. A., Russell, E., Kim, J. H., Chen, Q., Brad Johnson, F. & Pignolo, R., Apr 1 2016, In : Bone. 85, p. 29-36 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

Wang, H., Lindborg, C., Lounev, V., Kim, J. H., McCarrick-Walmsley, R., Xu, M., Mangiavini, L., Groppe, J. C., Shore, E. M., Schipani, E., Kaplan, F. S. & Pignolo, R. J., Sep 1 2016, In : Journal of Bone and Mineral Research. 31, 9, p. 1652-1665 14 p.

Research output: Contribution to journalArticle

50 Scopus citations